• BMB Reports
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• v.46 no.4
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• pp.219-224
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• 2013

The cell-fate specification of the anchor cell (AC) and a ventral uterine precursor cell (VU) in Caenorhabditis elegans is initiated by a stochastic interaction between LIN-12/Notch receptor and LAG-2/Delta ligand in two neighboring Z1.ppp and Z4.aaa cells. Both cells express lin-12 and lag-2 before specification, and a small difference in LIN-12 activity leads to the exclusive expressions of lin-12 in VU and lag-2 in the AC, through a feedback mechanism of unknown nature. Here we show that the expression pattern of lag-1/CSL, a transcriptional repressor itself that turns into an activator upon binding of the intracellular domain of Notch, overlaps with that of lin-12. Site-directed mutagenesis of LAG-1 binding sites in lag-1 maintains its expression in the AC, and eliminates it in the VU. Thus, AC/VU cell-fate specification appears to involve direct regulation of lag-1 expression by the LAG-1 protein, activating its transcription in VU cells, but repressing it in the AC.

• The Korean Journal of Pain
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• v.25 no.3
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• pp.168-172
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• 2012

Background: The aim of the study was to investigate the feasibility of fluoroscopy-guided anterior approach for suprascapular nerve block (SSNB). Methods: Twenty patients with chronic shoulder pain were included in the study. All of the nerve blocks were performed with patients in a supine position. Fluoroscopy was tilted medially to obtain the best view of the scapular notch (medial angle) and caudally to put the base of coracoid process and scapular spine on same line (caudal angle). SSNB was performed by introducing a 100-mm, 21-gauge needle to the scapular notch with tunnel view technique. Following negative aspiration, 1.0 ml of contrast was injected to confirm the scapular notch, and 1 % mepivacaine 2 ml was slowly injected. The success of SSNB was assessed by numerical rating scale (NRS) before and after the block. Results: The average NRS was decreased from $4.8{\pm}0.6$ to $0.6{\pm}0.5$ after the procedure (P < 0.05). The best view of the scapular notch was obtained in a medial angle of $15.1{\pm}2.2$ ($11-19^{\circ}$) and a caudal angle of $15.4{\pm}1.7^{\circ}$ ($12-18^{\circ}$). The average distance from the skin to the scapular notch was $5.8{\pm}0.6$ cm. None of the complications such as pneumothorax, intravascular injection, and hematoma formation was found except one case of partial brachial plexus block. Conclusions: SSNB by fluoroscopy-guided anterior approach is a feasible technique. The advantage of using a fluoroscopy resulted in an effective block with a small dose of local anesthetics by an accurate placement of a tip of needle in the scapular notch while avoiding pneumothorax.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.42 no.1
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• pp.286-290
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• 2017

In this paper, we have proposed a hexagonal patch UWB antenna with a band notch characteristic where the notch band of 5.15 ~ 5.85 GHz band of WLAN was induced by inserting a circular slit in the patch. The impedance bandwidth of the proposed antenna meet the band width criteria of UWB communication system where is mentioned as frequencies range form 3.1 ~ 11.8 GHz. The characteristic band at 5.2 ~ 5.8 GHz notch band was observed. The radiation pattern of the antenna shows a directinal radiation pattern at $0^{\circ}$ and $180^{\circ}$ in XZ-plane and YZ-plane is an omni-directional pattern, respectively. In addition, it is observed that increase in frequency results in increases of the antenna gain whereas the notch band section is decreased. The proposed antenna was designed TRF-45 substrate with thickness of 1.62 mm, a loss tangent of 0.0035, a relative permittivity of 4.5 and designed were used Ansys Inc. HFSS.

• Journal of the Korea institute for structural maintenance and inspection
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• v.20 no.4
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• pp.51-58
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• 2016

Concrete structure is a construction material with durability and cost-benefit, however the corrosion in embedded steel causes a critical problem in structural safety. This paper presents an evaluation of chloride resistance and pull-off performance with various corrosion level. For the work, OPC(Ordinary Portland Cement) concrete and GGBFS(Ground Granulated Blast Furnace Slag) concrete are prepared with normal steel. Artificially notch induced FRP Hybrid Bar is also prepared and embedded in OPC concrete and accelerated corrosion test is performed. Through the test, FRP Hybrid Bar with notch is evaluated to have insignificant effect on pull-off capacity when corroded steel shows only 21% level of pull-off capacity. Furthermore GGBFS concrete with normal steel shows over 70% level of pull-off capacity due to reduced corrosion currency.

• Journal of the Korean Recycled Construction Resources Institute
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• v.11 no.3
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• pp.177-183
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• 2023

Various failure modes occur in the concrete beams reinforced with GFRP(Glass Fiber Reinforced Plastic) under initial condition and repairing patterns. In this study, the failure behaviors of concrete beams restrengthened with GFRP sheet with slightly higher elastic modulus than concrete were investigated. For the tests, concrete beams with 24 MPa were manufactured, and the effects of initial notch, overlapping, end-strip reinforcement, and fiber anchors were analyzed on failure load. The cases of GFRP overlap around notch and the initial notch showed increasing failure loads similar to those of normal restrengthened case since the epoxy of the saturated GFRP sufficiently repaired the notch area. Compared to the control case without restrengthening of GFRP, the concrete with initial notch showed 0.78 of loading ratio and normal restrengthening showed 4.43~5.61 times of increasing ratio of failure loading, where interface-debonding from flexural crack were mainly observed. The most ideal failure behavior, break of GFRP, was observed when end-strip over 1/3 height from bottom and fiber anchor were installed, which showed increasing failure load over 150 % to normal restrengthening.

• Journal of Advanced Marine Engineering and Technology
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• v.31 no.7
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• pp.857-862
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• 2007

A novel compact ultra wideband(UWB) antenna for UWB application is proposed in this paper. The proposed antenna with $22mm{\times}26mm{\times}1.6mm$ covers the entire UWB bandwidth and has band notch characteristic for the frequency band of $5.15{\sim}5.825GHz$ limited by WLAN. The antenna has a concaved ground plane and staircase shape patch to achieve the wide bandwidth, and has an U shape slot with $\lambda/4$ length to notch the band. The return loss and group delay of the proposed antenna are measured.

• Transactions of The Korea Fluid Power Systems Society
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• v.8 no.3
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• pp.14-20
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• 2011

This study aims at aligning multiple wafers to reduce wafer handling time in wafer processes. We designed a multilevel structure for a prealigner which can handle multiple wafer simultaneously in a system. The system consists of gripping parts, kinematic parts, vacuum chucks, pneumatic units, hall sensors and a DSP controller. Aligning procedure has two steps: mechanical gripping and notch finding. In the first step, a wafer is aligned in XY directions using 4-point mechanical contact. The rotational error can be found by detecting a signal in a notch using hall sensors. A dual prealigner was designed for 300mm wafers and constructed for a performance test. The accuracy was monitored by checking the movement of a notch in a machine vision. The result shows that the dual prealigner has enough performance as commercial products.

• Transactions of the Korean Society of Automotive Engineers
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• v.4 no.1
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• pp.55-62
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• 1996

The dynamic photoelastic technique has been utilized to investigate the possibility of relieving the large local singular stresses which are induce in the corner of a right angled indenter. The indenter compresses a semi-infinite body dynamically with an impact load applied on the top of the indenter. The effect of geometric changes to the indenter in terms of the diameter (d) and the location (ℓ) of the notch on the relieving of the dynamic contact stresses are investigated. A multi-spark-high speed camera with twelve sparks was used to take dynamic photographs. The contact singular stresses were found to be released by introducing the relief notch along the indenter. The optimal location and geometry of the relief notch need further experimental investigation.

• Journal of the Korean Ceramic Society
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• v.34 no.10
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• pp.1053-1059
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• 1997

The dynamic fatigue behavior of alumina ceramics was observed at room temperature using four point bending system. The dynamic fatigue fracture strength and the dynamic fatigue lifetime were observed as a function of crosshead speed and the notch length. The notched specimen showed the smaller deviation in dynamic fatigue fracture strength than the unnotched specimen. The crack growth exponent n and the material constant A of the notched specimen could be represented as functions of the notch length. Fracture strength of the specimen calculated from the notch length, when the notch length was regarded as the crack size, was in good agreement with the measured 4 point bending strength. Fracture surface of the specimen showed the different fracture modes according to the crosshead speed. The four point flexural strength, fracture toughness, Young's modulus and Weibull modulus of the alumina were measured as 360 MPa, 3.91 MPa.m1/2, 159GPa, 17.64, respectively.

• Journal of the korean Society of Automotive Engineers
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• v.9 no.5
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• pp.41-48
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• 1987

The aerodynamic critical phenomenon of notch-back type automobile-like bodies was investigated experimentally. The aerodynamic forces were measured for the various bodies of different back-light rake angle at R$_{e}$0.8*10$^{5}$ , 1.0*10$^{6}$ and 1.4*10$^{6}$ . Also, surface flow visualization was effected by the oil mixture. It was found that the critical phenomenon for the notch-back type bodies was milder than for the hatch-back type bodies; the drag vs. slant angle curve for the notch-back type bodies exhibiting local maximum was much smoother. Surface oil flow visualization revealed that the flow pattern associated with the critical phenomenon was characterized by the reattachment of the separated flow on the boot. The effect of the forebody on the critical phenomenon was seen to be negligible.e.