• Molecules and Cells
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• v.40 no.1
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• pp.1-9
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• 2017

Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as constitutive and alternative splicing regulators. As splicing is linked to transcriptional and post-transcriptional steps, SR proteins are implicated in the regulation of multiple aspects of the gene expression program. Recent global analyses of SR-RNA interaction maps have advanced our understanding of SR-regulated gene expression. Diverse SR proteins play partially overlapping but distinct roles in transcription-coupled splicing and mRNA processing in the nucleus. In addition, shuttling SR proteins act as adaptors for mRNA export and as regulators for translation in the cytoplasm. This mini-review will summarize the roles of SR proteins as RNA binders, regulators, and connectors from transcription in the nucleus to translation in the cytoplasm.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.5 no.1
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• pp.173-182
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• 2001

In this paper, we discuss how ontology Plays roles in building a distributed and heterogeneous knowledge-base system. First, we discuss relationship between ontology and agent in the Knowledgeable Community which is a framework of knowledge sharing and reuse based on a multi-agent architecture. Ontology is a minimum requirement for each agent to join the Knowledgeable Community. Second we explain mediation by ontology to show how ontology is used in the Knowledgeable Community. A special agent called mediation analyzes undirected messages and infer candidates of recipient agents by consulting ontology and relationship between ontology and agents. Third we model ontology as combination of aspects each of which can represent a way of conceptualization. Aspects are combined either as combination aspect which means integration of aspects or category aspect which means choice of aspects. Since ontology by aspect allows heterogeneous and multiple descriptions for phenomenon in the world, it is appropriate for heterogeneous knowledge-base systems. We also show translation of messages as a wave of interpreting multiple aspects. A translation agent can translate a message with some aspect to one with another aspect by analyzing dependency of aspects. Mediation and translation of messages are important to build agents easily and naturally because less knowledge on other agents is requested for each agent.

• Journal of KIISE:Databases
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• v.34 no.6
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• pp.528-545
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• 2007

Recently ontology has been an attractive technology along with the business strategy of providing a plenty of more intelligent services. The essential problem in application domains using ontology is that all members, agents, and application programs in the domains must share the same ontology concepts. However, a variety of mobile devices, sensing devices, and network components manufactured by various companies, a variety of common carriers, and a variety of contents providers make multiple heterogeneous ontologies more likely to coexist. We can see many past researches fallen into resolving this semantic interoperability. Such methods can be broadly classified into by-mapping, by-merging, and by-translation. In this research, we focus on by-translation among them which uses a translation rule directly made between two heterogeneous ontology data like OntoMorph. However, the manual composition of the direct translation rule is not convenient by itself and if there are N ontologies, the direct method has the rule composition complexity of $O(N^2)$ in the worst case. Therefore, in this paper we introduce the cascade composition of translation rules based on web openness in order to improve the complexity. The research result made us recognize some important factors in an ontology translation system, that is speediness of translation, and conveniency of translation rule composition, and some experiments and comparing analysis with existing methods showed that our cascade method has more conveniency with insuring the speediness and the correctness.

• 제어로봇시스템학회:학술대회논문집
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• 1990.10b
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• pp.939-944
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• 1990

To recognize isomorphic transformation patterns, such as scale-change, translation and rotation transformed patterns, is an old difficult but interesting problem. Many researches have been done with a dominant approach of normalization by many eminent pioneers. However, there seems no a perfect system which can even recognize 90 .deg.-multiple rotation isomorphic transformation patterns for real needs. Here, as a new challenge, we propose a method of how to recognize 90 .deg.-multiple rotation isomorphic and symmetry isomorphic transformation patterns.

• Journal of the Korea Society of Computer and Information
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• v.25 no.9
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• pp.63-69
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• 2020

Image-image translation is a technology that creates a target image through input images, and has recently shown high performance in creating a more realistic image by utilizing GAN, which is a non-map learning structure. Therefore, there are various studies on image-to-image translation using GAN. At this point, most image-to-image translations basically target one attribute translation. But the data used and obtainable in real life consist of a variety of features that are hard to explain with one feature. Therefore, if you aim to change multiple attributes that can divide the image creation process by attributes to take advantage of the various attributes, you will be able to play a better role in image-to-image translation. In this paper, we propose Multi CycleGAN, a dual attribute transformation structure, by utilizing CycleGAN, which showed high performance among image-image translation structures using GAN. This structure implements a dual transformation structure in which three domains conduct two-way learning to learn about the two properties of an input domain. Experiments have shown that images through the new structure maintain the properties of the input area and show high performance with the target properties applied. Using this structure, it is possible to create more diverse images in the future, so we can expect to utilize image generation in more diverse areas.

• Journal of Korean Academy of Nursing
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• v.45 no.1
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• pp.129-138
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• 2015

Purpose: The purpose of this study was to report the instrument modification and validation processes to make existing health belief model scales culturally appropriate for Korean Americans (KAs) regarding colorectal cancer (CRC) screening utilization. Methods: Instrument translation, individual interviews using cognitive interviewing, and expert reviews were conducted during the instrument modification phase, and a pilot test and a cross-sectional survey were conducted during the instrument validation phase. Data analyses of the cross-sectional survey included internal consistency and construct validity using exploratory and confirmatory factor analysis. Results: The main issues identified during the instrument modification phase were (a) cultural and linguistic translation issues and (b) newly developed items reflecting Korean cultural barriers. Cross-sectional survey analyses during the instrument validation phase revealed that all scales demonstrate good internal consistency reliability (Cronbach's alpha=.72~.88). Exploratory factor analysis showed that susceptibility and severity loaded on the same factor, which may indicate a threat variable. Items with low factor loadings in the confirmatory factor analysis may relate to (a) lack of knowledge about fecal occult blood testing and (b) multiple dimensions of the subscales. Conclusion: Methodological, sequential processes of instrument modification and validation, including translation, individual interviews, expert reviews, pilot testing and a cross-sectional survey, were provided in this study. The findings indicate that existing instruments need to be examined for CRC screening research involving KAs.

• 한국HCI학회:학술대회논문집
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• 2009.02a
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• pp.606-610
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• 2009

We propose a method utilizing BLEU(BiLingual Evaluation Understudy), which is widely used in automatic evaluation of machine translations, for an autonomous assessment of a short essay answer. BLEU evaluates translations with an assumption that the translation by a machine is supposed to be more accurate as it is getting to be more similar to the translation by a human. BLEU scores the translation by comparing the n-grams of translations by a machine and humans. Similarly we score students answers by comparing to multiple reference answers with BLEU. In the experiment, we compute correlation coefficient values between scores of our system and human instructors.

• BMB Reports
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• v.49 no.4
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• pp.199-200
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• 2016

Gene regulation in the brain is essential for long-term plasticity and memory formation. Despite this established notion, the quantitative translational map in the brain during memory formation has not been reported. To systematically probe the changes in protein synthesis during memory formation, our recent study exploited ribosome profiling using the mouse hippocampal tissues at multiple time points after a learning event. Analysis of the resulting database revealed novel types of gene regulation after learning. First, the translation of a group of genes was rapidly suppressed without change in mRNA levels. At later time points, the expression of another group of genes was downregulated through reduction in mRNA levels. This reduction was predicted to be downstream of inhibition of ESR1 (Estrogen Receptor 1) signaling. Overexpressing Nrsn1, one of the genes whose translation was suppressed, or activating ESR1 by injecting an agonist interfered with memory formation, suggesting the functional importance of these findings. Moreover, the translation of genes encoding the translational machineries was found to be suppressed, among other genes in the mouse hippocampus. Together, this unbiased approach has revealed previously unidentified characteristics of gene regulation in the brain and highlighted the importance of repressive controls.

• Journal of Plant Biotechnology
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• v.36 no.3
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• pp.255-260
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• 2009

The translation elongation factor 1A, eEF1A, catalyzes the binding of aminoacyl-tRNA to the A-site of the ribosome by a GTP-dependent mechanism. By subtractive suppression hybridization technique, we have isolated a soybean low-temperature inducible gene, SLTI100 encoding translation elongation factor 1A. Multiple sequence alignments and phylogenic analysis showed that SLTI100 and other eEF1As originated from diverse organisms are highly conserved. RNA expression of SLTI100 was specifically induced by low temperature, high salt, ABA, or drought stress. Based on the subcellular localization of the corresponding gene product fused to GFP, we were able to confirm that SLTI100-GFP was restricted to the nucleus and cytoplasm. We propose that soybean eEF1A may play an important role in translational regulation during abiotic stress responses in plants.

• The Journal of Information Technology
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• v.5 no.1
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• pp.29-37
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• 2002

Distributed programming can be greatly simplified by language support for distributed communication. Many web browsers now offer some form of distributed objects and the number and types of them are growing daily in interesting and innovative ways CORBA IDL and Java RMI, the representative of distributed object model, support different approaches for distributed computing environments. CORBA approach does not support the application generated by java RMI, even though it supports multiple programming languages. Object translation system between RMI to CORBA is designed and implemented for interoperability of distributed objects on the two different distributed programming environments. Suggested system is considered binding, inheritance, polymorphism, object passing, and callback which are key properties on the distributed objects. Translation System we suggested is implemented on the Window/NT(version 4.0) with Java Development Kit(version 1.1.6).