• Journal of the Society of Naval Architects of Korea
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• v.35 no.4
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• pp.46-54
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• 1998

In this paper, the erect of notch geometries on dynamic stress concentration was investigated by using the dynamic photoelasticity and the drop weight loading system Dynamic stress fields arisen by elastic wave through the loading system around various types of notch geometries were captured by using $10^6/sec$ frame rate Cranz-Shardin camera system with 12 photographic frames. We found that dynamic stress concentrations around the notch tip and comer were highly dependent on the change in notch geometries. The elders of dynamic stress singularity ware determined with respect to varying geometries of notches and we explained dynamic stress concentration in terms of the orders of dynamic stress singularity.

• KSBB Journal
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• v.28 no.1
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• pp.1-6
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• 2013

Curcumin has diverse anticancer activities that lead to tumor growth inhibition of cancer cells and induction of apoptosis. Curcumin is involved in the regulation of multiple genes via transcription factors including NF-${\kappa}B$, STATs, AP1, and SP. Notch signaling plays critical roles in maintaining the balance between cell proliferation, differentiation and apoptosis, and thereby may contribute to the development of various cancers involving breast cancer. This study was to investigate the effects of curcumin on Notch1 gene expression and to explore the underlying mechanism. Here, we found that curcumin decreased the levels of Notch1 mRNA and protein in MDA-MB-231 human breast cancer cells, along with the downregulation of Sp family genes (Sp1, Sp2, Sp3, and Sp4). The repressive effect of curcumin on Notch1 gene transcription was confirmed by performing Notch1 promoter-driven reporter assay and three Sp-binding sites were identified on Notch1 promoter that may act as curcumin-respose elements. Moreover, treatment with mitramycin A, a specific Sp inhibitor, decreased the levels of Notch1 mRNA and protein in human breast cancer cells. Taken together, our results indicate that Notch1 gene expression is downregulated by curcumin, at least in part, through the suppression of Sp family, which may lead to apoptosis in human breast cancer cells.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.3
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• pp.343-348
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• 2013

This experiment was conducted to evaluate the development of T cells in intrauterine growth retarded (IUGR) piglets at different gestational stages, and tentatively explore the relationship between T cells development and the Notch signaling pathway. A total of 18 crossbred (Landrace${\times}$Large white) primiparous sows were mated at similar weights and estruses and euthanized at d 60, 90 and 110 of gestation with six replicates for each time point. One IUGR and one normal fetus were picked from each litter. The T-cell subsets, mRNA expression of Delta-like1, Delta-like4, Jagged1, and Notch2 genes in the thymus were investigated. Compared to normal piglets, $CD3^+CD4^-CD8^+$ cells in IUGR fetuses at d 90 was 0.13% lower (p<0.05). At d 110 of gestation $CD8^+$ T cells in IUGR fetuses was 0.19% lower (p<0.05). The percentage of $CD8^+$ T cells was 3.14% lower (p<0.05) of the total T cells in IUGR pigs at d 60. The abundance of Notch2 and Delta-like4 mRNA at d 110 was 20.93% higher and 0.77% (p<0.05) lower, and Delta-like1 mRNA at d 90 was 0.19% (p<0.05) higher compared to normal pigs. These results suggested that normal fetuses had a greater proportion of T-cell subsets at earlier gestation periods, and the Notch signaling pathway was likely partially responsible for these differences to some degree.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.4
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• pp.918-928
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• 1995

This paper deals with the various mechanical properties and fatigue strength in the FRW1 (friction welded interface) of high speed steel (HSS-Co) to SM55C through the tensile test, hardness test and fatigue test. The data of FRW specimens are also compared with those of the base materials (HSS-Co and SM55C steel). Three kinds of specimens used in this study are the friction welded joints, HSS-Co and SM55C carbon steel with circumferential notch, saw notch and smooth, respectively. It is confirmed that the applied welding conditions are optimum methods in order to minimize the heat affected zone (HAZ) and hardness distribution at the HAZ. The fatigue strengths at N = 10$^{6}$ cycles of smooth, circumferential notch and saw notch specimens in the FRW joints are about 299.2 MPa, 123.8 MPa and 247.5 MPA, respectively. The fatigue strength of the friction welded joints is almost equal to that of the SM55C carbon steel in the optimum welding conditions. The fatigue cracks initiated at the welded zone are propagated along the side of SM55C steel.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.4
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• pp.929-940
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• 1995

The fatigue strength and fracture topography in the friction welded interface of high speed steel (HSS-Co) to SM55C carbon steel have been investigated through the fatigue test, SEM fractograph and EDS (energy dispersive spectrometer) analysis. Three kinds of specimens used in this research are the friction welded joints, HSS-Co and SM55C carbon steel with circumferential notch, saw notch and smooth, respectively. The notch sensitivity factor, .eta. of the friction welded joints is lower than that of the base materials, and that represents a superiority of the joint performance of FRW. Fracture topography of the FRW specimens with a notch showed a cleavage or brittle appearance, while that of the FRW smooth specimen appeared to be ductile. Furthermore, although fatigue crack likely initiated near the weld interface of the FRW smooth specimen, crack propagation continued into the HAZ of SM55C steel. Finally, fatigue fractures of the base materials were associated primarily with the inclusions located at the outer periphery of the specimen.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.26 no.4
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• pp.391-397
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• 2016

Vibration disturbances induced by the reaction wheels can severely degrade the performance of high precision payloads on board satellites with high pointing stability requirements. The unwanted disturbances produced by the reaction wheels are composed of fundamental harmonic disturbances due to the flywheel imbalance and sub/higher harmonic disturbances due to bearing irregularities, motor imperfections and so on. Because the wheel speed is constantly changed during the operation of a reaction wheel, the vibration disturbance induced by the reaction wheels can magnify the satellite vibration when the rotating frequency of wheel meets the natural frequency of satellite structure. In order to provide an effective isolation of the reaction wheel disturbances, isolation performance of a hybrid vibration isolator is investigated. In this paper, hybrid vibration isolator that combines passive and active components is developed and its hybrid isolation performance using notch filter control is evaluated in single-axis. The hybrid isolation performance using notch filter control show additional performance improvement compared to the results using only passive components.

• Journal of information and communication convergence engineering
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• v.8 no.4
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• pp.365-369
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• 2010

In this paper, a novel notch resonator is proposed based on Rectangular Split Ring Resonator (RRSS) element. We represented the electrical characteristics for R-SRR elements coupled with microstrip line, and measured result is compared with electromagnetic simulation (HFSS) result. We also solved equivalent circuit for R-SRR element, and also discussed influences of change structural parameters of R-SRR. The size of R-SRR is the most important parameters for frequency tuning. Also we can make tunable resonator form the basic structure. This novel resonator can apply to design of tunable bandpass filter and voltage control oscillator.

• Geomechanics and Engineering
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• v.33 no.4
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• pp.393-400
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• 2023

Displacements near crack and stress intensity factor (SIF) are key parameters to solve rock failure issue when using fracture mechanics. In order to study the horizontal displacement and stress intensity factor of the mode I fracture, a series of three-point bending tests of granite specimens with central notch were carried out. The evolution of horizontal displacements of precast notch and crack tip opening displacements (CTOD) were analyzed based on the digital image correlation (DIC) method. Stress intensity factors for three-point bending beams with arbitrary span-to-width ratios(S/W) were calculated by using the WU-Carlsson analytical weight function for edge-crack finite width plate and the analytical solution of un-cracked stress by Filon. The present study provides a high efficient and accurate method for fracture mechanics analysis of the three-point bending granite beams.

• Journal of Welding and Joining
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• v.4 no.3
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• pp.26-31
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• 1986

(1) Implant 용접저온귀열시험은 용접 열cycle에 따른 금속조직의 경향과 구속상태의 경향을 분 리하여 평가할 수 있는 사용한 시험법이다. (2) 한계파단응력(.sfgma.$_{cr}$ .)은 재료의 탄소다량( $C_{eq}$ .) 및 융접부 광산성수소량 ( $H_{D}$)과 밀접한 관계를 가지며 $C_{eq}$ . 및 $H_{D}$가 작을수록 .sfgma.$_{cr}$ .가 높다. (3) 시험편의 notch형상이 circular이든 spiral이든 한계파단응력은 동일하다. (4) 시험편의 파단은 notch로 부터 발생하기 시작하여 그 부분에서는 수소포화 의벽개파면은 나타낸다.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05c
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• pp.359-364
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• 1996

'93.4월에 고리원자력 4호기 운전중(원자로 출력 100%, 발전기 출력 975MWe) 주증기 차단밸브 (MSIV)의 닫힘으로 인해 발전소가 정지되었다. 밸브분해 점검결과 밸브스템이 Back Seat Ring 조립부위 Notch 부위에서 Steam Flow와 평행한 방향으로 절단되어, 밸브스템의 손상원인을 규명하기 위한 본 연구에서는 피로해석절차도에 따라 S-N 곡선에 근거하여 피로해석을 수행하였다. 피로해석결과 밸브스템의 초기균열 생성원인은 Stem Notch 부위의 제작결함과 발전소 정지시 밸브를 급속히 닫을 때 작용하는 충격하중등에 의해 발생된 것으로 추정되며 인장평균응력과 관내 유체의 진동하중의 변동응력이 조합하여 피로균열을 가속시켜 파손을 일으킨 것으로 사교된다.