• 한국환경복원기술학회지
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• 제1권1호
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• pp.28-44
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• 1998

This study was conducted to suggest the ecological restoration strategies for the disturbed landscapes by theoretical study. Especially, it is aimed to suggest three objectives for restoration by using native plants ; (1) prevention or reduction of wind and water erosion, (2) provision of food and cover for variety of animal species, (3) improvement of the visual or aesthetic quality of disturbed sites. The main results were summarized as follows. 1. Cooperation between restoration ecologists and restoration practitioners is needed to delineate a scientific approach to restoration ; (1) Being aware of published literature that describes similar work and/or establish general principles. (2) Preparedness to carry out proper experiments to test ideas. (3) Preparedness to monitor fundamental parameters in a restoration scheme. (4) Providing information about the behavior of species. (5) Publish results. 2. There are three models of succession in theories of plant succession. The tolerance and facilitation models were recommended to ecological restoration. The inhibition model applies in most secondary succession, but the actual species which are introduced first may inhibit the germination and growth of slower-growing species, or they may prevent the growth of other species whose propagules arrive later. 3. The objectives of erosion control, wildlife habitat provision, and visual quality improvement are not mutually exclusive. However, many revegetation practices in the past have emphasized one of these aspects at the expense of the others. 4. A native plant community can be the model of ecological restoration. By stylization/abstraction of native plant community, trying to learn the most essential characteristics of community types - environmental factors ; dominant, prevalent, and "visual essence" species composition - in order to use such information in restoration. 5. After developing mass/spaces plan, match plant communities to the mass/space plan. In utilizing community grouping, there needs aesthetic ability to understand design elements. 6. Several hydrophytes such as Pennisetum saccharifluous, Themeda triandra, Cirsium pendulum show relatively good germination rates. In case of mesophytes and xerophytes, Arundinella hina, Artemisia princeps, Oenothera odorata and legumes seem to have quick-germinating abilities at barren sites. Pinus thunbergii, Rhus chinensis, Evodia daniellii, Alnus firma and Albizzia julibrissin can be considered as "late succession" woody plants because they show low germinating rates and slow growing habitat. 7. The seeds used for restoration should be collected within a certain radius of where it will be planted. Consideration in genetic issues in the collection and use of germplasm can increase the odds for successful restoration efforts. 8. The useful model in the "drift" pattern occurs so abundantly in naturally evolving landscapes. As one species diminishes in density, a second or third species are increased. Thus, dynamic interactions between species are created. Careful using of "drift phenomenon" in planting was recommended. 9. Virtually no stand of vegetation today is immune from the introduction and/or spreading of exotic species. Therefore, the perpetuation of a restored sites requires conscious monitoring and management. Thus, management would be the most important process in ecological restoration. 10. In order to keep the sites "natural", alternative management strategies would be applied in management ; Atenative management strategies are decelerating successional process, accelerating successional processes or modifying species composition. As management tools, mechanical, chemical, biological or environmental factor manipulation, e.g., fire could be used.

• 대한지역사회영양학회지
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• 제13권2호
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• pp.263-275
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• 2008

Impaired fasting glucose (IFG) is one of significant risk factors of developing diabetes. The persons with IFG are, thus, an important target group for primary prevention of diabetes. It is well known that plasma homocysteine concentration may be increased in poor folate nutritional status. Elevated level of plasma homocysteine is considered as a marker of enhanced oxidative stress. In addition, the protective effect against oxidative stress may be diminished in poor antioxidative nutrient status as vitamin C. It is, therefore, important to maintain adequate nutritional status of folate and vitamin C in the patients with type 2 diabetes or IFG. This study was performed to determine the effects of supplementation of folic acid or vitamin C on plasma concentrations of homocysteine, oxidized LDL, and lipids and on the activity of plasma anti-oxidative enzyme in patients with IFG. A total of 97 patients with IFG were participated voluntarily with written consents. They were divided into one of the four experimental groups; Control (C), Folatesupplemented (F), Ascorbate-supplemented (A), and Folate plus ascorbate-supplemented (FA). The subjects in C were taken placebo, those in F were supplemented 1 mg of folate, those in A were received 1,000 mg of vitamin C, and those in FA were given 1 mg of folate plus 1,000 mg of vitamin C daily for 4 weeks. No change in plasma concentrations of vitamin C, lipids, and oxidized LDL and the activity of GSH-Px were observed in vitamin C-supplemented group (A + FA) and folate-supplemented group (F + FA) compared to the placebo group (C + A). Only the folate-supplemented group (F + FA) had significantly increased average serum folate concentration and lowered plasma homocysteine concentration compared to the placebo group (C + A). Thus, it should be recommended the patients with IFG to increase folate intake through diets and, if it is not sufficient, to take folic acid supplements to prevent the development of complications induced by hyperhomocysteinemia as well as oxidative stress.

• Journal of Preventive Medicine and Public Health
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• 제19권2호
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• pp.203-212
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• 1986

Hypertension is one of the most well known risk factors for cerebrovascular or coronary heart disease and is a major public health problem. Early detection and treatment of hypertension are essential, but the compliance of treatment on hypertension is not easy to achive. Hypertensive workers are being detected by the annual screening under the Labour Standard Law in Korea but the solidified control system for them is not existing. This study about workers 'Motive-Belief-Action in non-drug and drug treatment of their hypertension would be worthwhile to interpret how the workers actually behave in coping with hypertension, and also would be advisable to construct the follow-up program in Korea. In the field research process two criteria were used to select sample group. The first criterion included the workers who were screened to be hypertensive with their blood pressure above 160/95 in this survey. The second one was used to classify study-group respondents who had known their hypertension by successive annual screening. From such criteria a total of 156 male workers were sampled in 21 industries, the author interviewed them using the structured questionnaire which consisted of Belief-Motive-Action items about non-drug and drug treatment for hypertension with open-ended question on symptom of hypertension. The summary is as follows: 1) Sixty-one percent of respondents had ever checked their blood pressure somewhere besides the annual screening. 2) Most respondents(97.2%) complained no symptoms of hypertension at all. 3) Belief level of non-drug treatment was relatively high (82.1%-64.7%), but motive(55.1%-28.2%) and action(38.5%-16.7%) levels were low. 4) Belief level of drug treatment was relatively lower than that of non-drug treatment, blue collar workers showed higher artier level of drug treatment than white collar workers, and correlation coefficient between belief and motive on drug treatment was lower in group of not-recognizing their family history of hypertension than recognized group. Such findings indicated that belief on drug treatment of hypertensive workers would be problematic. 5) White collar workers showed significant lower correlation coefficients between Motive and Action of salt restriction, restriction of fatty diet and relaxation than blue collar workers. 6) Mild hypertension group showed low levels of Motive and Action of non-drug treatment(salt restriction, restriction of fatty diet and relaxation) and also showed low correlation coefficient between Belief and Motive of above non-drug treatment.

• 대한지역사회영양학회지
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• 제9권2호
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• pp.161-172
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• 2004

The dietary habits of middle-aged obese, overweight and normal subjects were evaluated for the purpose of providing the background information of the degenerative disease control. A survey was conducted with 293 subjects (121 males and 172 females) between the ages 40-64 and they were divided into three groups of normal (BMI 18.5-22.9), overweight (BMI 23-24.9) and obese ($BMI\geq25$) based on the criteria of Korean Obesity Association (2000). The mean age of the subjects was $52.0\pm7.3(male)\;and\;51.9\pm6.9$ (female). Socioeconomic levels of subjects belong to the mid-upper class, since 71.9% of the males and 39.5% of the females received above a college education. More than 40% (44.6%) of males and 22.1% of females were obese, and educational background did not affect the obesity rate in males, whereas in females those who received lower education had a higher rate of obesity (p ＜ 0.001). The subjects had a similar degree of drinking to the national average value. but had a lower degree of smoking. The obese group had the higher rate of drinking (p ＜ 0.01) and smoking (p ＜ 0.01). The annual increase in weight, more than 4 kg, was 8.8% for normal group and 30.9% for obese group. However, there were no differences in the mean annual increase in weight among the three groups. In females there were greater tendencies of weight changes in obese group (p ＜ 0.05). About 44.9% of subjects responded that they were exercising regularly, and the obese group appeared to put into practice less than the other groups and to use more strenuous exercise. There was the greater rate of skipping dinner in the obese female group (p ＜ 0.05). The unbalanced dietary pattern was found more with normal group than the other groups (p ＜ 0.01). The food consumption frequency by food groups was not different among the groups. The obese group consumed less frequently meats, vegetables and fruits and had higher frequency in fish, legumes and their products, instant or fast food. In all subjects the higher rate of obesity was found with males than females and with those of heavier smoking and drinking, and in females the higher rate of obesity was found with lower education levels, skipping meals and having an unbalanced diet. In middle-aged subjects of this study with higher educational and socioeconomic background factors contributing to the effects of obesity may include smoking, drinking, educational background, skipping meals or unbalanced dietary pattern. The predictable characteristics for the development of obesity can be defined as sudden fluctuation of weights, exercise regularity and intakes of vegetables and fruits.

• Asian Pacific Journal of Cancer Prevention
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• 제17권6호
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• pp.2935-2940
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• 2016

Breast cancer is the most frequent type of cancer diagnosed among women worldwide and also in Thailand. Estrogen and estrogen receptors exert important roles in its genesis and progression. Several cytokines have been reported to be involved in the microenvironment that promotes distant metastasis via modulation of immune and inflammatory responses to tumor cells. Estrogen receptor genetic polymorphisms and several cytokines have been reported to be associated with breast cancer susceptibility and aggressiveness. To investigate roles of genetic polymorphisms in estrogen receptor alpha (ESR1) and interleukin 6 (IL6), breast cancer patients and control subjects were recruited from the Division of Head, Neck and Breast Surgery (Siriraj Hospital, Bangkok, Thailand). Polymorphisms in ESR1 (rs3798577) and IL6 (rs1800795 and rs1800797) were evaluated by real-time PCR in 391 breast cancer patients and 79 healthy controls. Associations between genetic polymorphisms and clinicopathological data were determined. There was no association between genetic polymorphisms and breast cancer susceptibility. However the ESR1 rs3798577 CT genotype was associated with presence of lymphovascular invasion (OR=2.07, 95%CI 1.20-3.56, p=0.009) when compared to the TT genotype. IL6 rs1800795 CC genotype was associated with presence of extranodal extension (OR= 2.30, 95%CI 1.23-4.31, p=0.009) when compared to the GG genotype. Survival analysis showed that IL6 rs1800797 AG or AA genotypes were associated with lower disease-free survival. These findings indicate that polymorphisms in ESR1 and IL6 contribute to aggressiveness of breast cancer and may be used to identify high risk patients.

• Journal of Yeungnam Medical Science
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• 제12권1호
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• pp.1-9
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• 1995

최근 3년간 영남대학교 의과대학 병리학교실에 의뢰되어 진단되었던 위선종 25례와 위선암종 64례를 대상으로 항 PCNA항체를 이용한 면역 조직화학적 염색을 시행하여 다음과 같은 결과를 얻었다. 1) PCNA 양성율은 대조군 $29.14{\pm}12.77%$, 위선종 $44.09{\pm}17.11%$, 위선암종 $80.15{\pm}10.69%$로서 대조군, 위선종, 위선암종 순으로 유의한 증가를 보였다. 2) 위선암종에 있어서 PCNA 양성율을 조직학적 분화도와 비교한 결과, 중분화형 및 저분화형은 고분화형에 비해 반응도가 증가하는 경향이 있지만 3등급 간에 통계적 유의성은 없었다. 3) 위선암종의 PCNA 양성율을 침습 정도와 비교한 결과, 그 정도가 심할수록 증가하는 경향을 보였으나 통계적 유의성은 없었고, 조기위암군과 진행성 위암군으로 대별할 경우 진행성 위암종에서 의의있는 증가를 보였다. 4) 위선암종의 PCNA 양성율을 림프절 전이상태와 비교한 결과, 림프절 전이가 있는 선암종에서 림프절 전이가 없는 선암종에 비해 의의있는 증가를 보였다. 이상의 결과를 종합하면 PCNA 양성반응은 위선종과 위선암종의 감별진단에 크게 도움을 주리라 사료되며, PCNA는 위선암종의 침윤과 전이에 밀접한 관계가 있을 것으로 생각되어 예후 측정에 보조적인 가치가 있을 것으로 추정되었다. 그러 나 PCNA 반응도만으로는 독립적인 예후 척도로 인정하기 어려울 것으로 생각되며 다른 예후 인자와 함께 고려하는 것이 유용할 것으로 생각되었다.

• Diabetes and Metabolism Journal
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• 제42권6호
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• pp.513-518
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• 2018

Background: Recent studies have correlated serum cystatin C (CysC) with vascular complications, but few studies have investigated this correlation in diabetes patients without nephropathy. This study aimed to evaluate if higher serum CysC levels increase the risk for vascular complications in type 2 diabetes mellitus patients with normal renal function or mild renal impairment. Methods: A total of 806 consecutive patients with type 2 diabetes mellitus who were admitted to the diabetes center of Soonchunhyang University Hospital for blood glucose control were retrospectively reviewed. Patients with nephropathy were excluded. Subjects were categorized into quartiles of serum CysC levels (Q1, ${\leq}0.65mg/L$; Q2, 0.66 to 0.79 mg/L; Q3, 0.80 to 0.94 mg/L; and Q4, ${\geq}0.95mg/L$). Results: The proportion of patients with diabetic retinopathy (DR) (P for trend <0.001), coronary heart disease (CHD) (P for trend <0.001), and stroke (P for trend <0.001) increased across the serum CysC quartiles. After adjustment for confounding factors, the highest serum CysC level remained a significant risk factor for DR (odds ratio [OR], 1.929; 95% confidence interval [CI], 1.007 to 4.144; P=0.040). Compared with Q1, a significant positive association was observed between serum CysC and CHD in Q2 (OR, 7.321; 95% CI, 1.114 to 48.114; P=0.012), Q3 (OR, 6.027; 95% CI, 0.952 to 38.161; P=0.020), and Q4 (OR, 8.122; 95% CI, 1.258 to 52.453; P=0.007). No associations were observed between CysC and stroke after additional adjustment for confounding variables. Conclusion: Serum CysC levels are independently associated with DR and CHD, suggesting that CysC may be useful for identifying type 2 diabetes mellitus patients without nephropathy who are at high risk for vascular complications.

• 한국어교육
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• 제29권1호
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• pp.1-23
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• 2018

This paper investigates how adult Mandarin- and English- speaking learners of Korean perceive Korean vowels, with focus on the effect of the first language (L1) and the second language (L2) acoustic relationship, as well as the influence of Korean language experience. For this study, native Mandarin and Canadian English speakers who have learned Korean as a foreign language, as well as a control group of native Korean speakers, participated in two experiments. Experiment 1 was designed to examine acoustic similarities between Korean and English vowels, as well as Korean and Mandarin vowels to predict which Korean vowels are relatively easy, or difficult for L2 learners to perceive. The linear discriminant analysis (Klecka, 1980) based on their L1-L2 acoustic similarity predicted that L2 Mandarin learners would have perceptual difficulty rankings for Korean vowels as follows: (the easiest) /i, a, e/ >> /ɨ, ʌ, o, u/ (most difficult), whereas L2 English learners would have perceptual difficulty rankings for Korean vowels as follows: (the easiest) /i, a, e, ɨ, ʌ/ >> /o, u/ (most difficult). The goal of Experiment 2 was to test how accurately L2 Mandarin and English learners perceive Korean vowels /ɨ, ʌ, o, u/ which are considered to be difficult for L2 learners. The results of a mixed-effects logistic model revealed that English listeners showed higher identification accuracy for Korean vowels than Mandarin listeners, indicating that having a larger L1 vowel inventory than the L2 facilitates L2 vowel perception. However, both groups have the same ranking of Korean vowel perceptual difficulty: ɨ > ʌ > u > o. This finding indicates that adult learners of Korean can perceive the new vowel /ɨ/, which does not exist in their L1, more accurately than the vowel /o/, which is acoustically similar to vowels in their L1, suggesting that L2 learners are more likely to establish additional phonetic categories for new vowels. In terms of the influence of experience with L2, it was found that identification accuracy increases as Korean language experience rises. In other words, the more experienced English and Mandarin learners of Korean are, the more likely they are to have better identification accuracy in Korean vowels than less experienced learners of Korean. Moreover, there is no interaction between L1 background and L2 experience, showing that identification accuracy of Korean vowels is higher as Korean language experience increases regardless of their L1 background. Overall, these findings of the two experiments demonstrated that acoustic similarity between L1 and L2 sounds using the LDA model can partially predict perceptual difficulty in L2 acquisition, indicating that other factors such as perceptual similarity between L1 and L2, the merge of Korean /o/ and /u/ may also influence their Korean vowel perception.

• 한국건설관리학회논문집
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• 제20권6호
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• pp.66-73
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• 2019

정부와 안전보건공단의 재해 절감을 위한 다양한 노력덕분에 산업과 건설업 전반에 걸쳐 재해 사고는 감소추세를 보이고 있다. 하지만 건설업에서의 추락재해는 감소하지 않고 오히려 증가하고 있다. 특히, 달비계에 의한 추락재해는 매년 발생빈도는 낮지만 발생 시 작업자의 사망과 직결한다는 측면에서 재해강도가 매우 크다고 할 수 있다. 국내 건설업에서의 달비계 작업환경은 매우 열악하다. 특히 소규모 건설현장에서의 달비계 작업자들은 안전에 대한 감독과 관리를 받을 수 있는 주체가 없다. 달비계 작업자들은 자신들이 직접 제작한 성능이 확인되지 않은 달비계를 가지고 불안전한 작업환경에 내몰리고 있다. 따라서 본 연구는 15년간 달비계에서 기인한 242건의 사고사례들을 분석하여 추락재해 발생 주요 원인 및 개선방안을 제시하였으며, 주요내용은 불안전한 행동에 의한 재해발생률이 높아서 작업대 안착 시, 안전난간을 넘어가는 과정, 몸의 불균형 등에서 사고가 많으며 설비개선 및 작업방법개선으로 해결이 요구된다. 또한, KOSHA Guide에서 제시하는 작업순서 상의 문제점으로 발생되는 재해는 없었으며, 다만 작업 순서를 따르지 않아 안전대를 안전대 걸이용 로프에 미설치 및 미부착에 의한 사망으로 이르는 재해가 다수 발생된 것으로 파악되어 작업방법의 개선에서 가장 중요한 사항은 수직구명줄 및 안전대의 설치 및 착용이 가장 중요한 사항으로 도출되었다.

• 대한화장품학회지
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• 제42권2호
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• pp.119-126
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• 2016

피부는 스모그, 담배연기 및 UV와 같은 외부환경으로부터 신체를 보호하는 가장 큰 기관이며, 보호 기작으로서 각질세포와 그 사이를 메우고 있는 세라마이드, 콜레스테롤, 지방산 등의 세포간지질이 라멜라 액정 구조로 피부 장벽을 이루고 있다. 본 연구에서는 세포간지질 중 세라마이드 생합성과 관련되어 있는 세린-팔미토일 전이효소(serine-palmitoyltransferase, SPT) 발현을 western blot으로 확인한 결과, 제주산양산삼 추출물이 농도의존적으로 SPT 단백질 발현을 증가시킴을 확인하였다. 또한 제주산양산삼 추출물을 5% 함유한 제형을 2주간 피부에 도포 후 TEWL을 측정하였을 때, 제주산양산삼 추출물을 함유한 에멀젼 도포부위의 TEWL이 대조군에 비해 유의적으로 감소하는 것을 확인하였다. 이 연구결과는 제주산양산삼 추출물이 SPT의 발현 증가를 통해 세포간 지질의 핵심성분인 세라마이드의 생합성을 증가시켰음을 보여준다. 따라서 제주산양산삼 추출물은 피부장벽기능을 개선시켜 TEWL 감소 효과를 나타내며, 이를 통해 화장품 분야에서 피부장벽 강화 및 보습소재로서 사용될 수 있다고 사료된다.