• 중환자간호학회지
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• 제15권1호
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• pp.35-46
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• 2022

Purpose : This study aimed to identify the factors affecting coronavirus disease 2019 (COVID-19) infection control practices of nurses in negative pressure isolation rooms. Methods : The participants were 150 nurses working in three hospitals with negative pressure isolation rooms. Data were collected using structured questionnaires and analyzed using an independent t-test, one-way ANOVA, Scheffé test, Pearson correlation coefficients, and multiple regression analysis using the SPSS/WIN 26.0 program. Results : Factors significantly influencing the subject's COVID-19 infection control practice include Being married (𝛽=.18, p =.016), working in a ward with negative pressure isolation rooms (𝛽=.44, p <.001), working in an ICU with negative pressure isolation rooms (𝛽=.27, p =.010), COVID-19 infection control attitude (𝛽=.28, p =.001), anxiety for COVID-19 (𝛽=.30, p <.001). The explanatory power of these variables for COVID-19 infection control practice was 24.6% (F=8.67, p <.001). Conclusion : It is expected that strategies that utilize positive attitudes which believe that COVID-19 disease may be overcome by COVID-19 infection control practice will help improve emerging infectious diseases infection control practice.

• 한국산학기술학회논문지
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• 제20권8호
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• pp.240-249
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• 2019

본 연구는 간호대학생의 감염관리 인지도, 진로결정자기효능감 및 비판적 사고성향이 감염관리 수행도에 미치는 영향요인을 파악하고자 시도하였다. 대상자는 D시와 K시에 소재한 4개 대학 간호학과 3, 4학년 404명이었다. 자료는 2018년 11월 5일부터 12월 21일까지 자가보고식 설문조사로 수집되었다. 수집된 자료는 SPSS WIN 17.0 프로그램을 이용하여 기술통계, 독립집단 t-test, one-way ANOVA, 사후분석은 Duncan's test, Pearson's correlation coefficients, multiple regression analysis로 분석하였다. 감염관리 인지도는 평균 4.75점, 진로결정자기효능감은 평균 3.02점, 비판적 사고성향은 평균 4.73점, 감염관리 수행도는 평균 4.46점이었다. 간호대학생의 감염관리 수행도에 영향을 미치는 요인은 연령, 감염관리 인지도 및 진로결정자기효능감으로 나타났으며, 설명력은 38.6%였다. 따라서 간호 대학생의 감염관리 수행도를 강화하기 위하여 감염관리 인지도와 진로결정자기효능감을 향상하기 위한 교육프로그램개발이 필요하다.

• 한국치위생학회지
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• 제14권4호
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• pp.463-470
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• 2014

Objectives : The purpose of this study was to investigate the association factors of infection control practice based on health belief model in the dental hygienists in dental clinics. Methods : A self-reported questionnaire was filled out by 278 dental hygienists in 160 dental clinics in Gwangju by a proportional stratified sampling method from September 13 to October 7, 2013. Data were analyzed by t-test, ANOVA, correlation analysis, and multiple regression analysis using SPSS version 12.0. Results : In multiple regression analysis, practice scores were significantly higher in aged dental hygienists and those who took infectious disease history from the patients before treatment. With regard to health belief model, perceived barrier was negatively associated with the practice(${\beta}$=-.16, p<.001), importance of infection control in hand hygiene(${\beta}$=.14, p=.026), and use of personal protective equipment(${\beta}$=.17, p=.043). The intention of action was positively associated with the practice(${\beta}$=.13, p=.002). Conclusions : This study will provide the basic evidence for the quality improvement of infection control and prevention. So the dental hygienists will be able to put into practice in infection control management.

• 미래기술융합논문지
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• 제2권3호
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• pp.25-32
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• 2023

본 연구는 응급구조(학)과 대학생을 대상으로 코로나19에 대한 지식 및 태도와 감염관리 수행도 간의 관련성을 알아보기 위해 시행하였다. 연구 대상은 전라남북도, 광주광역시에 소재한 3-4년제 응급구조(학)과에 재학 중인 대학생 154명이고, 수집된 자료는 SPSS/WIN 16.0을 이용하여 빈도와 백분율, 합(Sum), 평균 및 표준편차, t-test, ANOVA(Scheffe), Pearson's Correlation Coefficient, Multiple Linear Regression으로 분석하였다. 응급구조(학)과 대학생들의 감염관리 수행도에 코로나19에 대한 태도와 지식 순으로 영향을 미쳤다. 따라서 응급구조(학)과 대학생들의 감염관리 수행도를 높이기 위해 코로나19에 대한 지식 및 태도를 향상시킬 수 있는 정규 또는 비정규 교육과정, 다학제적 교육과정 개발 및 적용이 필요하다.

• 한국응용과학기술학회지
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• 제41권1호
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• pp.119-127
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• 2024

본 연구의 목적은 종합병원 간호사의 임파워먼트와 직무소진이 감염관리 수행에 미치는 영향요인을 확인하기 위한 서술적 조사연구이다. 대상자는 D시에 소재한 종합병원에서 근무하고 있는 간호사 총 210명을 대상으로 2023년 9월 15일부터 10월 31일까지 자료를 수집하였다. 수집된 자료는 SPSS/WIN 25.0 프로그램을 이용하여 기술통계, t-test, ANOVA, Sheffe, Pearson's correlation, multiple regression을 이용하여 분석하였다. 연구결과, 임파워먼트와 감염관리 수행은 양의 상관관계를 보였으며, 임파워먼트가 감염관리 수행에 가장 영향을 미치는 요인으로 분석되었으며, 14.8%의 설명력을 보였다. 따라서 간호사의 임파워먼트를 향상시킬 수 있는 효율적인 감염관리 수행을 위한 프로그램 및 정책반영이 필요하다.

• IMMUNE NETWORK
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• 제11권5호
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• pp.245-252
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• 2011

Antimicrobial peptides/proteins are ancient and naturally-occurring antibiotics in innate immune responses in a variety of organisms. Additionally, these peptides have been recognized as important signaling molecules in regulation of both innate and adaptive immunity. During mycobacterial infection, antimicrobial peptides including cathelicidin, defensin, and hepcidin have antimicrobial activities against mycobacteria, making them promising candidates for future drug development. Additionally, antimicrobial peptides act as immunomodulators in infectious and inflammatory conditions. Multiple crucial functions of cathelicidins in antimycobacterial immune defense have been characterized not only in terms of direct killing of mycobacteria but also as innate immune regulators, i.e., in secretion of cytokines and chemokines, and mediating autophagy activation. Defensin families are also important during mycobacterial infection and contribute to antimycobacterial defense and inhibition of mycobacterial growth both in vitro and in vivo. Hepcidin, although its role in mycobacterial infection has not yet been characterized, exerts antimycobacterial effects in activated macrophages. The present review focuses on recent efforts to elucidate the roles of host defense peptides in innate immunity to mycobacteria.

• IMMUNE NETWORK
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• 제13권5호
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• pp.168-176
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• 2013

In the last few years major progress has been made in better understanding the role of natural killer (NK) cells in hepatitis C virus (HCV) infection. This includes multiple pathways by which HCV impairs or limits NK cells activation. Based on current genetic and functional data, a picture is emerging where only a rapid and strong NK cell response early on during infection which results in strong T cell responses and possible subsequent clearance, whereas chronic HCV infection is associated with dysfunctional or biased NK cells phenotypes. The hallmark of this NK cell dysfunction is persistent activation promoting ongoing hepatitis and hepatocyte damage, while being unable to clear HCV due to impaired IFN-${\gamma}$ responses. Furthermore, some data suggests certain chronically activated subsets that are $NKp46^{high}$ may be particularly active against hepatic stellate cells, a key player in hepatic fibrogenesis. Finally, the role of NK cells during HCV therapy, HCV recurrence after liver transplant and hepatocellular carcinoma are discussed.

• Pediatric Infection and Vaccine
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• 제23권2호
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• pp.137-142
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• 2016

여러 기관을 침범하는 중증 주산기 거대세포바이러스 감염은 극저출생체중아 또는 면역저하 환자 이외의 경우에는 매우 드물다. 저자들은 재태연령 34주 6일, 2,460 g으로 출생한 후기 미숙아에서 다기관(중추신경계, 간, 폐, 위장관)을 침범한 거대세포바이러스에 의한 주산기 감염을 의심하고 ganciclovir 투약 후 회복된 증례를 경험하여 문헌 보고하는 바이다.

• IMMUNE NETWORK
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• 제23권5호
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• pp.41.1-41.21
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• 2023

CD4 and CD8 T cells are key players in the immune response against both pathogenic infections and cancer. CD4 T cells provide help to CD8 T cells via multiple mechanisms, including licensing dendritic cells (DCs), co-stimulation, and cytokine production. During acute infection and vaccination, CD4 T cell help is important for the development of CD8 T cell memory. However, during chronic viral infection and cancer, CD4 helper T cells are critical for the sustained effector CD8 T cell response, through a variety of mechanisms. In this review, we focus on T cell responses in conditions of chronic Ag stimulation, such as chronic viral infection and cancer. In particular, we address the significant role of CD4 T cell help in promoting effector CD8 T cell responses, emerging techniques that can be utilized to further our understanding of how these interactions may take place in the context of tertiary lymphoid structures, and how this key information can be harnessed for therapeutic utility against cancer.

• Urogenital Tract Infection
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• 제13권3호
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• pp.58-65
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• 2018

Purpose: This study aimed to investigate the relationship between uropathogens of infants with febrile urinary tract infection (UTI) and vesicoureteral reflux (VUR). Materials and Methods: We analyzed 308 infants hospitalized for febrile UTI between January 2010 and December 2015, and assessed the voiding cystourethrography (VCUG). The medical records, including clinical symptoms, laboratory findings, urinalysis, urine culture tests, ultrasound (US), dimercaptosuccinic acid scan, and VCUG, were retrospectively obtained. The incidences of VUR and high-grade VURs (III, IV, and V) were analyzed in 4 groups categorized by uropathogens and renal US findings. Results: The mean age of 308 infants was $3.29{\pm}2.18months$. The male-to-female ratio was 3.46:1. In urine culture tests, 267 infants (86.69%) showed single bacterial uropathogen; Escherichia coli in 241 infants (78.25%) and non-E. coli uropathogens in 26 infants (8.44%). Multiple distinctive microorganisms were identified as causative uropathogens in 41 infants (13.31%). Abnormal findings of US and VCUG were identified in 216 and 64 patients, respectively. In 308 infants, the incidences of VUR and high-grade VUR were not different among the 4 groups. In 239 male infants, the incidences of high-grade VUR were higher in patients with non-E. coli single or multiple uropathogen and with abnormal US findings (p=0.042). Conclusions: In male infants with non-E. coli uropathogen or multiple uropathogens and with abnormal US findings at febrile UTI, there was an increased chance of finding high-grade VURs on subsequent VCUG tests.