• 한국동물학회지
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• 제31권2호
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• pp.104-110
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• 1988

한국산 청개구리 두 종(Hyla japonica와 Hyla suweonensis)의 핵형을 비교 분석한 결과 두 종의 핵형은 2n=24로 동일하였으나 두 종의 6번 염색체는 동일한 % length를 보이나 Hyla japonica의 6번염색체는 subtelocentric chromosome인 반면에 Hyla suweonensis의 6번염색체는subtelocentric chromosome이었다. 6번염색체의 이러한 형태적 차이는 pericentric inversion에 의한 것으로 설명할 수 있다. 또한 두 종은 모두 6번 염색체의 1쌍의 NOR을 가지고 있다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2009년도 제38회 동계학술대회 초록집
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• pp.250-250
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• 2010

The random telegraph signal (RTS) for the NOR flash cell scaling is investigated. An innovative method to suppress the RTS, based on the device engineering, is proposed. By optimizing the channel doping profile and using the high-k tunnel dielectric, it is confirmed from three-dimensional (3-D) simulation, that the $V_{th}$ amplitude, dueto RTS, is significantly suppressed, from approximately 0.5 to 0.07 V in the middle of the channel at 45 nm NOR Flash technology. From this result, it is expected that the proposed method to suppress the RTS amplitude is essential for further cell size scaling in Flash memory.

• Natural Product Sciences
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• 제26권4호
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• pp.283-288
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• 2020

Microbial transformation of a potent progestin, norethisterone (17��-hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one) (1) was carried out by using two filamentous fungi Aspergillus niger and Penicillium citrinum. Biotransformation of 1 with A. niger yielded a hydroxylated transformed product 10��,17��-diydroxy-19-nor-17α-pregn-4-en-20-yn-3-one (2) whereas 11��,17��-diydroxy-19-nor-17α-pregn-4-en-20-yn-3-one (3) was obtained through microbial transformation of 1 by P. citrinum. It is the first report of their production from 1 by using A. niger and P. citrinum with complete 1H- and 13C-NMR assignment. The structures of both metabolites were characterized by various spectroscopic techniques and reported data.

• Natural Product Sciences
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• 제29권1호
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• pp.17-23
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• 2023

A phytochemical investigation of the fruits extract of Melia toosendan afforded the isolation of two new nor-neolignans, meliasendanins E (1) and F (2), as well as twelve known compounds (3 - 14) using various separation technique such as Diaion HP20, silica, RP-18 gel column chromatography and semi-preparative HPLC. Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D-NMR, and HR-ESI-MS as well as ECD data. Among the twelve known compounds, the absolute structures of 3 - 6 were determined first, and given the trivial names as meliasendanins G-J (3 - 6). Based on the evaluation of anti-inflammatory activity, compounds 7 - 8 exhibited inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages with IC₅₀ values of 34.6 and 39.5 µM, respectively.

• Biomolecules & Therapeutics
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• 제5권2호
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• pp.107-109
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• 1997

For metabolic study of pinusolide, a naturally occurring platelet activating factor antagonist, a synthetic method for preparation of radiolabeled pinusolide was studied. Pinusolide was first oxidized with $OsO_4/NaIO_4 $to 17-nor-8-oxo compound (2), which was subsequently converted to pinusolide by treatment with the Lombardo reagent $(Zn/CH_2Br_2/TiCI_4)$. The Wittily reaction was unsuccessful in the latter carbonyl methylenation of 2.

• Natural Product Sciences
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• 제4권2호
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• pp.95-99
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• 1998

The $^{13}C-NMR$ spectrum of nor-rubrofusarin showing strong radical scavenging effect has been assigned by using HMBC and HMQC experiments.

• Journal of Forest and Environmental Science
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• 제9권1호
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• pp.96-100
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• 1993

• 전기화학회지
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• 제13권1호
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• pp.63-69
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• 2010

플루오로퀴놀론 계 항생제들의 전기화학적 거동을 카본 페이스트 전극 (carbon paste electrode ; CPE)을 사용하여 순환 전압전류법 (cyclic voltammetry)과 네모파 흡착 벗김 전압전류법 (square wave adsorptive stripping voltammetry)으로 연구하였다. Enrofloxacin (ENR), Norfloxacin (NOR), Ciprofloxacin (CIP), Ofloxacin (OFL), Levofloxacin (LEV) 등 5가지 플루오로퀴놀론 계 항생제에 대한 전기화학적 분석을 수행하였다. pH 4.5인 아세트산 완충 용액 (acetate buffer) 에서 플루오로퀴놀론 계 항생제의 산화 전위는 Ag/AgCl 기준 전극에 대하여 각각 ENR : 0.952V, NOR : 1.052 V, CIP : 1.055 V, OFL : 0.983 V, LEV : 0.990 V 의 값을 나타내었으며, 네모파 흡착 벗김 전압전류법에 의한 산화 전류는 $0.2\;{\mu}M$에서 $1\;{\mu}M$ 사이의 농도영역에서 각 항생제의 농도와 선형을 나타내었다.

• 동의생리병리학회지
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• 제27권5호
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• pp.644-649
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• 2013

In this study, we aimed to investigate the effect of GamiChungYi-tang(GCY-t) on caerulein-induced acute pancreatitis (AP). It is performed by detecting oxidative stress markers and observing histopathological examination. Thirty adult male rats(Sprague-Dawley) were divided into six groups as follows: normal (NOR,n=5), caerulein-induced (CON,n=5), caerulein+Cefotaxime Sodium(CT,n=5), caerulein+GCY-t (130 mg/kg, CHA,n=5), caerulein+GCY-t (260 mg/kg, CHB,n=5) and caerulein+GCY-t (520 mg/kg, CHC,n=5) groups. Pancreatic tissues of rats from all groups were removed for apoptosis and light, and electron microscopic examination. Blood of rats from all groups were collected for oxidative stress markers inspection and pathological examination. Pancreatic oxidative stress markers were evaluated by the measurements of leukocyte, serum amylase and platelet activating factor (PAF), Interleukin-6 (IL-6) levels were determined spectrophotometrically. CON group has a significant increase (p<0.05) in amylase compared with NOR, but CT and CHA, CHB, CHC groups reduced the levels of these enzyme. The levels of Platelet activating factor (PAF) were increased in CON compared with NOR, but decreased in CT and CHA, CHB, CHC groups compared with CON. Interleukin-6 (IL-6) levels were increased significantly in CON compared with NOR, but reduced in CT and CHA, CHB, CHC groups. In the observations of Optical microscopy and electron microscopy, The experimental groups showed the significant decreases in pancreatic tissue inflammation, edema, vacuolization, necrosis compared to the control group. After all, GCY-t is potentially capable of limiting pancreatic damage produced during AP by restoring the fine structure of acinar cells and tissue.

• 분석과학
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• 제23권1호
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• pp.83-88
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• 2010

대검찰청 마약감식실은 대마 흡연여부를 판별하는 수단인 소변 중 대마 대사체 성분 분석법 에 대한 신뢰도 평가를 위하여 인증표준물질을 이용한 시험을 실시하였다. 시험에 사용된 인증표준물질은 미국 NIST에서 판매하는 Standard Reference Material 1507b로, 11-nor-${\Delta}^9$-tetrahydrocannabinol-9-carboxylic acid (THCCOOH)가 함유된 냉동 건조 소변이었다. NIST에서 구매한 인증표준물질의 농도값과 실험실에서 측정한 농도값을 비교 평가해 본 결과, 약 95% 신뢰수준에서 일치하였다.