• 대한한의학방제학회지
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• 제17권2호
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• pp.133-142
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• 2009

Objective : Recently, obesity has increased at an alarming rate and is now a worldwide health problem. Natural dietary supplement, $CharmSlim^{(R)}$(C), is mixed pills, which consists of beans, black sesames, kelps, onions, adlay seeds, anchovies, pyogo mushrooms, green tea. Our study was performed to determine the weight-loss effects of natural dietary supplement, based on natural ingredients, in mice fed high-fat diet with an abundance of carbohydrates. Methods : Four groups of male ICR mice were fed different diets during 6 weeks: normal diet(NOR), high-fat (15%, w/w) diet(HF), high-fat supplemented with natural dietary supplement powdered 5%(C5) and 10%(C10) groups. We measured the changes of food intake, body weight and adipose tissues weights. Also we examined levels of lipid profiles in serum. Results : Body weight, liver weight and food efficiency ratio were significantly higher in the HF group than in NOR group. After 6 weeks of treatment, body weight, liver weight and adipose tissues weights (epididymal, perinephric, visceral and BAT) were significantly decreased in the C10 group when compared to the control HF group. The C10 group had markedly lower serum levels of total cholesterol and triglyceride when compared with HF group. Conclusion : These results demonstrate that this dietary supplement can suppress the increased lipid profiles, body weight and fat gains, thus could be considered as an effective adjunct in the treatment of obesity.

• 한국수산과학회지
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• 제39권2호
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• pp.59-65
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• 2006

Fluoroquinolones are the most common group of antibacterial agents currently used in the Korean aquaculture industry, and use of these agents has been increasing steadily. High performance liquid chromatography (HPLC) with fluorescence detection was used for the simultaneous determination of five fluoroquinolones in fish and shellfish: ofloxacin (OFL), pefloxacin (PEF), norfloxacin (NOR), ciprofloxacin (CIP), and enrofloxacin (ENRO). Fish and shellfish muscle was homogenized, and protein, lipid, and low molecular weight pigments were then excluded from the homogenate. The final eluates were analyzed by HPLC equipped with a Shiseido UG-120 type C18 reverse-phase column ($4.6{\times}250 mm$, $5{\mu}m$) and a fluorescence detector (excitation at 280 nm, emission at 450 nm). The mobile phase was 0.1 M phosphoric acid and acetonitrile solution (91:9, v/v) and tetrahydrofuran (THF) was added to it at a rate of 5 mL per a liter of the mobile phase. Adequate chromatography separation was obtained using the above method. Average recoveries of fortified samples at levels from 0.05 to 0.5 mg/kg were $72.3{\pm}2.5-84.5{\pm}1.2%$ for OFL, $82.7{\pm}3.3- 109.3{\pm}7.5%$ for NOR, $85.3{\pm}6.6-116.0{\pm}7.9%$ for PEF, $76.0{\pm}4.3-109.3{\pm}12.4%$ for CIP, and $78.7{\pm}5.9-100.0{\pm}9.8%$ for ENRO. The limit of detection of OFL was $5{\mu}g/L$, the others were $1{\mu}g/L$. We concluded that the new analytical method was suitable for the determination of fluoroquinolones in fish and shellfish.

• The Korean Journal of Physiology and Pharmacology
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• 제14권5호
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• pp.305-310
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• 2010

The human $ether$-$a$-$go$-$go$-related gene ($hERG$) channel is important for repolarization in human myocardium and is a common target for drugs that prolong the QT interval. We studied the effects of two antipsychotics, tiapride and sulpiride, on hERG channels expressed in $Xenopus$ oocytes and also on delayed rectifier $K^+$ currents in guinea pig cardiomyocytes. Neither the amplitude of the hERG outward currents measured at the end of the voltage pulse, nor the amplitude of hERG tail currents, showed any concentration-dependent changes with either tiapride or sulpiride ($3{\sim}300{\mu}M$). However, our findings did show that tiapride increased the potential for half-maximal activation ($V_{1/2}$) of HERG at $10{\sim}300{\mu}M$, whereas sulpiride increased the maximum conductance ($G_{max}$) at 3, 10 and $100{\mu}M$. In guinea pig ventricular myocytes, bath applications of 100 and $500{\mu}M$ tiapride at $36^{\circ}C$ blocked rapidly activating delayed rectifier $K^+$ current ($I_{Kr}$) by 40.3% and 70.0%, respectively. Also, sulpiride at 100 and $500{\mu}M$ blocked $I_{Kr}$ by 38.9% and 76.5%, respectively. However, neither tiapride nor sulpiride significantly affected the slowly activating delayed rectifier $K^+$ current ($I_{Ks}$) at the same concentrations. Our findings suggest that the concentrations of the antipsychotics required to evoke a 50% inhibition of IKr are well above the reported therapeutic plasma concentrations of free and total compound.

• The Journal of Korean Physical Therapy
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• 제23권6호
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• pp.85-92
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• 2011

Purpose: This study is executed to examine the effects of Korean somatotype on energy consumption and hormone changes during treadmill gait. Methods: The objects of study were a total of 70 university students in their 20s and 30s divided into 7 groups according to somatotype with 10 members each, 4 groups of male (M1, M2, M3, M4) and 3 groups of female (F1, F2, F3). Results: In case of male groups, there was a significant difference in VO2 and VCO2 between group M1, M2 and M3 (p<0.05). There was also a meaningful difference between Phase1 and Phase2, Phase3 and Phase4 in a phase (p<0.01). In case of female groups, there was a meaningful difference in VO2 between F1 and F2, F3 (p<0.01). There was also a significant difference between Phase1 and Phase2, Phase3 and Phase4 in a phase (p<0.01). There was no significant difference in VCO2 among them, but there was a significant difference in it between Phase1 and Phase2, Phase3 and Phase4 (p<0.01). There was equally no significant difference in the concentration of adrenaline and nor-adrenaline among both male and female groups, but such concentration showed meaningful difference before and after exercise (p<0.01). Conclusion: Energy consumption differs according to somatotype. There is a difference in hormone change, indicating that somatotype has effects on the physiological change. Therefore, in future exercise should be executed in more diverse conditions to further study somatotype with energy consumption and the correlations of hormone change.

• 대한불안의학회지
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• 제10권1호
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• pp.3-10
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• 2014

Reactive disorder is a group of diagnosis with a definitely known etiology and whose etiological factor is essential to the diagnosis. In DSM system, such reactive disorders are listed as adjustment disorder, acute stress disorder, brief psychotic disorder with marked stressor and posttraumatic stress disorder (PTSD). However, a growing number of individuals is suffering from a prolonged feeling of embitterment after exceptional negative life events and this condition could be diagnosed neither PTSD nor adjustment disorder nor depressive disorder in the context of DSM-IV diagnostic system. This clinical condition can be described as 'posttraumatic embitterment disorder' (PTED). PTED is a reactive disorder triggered by exceptional, though normal negative life events such as conflict in the workplace, unemployment, death of a relative, divorce, severe illness, or experience of loss or separation. The common feature of such events is that they are experienced as unjust, as a personal insult, accompanied by psychological violation of basic beliefs and values. The central psychopathological response pattern in PTED is a prolonged feeling of embitterment. In particular, the core emotion of embitterment can lead to the rejection of treatment. Therefore, "wisdom therapy" as a new treatment approach specifically designed for PTED has been developed. It is assumed that many patients suffering from PTED are often misunderstood and misdiagnosed. This review would help to introduce PTED into the clinical field in psychiatry.

• Journal of the Korean Wood Science and Technology
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• 제15권2호
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• pp.105-112
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• 1987

대기오염(大氣汚染)이 극심한 것으로 알려져있는 온산(溫山) 및 여천(麗川) 지역의 소나무 (Pinus densiflor)를 대상수종으로, 해부학적 특성을 조사하였던 바, 지난 10년간 전반적인 생장의 감소를 확인할 수 있었으며, 이 생장감소의 시작년대와 상기(上記)지역에서의 공단(工團)의 가동 년도(年度)가 거의 일치하고 있음을 연륜년대학적(年輪年代學的) 고찰을 통해 입증할 수 있었다. 대기오염 피해지역의 소나무에 있어서 반경방향의 생장의 감소는 지난 10년간 온산(溫山)의 경우 70%, 여천(麗川)의 경우 60%에 달하였다. 이들 소나무는 춘재(春材)의 형성이 억제된 반면 피해기간 중의 추재율(秋材率)은 약 30% 정도 증가되었다. 대기오염 피해기간중 형성된 연륜내(年輪內)의 최대밀도(最大密度)는 건전재의 그것에 비해 약간 낮게 나타났다. 가도관의 치수의 경우 가도관장(假導官長)의 변이(變異)는 찾아볼 수 없었으나, 피해기간중 가도관벽(壁)의 두께와 그 직경은 감소하였다. 이같은 변화에도 불구하고 미시구조(微視構造)의 관찰결과, 하등의 이상조직(異常組織)이나 미생물(微生物)을 발견(發見)할 수 없었다.

• 전자공학회논문지 IE
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• 제48권2호
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• pp.6-11
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• 2011

본 논문은 나노 구조에서 ASIC 표준 라이브러리 셀의 특성에 대하여 전파지연시간 측정의 새로운 설계 방법을 제시하였다. 라이브러리 셀((NOR, AND, XOR 등)에 대한 정확한 시간 정보를 제공함으로서 ASIC 설계 흐름 공정의 시간적 분석을 증진시킬 수 있다. 이러한 분석은 기술 공정에서 반도체 파운드리 팀에게 유용하게 사용할 수 있다. CMOS 소자의 전파지연시간과 SPICE 시뮬레이션 은 트랜지스터 파라미터의 정확도를 예측할 수 있다. 위상오차 축적방법 물리적 실험은 반도체 제조공정($0.11{\mu}m$, GL130SB)으로 실현하였다. 표준 셀 라이브러리에서 전파지연시간은 $10^{-12}$초 단위까지 정확성을 측정할 수 있었다. VLSI STPE를 위한 솔루션은 배치, 시뮬레이션, 그리고 검증에 사용할 수 있다.

• 한국한의학연구원논문집
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• 제10권2호
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• pp.37-49
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• 2004

In the existing Medical Literatures in Korea and China, there is neither the same book name nor same contents of the Medical Book named ${\ulcorner}$Yoryak(要略)${\lrcorner}$, but in viewing of the different name as written as ${\ulcorner}$GyoinYoryak(敎人要略)${\lrcorner}$, it is considered that written as an unpublished manuscript-book for the purpose of Medical Education in the latter period of Chosun Dynasty. While the author, Songgyesanin(松溪散人) is even anonymous as yet, it is regarded that he was much familiar with medical science as a secluded ascetic aiming for Taoism-like Life In ${\ulcorner}$Yoryak${\lrcorner}$, the contents of Taoism Literature named as ${\ulcorner}$OjangYukbudo(五臟六腑圖)${\lrcorner}$ which was regarded that had been actually initiated since ${\ulcorner}$Euibangyoochui(醫方類聚)${\lrcorner}$ is being quoted thereat, also it attempts to combine with ${\ulcorner}$DonguiBogam(東醫寶鑑)${\lrcorner}$, the typical Medical Literature of Chosun Dynasty. With reference to Cause of Disease, since Chin Moo-Taek(陳無擇) asserted 'Theory of Three-Causes(三因說)' in his Book ${\ulcorner}$Samin Keukilbyungjeung Bangron(三因極一病證方論)${\lrcorner}$, it effects many influences to the coming generation, However, on coming up to ${\ulcorner}$Yoryak${\lrcorner}$, the medical science book of Chosun Dynasty, the 'Theory of Two-Causes(二因說)' which consisted of 'Internal Causes by Seven Emotions' and 'Exterior Causes by Six Harmful Surroundings' is also being asserted. In accordance with this Theory, it refers to the 'Seven Emotions(七情)' as the fundamental factor to possibly weaken the viscera and entrails, and also regards that the Exterior Harmful Surroundings invade to body when the viscera and entrails are under weakened condition. Therefore, since Cause of Disease naming as 'Cause Theory at Neither Interior Nor Exterior' is not tolerable in such Diagnostic System, it is daringly advocating the 'Two Causes Theory', getting free from the viewpoint of 'Three Causes Theory' that Chin Moo-Taek has ever maintained.

• 한국지역사회생활과학회지
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• 제28권4호
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• pp.537-546
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• 2017

This study was performed to determine the hepatoprotective effects of ethanol extract of loquat leaf (LL) on alcohol-induced liver damage in rats. Sprague-Dawley rats (n=32) were divided into the following four groups: normal group (NOR), ethanol administrated group (ET), ethanol plus LL 200 mg/kg BW/day administrated group (ET-LLL), and ethanol plus LL 400 mg/kg Bw/day administrated group (ET-LLH). Body weight gain and food intake of the ET group were significantly reduced compared to those of the ET-LLL and ET-LLH groups. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) activities elevated by ethanol administration were significantly reduced by LL administration. Serum triglyceride (TG) and total cholesterol (TC) contents and hepatic TG and TC contents of the ET group were significantly elevated compared to those of the NOR group. However, TG and TC contents in the serum and liver were significantly reduced in the ET-LLH group. Hepatic glutathione (GSH) contents of the ET-LLL and ET-LLH groups were significantly elevated, and hepatic thiobarbituric acid reactive substances (TBARS) contents were reduced compared to that of the ET group. Taken together, these results suggest that LL may have a possible protective effect on the improvement of hepatic injury by ethanol administration.

• 대한간호학회지
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• 제47권6호
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• pp.713-730
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• 2017

Purpose: This study was a systematic review and meta-analysis designed to evaluate the effects of breastfeeding intervention on breastfeeding rates. Methods: Based on the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), a systematic search was conducted using eight core electronic databases and other sources including gray literature from January 9 to 19, 2017. Two reviewers independently select the studies and assessed methodological risk of bias of studies using the Cochrane criteria. The topics of breastfeeding interventions were analyzed using descriptive analysis and the effects of intervention were meta-analyzed using the Review Manager 5.2 software. Results: A total of 16 studies were included in the review and 15 were included for meta-analysis. The most frequently used intervention topics were the importance of good latch-on and frequency of feeding and determining adequate intake followed. The pooled total effect of breastfeeding intervention was 1.08 (95% CI 1.03~1.13). In the subgroup analysis, neither pre-nor post-childbirth intervention was effective on the breastfeeding rates at 1, 3, and 6 months, and neither group nor individual interventions had an effect. Only the 1 month breastfeeding rate was found to be affected by the individual intervention with the persistent strategies 1.21 (95% CI 1.04~1.40). Conclusion: Effective breastfeeding interventions are needed to help the mother to start breastfeeding after childbirth and continue for at least six months. It should be programmed such that individuals can acquire information and specific breastfeeding skills. After returning home, there should be continuous support strategies for breastfeeding as well as managing various difficulties related to childcare.