• 대한간호학회지
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• 제31권3호
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• pp.401-416
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• 2001

현재의 보건의료체계에서는 모든 것이 급박하게 변화하고 있으며 또 구체적인 자료를 요구한다. 컴퓨터의 보급과 함께 이러한 변화에 능동적으로 대처하기 위해 간호학에서도 표준화된 대규모 데이터베이스의 개발이 필수적이다. Nursing Minimum Data Set (NMDS)은 간호학분야에서 개발된 최초의 표준화된 대규모 데이터 베이스로서, 간호가 일어나는 모든 상황에서 반드시 수집되어야 할 핵심적인 간호요소를 포함하고 있다. 따라서 본 논문에서는 NMDS 개발의 역사적인 배경, 목적, 요소, 그리고 간호계의 세계적인 동향과 관련하여 NMDS가 이루어야 할 방향, 그리고 NMDS를 완성하기 위해 선행되어 할 문제로 표준화된 분류체계에 대해 논의하였다. 그리고 미국이외에도 몇몇나라에서 NNDS나 혹은 유사한 데이터베이스가 개발 중이거나 이미 수집되고 있는 나라들이 있으므로 이들에 대한 비교와 분석도 제시하였다. 그리고 보다 최근에 개발된 데이터 베이스로 주로 행정적인 목적을 위해 개발된 Nursing Management Minimum Data Set (NMMDS)을 소개하였다. 즉 NMDS가 임상적인 자료의 수집에 초점을 맞춘 데 비해, NMMD는 효과적인 간호관리에 필수적인 요소들을 포함시켰다. 그래서 간호행정가들이 의사결정에 필요한 재정적자원, 환경적자원, 간호자원에 대한 정보를 수집할 수 있게 고안되었다. 이러한 데이터 베이스들은 관계형 데이터베이스로 서로 연결되어야 하며, 다른 학문분야와도 연계되어 활용되어져야 할 것이다. 만약 이러한 대규모 데이터베이스 들이 한국에서도 개발되고 사용되어 진다면 환자간호에 더욱 비용 효과적인 관리가 가능하게 될 것이다. 마지막으로 우리나라에서 NMDS나 NMMDS 같은 대규모데이터 베이스의 개발이 시급히 요청됨을 강조하였다.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2006년도 정기 학술대회 논문집
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• pp.778-785
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• 2006

In this paper, two possible ways for mode shape expansion are proposed and opened for discussion for future use. The first method minimizes the modal flexibility error between the experimental and analytical mode shapes corresponding to the measured DOFs to find the multiplication matrix which can be treated as the least-squares minimization problem. In the second method, Normalized Modal Difference (NMD) is used to calculate multiplication matrix using the analytical DOFs corresponding to measured DOfs. This matrix is then used to expand the measured mode shape to unmeasured DOFs. A simulated simply supported beam is used to demonstrate the performance of the methods. These methods are then compared with two most promising existing methods namely Kidder dynamic expansion and Modal expansion methods. It is observed that the performance of the modal flexibility method is comparable with existing methods. NMD also have the potential to expand the mode shapes though it is seen more sensitive to the distribution of error between FEM and actual test data.

• 한국전문물리치료학회지
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• 제25권3호
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• pp.60-67
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• 2018

Background: Progressive muscle weakness is aggravated not only in the skeletal muscles but also in the respiratory muscles in many patients with neuromuscular diseases (NMD). Inspiratory muscle training (IMT) has been reported as therapy for pulmonary rehabilitation to improve respiratory strength, endurance, exercise capacity, and quality of life, and to reduce dyspnea. Objects: The purpose of this study was to determine the effect of playing harmonica for 5 months on pulmonary function by assessing the force vital capacity (FVC), peak cough flow (PCF), maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), and maximal voluntary ventilation (MVV) in patients with NMD. Methods: Six subjects with NMD participated in this study. The subjects played harmonica once a week for 2 hours at a harmonica academy and twice a week for 1 hour at home. Thus, training was performed thrice a week for 23 weeks. The examiner assessed pulmonary function by measuring FVC in the sitting and supine positions and PCF, MIP, MEP, and MVV in the sitting position at the beginning of training and once a month for 5 months. Results: Both sitting and supine FVC significantly increased after playing harmonica (p=.042), as did MIP (p=.043) and MEP (p=.042). Conclusion: Playing harmonica can be used as an effective method to improve pulmonary function in patients with NMD.

• 한국지하수토양환경학회지:지하수토양환경
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• 제10권5호
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• pp.45-51
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• 2005

본 연구에서는 다환방형족화합물의 하나인 phenanthrene를 이용하여 천연망간산화물에 흡착/탈착되는 특성을 평가하였다. 토양, 퇴적물이나 수체에 다양한 오염물이 동시에 존재하는 경우를 고려하여 페놀계 오염물이 있는 경우, 다환 방형족화합물의 흡탈착에 미치는 영향을 조사하였다. 망간산화물에 의하여 4-클로로페놀은 효과적으로 산화되었으며 반응산물은 고분자화(휴믹화) 되는 경향을 나타내었다. 4-클로로페놀이 분해됨에 따라 망간산화물 표면에 흡착되는 phenanthrene의 양은 급격히 증가하였다. 또한, 4-클로로페놀이 존재하는 경우 흡착된 phenanthrene의 탈착에 대한 저항성은 4-클로로페놀 농도가 증가할수록 강하게 나타남으로써 고분자화된 4-클로로페놀 반응산물에 phenanthrene이 강하게 흡착되어 있다는 결과를 도출하였다. 결과적으로 망간산화물은 페놀계 오염물과 다환방향족화합물을 동시에 처리하는데 효과적으로 사용될 수 있음을 보여주었다.

• 대한임베디드공학회논문지
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• 제2권1호
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• pp.1-8
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• 2007

In this paper, we developed a file system architecture for portable multimedia devices. To enhance user convenience, the information about the stored files should be easily retrieved and organized. We defined NMD (Networked MetaData), which can organize the files in networked fashion by attaching user-defined attributes and relation between files. The NMD is stored in flash memory to utilize its nonvolatile property and low-power consumption, while multimedia files are stored in hard disk, an inexpensive mass storage. The experimental implementation showed that this architecture was able to save about 10% power compared to the hard disk NMD-store.

• Molecules and Cells
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• 제37권1호
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• pp.1-8
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• 2014

Mammalian-cell messenger RNAs (mRNAs) are generated in the nucleus from precursor RNAs (pre-mRNAs, which often contain one or more introns) that are complexed with an array of incompletely inventoried proteins. During their biogenesis, pre-mRNAs and their derivative mRNAs are subject to extensive cis-modifications. These modifications promote the binding of distinct polypeptides that mediate a diverse array of functions needed for mRNA metabolism, including nuclear export, inspection by the nonsense-mediated mRNA decay (NMD) quality-control machinery, and synthesis of the encoded protein product. Ribonucleoprotein complex (RNP) remodeling through the loss and gain of protein constituents before and after pre-mRNA splicing, during mRNA export, and within the cytoplasm facilitates NMD, ensuring integrity of the transcriptome. Here we review the mRNP rearrangements that culminate in detection and elimination of faulty transcripts by mammalian-cell NMD.

• Molecules and Cells
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• 제42권7호
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• pp.523-529
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• 2019

mRNA quality is controlled by multiple RNA surveillance machineries to reduce errors during gene expression processes in eukaryotic cells. Nonsense-mediated mRNA decay (NMD) is a well-characterized mechanism that degrades error-containing transcripts during translation. The ATP-dependent RNA helicase up-frameshift 1 (UPF1) is a key player in NMD that is mostly prevalent in the cytoplasm. However, recent studies on UPF1-RNA interaction suggest more comprehensive roles of UPF1 on diverse forms of target transcripts. Here we used subcellular fractionation and immunofluorescence to understand such complex functions of UPF1. We demonstrated that UPF1 can be localized to the nucleus and predominantly associated with the chromatin. Moreover, we showed that UPF1 associates more strongly with the chromatin when the transcription elongation and translation inhibitors were used. These findings suggest a novel role of UPF1 in transcription elongation-coupled RNA machinery in the chromatin, as well as in translation-coupled NMD in the cytoplasm. Thus, we propose that cytoplasmic UPF1-centric RNA surveillance mechanism could be extended further up to the chromatin-associated UPF1 and co-transcriptional RNA surveillance. Our findings could provide the mechanistic insights on extensive regulatory roles of UPF1 for many cellular RNAs.

• 국방과기술
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• 6호통권256호
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• pp.14-21
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• 2000

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2014년도 춘계학술대회
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• pp.43-45
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• 2014

DPO(Dynamic positioning Operator)는 Dynamic positioning 기능이 있는 선박에 승선하는 항해사로서 항해, 정박 당직 뿐만 아니라 Dynamic positioning이 요구되는 다양한 offshore 작업시에 DP 당직을 수행한다. 정식 DPO가 되기 위하여는 SCTW 항해사 면허뿐만 아니라 NI 혹은 NMD에서 규정한 training 과정을 이수하여 DP limited 혹은 DP unlimited certificate를 취득하여야 한다. 본 연구에서는 1982년부터 업계 표준 DPO의 training과 certification을 담당하고 있는 NI (Nautical Institute) 산하 DPTEG(Dynamic Positioning Training Executive Group)의 DPO 양성과정을 조사하였다. 특히 업계의 보다 현실적인 DPO training 과정에 대한 요구에 대응하여 2014년 3월에 발표되어 2015년 1월1일부터 발효될 더욱 강화된 training과 verification 절차를 담은 새로운 DPO training scheme을 분석하여 한국 해기사들이 DPO로서 offshore sector에 진출하기 위한 방안을 제시하였다.

• BMB Reports
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• 제46권1호
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• pp.9-16
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• 2013

In mammalian cells, aberrant transcripts harboring a premature termination codon (PTC) can be generated by abnormal or inefficient biogenesis of mRNAs or by somatic mutation. Truncated polypeptides synthesized from these aberrant transcripts could be toxic to normal cellular functions. However, mammalian cells have evolved sophisticated mechanisms for monitoring the quality of mRNAs. The faulty transcripts harboring PTC are subject to nonsense-mediated mRNA decay (NMD), nonsense-mediated translational repression (NMTR), nonsense-associated alternative splicing (NAS), or nonsense-mediated transcriptional gene silencing (NMTGS). In this review, we briefly outline the molecular characteristics of each pathway and suggest mRNA quality control mechanisms as a means to regulate normal gene expression.