• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2012년도 춘계학술대회
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• pp.880-883
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• 2012

본 논문에서는 CMOS 논리소자의 과도방사선 피해 영향을 분석하기 위해 0.18um CMOS 공정으로 NMOSFET, PMOSFET을 이용하여 기본 논리소자인 INVERTER, NAND, NOR를 설계하고 제작하였다. 제작된 논리 소자 실측결과 1.8V 전원에서 1kHz의 Pulse 입력을 가하였을 때 소모 전류는 70uA 이내, Rising Time, Falling Time 또한 4us 이내이며 펄스 방사선 실측시험을 위해 50M Cable을 이용하여 측정결과 Line Delay가 발생하는 것을 확인하였다.

• 대한전자공학회논문지SD
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• 제44권11호
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• pp.56-64
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• 2007

본 논문은 CMOS-나노 혼성 소자들 중 실현 가능성이 높은 CMOL 회로 설계 자동화 전용 시스템을 최초로 제안한다. CMOL 아키텍처는 NOR 게이트를 이용하여 조합회로의 구현한다. 이 CMOS-나노 혼성 구조는 논리 함수 및 연결 구조가 동일 나노 소자 하드웨어 자원을 공유하는 특징을 가진 새로운 설계 자동화 문제를 제기한다. CMOL의 물리 설계 자동화를 위해 먼저 CMOL 하드웨어 아키텍처 모델을 개발하고 이 CMOL 구조를 위한 배치 배선 문제에서 CMOL만의 특수한 제약조건을 도출하였으며 배치 알고리즘과 게이트 지정 알고리즘을 루프 형태로 조합하여 해를 구하는 접근 방법을 제안하였다. 제안된 접근 방법을 사용하여 CMOL 나노 전자 아키텍처를 위한 전용 설계 자동화 시스템을 개발하였으며 이 시스템을 이용하여 마이크로프로세서 설계에 실제 사용되는 모듈들을 구현함으로써 그 효용성을 증명하였다.

• 한국환경성돌연변이발암원학회지
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• 제18권2호
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• pp.104-108
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• 1998

In the present study, we have evaluated cytotoxic effects of Taraxaci Herba extract in human oral epitheloid carcinoma cells. An antitumor activity was measured by colorimetric assays using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and sulforhodamine protein B (SRB). The light microscopic study showed morphological changes, Ag-NOR (argyrophylic nucleolar organizer region) number and PAS positive reaction or the treated cells. These results obtained are as follows : MTT and SRB quantities were significantly decreased in cultured KB cells treated with 10$^{-2}$ /mg/ml and 10$^{-3}$ /mg/ml concentrations. The number of Ag-NORs were significantly decreased in cultured KB cells treated with 10$^{-2}$ /mg/ml and 10$^{-3}$ /mg/ml concentrations and the rate of Ag-NORs was shifted to left side (one Ag-Nounucleus was increased and five Ag-NORs/nucleus were decreased) by the high concentration. PAS reaction of cultured KB cells treated with 10$^{-2}$ /mg/ml and 10$^{-3}$ /mg/ml concentrations was negative. These results suggest that Taraxaci Herba retains a potential antitumor activity.

• 약학회지
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• 제43권2호
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• pp.173-179
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• 1999

In the present study, we have evaluated cytotoxic effects, antitumor activities and metastasis inhibitory effects of Palsun brewing water in NIH 3T3 cells, human epitheloid carcinoma cells, and human skin melanoma cells. The light microscopic study showed morphological changes, AG-NOR (argyrophylic nucleolar organizer region) by silver chloride stain, and glycoprotein by PAS (periodic acid stain) reaction of the treated cells. Disruptions in cell organelles were determined by colorimetric methods; MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazoliumbromide) and SRB (sulforhodamine B protein) assays. These results suggest that Palsun Brewing Water retains no cytotoxic effects in NIH 3T3 cells and a growth-inhibitory activity in cancer cell lines.

• 아동학회지
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• 제37권5호
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• pp.65-82
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• 2016

Objective: The main purpose of this study was to examine the direct and indirect effects of parent-adolescent communication (through adolescent optimism) on adolescent conflict-coping styles. Methods: A total of 337 high school students participated in this study. They completed questionnaires about communications with their parents and their own optimism and conflict-coping styles. Data were analyzed using t-tests, correlations, and SEM. Results: Neither father- nor mother-adolescent communication had direct effects on adolescent conflict-coping styles. However, mother-adolescent communication had an indirect effect on conflict-coping styles, mediated by adolescent optimism. Adolescents who had open communication with mothers displayed higher levels of optimism, which led to more positive conflict-coping styles. In addition, multigroup analyses revealed that there were significant gender differences in direct and indirect effects. For boys, mother-adolescent communication directly influenced adolescent conflict-coping styles; however, father-adolescent communication did not directly or indirectly affect adolescent conflict-coping styles. For girls, neither father- nor mother-adolescent communication had direct effects on conflict-coping styles; only optimism had a significant effect on conflict-coping styles. Conclusion: The findings from this study suggest that communication with mothers and fathers have different effects on adolescents' conflict-coping styles. These findings have implications for future research and practice by emphasizing the importance of parent-adolescent communication and optimism in designing conflict-coping programs for adolescents.

• 한국약용작물학회지
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• 제14권6호
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• pp.354-359
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• 2006

Chromosome analysis using mitosis, meiosis and bicolor FISH were carried out in Bupleurum latissimum Nakai, which is one of the endemic plants in Ulleung island of korea. The somatic methaphase chromosomes number of this plant was 2n = 2x = 16 and the chromosome complements consisted of six pairs of metacentrics and two pairs of submetacentrics. The size of chromosomes ranged 2.40${\sim}$4.20 ${\mu}$m and NOR (nucleolus organizer region) chromosome did not observed using conventional staining. In meiosis chromosomes, metaphase-I and anaphase-I were observed. Metaphase-I anaphase-I showed 8 bivalents and chromosomes migration to make two daughter cells. Using bicolor FISH, one pair of 5S and 45S rDNA signals were detected on the centromeric region of chromosome 3 and the end of short of chromosome 2,respectively. We also observed the NOR using 45S rDNA probe.

• 한국환경과학회지
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• 제26권4호
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• pp.447-456
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• 2017

Chemical properties of aerosols were investigated by analyzing the inorganic water-soluble content in $PM_{2.5}$ collected in the downtown area of Jeju City in Jeju Island. Due to an increase in both the number of visiting tourists and the size of local population, the number of cars in this area is increasing, causing an increase in $PM_{2.5}$. Eight $PM_{2.5}$-bound major inorganic ions were analyzed during the summer and winter periods. The water-soluble inorganic component represents a significant fraction of $PM_{2.5}$. In particular, secondary inorganic aerosols contribute 36.2% and 47.5% of $PM_{2.5}$ mass in summer and winter, respectively. Nitrate concentrations increase for $[NH_4{^+}]/[SO_4{^{2-}}]$>1.5, and excess ammonium, which is necessary for ammonium nitrate formation, is linearly correlated with nitrate. These results are clearly observed during the winter because conditions are more conducive to the formation of ammonium nitrate. A significant negative correlation between Nitrogen Oxidation Ratio (NOR) and temperature was observed. The obtained results can be useful for a better understanding of the aerosol dynamics in the downtown area in Jeju City.

• Journal of Nutrition and Health
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• 제29권10호
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• pp.1072-1079
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• 1996

This study was performed to elucidate the mechanism of dietary protein level on renal function through lipid and eicosanoids metabolism. Male rats of 337.8$\pm$5.7g body weight were undergone unilateral nephrectomy or sham-operation. The rats were divided into high protein(40% casein), normal protein(15% casein) and low protein(8% casein) diet groups and fed experimental diets ad libitum for 24 weeks. The results are summarized as follows. Serum total lipid, cholesterol and HDL-cholesterol of rats in 15% and 40% casein groups were higher than those of 8% casein group. But serum triglyceride was affected neither by uninephrectomy nor by dietary protein level. Serum thromboxane(TX) B2 and 6-keto prostaglandin F1$\alpha$ increased with increasing dietary protein level. Serum prostaglandin(PG) E2 was not affected by uninephrectomy nor by dietary protein level. Urinary PGE2 and TXB2 excretion tended to be lower in uninephrectomized groups. Renal tissue concentration of TXB2 was lower in uninephrectomized groups and in high protein group. These results suggest the possibility that the effects of dietary protein level on renal function could be due to changes in lipid and eicosanoids metabolism.

• Structural Engineering and Mechanics
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• 제63권1호
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• pp.55-64
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• 2017

The paper concerns concrete carbonation, the phenomena that occurs in every type of climate, especially in urban-industrial areas. In European Standards, including Eurocode (EC) for concrete structures the demanded durability of construction located in the conditions of the carbonation threat is mainly assured by the selection of suitable thickness of reinforcement cover. According to EC0 and EC2, the thickness of the cover in the particular class of exposure depends on the structural class/category and concrete compressive strength class which is determined by cement content and water-cement ratio (thus the quantitative composition) but it is not differentiated for various cements, nor additives (i.e., qualitative composition), nor technological types of concrete. As a consequence the selected thickness of concrete cover is in fact a far estimation - sometimes too exaggerated (too safe or too risky). The paper presents the elaborated "self-terminated carbonation model" that includes abovementioned factors and enables to indicate the maximal possible depth of carbonation. This is possible because presented model is a hyperbolic function of carbonation depth in time (the other models published in the literature use the parabolic function that theoretically assume the infinite increase of carbonation depth value). The paper discusses the presented model in comparison to other models published in the literature, moreover it contains the algorithm of concrete cover design with use of the model as well as an example of calculation of the cover thickness.

• 한국수산과학회지
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• 제47권4호
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• pp.431-434
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• 2014

Cytogenetic analysis was conducted to obtain basic information for chromosome manipulation of starry flounder Platichthys stellatus. Nuclear surface area and volume of erythrocyte were $7.60{\pm}0.93{\mu}m^2$ and $12.80{\pm}1.75{\mu}m^3$, respectively. The haploid DNA content of the species was 0.66 pg/haploid cell which correspond to 93% of olive flounder Paralichthys olivaceus. A karyotype analysis was also carried out with the species using conventional staining and Ag-NOR banding techniques. It was consisted of 48 acrocentric chromosomes and inter-sex or intra-individual polymorphism was not detected in all specimens analyzed. The NOR regions, appearing a terminal position of the short arm of the smallest acrocentric pairs.