• Asian Pacific Journal of Cancer Prevention
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• 제17권6호
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• pp.2741-2744
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• 2016

The CKLF-like MARVEL transmembrane domain-containing family (CMTM) is a novel family of genes first reported at international level by Peking University Human Disease Gene Research Center. The gene products act between chemokines and the transmembrane-4 superfamily. Located in several human chromosomes, the CMTMs CKLF and CMTM1 to CMTM8 may be unregulated in tumors and act as potential tumor suppressor genes with important roles in the immune, male reproductive and hematopoietic systems. In-depth studies in recent years established a close relation between CMTMs and tumorigenesis and metastasis. The CMTM family has a significant clinical value in diagnosis and treatment of diseases linked to tumors and the immune system.

• 한국물환경학회지
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• 제22권5호
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• pp.784-795
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• 2006

The purpose of this study was to assess biological river water quality by using epilithic diatoms at 40 selected sites in Geum, Youngsan, and Seomjin River systems. The sampling and analyses were performed during three seasons including January, April and June in 2005. Various water quality parameters also were analyzed. We attempted to classify the water quality condition by epilithic diatom indices (DAIpo and TDI) with the results of corresponding analyses of various chemical water quality parameters. A five class system was delivered to describe the water quality condition ranged from "very good" to "very poor." We also proposed a way of classifying water quality condition by combining two diatom indices of DAIpo and TDI. Our results showed that biomass of epilithic diatoms varied not only seasonally but spatially; it was not likely that winter diatoms represent average water quality condition, due to high concentration of nutrients. Water quality status assessed by diatom indices was generally worse than that assessed by BOD, indicating that BOD standard likely underestimates the biological condition of the water body. Importantly, nutrient-based diatom index (TDI) generally overestimated organic matter-based index (DAIpo) at most study sites, indicating that diatoms in studied rivers were likely more affected by nutrients than organic matter. Thus, management strategy to improve river water quality in Korea is suggested to emphasize more on the nutrients than organic matters.

• 보건행정학회지
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• 제30권1호
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• pp.100-111
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• 2020

Background: Few studies have examined the performance of the public long-term care insurance (LTCI) from the perspective of geographic equity. This study investigated regional variations and associated factors in the supply and utilization of nursing home care within and also between Japan and Korea. Methods: A comparative dataset was developed by extracting data from 2013-2015 LTCI statistics yearbooks and Organization for Economic Cooperation and Development regional statistics, as well as other comparable data in Japan and Korea. The unit of analysis was the prefecture in Japan and the province in Korea. We computed variation indices and conducted regression analyses for regional variations within each country and decomposition analyses to examine the variations between the countries. Results: The overall regional supply and use of nursing home care were higher in Japan, but the regional variations in Korea were larger than in Japan. In both countries, the nursing home supply was negatively associated with the proportion of older people with independent living. Nursing home use was also negatively associated with the supply of hospital beds and home care agencies in Korea; the relationship was the opposite in Japan, however. The country-based differences were more likely to be explained by differences in the distributions of the variables included in the analytical model than country-specific characteristics. Conclusion: Regional-level nursing home supply and use were unequal in both countries, and the contributing factors were not the same. Policy efforts are needed to advance regional equality in long-term care (LTC) and collaboration between health and LTC institutions for frail older people, especially in Korea.

• Animal cells and systems
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• 제15권3호
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• pp.227-233
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• 2011

The Nramp1/Slc11a1 locus encodes a proton-coupled divalent cation transporter, expressed in late endosomes/lysosomes of macrophages, that constitutes a component of the innate immune response to combat intracellular pathogens and it was shown to play an important role in regulating inherent immunity. The previously identified Z-DNA forming polymorphic repeat(GT)n in the promoter region of the human Nramp1 gene does act as a functional polymorphism influencing gene expression. Research has shown that INF-${\gamma}$, TNF-${\alpha}$, IL-$1{\beta}$ and bacteria LPS increase the level of Nramp1 expression. However, the molecular mechanism for Nramp1 gene regulation is unclear. In this research, bovine Nramp1 5'-flanking region (-1748~+769) was cloned and analyzed by bioinformatics. Then to find the core promoter and the cis-acting elements, deletion analysis of promoter was performed using a set of luciferase reporter gene constructs containing successive deletions of the bovine Nramp1 5'-flanking regions. Promoter activity analysis by the dual luciferase reporter assay system showed that the core promoter of Nramp1 was located at +58~-89 bp. Some positive regulatory elements are located at -89~-205 bp and -278~-1495 bp. And the repressor elements were in region -205~-278 bp, intron1 and -1495~-1748 bp. LPS-responsive regions were located at -1495~-1748 bp and -278~-205 bp. The present study provides an initial effort to explore the molecular mechanism of transcriptional activation of the bovine Nramp1 gene and should facilitate further studies to decode the complex regulatory process and for molecular breeding for disease resistance in bovines.

• Smart Structures and Systems
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• 제15권5호
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• pp.1373-1392
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• 2015

Placing sensors at appropriate locations is an important task in the design of an efficient structural health monitoring (SHM) system for a large-scale civil structure. In this paper, a hybrid optimization algorithm called virus monkey algorithm (VMA) based on the virus theory of evolution is proposed to seek the optimal placement of sensors. Firstly, the dual-structure coding method is adopted instead of binary coding method to code the solution. Then, the VMA is designed to incorporate two populations, a monkey population and a virus population, enabling the horizontal propagation between the monkey and virus individuals and the vertical inheritance of monkey's position information from the previous to following position. Correspondingly, the monkey population in this paper is divided into the superior and inferior monkey populations, and the virus population is divided into the serious and slight virus populations. The serious virus is used to infect the inferior monkey to make it escape from the local optima, while the slight virus is adopted to infect the superior monkey to let it find a better result in the nearby area. This kind of novel virus infection operator enables the coevolution of monkey and virus populations. Finally, the effectiveness of the proposed VMA is demonstrated by designing the sensor network of the Canton Tower, the tallest TV Tower in China. Results show that innovations in the VMA proposed in this paper can improve the convergence of algorithm compared with the original monkey algorithm (MA).

• Nuclear Engineering and Technology
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• 제27권3호
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• pp.317-326
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• 1995

증기발생기의 수위제어시스템에 대해 특히 저출력시 수위제어의 문제점을 분석고찰하고 퍼지제어기 법을 기반으로 한 안정되고도 신속한 수위제어에 관한 연구가 주로 수행되었다. 문제해결의 한 방안으로서, 중요 제어변수임에도 불구하고 저출력운전시 저유량구간의 추정불량으로 인해 사용할 수 없는 유량신호를 대신하여 밸브개도를 이용한 대체정보를 채용하였으며 또한 소속함수크기의 유동적인 조정방법을 이용하여 수위오차가 크게 발생한 과도상태시에는 신속한 수위회복이 이루어지도록 하였다. 실제운전환경에서 제시된 제어기를 튜닝 하기 위한 방법으로서 제어성능지수 및 decent method를 이용한 소속함수의 self-tuning 기법을 제시하였다. 원자력 연구소의 연수원에 설치된 교육훈련용 시뮬레이터에서 수행된 실험결과는 제시된 제어기 및 튜닝방법의 안정되고 우수한 성능구현 및 실질적 인 유용성을 보여주고 있다.

• 대한간호학회지
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• 제38권6호
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• pp.853-865
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• 2008

Purpose: The aim of this study was to develop and to analyze the task of gerontological nurse practitioners (GNPs) in Korea. Methods: The definition of GNP and job description was developed based on developing a curriculum (DACUM) by 7 panels who have experienced in DACUM analysis and gerontological nursing. One hundred sixty nurses who were working at long term care facilities were participated. The questionnaire included frequency, importance, and difficulty of duties, tasks, and task elements. The data were collected in November 2006, analyzed by descriptive statistics. Results: The job description of GNPs in Korea revealed 5 duties, 23 tasks, and 86 task elements. On the all five duties, the highest duty in frequency and in importance was professional nursing care ($3.25{\pm}0.35$, $3.49{\pm}0.29$). But the highest duty in difficulty was research ($3.24{\pm}0.46$). 'Prevent health problem ($3.42{\pm}0.43$, $3.56{\pm}0.33$)', 'Teach other staffs ($2.83{\pm}0.77$, $3.39{\pm}0.43$)', 'Develop the evidence-based standards ($2.43{\pm}0.76$, $3.22{\pm}0.43$)', 'Develop the self ($2.81{\pm}0.65$, $3.26{\pm}0.42$)', and 'Participate the team activities' were the highest score in frequency and in criticality of tasks. 'Provide emotional support to older adults and families ($3.16{\pm}0.41$)', 'Counsel older adults and their families ($3.14{\pm}0.49$)', 'Do clinical research ($3.32{\pm}0.49$)', 'Quality insurance ($3.25{\pm}0.49$)', and 'Build collaborative system ($3.18{\pm}0.47$)' were perceived the most difficult tasks. Conclusion: The political efforts for the legislation of role and task of GNPs were needed.

• Bulletin of the Korean Chemical Society
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• 제34권5호
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• pp.1407-1413
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• 2013

A new compound, perforaphenonoside A (1), along with 11 known compounds (2-12) were isolated from a methanol extract of adventitious roots of Hypericum perforatum. Their chemical structures were elucidated using chemical and physical methods as well as comparison of NMR and mass spectral data with previously reported data. Their inhibition of NF-${\kappa}B$ and activation of PPAR was measured in HepG2 cells using a luciferase reporter system. Among the compounds 3, 6, 7 and 12 inhibited NF-${\kappa}B$ activation stimulated by TNF${\alpha}$ in a dose-dependent manner, with $IC_{50}$ values ranging from 0.85 to $8.10{\mu}M$. Moreover, compounds 1-3, 7, 11 and 12 activated the transcriptional activity of PPARs in a dose-dependent manner, with $EC_{50}$ values ranging from 7.3 to $58.7{\mu}M$. The transactivational effects of compounds 1-3, 7, 11 and 12 were evaluated on three individual PPAR subtypes. Among them, compound 2 activated $PPAR{\alpha}$ transcriptional activity, with 153.97% stimulation at $10{\mu}M$, while compounds 1, 2 and 11 exhibited transcriptional activity of $PPAR{\gamma}$, with stimulation from 124.76% to 126.91% at $10{\mu}M$.

• Journal of Electrical Engineering and Technology
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• 제13권3호
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• pp.1317-1325
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• 2018

A generator-grid coupling calculation model is established to study the leading-phase operational capability of a 770 MW jumbo hydro-generator in a Chinese ultra-mega hydropower station. The static and dynamic stability of the generator are analyzed and calculated to obtain stability limits under leading-phase operating conditions. Three-dimensional (3D) time-varying nonlinear moving electromagnetic and temperature field models of the generator end-region are also established and used to determine the magnetic field, loss, and temperature of the end-region under the leading-phase operating condition. The simulation results agree with data measured from the actual 770 MW hydro-generator. This paper provides reliable reference data for the leading-phase operation of a jumbo hydro-generator, which will help to improve in the design and manufacture of future hydro-generators.

• Nutritional Sciences
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• 제9권1호
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• pp.14-19
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• 2006

Breast cancer may be the consequence of free radical damage, which is partially caused by the excessive intake of dietary fat and imbalances in antioxidant scavenger system;. In this experiment, we examined! the effects of dietary peroxidizability index (PI) values on hepatic thiobmbituric acid reaction substances (TBARS) and antioxidant enzyme activities in rats treated with 7,12-dimethylbenz[$\alpha$]anthracene (DMBA). Female Sprague-Dawley rats were used and 7,12-DMBA (20 mg/kg body weight) was gastrically intubated at seven weeks of age in order to induce mammary tumors (MT). The levels of dietary PI were 36, 81, 126 and 217 (LPI, MLPI, MHPI and HPI), while dietary polyunsaturated/saturated fatty acids ratio was maintained at the same level (1.0). Fat used in the experiment was mixed with soybean oil, com oil, palm oil, perilla oil, sesame oil, fish oil, and beef tallow. Experimental diets were given for the following 20 weeks. We measured tumor numbers and weights, and then assayed the hepatic TBARS levels and antioxidant enzyme activities such as superoxide dismutase (SOD), catalase, glutathione peroxidase, glutathione-S-transferase (GST) and glutathione reductase (GR). The incidence of Mr was the lowest in the MHPI group. The hepatic TBARS level was significantly raised with increasing dietary PI value. The hepatic SOD and GR activities were differed significantly by dietary PI value. The hepatic SOD activity was negatively correlated with dietary PI value and GR activity was the highest in the rats fed the MHPI diet. When the dietary P/S ratio is kept at 1.0, adequate dietary PI value (PI value of 126) may reduce the incidence and growth of Mr, but this benefit may be lost with higher dietary PI value. These results suggest that the awareness of dietary PI values may help to decrease breast cancer incidence and growth.