• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8135-8140
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• 2016

Background: Cell cycle regulatory proteins are suitable targets for cancer therapeutic development since genetic alterations in many cancers also affect the functions of these molecules. Strobilanthes crispus (S. crispus) is traditionally known for its potential benefits in treating various ailments. We recently reported that an active sub-fraction of S. crispus leaves (SCS) caused caspase-dependent apoptosis of human breast cancer MCF-7 and MDA-MB-231 cells. Materials and Methods: Considering the ability of SCS to also promote the activity of the antiestrogen, tamoxifen, we further examined the effect of SCS in modulating cell cycle progression and related proteins in MCF-7 and MDA-MB-231 cells alone and in combination with tamoxifen. Expression of cell cycle-related transcripts was analysed based on a previous microarray dataset. Results: SCS significantly caused G1 arrest of both types of cells, similar to tamoxifen and this was associated with modulation of cyclin D1, p21 and p53. In combination with tamoxifen, the anticancer effects involved downregulation of $ER{\alpha}$ protein in MCF-7 cells but appeared independent of an ER-mediated mechanism in MDA-MB-231 cells. Microarray data analysis confirmed the clinical relevance of the proteins studied. Conclusions: The current data suggest that SCS growth inhibitory effects are similar to that of the antiestrogen, tamoxifen, further supporting the previously demonstrated cytotoxic and apoptotic actions of both agents.

• 동의생리병리학회지
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• 제20권3호
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• pp.651-656
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• 2006

Activation of $NF-{\kappa}B$ is known to be a trigger of various cellular disorders including inflammatory and autoimmune diseases such as rheumatoid arthritis. Numerous approaches are ongoing within laboratories to identify potential therapeutic agents which inhibit the $NF-{\kappa}B$ activation. In this study, we have tested the inhibitory effects of five traditional medicines on the activation of $NF-{\kappa}B$ by NIK. Among three medicines which exhibited inhibitory effect on the expression of $NF-{\kappa}B$ repoter plasmid, we investigated further the inhibitory mechanism of Dichroa febrifuga in connection with IKKY activity. Wild type $IKK{\gamma}$ inhibited the $NF-{\kappa}B$ activation by NIK but the C-terminal deletion mutant of IKKY did not show the inhibitory effect, indicating that the C-terminal leucine zipper domain of $NF-{\kappa}B$ is important for the inhibition of $NF-{\kappa}B$ activation. The water extract of Dichroa febrifuga(DFE) also strongly inhibited the $NF-{\kappa}B$ activation by NIK. The inhibitory activity of DFE appeared to be independent of the expression of $IKK{\gamma}$, suggesting that the pathways of inhibition by Dichroa febrifuga and $IKK{\gamma}$ are different. Our results suggest that Dichroa febrifuga can be used as a medicine for inhibition of the $NF-{\kappa}B$ activation in a wide range of cells without relation to the expression of $IKK{\gamma}$.

• 디지털콘텐츠
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• 2호통권93호
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• pp.48-53
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• 2001

인터넷 기업에 있어서 콘텐츠는 회사의 자산이며 제조업의 생산물에 비유된다. 또한 모든 회사는 콘텐츠의 소비자이기도 하다. 회사 차원의 콘텐츠 구매는 비용에 해당한다. 따라서 콘텐츠의 구매는 회사차원에서 체계적인 관리와 투자가 필요한 부분이다. 나아가 미래 사회는 정보가 회사의 운명을 결정하는 사회가 될 것이기 때문에 콘텐츠 자산관리는 기업들이 지금부터 준비해야할 것이다.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2002년도 제35회 학술심포지움 및 춘계학술대회
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• pp.123-123
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• 2002

• International Journal of Industrial Entomology and Biomaterials
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• 제33권2호
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• pp.121-131
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• 2016

Ten microsporidian isolates from Samia cynthia ricini, and Antheraea assamensis in India along with a Nosema reference strain (NIK-1s_mys) from B. mori India were characterised morphologically and molecular based tools. The test isolates observed elongated oval in shape while reference strain was oval and ranging from 3.80 to 4.90 m in length and 2.60 to 3.05 m in width. The ribosomal DNA region 'IGS' of test isolates assessed by PCR amplification, followed by cloning and sequencing. IGS sequence and phylogenetic analysis of test microsporidian isolates showed very close relationship with three Nosema references species: N. philosamia, N. antheraea isolated from Philosamia cynthia ricini and Antheraea perny in China respectively and N. disstriae from Malacosma disstriae in Canada. The clustering pattern of dendogram reveals all test isolates appear distinct from Nosema std. (NIK-1s_mys) India used as reference strain in the study. The result suggests IGS indeed a suitable and highly applicable molecular tool for identifying and characterise the microsporidian isolates in similar population.

• Journal of Power Electronics
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• 제11권2호
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• pp.148-155
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• 2011

Direct torque control(DTC) of induction machines is known to offer fast instantaneous torque and flux control with a simple control structure. However, this scheme has two major disadvantageous, namely, a variable inverter switching frequency and a high torque ripple. These problems occur due to the use of hysteresis comparators in conventional DTC schemes, particularly in controlling the output torque. This paper reviews the utilization of constant frequency torque controllers (CFTC) in DTC to solve these problems while retaining the simple control structure of DTC. Some extensions of the work in utilizing a CFTC will be carried out in this paper which can further reduce the torque ripple. This is particularly useful for a system which has a limited/low sampling frequency. The feasibility of a CFTC with an extended carrier frequency in minimizing the torque ripple is verified through experimental results.

• Structural Engineering and Mechanics
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• 제64권6권
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• pp.793-802
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• 2017

The damage of concrete due to the expansion of alkali-aggregate reaction (AAR) and thermal-chemical reactions affecting the strength of concrete is studied. The empirical equations for the variations of expansion of AAR, compressive strength and degradation of the modulus of elasticity with time, and compressive strength with degradation of the modulus of elasticity are proposed by analysing numerous experimental data. It is revealed that the expansion of AAR and compressive strength increase with time. The proposed combination of the time variations of chemical and mechanical parameters provides a satisfactory prediction of the concrete strength. Seismic analysis of the aged Koyna dam is conceded for two different long-term experimental data of concrete incorporating the proposed AAR based properties. The responses of aged Koyna dam reveal that the crest displacement of the Koyna dam significantly increases with time while the contour plots show that major principal stress at neck level reduces with time. As the modulus of elasticity decreases with ages the stress generated in the concrete structure get reduces. On the other hand with lesser value of modulus of elasticity the structure becomes more flexible and the crest displacement becomes very high that cause the seismic safety of the dam reduce.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.153-158
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• 2013

This paper reports on part of a large study to identify competencies of oncology nurses in Malaysia. It focuses on oncology nurses' communications-related competency. As an important cancer care team member, oncology nurses need to communicate effectively with cancer patients. Literature shows that poor communication can make patients feel anxious, uncertain and generally not satisfied with their nurses' care. This paper deliberates on the importance of effective communication by oncology nurses in the context of a public hospital. Four focus group discussions were used in this study with 17 oncology/cancer care nurses from Malaysian public hospitals. The main inclusion criterion was that the nurses had to have undergone a post-basic course in oncology, or have work experience as a cancer care nurse. The findings indicated that nurses do communicate with their patients, patients' families and doctors to provide information about the disease, cancer treatment, disease recurrence and side effects. Nurses should have good communication skills in order to build relationships as well as to provide quality services to their patients. The paper concludes by recommending how oncology nursing competencies can be improved.

• The Journal of Asian Finance, Economics and Business
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• 제7권10호
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• pp.717-728
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• 2020

The objective of this study is to explore the whole process of fraud risk management strategies that should be implemented by the organizations. Secondly, this study discusses the governance issues that arise at each stage of the process. For the purpose of this study, a content analysis of previous literatures is used as a technique for gathering data. This process usually involves codifying qualitative and quantitative information into pre-defined categories in order to derive patterns in the presentation and reporting of information. Based on our content analysis, we found that the fraud risk management process should be made of at least five stages which are inculcating the culture of managing risks in an organization, identifying the risks, evaluating the risks, determining preventive actions and implementing and reviewing stages. Our extended analysis of the fraud risk management process finds that a lot of governance issues arise in the fraud risk management process that should be solved by regulators and companies in order to ensure that fraud risk management process is embedded as corporate culture, not merely as a process. Among them are how to create the risk culture in an organization and whether auditors and risk management committees identify risks from each available source.

• Journal of Power Electronics
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• 제16권3호
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• pp.982-993
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• 2016

A method for the fault-tolerant vector control of star-connected 3-phase Induction Motor (IM) drive systems based on Field-Oriented Control (FOC) is proposed in this paper. This method enables the control of a 3-phase IM in the presence of an open-phase failure in one of its phases without the need for control structure changes to the conventional FOC algorithm. The proposed drive system significantly reduces the speed and torque pulsations caused by an open-phase fault in the stator windings. The performance of the proposed method was verified using MATLAB (M-File) simulation as well experimental tests on a 1.5kW 3-phase IM drive system. This paper experimentally compares the operation of the proposed fault-tolerant vector controller and a conventional vector controller during open-phase fault.