• Biomolecules & Therapeutics
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• 제31권5호
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• pp.573-582
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• 2023

Muscle atrophy is characterized by the loss of muscle function. Many efforts are being made to prevent muscle atrophy, and exercise is an important alternative. Methylglyoxal is a well-known causative agent of metabolic diseases and diabetic complications. This study aimed to evaluate whether methylglyoxal induces muscle atrophy and to evaluate the ameliorative effect of moderate-intensity aerobic exercise in a methylglyoxal-induced muscle atrophy animal model. Each mouse was randomly divided into three groups: control, methylglyoxal-treated, and methylglyoxal-treated within aerobic exercise. In the exercise group, each mouse was trained on a treadmill for 2 weeks. On the last day, all groups were evaluated for several atrophic behaviors and skeletal muscles, including the soleus, plantaris, gastrocnemius, and extensor digitorum longus were analyzed. In the exercise group, muscle mass was restored, causing in attenuation of muscle atrophy. The gastrocnemius and extensor digitorum longus muscles showed improved fiber cross-sectional area and reduced myofibrils. Further, they produced regulated atrophy-related proteins (i.e., muscle atrophy F-box, muscle RING-finger protein-1, and myosin heavy chain), indicating that aerobic exercise stimulated their muscle sensitivity to reverse skeletal muscle atrophy. In conclusion, shortness of the gastrocnemius caused by methylglyoxal may induce the dynamic imbalance of skeletal muscle atrophy, thus methylglyoxal may be a key target for treating skeletal muscle atrophy. To this end, aerobic exercise may be a powerful tool for regulating methylglyoxal-induced skeletal muscle atrophy.

• 대한물리의학회지
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• 제18권3호
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• pp.31-37
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• 2023

PURPOSE: This study aimed to investigate the relationship between being underweight and respiratory function indicators such as pulmonary function, respiratory muscle strength, and diaphragm thickness in normal adults without lung disease. METHODS: The participants in this experiment were thirty young adults. To compare the respiratory function between the underweight and normal weight individuals, 15 participants were selected from each of the underweight and normal weight groups based on body mass index. Respiratory function tests were conducted through pulmonary function tests and respiratory muscle strength tests. Diaphragm thickness was measure with ultrasonography, and physical characteristics were obtained from grip strength and waist circumference. An independent t-test was used to compare the averages of the parameters measured in the two groups. RESULTS: In the respiratory function tests between the two groups, statistically significant differences (p < .05) emerged in the ratio of the predicted forced vital capacity (%FVC), the ratio of the predicted forced expiratory volume in one second (%FEV1), maximal expiratory pressure (MEP), and diaphragm thickness at the functional residual capacity (FRC). There was no statistically significant difference in the forced vital capacity, forced expiratory volume in one second, maximal inspiratory pressure, diaphragm thickness at the total lung capacity, and thickening ratio (p > .05). CONCLUSION: Decreases in some variables of respiratory function, such as the %FVC, %FEV1, MEP, and diaphragm thickness at the FRC were observed in underweight subjects. However, it is difficult to determine whether it affected the overall respiratory function. Future studies are needed to clearly identify the relationship between being underweight and respiratory function.

• Animal Bioscience
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• 제34권10호
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• pp.1590-1599
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• 2021

Objective: This study investigates the expression patterns of toll-like receptors (TLRs) and intracellular mediators in horse muscle cells after exercise, and the relationship between TLRS expression in stressed horse muscle cells and immune cell migration toward them. Methods: The expression patterns of the TLRs (TLR2, TLR4, and TLR8) and downstream signaling pathway-related genes (myeloid differentiation primary response 88 [MYD88]; activating transcription factor 3 [ATF3]) are examined in horse tissues, and horse peripheral blood mononuclear cells (PBMCs), polymorphonuclear cells (PMNs) and muscles in response to exercise, using the quantitative reverse transcription-polymerase chain reaction (qPCR). Expressions of chemokine receptor genes, i.e., C-X-C motif chemokine receptor 2 (CXCR2) and C-C motif chemokine receptor 5 (CCR5), are studied in PBMCs and PMNs. A horse muscle cell line is developed by transfecting SV-T antigen into fetal muscle cells, followed by examination of muscle-specific genes. Horse muscle cells are treated with stressors, i.e., cortisol, hydrogen peroxide (H₂O₂), and heat, to mimic stress conditions in vitro, and the expression of TLR4 and TLR8 are examined in stressed muscle cells, in addition to migration activity of PBMCs toward stressed muscle cells. Results: The qPCR revealed that TLR4 message was expressed in cerebrum, cerebellum, thymus, lung, liver, kidney, and muscle, whereas TLR8 expressed in thymus, lung, and kidney, while TLR2 expressed in thymus, lung, and kidney. Expressions of TLRs, i.e., TLR4 and TLR8, and mediators, i.e., MYD88 and ATF3, were upregulated in muscle, PBMCs and PMNs in response to exercise. Expressions of CXCR2 and CCR5 were also upregulated in PBMCs and PMNs after exercise. In the muscle cell line, TLR4 and TLR8 expressions were upregulated when cells were treated with stressors such as cortisol, H₂O₂, and heat. Migration of PBMCs toward stressed muscle cells was increased by exercise and oxidative stresses, and combinations of these. Treatment with methylsulfonylmethane (MSM), an antioxidant on stressed muscle cells, reduced migration of PBMCs toward stressed muscle cells. Conclusion: In this study, we have successfully cultured horse skeletal muscle cells, isolated horse PBMCs, and established an in vitro system for studying stress-related gene expressions and function. Expression of TLR4, TLR8, CXCR2, and CCR5 in horse muscle cells was higher in response to stressors such as cortisol, H₂O₂, and heat, or combinations of these. In addition, migration of PBMCs toward muscle cells was increased when muscle cells were under stress, but inhibition of reactive oxygen species by MSM modulated migratory activity of PBMCs to stressed muscle cells. Further study is necessary to investigate the biological function(s) of the TLR gene family in horse muscle cells.

• 한국전자통신학회논문지
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• 제8권8호
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• pp.1187-1193
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• 2013

본 논문은 사실적인 3D 얼굴 모델링과 얼굴 표정 생성 시스템을 제안한다. 사실적인 3D 얼굴 모델링 기법에서 개별적인 3D 얼굴 모양과 텍스쳐 맵을 만들기 위해 Generic Model Fitting 기법을 적용하였다. Generic Model Fitting에서 Deformation Function을 계산하기 위해 개별적인 얼굴과 Generic Model 사이의 대응점을 결정하였다. 그 후, Calibrated Stereo Camera로부터 캡쳐 된 영상들로부터 특징점을 3D로 복원하였다. 텍스쳐 매핑을 위해 Fitted된 Generic Model을 영상으로 Projection하였고 사전에 정의된 Triangle Mesh에서 텍스쳐를 Generic Model에 매핑 하였다. 잘못된 텍스쳐 매핑을 방지하기 위해, Modified Interpolation Function을 사용한 간단한 방법을 제안하였다. 3D 얼굴 표정을 생성하기 위해 Vector Muscle기반 알고리즘을 사용하고, 보다 사실적인 표정 생성을 위해 Deformation 과 vector muscle 기반의 턱 rotation을 적용하였다.

• 대한통합의학회지
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• 제4권3호
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• pp.1-15
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• 2016

Purpose : The purpose of this study was to evaluate the difference of early muscle strengthening exercise(starting at 1 week) on pain, function and sleep quality for rotator cuff partial tear patients. Method : Experimental group 15 people, control group 15 people, was a total of 30 people. Group-specific arbitration method, was applied to early muscle strengthening exercise (experimental group) and general movement treatment(Starting at 6 week) (control group). Both groups were subjected to 40 minutes of basic physical therapy interventions four times a week over an six-week intervention period. In this study, Pain, function and sleep quality measured by VAS, PPT and ROM, CMS, SST and PSQI. Result : 1. The VAS and PPT in the experimental group and control group before and after treatment were significant difference(p<.01). Comparison between the two groups in the change in motion before and after treatment also showed a statistically significant(p<.01). 2. Comparison functional Assessment of the shoulder ROM, CMS and SST in the experimental group and control group before and after treatment were significant difference(p<.01). ROM was not significant differences between the groups but CMS and SST were significant differences between the groups. 3. PSQI in the experimental group and control group before and after treatment were significant difference(p<.01). Comparison between the two groups in the change in motion before and after treatment also showed a statistically significant(p<.01). Conclusion : Therefore, early muscle strengthening exercise is useful to improve the shoulder function and pain for rotator cuff tear patients.

• The Journal of Korean Physical Therapy
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• 제20권1호
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• pp.1-9
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• 2008

Purpose: This study examined the effects of pre-eccentric exercise to the quadriceps for the prevention of delayed onset muscle soreness (DOMS) and recovery of muscular function, depending on the training intensities. Methods: Subjects were divided into one of three groups that control group, a low intensity eccentric exercise group (LIEE group) and a high intensity eccentric exercise group (HIEE group). Subjects who underwent pre-eccentric exercise undertook exercise at an intensity of 25% and 75% of maximal voluntary contractions, respectively. After undertaking pre-eccentric exercise for eight weeks, eccentric exercise was applied again to induce DOMS. Measurements were conducted to examine pain and muscular function changes before, immediately after, after the induction of DOMS, and at the first, third, fifth and seventh days after the induction of DOMS. Results: Subjects who underwent pre-eccentric exercise showed a significant difference from the control group for the changes in the visual analogue scale (VAS) pain threshold, pressure pain threshold and muscle thickness by isometric contraction from measuring DOMS, and in particular, pain threshold by isometric contraction had remarkable effect in the LIEE group of subjects. For the change of the root mean square values using mechanomyography (MMG) as the measurement of muscular function recovery, subjects who had undertaken pre-eccentric exercise group showed a significant difference as compared to the control group. Conclusion: Pre-eccentric exercise was very effective in preventing and recovering delayed onset muscle soreness and was helpful to prevent and recover from decreased muscular function. The difference based on the intensity of exercise was not great, but it was more effective in the low intensity eccentric exercise group of subjects. Therefore, it can be considered that pre-eccentric exercise has a high application value as a physical therapy intervention for prevention and rehabilitation of sports injuries.

• 한국응용과학기술학회지
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• 제38권6호
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• pp.1606-1615
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• 2021

본 연구에서는 남자 실업팀 핸드볼 선수들을 대상으로 플라이휠 운동을 적용한 웨이트 트레이닝 프로그램을 개발하여 상해예방과 경기력 향상을 위한 기초자료를 제공하는데 그 목적이 있다. 12주간 복합 플라이휠 운동 프로그램을 적용하여 신체조성, 체력요인, 무산소성파워, 등속성근기능에 미치는 영향을 분석한 결과는 다음과 같다. 팔굽혀펴기는 그룹 간 유의한 차이가 나타났다. 체지방률, 무산소성 파워는 시기별 상호작용에서 유의한 차이가 나타났다. 제자리멀리뛰기, 제자리높이뛰기, 악력, 배근력, 무산소성평균파워 그리고 등속성근기능검사는 좌굴근과 우굴근에서 시기별로 유의한 차이가 나타났다. 따라서 12주간 플라이휠 운동을 활용한 웨이트 트레이닝 결과는 상해예방과 경기력 향상을 위한 기초자료로 제공할 수 있을 것으로 판단된다.

• 한국정밀공학회지
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• 제26권6호
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• pp.122-130
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• 2009

The analysis of human movement requires the knowledge of the Hill type muscle parameters, the muscle-tendon and moment arm length change as a function of joint angles. However, values of a subject's muscle parameters are very difficult to identify. It turns out from a sensitivity analysis that the tendon slack length and maximum muscle force are the two critical parameters among the Hill-type muscle model. Therefore, it could be claimed that the variation of the tendon slack length and maximum muscle force from the Delp's reference data will change the muscle characteristics of a subject remarkably. A numeric optimization method to search these tendon parameters specific to a subject is proposed, and the accuracy of the developed algorithm is evaluated through a numerical simulation.

• 음성과학
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• 제12권4호
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• pp.203-213
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• 2005

This study was conducted to investigate the respiratory and aerodynamic function of adductor spasmodic dysphonia (ADSD) patients. Participants were (1) 18 females SD patients with non- Botulinum toxin injection (2) 14 females SD patients who had taken treatment of Botulinum toxin injection. (3) 14 age- and sex- matched normal female controls. Spirometer and phonatory function analyzer were used for respiratory muscle pressure (MIP: Maximum inspiratory pressure), MEP: Maximum expiratory pressure)& MPT(Maximum phonation time) and aerodynamic(F0:Fundamental frequency, intensity, MFR: Mean flow late, Psub: Subglottal pressure) measurement. The results were as follows: (1) Normal group was significantly higher in MIP, MEP, MPT than two SD groups (p < .05); (2) MPT was significantly lower in SD with non-Botulinum toxin injection group than SD with the treatment experience of Botulinum toxin injection (p < .05); (3) All aerodynamic parameters, F0, intensity, MFR, Psub, were not significantly different among three groups(p > .05).The reason of short MPT in ADSD may use lower respiratory pressure than normal group as strategy to decrease their tremulous voice quality. Moreover respiratory muscle pressure was lower than normal group regardless of botulinum toxin injection treatment.

• Physical Therapy Rehabilitation Science
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• 제12권2호
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• pp.201-205
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• 2023

Objective: Resistance exercise is a necessary element to improve quality of life, and measurement and evaluation of muscle strength provide important information for prescription and management of rehabilitation and exercise programs. This study analyzed the correlation between direct and indirect 1RM for isokinetic maximum torque of the knee joint in order to provide useful information in the field of exercise programs. In addition, the flexion-extension ratio and the difference in left-right deviation were verified. Design: A cross-sectional study Methods: The subjects of this study were 33 healthy adult men and women without medical problems who participated in the health exercise class program at S University in Seoul. The correlation between isokinetic maximum torque and direct and indirect 1RM was analyzed, and a dependent t-test was performed to analyze the flexion-extension ratio and left-right deviation. Results: There was a high correlation between the isokinetic maximum torque and direct and indirect 1RM, and no statistically significant difference was shown between the test methods in the analysis of the flexion-extension ratio and left-right deviation. Conclusions: Isokinetic muscle function measuring equipment is expensive, so it is difficult to use it in local exercise rehabilitation and training sites. Through this study, it was found that direct and indirect 1RM isokinetic maximum torque showed a high correlation, and there was no difference in evaluating muscle function such as flexion-extension ratio and left-right deviation. Therefore, it is considered that the muscle function evaluation using 1RM in general field can be usefully utilized.