• Molecular & Cellular Toxicology
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• v.5 no.4
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• pp.354-363
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• 2009

Cytotoxic Nitric oxide (NO) overproduced by inducible NO Synthase (iNOS or NOS2), which was induced in inflammatory reactions and immune responses directly or indirectly affects the functions as host defense and can cause normal tissue damage. Microarray analysis was performed to identify gene profiles of both NO-dependent and -independent transcripts in RAW 264.7 macrophages that use selective NOS2 inhibitors aminoguanidine ($100\;{\mu}M$) and L-canavanine (1 mM). A total of 3,297 genes were identified that were up- or down-regulated significantly over 2-fold in lipopolysaccharide (LPS)-treated macrophages. NO-dependency was determined in the expressed total gene profiles and also within inflammatory conditions-related functional categories. Out of all the gene profiles, 1711 genes affected NO-dependently and -independently in 567 genes. In the categories of inflammatory conditions, transcripts of 16 genes (Pomp, C8a, Ifih1, Irak1, Txnrd1, Ptafr, Scube1, Cd8a, Gpx4, Ltb, Fasl, Igk-V21-9, Vac14, Mbl1, C1r and Tlr6) and 29 geneas (IL-1beta, Mpa2l, IFN activated genes and Chemokine ligands) affected NO-dependently and -independently, respectively. This NO dependency can be applied to inflammatory reaction-related functional classifications, such as cell migration, chemotaxis, cytokine, Jak/STAT signaling pathway, and MAPK signaling pathway. Our results suggest that LPS-induced gene transcripts in inflammation or infection can be classified into physiological and toxic effects by their dependency on the NOS2-mediated NO release.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.7
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• pp.27-34
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• 2020

The study investigates herding behavior in cryptocurrencies in different situations. This study employs daily returns of major cryptocurrencies listed in CCI30 index and sub-major cryptocurrencies and major stock returns listed in Dow-Jones Industrial Average Index, from 2015 to 2018. Quantile regression method is employed to test the herding effect in market asymmetries, inter-dependency and intra-dependency cases. Findings confirm the presence of herding in cryptocurrency in upper quantiles in bullish and high volatility periods because of overexcitement among investors, which lead to high volume trading. Major cryptocurrencies cause herding in sub-major cryptocurrencies, but it is a unidirectional relation. However, no intra-dependency effect among cryptocurrencies and equity market is observed. Results indicate that in the CKK model herding exists at upper quantile in market that may be due when the market is moving fast, continuously trading, and bullish trend are prevailing. Further analysis confirms this narrative as, at upper quantile, the beta of bullish regime is negative and significant, meaning the main source of market herding is a bullish trend in investment, which increases market turbulence and gives investors opportunity to herd. Also, we found that herding in cryptocurrencies exits in high volatility periods, but this herding mostly depends on market activity, not market movement.

• Journal of Biomedical Engineering Research
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• v.11 no.1
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• pp.121-130
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• 1990

In this study, the coefficients of ultrasound attenuation for human liver were determined in 6 normal humans and in 38 patients with diffuse liver disease. The coefficients with linear frequency dependency as well as nonlinear frequency dependency were evaluated. Gaussian pulse propagating in a lossy medium suffers downshifting of a center frequency and decreasing in the bandwidth. Such changes in frequency domain spectrum were quantified in terms of changes in the attenuation coefficients with nonlinear dependency, which in turn improve clinical Implications of the coefficients. Statistical analysis shows that the attenuation coefficients evaluated with nonlinear dependency reflect an improved accuracy for the diffuse liver disease than those with linear dependency. The discriminant analysis also indicate the improved classification with nonlinear dependency(75%) than with linear dependency(61%).

• Human Ecology Research
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• v.56 no.2
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• pp.145-156
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• 2018

This study investigates the effects of over-parenting behavior and peer-alienation on adolescents' school adjustment and explores the mediating effects of smartphone dependency on the above relations. The subjects were 1,882 first grade students in middle school selected from the 7th year data of the 2010 Korea Children and Youth Panel Survey (2010 KCYPS). Data were analyzed by descriptive statistics, Pearson's correlation, structural equational models, and Sobel test with SPSS 21.0 and Amos 18.0. The findings were as follows. First, there was no significant difference in the school adjustment according to gender. However, boys were higher in the perception of over-parenting behavior and peer-alienation, and girls were higher in smartphone dependency. Second, peer-alienation and smartphone dependency had negative impacts on the school adjustment. But over-parenting behavior had no significant effect on school adjustment. Third, smartphone dependency played a mediator role between over-parenting behavior and peer-alienation as well as the school adjustment. Fourth, there were no significant differences between boys and girls in the relations among over-parenting behavior, peer-alienation, smartphone dependency and school adjustment. But there was a slight difference in influence. The findings of this study suggest that interventions on how to use smartphone correctly are important for improving adolescents' school adjustment. In addition, gender differences in school adjustment should be considered for a better understanding.

• Journal of Astronomy and Space Sciences
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• v.30 no.1
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• pp.43-48
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• 2013

The geomagnetic activity shows the semiannual variation stronger in vernal and autumnal equinoxes than in summer and winter solstices. The semiannual variation has been explained by three main hypotheses such as Axial hypothesis, Equinoctial hypothesis, and Russell-McPherron Effect. Many studies using the various geomagnetic indices have done to support three main hypotheses. In recent, Oh & Yi (2011) examined the solar magnetic polarity dependency of the geomagnetic storm occurrence defined by Dst index. They reported that there is no dependency of the semiannual variation on the sign of the solar polar fields. This study examines the solar magnetic polarity dependency of quiet time geomagnetic activity. Using Dxt index (Karinen & Mursula 2005) and Dcx index (Mursula & Karinen 2005) which are recently suggested, in addition to Dst index, we analyze the data of three-year at each solar minimum for eight solar cycles since 1932. As a result, the geomagnetic activity is stronger in the period that the solar magnetic polarity is anti-parallel with the Earth's magnetic polarity. There exists the difference between vernal and autumnal equinoxes regarding the solar magnetic polarity dependency. However, the difference is not statistically significant. Thus, we conclude that there is no solar magnetic polarity dependency of the semiannual variation for quiet time geomagnetic activity.

• Korean Journal of Occupational Health Nursing
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• v.14 no.2
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• pp.129-137
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• 2005

Purpose: This study was performed to verify the effect of acupressure on the spots of auricular with semen sinapis albae in male grown up employees for nicotine dependency. Method: The subjects investigated for this study were fifty male grown up employees(the 25 subjects belong to experimental group and the remaining 25 subjects belong to control group) who are employed at a company. The experimental group(N=25) underwent acupressure on the spots of auricular with semen sinapis albae and the control group(N=25) underwent no treatment. Result: The nicotine dependency of experimental group who underwent acupressure with semen sinapis albae on the spots of auricular decreased much more than in those of control group who didn't undergo acupressure with semen sinapis albae on the spots of auricular. Conclusion: Accounting from the research, it was proved that the acupressure on the spots of auricular with semen sinapis albae is very effective for nicotine dependency.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1997.11a
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• pp.109-111
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• 1997

In this paper, we have evaluated temperature, electric field, Pressure dependency and dielectric properties of EPDM XLPE and EPDM/XLPE\`s interface. Temperature dependency of EPDM had great influence with dielectric properties, but pressure and applied voltage of EPDM had no effect on dielectric properties. Dielectric properties of XLPE were influenced by not only temperature but also pressure and applied voltage. We knowed that dielectric properties of EPDM/XLPE were trended toward tendency of those of EPDM

• Journal of Families and Better Life
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• v.31 no.6
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• pp.83-96
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• 2013

The aim of this study was to identify the differences in cellular phone dependency and its use levels of usage purposes according to children's gender, and also to analyze the differences in individual and interpersonal relations development due to cellular phone dependency in children based on gender. Using the first year data of the Korean Child and Youth Panel Survey(KCYPS) 2010, this study analyzed 1,604 fourth graders who have their own cellular phones. For statistical analysis, descriptive statistics were calculated and mean difference analyses were conducted. The results showed that there was no difference between boys and girls in cellular phone dependency. The girls' total phone use level was higher than that of boys and meaningful gender differences in the phone use levels were found in the five phone usage purposes. In both boys and girls, the higher phone dependency groups demonstrated higher levels of phone use in more than eight usage purposes, lower self-resilience and self-regulating learning ability, and less positive peer and teacher relations. These findings show the importance of being concerned about and educating children in the fourth grade about the proper uses of cellular phones.

• Science of Emotion and Sensibility
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• v.21 no.4
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• pp.103-112
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• 2018

This study aimed to identify specific psychological and brain activation responses relating to the processing of negative emotions in patients with alcohol dependency. The authors hypothesized that patients with alcohol dependency would demonstrate the abnormal functioning of brain regions involved in negative emotions. Eleven male patients diagnosed with alcohol dependence in an inpatient alcohol treatment facility and 13 social drinkers with similar demographics were scanned using functional magnetic resonance imaging (fMRI) as they viewed film clips that evoked negative emotions. During exposure to negative emotional stimuli, the control group evinced significantly greater activity in the right anterior cingulate cortex (ACC) in comparison to patients with alcohol dependency. Correlation analyses demonstrated a negative association in the relationship between beta values from the right ACC and amygdala in participants classified in the control group. No statistically significant relationship was observed for blood oxygenation level-dependent (BOLD) changes between the two regions in the patient group during the elicitation of negative emotions. On the other hand, patients exhibited a greater activation of the amygdala as negative emotions were induced. These results suggest that alcoholism presents pathophysiology of brain activation that is distinct from the responses of healthy individuals functioning as controls.

• The Journal of Asian Finance, Economics and Business
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• v.9 no.2
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• pp.71-79
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• 2022

The aim of this study is to see how government spending on education, health, and social security affects ratios in Indonesia. The third sector has a critical role to play in reducing the dependency ratio. It also aims to lower unemployment and poverty rates. This study uses the GMM panel data model. This model can determine the dynamic response of the ratio that comes from a number of variables. This study uses data from 33 provinces from 2010 to 2018. The results show that government spending in the education and health sectors has a positive effect on the dependency ratio, both in the short and long term. Social security has a significant effect on the dependency ratio in the long term, but not in the short term. Government spending in the education sector and health sector and social security sector have a positive and significant effect on disease and illness. The study's findings show a high level of poverty with a large standard deviation. The high ratio value is due to the large number of restrictions placed on a number of regions. Each province has made a significant contribution to overcoming these challenges, particularly in terms of the comparative ratio.