• Journal of Yeungnam Medical Science
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• v.12 no.1
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• pp.105-112
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• 1995

During the period of 9.5 years from September, 1985 to March, 1995, 32 cases with spontaneous closure in simple ventricular septal defect(VSD) were observed and evaluated at Yeungnam University Hospital, and those were confirmed by 2D-echocardiogram. The results were as follows: 1. Among these 32 cases, there were 23 cases(71.9%) of perimembranous VSD, 8 cases(25.0%) of muscular VSD and 1 case(3.1%) of subarterial VSD. Septal aneurysms appears to be main mechanism of spontaneous closure of VSD because of the presence of septal aneurysm in all cases with spontaneous closure of a perimembranous VSD. 2. The size of the defect was variable in diameter, but 27 cases(81.2%) were less than 5 mm. 3. The mean age was 12.1 months at spontaneous closure with the range from 1 month old to 72 months. 4. The mean weight was 9.0 kg at spontaneous closure. 5. Among these 32 cases, 3 cases had the clinical evidence of cardimegaly or congestive hert failure during infancy. 6. Male to female sex ratio was 1.5:1.

• Journal of Sport and Applied Science
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• v.5 no.4
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• pp.1-8
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• 2021

Purpose: Sarcopenia is defined as a decrease in muscle mass, strength, and function with age that affects overall body function. We aimed to investigate the effect of combined training on body composition, balance, and muscle function in sarcopenia elderly. Research design, data, and methodology: Twenty-eight sarcopenia elderly (age 74.9±4.5 years) were randomly assigned to an exercise, EG (n=14), or a control, CG (n=14), group. The EG performed an intervention consisting of combined exercise training (60-75 min) for a total of 12 weeks, three times a week. The CG maintained their usual daily lifestyle during the intervention period. We measured body weight, body mass index (BMI), % body fat, free fat mass, balance ability, peak torque in shoulder, knee, and lumbar joints normalized for bodyweight in one second. Results: The EG showed improved body composition (i.e., BMI, fat-free body mass, fat mass; all p < 0.031, η² > 0.179), balance (i.e., right and left of static and dynamic balance and fast 10 m walk; all p < 0.049, η² > 0.152), and muscular function (i.e., 90°/sec and 180°/sec peak power per kg bodyweight, 90°/sec average power per kg bodyweight, 180°/sec total work, and 180°/sec endurance ratio; all p < 0.045, η² > 0.158). Conclusions: Combined exercise training improves muscle mass and strength, body composition, balance, and muscle function in sarcopenia elderly.

• Journal of Sport and Applied Science
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• v.7 no.2
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• pp.21-28
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• 2023

Purpose: This study was to investigate the effect of a 12-week plyometric training on body composition, physical fitness and bone mineral density in obese male adolescents. Method: Twenty adolescent boys who are obese were randomly assigned to a control group (CON, n=10) or plyometic exercise group (EXE, n=10). The EXE group was performed 3 times per week for 12 weeks. The body composition, physical fitness, and bone mineral density were measured before and after the 12 weeks intervention. Results: The results of this study were as follows: i) In EXE group, the fat mass was significantly decreased between pre and post, whereas the difference of the body weight, BMI, and LBM were not significant. ii) Among the physical fitness factors, grip strength, muscular endurance, and 2 0m shuttle running were significantly improved but flexibility did not show any significant difference. iii) The bone mineral density was significantly improved between pre and post in EXE group. Conclusion: These results suggested that plyometric training for 12 weeks may be effective in improving body composition, physical fitness, and bone mineral density in obese adolescents. Further implications were discussed.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.35 no.6
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• pp.353-359
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• 2013

Purpose: Extensive research is actively ongoing for development of an ideal bone substitute that meets the gold standard. Tooth was selected as a donor site for evaluation of potentials in bone substitutes based on its similar chemical compositions to alveolar bone. Previous studies have evaluated inorganic components of autogenous tooth bone graft material (AutoBT) and osteoconductivity. In continuation from the previous studies, the current study was conducted for analysis of organic components and evaluation of osteoinductivity of AutoBT. Methods: Forty-six extracted teeth were collected from actual patients (Korea Tooth Bank, R&D Institute). Extracted teeth were processed into AutoBT and implanted in dorsal subcutaneous muscular tissues of 15 athymic mice. Biopsy samples were harvested at two, five, and eight weeks. The Bradford assay, sodium dodecyl sulphate polyacrylamide gradient gel, and western blotting were performed for investigation of organic contents of AutoBT. Results: Histology analyses showed signs of new bone formation as early as two weeks. Results of the Bradford assay indicated the existence of noncollagenous proteins (NCP). 0.29% (2.89 mg/g) of proteins were extracted by weight in the root portion of AutoBT; 0.02% (0.029 mg/g) and 1.79% (17.93 mg/g) of proteins were measured by weight in crown and block-form of AutoBT, respectively. However, recombinant human bone morphogenetic protein-2 was not observed in AutoBT. Conclusion: Within the limitation of the current study, AutoBT induced new bone formation by NCP embedded in dentin.

• Toxicological Research
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• v.33 no.1
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• pp.15-23
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• 2017

Acanthopanax divaricatus (Siebold & Zucc.) Seem. var. albeofructus (ADA), a traditional medical herb, has been used to treat arthritis and muscular injury, to strengthen muscle and bone, and to get vital energy. However, information regarding its toxicity is limited. ADA was administered by oral gavage to groups of rats at doses of 0 (control), 1,000, 1,500, 2,000, 2,500, and 3,000 mg/kg five times per week for 13 weeks. Mortality, clinical signs, body weights, food consumption, hematology, serum chemistry, urinalysis, organ weights, necropsy, histopathological finding, vaginal cytology, and sperm morphology were compared between control and ADA-treated groups. Salivation was intermittently observed in both sexes receiving 2,500 and 3,000 mg/kg directly after dosing. Absolute liver weights increased in females receiving 2,000, 2,500, and 3,000 mg/kg ADA (P < 0.05, P < 0.01, and P < 0.01, respectively) and so did the relative liver weights (P < 0.001). Salivation and increased liver weight were ADA-related changes but not considered to be adverse effects. Salivation was intermittent and transient, and the liver weight increase was minor and not accompanied by other changes such as hepatic morphological or functional alterations. The no-observed-adverse-effect-level was determined to be at least 3,000 mg/kg in both sexes of rats.

• Journal of the Korean Society of Clothing and Textiles
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• v.21 no.2
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• pp.286-291
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• 1997

The purpose of this study is to examine the effect of clothing habits wearing cool or warm in daily life on motor ability. A group of ten healthy young females were divided into a cold (C) group and a warm (W) group. From autumn to winter, C group was advised to wear cool clothing, and W group, warm Clothing. The subject's physical fitness were tested in October, initial stage of the clothing training and March of the following year, final stage of the training. The measurements were taken after the subjects rested in a thermoneutral room conditioned at 23$\pm$2$^{\circ}C$ over 1 hour. The test items were weight, skinfold thickness, grip strength (right, left), back-lift strength, vertical jump, sit-ups, Irosmax, side step test, single-foot standing test with eyes closed, and standing trunk flexion. Changes in motor ability of each group between initial stage and final stage of the training were compared. 1. Muscle strength, part of the motor revelation capacity, showed no significant change in the both ,Troops. On the other hand, strength and power showed a decrease in the both groups and C group showed a sharp decrease. 2. Muscular endurance and cardio-pulmonary fitness, part of the motor continuation capacity, were increased after the training and the degree of increase was great in C group. 3. C group showed significant increase in motor coordination capacity including agility, balance, and flexibility after the training, while Wgroup showed significant increases only in balance. 4. Weight and skinfold thickness as a part of the physique showed no significant change.

• Environmental Analysis Health and Toxicology
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• v.22 no.2 s.57
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• pp.119-128
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• 2007

The present study was conducted to find out effect of PFOS on survival, activity, growth and organ structure of the melania snail, Semisulcospira gottschei. Experimental groups were composed of one control condition and four PFOS exposure condition (0.1, 0.5, 1.0 and 5.0 mg/L). After 16 week exposure, survival rate and activity were not significantly influenced at the two lower exposure groups, 0.1 and 0.5 mg/L, but they were significantly reduced in 1.0 and 5.0 mg/L groups. Total weight and meat weight rate (MWR) were reduced in PFOS exposure group in comparison to control group. Also, histological degenerations such as acidification of mucous, necrosis and split of muscular fiber bundle, atrophy of anterior pedal gland were recognized in the foot. Hepatopancreas showed the atrophy and degeneration of the digestive cell, vacuolation of digestive gland and closure of lumen in digestive gland.

• Journal of Haehwa Medicine
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• v.22 no.1
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• pp.171-184
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• 2013

Single-and repeated-dose toxicities of Compound K (CK) were evaluated according to Toxicity Test Guidelines of Korea Food and Drug Administration using Sprague-Dawley rats. For single-dose toxicity study, CK was dissolved in drinking water, orally administered and examined for 14 days. As results, CK up to a dose of 5,000 mg/kg, the limited dose, neither induced death, clinical signs and necropsy findings, nor affected body weight gain and organ weights, in which 10% lethal dose could not be estimated. Based on the results of single-dose toxicity test, CK was administered at doses of 500, 1,000 or 2,000 mg/kg for 28 days for the evaluation of repeated-dose toxicity. All doses including the limited dose (2,000 mg/kg) of CK did not cause any abnormalities of rats, including mortality, clinical signs, body weight gain, feed/water consumption, necropsy findings, organ weights, hematology, blood biochemistry. Rather, high doses (1,000 - 2,000 mg/kg) of CK reduced the serum levels of alanine transaminase (ALT), aspartate transaminase (AST), creatinine phosphokinase (CPK), lactate dehydrogenase (LDH) and triglycerides, in addition to an increase in glucose, indicative of protective effects on hepatic and muscular injuries. Thus, both maximum tolerable dose (MTD) and no observed adverse effect level (NOAEL) were not determined. The results indicate that long-term intake of high-dose CK might not induce general adverse effects.

• Journal of the Korea Fashion and Costume Design Association
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• v.15 no.4
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• pp.17-27
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• 2013

This study has the purpose to examine the effects of stone massage therapy on abdominal obesity reduction. 10 sessions for 5 weeks two times a week of stone massage therapy were offered to 43 adult females who were 40s through 70s with 27% or more of body fat and the results were analyzed. The body composition like body fat mass, fat free mass, weight and skeletal muscular mass etc and the degrees of obesity like body fat ratio abdominal fat ratio were measured and analyzed before and after stone massage therapy. The results are as follows: First, the subjects were obese body type and stone massage therapy produced positive effects with body fat mass, fat free mass, weight and BMI value slightly less than before the therapy. Second, as the average values of body fat ratio and waist hip ratio of subject were significantly different statistically before and after the therapy, stone massage therapy was found to be effective in reducing abdominal obesity. Third, as for the change of waist hip ratio, the therapy was found to be effective in reducing waist hip ratio that 40s decreased insignificantly after the therapy, and 50s and 60s significantly at p<0.05 level respectively from 0.92 to 0.90 and from 0.93 to 0.92. In conclusion, the results of this study indicated that stone massage therapy has positive effects on abdominal obesity reduction, and can contribute to healthy life and well-being culture.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.8
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• pp.1171-1176
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• 2003

The effects of dietary conjugated linoleic acid (CLA) on lipid concentrations and fatty acid composition of various tissues were studied in young chicks. From 7 days of age, a total of 160 chicks were divided into 4 groups, placed into 4 pens per group (10 birds per pen) and fed one of four experimental diets containing 6% tallow (TO 6%), 4% tallow plus 2% CLA (TO 4%-CLA 2%), 2% tallow plus 4% CLA (TO 2%-CLA 4%) or 6% CLA (CLA 6%) for 3 weeks. There were no significant differences in growth performances and the relative weights of various organs, but relative liver weight of chicks fed dietary CLA at 4 and 6% levels was significantly higher (p<0.05) than that of TO 6% group. The chemical compositions of leg muscle were not affected by CLA feeding. However, hepatic total lipid of chicks fed 6% CLA diet was significantly higher (p<0.05) than those of TO 6% and TO 4%-CLA 2% groups. The concentrations of various lipid fractions in serum were not affected by CLA feeding. With the increase in dietary CLA levels, cis 9-trans 11 CLA, trans 10-cis 12 CLA and total CLA of leg muscle increased linearly. The relative proportions of C18:1 $\omega$ -9 and C20:4 $\omega$-6 fatty acids in the leg muscles of chicks fed the CLA containing diets were significantly lower (p<0.05) than those of TO 6% group. These results indicate that the levels of CLA isomers were increased linearly in dose-dependent manner after feeding of synthetic CLA source. But it was also observed that excessive amount of dietary CLA resulted in the possible adversely effects, such as increase of liver weight, hepatic lipid accumulation and serum GOT level.