Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Effects of Natural Dietary Supplement on Body Weight and Lipid Metabolism in High Fat Diet-induced Obese Mice

고지방 식이 비만 모델 마우스의 체중 및 혈장 지질 대사에 미치는 한방보조식품의 영향

  • Choi, Hye-Min (R&D Team for the New Drug of Oriental Medicine (BK21)) ;
  • Suk, Jang-Mi (Oriental Medicine Industry Support Center) ;
  • Yang, Chae-Ha (R&D Team for the New Drug of Oriental Medicine (BK21)) ;
  • Kim, Sang-Chan (R&D Team for the New Drug of Oriental Medicine (BK21)) ;
  • Kim, Mi-Ryeo (R&D Team for the New Drug of Oriental Medicine (BK21))
  • 최혜민 (대구한의대학교 BK21 한방신약개발연구팀) ;
  • 석장미 ((재)대구TP 한방산업지원센터) ;
  • 양재하 (대구한의대학교 BK21 한방신약개발연구팀) ;
  • 김상찬 (대구한의대학교 BK21 한방신약개발연구팀) ;
  • 김미려 (대구한의대학교 BK21 한방신약개발연구팀)
  • Published : 2009.12.30
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Abstract

Objective : Recently, obesity has increased at an alarming rate and is now a worldwide health problem. Natural dietary supplement, $CharmSlim^{(R)}$(C), is mixed pills, which consists of beans, black sesames, kelps, onions, adlay seeds, anchovies, pyogo mushrooms, green tea. Our study was performed to determine the weight-loss effects of natural dietary supplement, based on natural ingredients, in mice fed high-fat diet with an abundance of carbohydrates. Methods : Four groups of male ICR mice were fed different diets during 6 weeks: normal diet(NOR), high-fat (15%, w/w) diet(HF), high-fat supplemented with natural dietary supplement powdered 5%(C5) and 10%(C10) groups. We measured the changes of food intake, body weight and adipose tissues weights. Also we examined levels of lipid profiles in serum. Results : Body weight, liver weight and food efficiency ratio were significantly higher in the HF group than in NOR group. After 6 weeks of treatment, body weight, liver weight and adipose tissues weights (epididymal, perinephric, visceral and BAT) were significantly decreased in the C10 group when compared to the control HF group. The C10 group had markedly lower serum levels of total cholesterol and triglyceride when compared with HF group. Conclusion : These results demonstrate that this dietary supplement can suppress the increased lipid profiles, body weight and fat gains, thus could be considered as an effective adjunct in the treatment of obesity.

Keywords

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