• BMB Reports
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• v.55 no.7
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• pp.354-359
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• 2022

MitoNEET, a mitochondrial outer membrane protein containing the Asn-Glu-Glu-Thr (NEET) sequence, controls the formation of intermitochondrial junctions and confers autophagy resistance. Moreover, mitoNEET as a mitochondrial substrate undergoes ubiquitination by activated Parkin during the initiation of mitophagy. Therefore, mitoNEET is linked to the regulation of autophagy and mitophagy. Mitophagy is the selective removal of the damaged or unnecessary mitochondria, which is crucial to sustaining mitochondrial quality control. In numerous human diseases, the accumulation of damaged mitochondria by impaired mitophagy has been observed. However, the therapeutic strategy targeting of mitoNEET as a mitophagy-enhancing mediator requires further research. Herein, we confirmed that mitophagy is indeed activated by mitoNEET inhibition. CCCP (carbonyl cyanide m-chlorophenyl hydrazone), which leads to mitochondrial depolarization, induces mitochondrial dysfunction and superoxide production. This, in turn, contributes to the induction of mitophagy; mitoNEET protein levels were initially increased before an increase in LC3-II protein following CCCP treatment. Pharmacological inhibition of mitoNEET using mitoNEET Ligand-1 (NL-1) promoted accumulation of Pink1 and Parkin, which are mitophagy-associated proteins, and activation of mitochondria-lysosome crosstalk, in comparison to CCCP alone. Inhibition of mitoNEET using NL-1, or mitoNEET shRNA transfected into RAW264.7 cells, abrogated CCCP-induced ROS and mitochondrial cell death; additionally, it activated the expression of PGC-1α and SOD2, regulators of oxidative metabolism. In particular, the increase in PGC-1α, which is a major regulator of mitochondrial biogenesis, promotes mitochondrial quality control. These results indicated that mitoNEET is a potential therapeutic target in numerous human diseases to enhance mitophagy and protect cells by maintaining a network of healthy mitochondria.

• Land and Housing Review
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• v.14 no.3
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• pp.1-15
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• 2023

Using youth panel data, this study attempted to diagnose the effect of residential characteristics (housing type and housing type) and various household background variables on the implementation of youth NEET (Not in Employment, Education or Training), and to suggest appropriate policy directions. As a result of the analysis, it was found that young individuals residing in unfavorable living conditions such as those who rent on a monthly basis or live in multi-household, villa, or officetel settings, had a higher likelihood of transitioning to NEET. Those who received financial support from their parents were more likely to transition to NEET. Therefore, comprehensive youth NEET support policies such as customized housing and job policies according to the characteristics of NEET should be established. In particular, even though they have reached adulthood, it is shown that the likelihood of becoming NEET is very high for youth who live together with their parents without being economically independent or who receive financial assistance from their parents. In order to mitigate and prevent these young people from NEET transition, transitioning from school to the labor market should be facilitated with policy support.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.4
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• pp.1502-1520
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• 2021

This paper attempts to investigate Korean youth Not in Education, Employment and Training (NEET) and how daily activities and community participation may influence their positive emotions and job search desire. First, we conducted a focus group interview with 16 NEETs who participated in the Kakao NEET Company project. The project allowed participants to experience employment by founding a virtual company in which each participant selected a daily activity to perform as part of the company's operations. Second, the interview responses were categorized and assigned emotional values using the card sorting technique and multi-dimensional analysis (MDS). A total of 11 emotional values were derived through this process. Finally, a social network analysis was conducted in order to measure the density of relations among the emotional values. Results suggest that immersion, confidence, belongingness were the three highest values evaluated by participants. Furthermore, network diagrams imply that the stronger participants perceived social support and belongingness with others, the stronger their responsibility grew, further leading them to establish steady goals. In particular, the high eigenvector score for "desire for job" suggests that emotional values are sequentially connected to the immersion-social support-responsibility-goal-job desire. This sequence suggests that digital services that are developed with the aim to enhance social values such as the Kakao NEET Project may engender motivation and confidence in youth NEETs. The overall results suggest that a systematic approach to policymaking should be considered in order to provide fundamental solutions and expand opportunities for social participation and emotional comfort, as social isolation due to low self-esteem has been reported as one of the reasons for NEETs' failure in the labor market.

• Korean Journal of Social Welfare Studies
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• v.49 no.2
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• pp.125-157
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• 2018

In the reality that the seriousness and concern about the youth problem is increasing, this study focuses on the vision plan project supporting the NEET youth in the social welfare field. Therefore, this study analyzed how the social workers recognized the NEET problem before participating in the project, what difficulties they experienced in the process of the project, and how they coped with these difficulties. The results of the study are as follows. Social workers were saddened by the seriousness of the youth problem before their participation, but they recognized that there was no way to solve it and many social workers were not fully aware of the youth or NEET issues. In this context, in the course of running a project with NEET youth, social workers experienced difficulties due to the nature of the NEET youth, difficulty in forming a relationship with NEET youth, and difficulties for young people not to spend time in the program. And social workers also faced difficulties due to the lack of know-how in the project, difficulties in operating the center alone, and difficulty in achieving employment goals. In the process of coping with these difficulties, social workers have actively sought, persuaded and supported the NEET youths to participate in the project, adapted the time, place and method to the youth, and removed the stigmatization element in the project. They also worked closely with local residents, local institutions and municipalities, formed networks, and changed the viewpoint of providing work experience rather than getting young people, but seeing long-term outcome. As a result, social workers have experienced not only individual change but also social welfare organization, field, community and local institutional change. Based on these results, this study suggested that the social welfare practice field should provide various activities in the process of supporting the youth gap year policy. In addition, this study suggests that the social workers play a role in connecting various actors rather than suppliers when working with young people, and that the social welfare field should expand the scope of project to include youth.

• Journal of the Korean Society of Child Welfare
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• no.57
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• pp.9-42
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• 2017

The purpose of this study is to understand the life experience of youth who discharged from out-of-home-care and lived as the unemployed NEET(Not in Education, Employment or Training) youth not established in life. For this study, we collected in-depth interviews with five youth in career moratorium or early discharge from out-of-home care. The results of the study were as follows: we divided into six themes such as "I cannot lean on family of origin", "unstable life", "strayed by wandering and prejudice", "I need someone to rely on", "belated regrets", and "constantly dreaming of resurgence"; and the six themes were analyzed separately in the sub-categories. As a result, we found out that the youth in career moratorium lived a life of regret and recovery in the unstable life journey. Based upon the results, we suggested social welfare practice and policy implications in order to systematically support the NEET youth after discharge from out-of-home-care.

• Journal of the Korea Society of Computer and Information
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• v.22 no.12
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• pp.155-161
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• 2017

Recently, as the number of multicultural families and foreigners living in korea increase, the proportion of various types of families and middle-admitted youths is increasing. These youths are less educated than their domestic counterparts, and their conversation time with their family members is relatively weak. Therefore, there is a need for a specialized education system for education and socialization. Immigration background among middle-admitted adolescents, children arrived in korea regardless of their will, with socialization already in the country where they were born, it is a reality that various difficulties are experienced in the socialization of korea society about language, education, emotion and employment. For this reason, some of the migrant background youths are pointed out as a big problem of the multicultural society, which is 18% of the NEET(Not in Education, Employment or Training) classes, which are not educated and are not willing to find jobs or employment. Therefore, in this study, we identified the problems of middle-admitted children of multicultural families as the number of middle-admitted adolescents increased, and suggested the necessary ways for them to achieve rapid socialization and settlement in korea society. For this purpose, we analyzed the problem of education of middle-admitted children as a discriminative approach which is different from general support method for middle-admitted children presented in previous reaearch, since then, we have presented an alternative to carry out realistic, systematic and successful education considering the characteristics of the region centered on the middle-admitted youths of Gwangju city.

• Journal of the Economic Geographical Society of Korea
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• v.9 no.3
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• pp.396-409
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• 2006

In this paper, first I try to sketch the changing Japanese labor market after 1990s, and then examine the so-called "Job $Caf{\acute{e}}$ program" in detail, which was initiated in 2004 by central and local governments to help young people fine suitable jobs, and finally investigate the possible direction for future labor policy as an important tool for revitalize the local economy. Latter half of 1990s witnessed the high unemployment rate among the population aged twenties in Japan, and the number of 'shinsotsu-mugyo', i.e. population not at work after completing high school or university, NEET (not in employment, education or training) and 'freeters' have grown rapidly. "Job $Caf{\acute{e}}$ program" was initiated as a public response to the increased youth unemployment, aiming at assisting young people's transition from education to career. In the Job $Caf{\acute{e}}$ program, job information service by MHLW, information service for high school students and university students by MEXT, placement service of career internship by METI are integrated into one service, and are provided by local government initiative, therefore named as "one stop service of employment". Although it is highly appreciated for one stop service, the Job cafe program has criticized for paying too much attention to the performance of projects, such as the number of users, and the number of successful job matching. At the final section of the paper, more practical spatial unit for executing effective regional plan on local employment and more empirical research on job search behavior are discussed.

• Nuclear Engineering and Technology
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• v.38 no.2
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• pp.155-162
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• 2006

It is necessary to monitor periodically the operability of safety-related motor-operated valves (MOVs) in nuclear power plants. However, acquiring diagnostic signals for MOVs is very difficult, and doing so requires an excessive amount of time, effort, and expenditure. This paper introduces an accurate and economical method to evaluate the performance of MOVs remotely. The technique to be utilized includes electrical measurements and signal processing to estimate the motor torque and the stem thrust, which have been cited as the two most effective parameters in diagnosing MOVs by the US Nuclear Regulatory Commission. The motor torque is calculated by using electrical signals, which can be measured in the motor control center (MCC). Some advantages of using the motor torque signature over other signatures are examined. The stem thrust is calculated considering the characteristics of the MOV and the estimated motor torque. The basic principle of estimating stem thrust is explained. The developed method is implemented in diagnostic equipment, namely, the Motor Operated Valve Intelligent Diagnostic System (MOVIDS), which is used to obtain the accuracy of and to validate the applicability of the developed method in nuclear power plants. Finally, the accuracy of the developed method is presented and some examples applied to field data are discussed.

• The Journal of the Korea Contents Association
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• v.20 no.6
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• pp.623-639
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• 2020

This study explores the factors associated with the amount of time use in leisure and social gathering activities. The analysis shows that the engaging role types of the youth, for example housekeeping and care giving, or working on the paid job are associated with the amount of time use in leisure activities. However, the factors related to time use in social gathering activities are the engaging role types of youth as well as the socializing opportunity. Compared to the other role types of the youth, the youth who are preparing for a job and is not engaged in employment, education, and training(NEET) spend more time in media leisure, travel and cultural activities, sports and reports activities, however spend less time in social gathering compared to students. The youth who have a job spend the least time in all of the leisure activities except travel and cultural activities for a weekend. Policy should remove the barriers in leisure activities and increase the opportunities for socializing.

• Journal of the Korean Society for Library and Information Science
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• v.15
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• pp.119-140
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• 1988

This paper is the study on the Medium Designator in Non-book materials. Main contents of this study were as follows; 1. The medium designator serves to indicate the class of material to which an item belongs. This is used to give an 'early warning' ;to the catalogue user. 2. This medium designator may be further divided into two elements ; a general material designation (GMD), for example video-recording, and a specific material designation (SMD), for example, videodisc. 3. GMD: In cataloging, a term indicating the broad class of material to which a bibliographic item belongs, such as 'motion picture', and SMD : In descriptive cataloging, a term indicating the special class of material (usually the class of physical object) to which a biblographic item belongs, such as videocassette. 4. Locating the medium designator after the title proper was not prescribed until ISBD(G) and AACR2. In pre-ISBD(G) codes, the ,early, warning type of medium designator was placed after all title information. But in AACR2, the medium designator is placed after the title proper, but before parellel title and other title information. 5. In Terminology, Two separate lists of designations are given in AACR2, l.1C1, one for British and one for North American use. The British list contains fewer terms, and uses generic categories to group together some of the North American list. 6. The problem of where to place the medium designator might be circumvented by using some kind of early alerting device other than a formal element of biblliographic description. Various alternatives have been suggested. A more popular device is the provision of symbols or 'media code' which are part of the call number and indicate the porticular medium type. 'Colour-coding' the use of used by some libraries but is now longly discouraged. 7. According to Frost. The medium designatorhas been generally reeognized as serving three functions; 1) as a statement of the nature or basic format of the item cataloged and thus as a meant of informing the user as to the type of material at hand; 2) as a description of the physical charaetistics of medium and as a means of alerting the user to equipment needed to make use of the item. 3) as a device to distinguish different physical formats which share the same title. 8. AACR2 raises some problems which decision makers have neet had to face preriously It provides a GMD for every item in the collection including books and it makes the application of any or all GMD's optional.