• Title/Summary/Keyword: NMP

Search Result 219, Processing Time 0.023 seconds

Removal efficacy and cytotoxicity of a calcium hydroxide paste using N-2-methyl-pyrrolidone as a vehicle

  • Lim, Myung-Jin;Jang, Hyun-Jin;Yu, Mi-Kyung;Lee, Kwang-Won;Min, Kyung-San
    • Restorative Dentistry and Endodontics
    • /
    • v.42 no.4
    • /
    • pp.290-300
    • /
    • 2017
  • Objectives: This study investigated the removal efficacy and cytotoxicity of a newly developed calcium hydroxide paste (cleaniCal, Maruchi) using N-2-methyl-pyrrolidone (NMP) as a vehicle in comparison with ApexCal (Ivoclar Vivadent) and Calcipex II (Nishika), which use different vehicles such as polyethylene glycol and propylene glycol, respectively. Materials and Methods: Thirty maxillary premolars with oval-shaped canals were divided into 3 groups and the teeth were filled with one of the pastes. After removal of the paste, micro-computed tomographic (${\mu}$-CT) imaging was obtained to assess the volume of residual paste in the root canal of each tooth. The teeth were then split longitudinally and the area of the paste-coated surface was evaluated by stereomicroscopy. The cytotoxicity of each product was assessed using an agar overlay assay. The effect of each vehicle on cell viability was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The data were analyzed using one-way analysis of variance and Tukey's tests to detect any significance (p < 0.05). Results: In the ${\mu}$-CT and stereomicroscopic analysis, cleaniCal exhibited less remnants of medicament than ApexCal and Calcipex. cleaniCal showed a higher cytotoxicity than the other pastes in the agar overlay assay. Furthermore, NMP exhibited lower cell viability compared to the other vehicles. Conclusions: cleaniCal showed better removal efficacy compared to the other products. However, clinicians should be aware of the higher cytotoxicity of the NMP-based material and consider its possible adverse effects on periradicular tissue when it is overfilled.

Design of Robust Controller for Non-minimum Phase System with Parametric Uncertainty using QFT (QFT를 이용한 파라미터 불확실성을 갖는 비최소위상 제어시스템의 강인한 제어기 설계)

  • Kim, Young-Chol;Kim, Shin-Ku;Cho, Tae-Shin;Choi, Sun-Wook;Kim, Keun-Sik
    • Journal of the Institute of Electronics Engineers of Korea SC
    • /
    • v.38 no.3
    • /
    • pp.1-12
    • /
    • 2001
  • We consider the robust control problem for non-minimum phase(NMP) systems with parametric uncertainty. First, a new method that translates such an uncertain NMP system into a interval family of minimum phase(MP) transfer functions followed a time delay term in the form of Pade' approximation is presented. The controller to be proposed consists of a compensator with Smith predictor structure, so that it can compensate the time delay behaviour due to NMP plant. Therein, the main feedback controller for a family of MP plants has been designed by using quantitative feedback theory(QFT) such that satisfies the robust stability against the structured uncertainty. The stability and performance of overall system are examined through an illustrative example.

  • PDF

A Study for Carbon Dioxide Removal Process Using N-Methyl-2-Pyrrolidone Solvent in DME Production Process (DME 생산공정에서 노말 메틸 피로리돈(N-Methyl-2-Pyrrolidone) 용매를 이용한 이산화탄소 제거공정 연구)

  • Jung, Jongtae;Roh, Jaehyun;Cho, Jungho
    • Clean Technology
    • /
    • v.18 no.4
    • /
    • pp.347-354
    • /
    • 2012
  • In this study, simulation works have been performed for the $CO_2$ removal process contained in the DME production process using NMP (N-methyl-2-pyrrolidone) as a solvent. PRO/II with PROVISION release 9.1 at Invensys was used as a chemical process simulator and NRTL activity coefficient model with Henry's law option and Soave-Redlich-Kwong equation of state were used for thermodynamic models. For the determination of the binary interaction parameters in NRTL model, regression works have been performed to match the experimental thermodynamic data. Optimal feed tray location which minimizes the reboiler heat duty was determined.

Enhanced Solubility and In vitro Skin Permeation of Lovastatin Using Some Vehicles and Penetration Enhancers (수종 용제와 투과 촉진제를 이용한 로바스타틴의 용해성 및 피부 투과 증진)

  • Lee, Na Young;Chun, In Koo
    • YAKHAK HOEJI
    • /
    • v.58 no.3
    • /
    • pp.171-180
    • /
    • 2014
  • To enhance the in vitro permeation of lovastatin through excised hairless mouse and human cadaver skins, solubility was determined in various hydrophilic and lipophilic vehicles, and the effects of vehicles and penetration enhancers on the skin permeation from solution formulations were investigated. Solubility of lovastatin was highest in N-methyl-2-pyrrolidone (NMP) ($278.2{\pm}10.1$ mg/ml) and dimethyl sulfoxide (DMSO) ($162.2{\pm}9.7$ mg/ml). Among different pure vehicles used, NMP, DMSO, propylene glycol and isopropyl myristate provided some drug permeation ($6.9{\pm}1.1$, $5.9{\pm}1.6$, $3.0{\pm}0.5$ and $2.2{\pm}0.3{\mu}g/cm^2$ at 24 hr, respectively) through hairless mouse skin. The addition of oleic acid, linoleic acid and oleyl alcohol to DMSO showed the maximum permeation at around 5 v/v%, however, capric acid and caprylic acid had no enhancing effect. The increase of enhancer concentrations showed bell-shaped permeation rate, suggesting the presence of optimal concentration in lovastatin penetration. Increasing donor concentration from 10 mg/ml to 80 mg/ml in DMSO and a cosolvent of DMSO, NMP and DGME (3 : 3 : 4 v/v) did not show significant dose dependent permeation in both hairless mouse and human cadaver skins. The maximum lovastatin flux through human cadaver skin was found to be $0.87{\pm}0.46{\mu}g/cm^2$/hr with 5 v/v% linoleic acid and donor dose of 4 mg/0.64 $cm^2$ in the cosolvent. These results suggest that transdermal delivery of lovastatin would be feasible by establishing the optimal concentrations of donor dose and unsaturated fatty acids in appropriate vehicles.

The Cause Analysis of a Fire Accident on Boryeong Thermal Power Plant using New Public Management Theory (신공공관리론으로 바라본 보령화력발전소 화재 사고의 원인)

  • Lee, Wonjoo;Park, Chanseok
    • Journal of the Society of Disaster Information
    • /
    • v.15 no.2
    • /
    • pp.268-281
    • /
    • 2019
  • Purpose: The purpose of this study was to find out how the administrative paradigm of the times affected the public sector's fire. Method: For this purpose, we investigated the New Public Management (NPM). In addition, the reasons of fire accident of Boryeong thermal power plant were analyzed in the limited values of NMP. Result: In theoretical investigation, the 3 values (managerial accountability, efficiency, expertise) of NMP and evaluation criteria were drew out. In investigation on reasons of fire accident, the improvement of accountability and expertise was insufficient due to the emphasis of the efficiency based on the introduction to free market by neoliberalism in public sector. Conclusion: In conclusion, we confirmed that the values of NMP were limited to forcingly apply to the public sector. This study is expected to contribute basic research references to fire administration theory.

Preparation and Characterization of Organic Solvent-resistant Polybenzimidazole Membranes (용매저항성 폴리벤즈이미다졸 분리막의 제조 및 특성평가)

  • Jeong, Moon Ki;Nam, Sang Yong
    • Applied Chemistry for Engineering
    • /
    • v.28 no.4
    • /
    • pp.420-426
    • /
    • 2017
  • Recently, solvent-resistant nanofiltration membranes have been studied for the separation of solvents or solutes using a molecular weight cut-off system of the polymer which is resistant to a specific solvent. Required conditions for these membranes must have are excellent physical properties and solvent resistance. Polybenzimidazole, which is known to be one of the most heat-resistant commercially available polymers, has an excellent inherent solvent resistance and it is even insoluble in stronger organic solvents when cross-linked. Therefore, in this study, the applicability of polybenzimidazole as a solvent resistant nanofiltration membrane was discussed. The membrane was fabricated using the non-solvent induced phase separation method and showed a suitable morphology as a nanofiltration membrane confirmed by field emission scanning electron microscopy. In addition, the permeance of the solvent in the presence or absence of cross-linking was investigated and the stability was also confirmed through long operation. The permeance test was carried out with five different solvents: water, ethanol, benzene, N, N-dimethylacetamide (DMAc) and n-methyl-2-pyrrolidone (NMP); each of the initial flux was $6500L/m^2h$ (water, 2 bar), $720L/m^2h$ (DMAc, 5 bar), $185L/m^2h$ (benzene, 5 bar), $132L/m^2h$ (NMP, 5 bar), $65L/m^2h$ (ethanol, 5 bar) and the pressure between 2 and 5 bar was applied depending on the type of membrane.

Solvent-Polymer Interactions for Stable Non-Aqueous Graphene Dispersions in the Presence of PVK-b-PVP Block Copolymer (PVK-b-PVP 블록 공중합체의 존재 하에서 안정한 비 수계 그래핀 분산액을 위한 용매-고분자 상호작용에 관한 연구)

  • Park, Kyung Tae;Perumal, Suguna;Lee, Hyang Moo;Kim, Young Hyun;Cheong, In Woo
    • Journal of Adhesion and Interface
    • /
    • v.18 no.3
    • /
    • pp.109-117
    • /
    • 2017
  • Poly(N-vinyl carbazole) (PVK) homopolymer, poly(4-vinylpyridine) (PVP) homopolymer, and PVK-b-PVP block copolymer were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and the polymers were used to prepare non-aqueous graphene dispersions with four different solvents, ethanol, N-methyl-2-pyrrolidone (NMP), dichloromethane (DCM), and tetrahydrofuran (THF). $^1H-$ and $^{13}C-NMR$ spectroscopy, size exclusion chromatography (SEC), and differential scanning calorimetry (DSC) were carried out to confirm the chemical structure of the polymers. Stability of graphene dispersions was measured by on-line turbidity measurement. Time-dependent Turbiscan Stability Index (TSI) values were interpreted in terms of surface tension (${\sigma}$) and solubility parameter (${\delta}$) among solvents, polymers, and graphene. It was confirmed that the solubilities of polymer and surface tension between solvent and graphene affected the dispersion stability of graphene. PVK-b-PVP block copolymer could effectively maintain the low TSI values of graphene dispersions in ethanol and THF, which have been known as poor solvents for graphene dispersions. It can also be noted that DCM shows good dispersion stability comparable to NMP, which has been known as the best solvent for graphene dispersion.

The Observation of Scattering Patterns During Membrane Formation: Spinodal Decomposition and Nucleation Growth (스피노달 분해와 기핵성장에 따른 상분리 과정의 광산란 패턴의 관찰)

  • Kang, Jong-Seok;Huh, Hoon;Lee, Young-Moo
    • Membrane Journal
    • /
    • v.12 no.2
    • /
    • pp.97-106
    • /
    • 2002
  • Small angle light scattering (SALS) and field emission scanning electron microscope (FE-SEM) have been used to investigate the light scattering patterns with time evolved during water vapor quenching (relative humidity of 53 (${\pm}3)%$ at $26^{\circ}C$ of polysulfone (PSf)/NMP/Alcohol and chlorinated poly(vinyl chloride) (CPVC)/THF/Alcohol, respective1y. Time dependence of the position of the light scattering maximum was observed at PSf dope solutions, confirming spinodal decomposition (SD), while CPVC dope solutions showed a decreased scattered light intensity with an increased q-value, indicating nucleation & growth (NG). For the each system, domain growth rate in the intermediate and late stage of phase separation decreased with increasing the number of carbon of alcohol used as additive (non-solvent). Also, in the early stage for SD, the scattering intensity with time was in accordance with Cahn's linear theory of spinodal decomposition, regardless of types of non-solvent additive. Also, the size scales obtained by SALS were mutually compared to domain sizes gained by FE-SEM measurement. These observations of scattering pattern were much clearly observed for the 20PSf/70NMP/10n-butanol (w/w%) and agreed with the theoretical predictions for scattering patterns of each stage like the early, the intermediate, and the late stage of SD type phase separation. As the scattering maximum was observed at the larger angles (larger q) in the order of n-butanol > n-propanol > methanol > no alcohol, the pore size of final morphology decreased.