• Korean Journal of Poultry Science
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• v.34 no.1
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• pp.57-76
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• 2007

Marek's disease (MD) is caused by a ubiquitous, lymphotropic alphaherpesvirus, MD virus (MDV). MD has been a major concern in the poultry industry due to the emergence of increasingly virulent strains over the last few decades that were isolated in the face of comprehensive vaccination. MD is characterized by a variety of clinical signs, amongst them neurological symptoms, chronic wasting, and most notably the development of multiple lymphomas that manifest as solid tumors in the viscera and musculature. Much work has been devoted to study MD-induced oncogenesis and genes involved in this process. Among the many genes encoded by MDV, a number have recently been shown to affect the development of tumors in chickens, one protein directly causing transformation of cells (Meq) and another being involved in maintaining transformed cells (vTR). Other MDV gene products modulate and are involved in early lytic in vivo replication, thereby increasing the chance of transformation occurring. In this review, specific genes encoded by MDV that are involved in the initiation and/or maintenance of transformation were briefly summarized, and limits of current vaccination and new control strategies against MD, particularly how modem molecular biological methods may be used to improve strategies to combat the disease in the future, were discussed.

• Journal of Sensor Science and Technology
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• v.18 no.5
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• pp.337-342
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• 2009

This paper describes a robust mobile u-healthcare system with multiple physiological signs measurement capability in real time with integration of WSN(wireless sensor network) technology and CDMA(code division multiple access) network. A cellular phone receives health data in WSN and performs local physiological signs analysis at a phone processor, and then transmits abnormal data to server for further detail or precise health signal evaluation by a medical doctor over a CDMA network. Physiological signs of the patients are continuously monitored, processed and analyzed locally at cellular phone process to produce useful medical information for diagnosis and tracking purposes. By local simple analysis in cellular phone processor we can save the data transmission cost in CDMA network. By using the developed integrate ubiquitous healthcare service architecture, patients can realize self-health checking so that the prevention actions can be taken earlier. Appropriate self-monitoring and self-management can cure disease and relieve pain especially for patients who suffer from chronic diseases that need long term observation.

• Korean Journal of Occupational Health Nursing
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• v.28 no.1
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• pp.44-52
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• 2019

Purpose: This study aimed to identify the level of health problems and the factors that affect health problems for concrete mixer truck divers. Methods: The questionnaires were administered to 111 drivers in 6 Remicon workplaces located in D city and 7 Remicon workplaces located in K city from September 10 to 28, 2018. A total of 111 questionnaires were collected and 106 were used, excluding 5 incomplete ones. Data were analyzed with frequency, percentage, $x^2$ test, multiple logistic regression analysis by SPSS/WIN 23.0. Results: The factors affecting subjective health were eating habits, sleeping hours and drinking conditions. The factors that affected chronic diseases were age, eating habits, sleep hours, and drinking conditions. The factors influencing musculoskeletal complaints were work experience, eating habits, and sleep hours. Conclusion: The major influencing factors of health problems were eating habits, sleeping hours. This study suggests that it is necessary to run a systematic health care program for the desirable health behaviors in the communities and industrial fields.

• Yonsei Medical Journal
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• v.59 no.9
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• pp.1015-1025
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• 2018

Kidney diseases including acute kidney injury and chronic kidney disease are among the largest health issues worldwide. Dialysis and kidney transplantation can replace a significant portion of renal function, however these treatments still have limitations. To overcome these shortcomings, a variety of innovative efforts have been introduced, including cell-based therapies. During the past decades, advances have been made in the stem cell and developmental biology, and tissue engineering. As part of such efforts, studies on renal cell therapy and artificial kidney developments have been conducted, and multiple therapeutic interventions have shown promise in the pre-clinical and clinical settings. More recently, therapeutic cell-secreting secretomes have emerged as a potential alternative to cell-based approaches. This approach involves the use of renotropic factors, such as growth factors and cytokines, that are produced by cells and these factors have shown effectiveness in facilitating kidney function recovery. This review focuses on the renotropic functions of bioactive compounds that provide protective and regenerative effects for kidney tissue repair, based on the available data in the literature.

• Childhood Kidney Diseases
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• v.28 no.1
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• pp.44-50
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• 2024

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that affects multiple organs. More than half of the patients with SLE have kidney involvement, and up to 10% of patients with lupus nephritis develop end-stage renal disease (ESRD). Central nervous system (CNS) involvement in SLE occurs in 21% to 95% of patients. Severe neurological manifestations such as seizures, cerebrovascular disease, meningitis, and cerebrovascular accidents can develop in childhood-onset SLE, but cerebral infections, such as brain abscess and hemorrhage, are seldom reported in lupus nephritis, even in adults. Here, we report a rare case of childhood-onset SLE with ESRD, cerebral abscess, and hemorrhage. A 9-year-old girl diagnosed with lupus nephritis was administered high-dose steroids and immunosuppressant therapy to treat acute kidney injury (AKI) and massive proteinuria. The AKI deteriorated, and after 3 months, she developed ESRD. She received hemodialysis three times a week along with daily peritoneal dialysis to control edema. She developed seizures, and imaging showed a brain abscess. This was complicated by spontaneous cerebral hemorrhage, and she became unstable. She died shortly after the hemorrhage was discovered. In conclusion, CNS complications should always be considered in clinical practice because they increase mortality, especially in those with risk factors for infection.

• Health Policy and Management
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• v.1 no.1
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• pp.116-135
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• 1991

Few studies have been conducted on the detailed routes of medical care utilization under the National Health Insurance. This study was undertaken to identify the utilization patte군 of health care facilities among industrial workers and their dependents. One of the largest health insurance association was purposively chosen for this objective. The association had 345, 757 members as of 31 December, 1990. The study sample of 297, 948 subjects have been drawn from the membership pool on the basis of their continuous membership status during 1 January through 31 December 1990. This study has tried to identify differential utilization patterns between acute and chronic conditions, and among standard income classes. All the diagnoses were recoded in a manner to achieve the objective of this study. As for acute diseases, most age group had used one medical facility as much as by 60% except the age group of 1-4, This young age group had used over three different health facilities as much as by 10.9-15.8%. The finding suggests that some policy measures by sought for remedying the excessive/inappropriate use of services. In addition, mid-income classes(between 17 and 48) were more likely to use multiple sources of care than lower income classes(between 1 and 16) and upper income classes(above 49). This study has revealed that chronic cases are more likely to pursue multiple sources of care, however those with chronic conditions tend to use single health facility more than those with acute conditions(67.9% versus 52.4%). As many as 12.2% have visited more than three health facilities in chronic conditions, but 5.9% for acute conditions. The most likely source of care was primary clinics for both acute and chronic conditions. Compared with the role of general hospital, small-size hospitals found to play a minimal role in the care and referral of patients. This indicates the need of strengthening the function of small-size hospitals. While a minor cross utilization of western medicine and pharmacy was noted, no significant boundary crossing was identified between western medicine and oriental medicine, or between pharmacy and oriental medicine. It is too early to confirm that whether there is substitutability or cross utilization among these alternative sources of care. A further study is needed to identify these relationship.

• Journal of Society of Preventive Korean Medicine
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• v.22 no.1
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• pp.1-14
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• 2018

Objectives : This study aimed to analyze the characteristics of uninsured herbal medicine(UHM) users and the economic and social barriers of UHM utilization. Methods : We used the Korea Health Panel Data, representative national survey on medical utilization and cost, provided by National Health Insurance Service and Korea Institiute of Health and Social Affairs. The frequency analysis was used to identify the characteristics of the respondents, and the cross-analysis (${\chi}^2-test$) was used to verify the relationship between their characteristics and the usage of UHM. In order to analyze the determinants of using the UHM considering the individual's characteristics, logistic regression analysis and multiple regression analysis were conducted for those who used the Korean medicine (KM) outpatient service in 2015. Results : The usage of UHM was significantly lower for those (1) who's age of 20 to 65; (2) who have the university or higher education degree; (3) who live in Jeju province, and (4) who bought the herbal medicine for other health related purposes. On the other hand, the usage of UHM for those (1) who have the first quintile of household income; (2) who have the chronic respiratory disease; (3) who have been taking the medicine for health promotion purpose for more than 3 months and (4) who have purchased the food which has health promotion function was significantly higher than others. The patients who have chronic musculoskeletal diseases accounted the most among the UHM users. Conclusions : There was the considerable inequality in the usage of UHM among household income groups, which provides policy rationale for UHM to be covered by national health insurance. To facilitate the coverage expansion, restrictive covering model can be considered for children and adolescents, or for patients with muskuloskeletal diseases who have the high demand for UHM.

• Journal of Nutrition and Health
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• v.31 no.3
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• pp.324-332
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• 1998

Studies on relationships between antioxidant nutrients and various chronic diseases are increasing. In this study , serum concentrations of antioxidant minerals(Se, Cu, Zn & Mn) wee measured and compared among normal Korean adults. The ICP -MS method was employed to measure mineral concentrations. The subjects consisted of 329 healthy adults(154 men & 175 women) aged 20-79 years. The mean serum concentration appeared to be 26.4$\pm$0.41 (Se), 89.6$\pm$1.53(Cu), 113.3$\pm$1.56(Zn) & 0.34$\pm$0.05(Mn)$\mu\textrm{g}$/㎗ for men and 24.5$\pm$0.32(Se), 95.1$\pm$1.58(Cu), 133.6$\pm$1.79(Zn) & 0.35$\pm$0.02(Mn) $\mu\textrm{g}$/㎗ for women respectively. Among antioxidant minerals measured, the mean serum levels of Se and Zn were higher in men than in women(p<0.001), whereas that of Cu was higher in women(p<0.01). No significant difference between sex was observed for the mean Mn concentrations. The mean serum levels of Se(p<0.01) and Zn(p<0.05) decreased significantly in the 60's women On the other hand, the Mn concentrations in the 60's of women showed a significant increase(p<0.01). This difference seems to be due to the changes in menopausal status . The Cu levels in men showed a consistent increase with advancing age. The mean Cu/Zn ratios were 0.83 $\pm$0.04 for men and 0.95$\pm$0.02(p<0.01) for women respectively. The fact that this ratio increased significantly at the 60's of men (1.26 ; p<0.001) requires further study in relation to chronic diseases. When analyzed by stepwise multiple regression, drinking positively influenced serum Se and Cu levels for both men and women , smoking, however, negatively influenced all serum mineral levels for women. Further studies are needed to clarify precise roles of antioxidant minerals, their interactions and their relation to disease status.

• Journal of Korean Academy of Nursing
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• v.26 no.1
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• pp.53-72
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• 1996

The Purpose of this study was to identify characteristics of fatigue and the relationship between fatigue and related factors in patients on hemodialysis. This study was a survey study using a cross-sectional design. The subjects for this study were 101 patients on hemodialysis who were registered in the six hemodialysis clinics among a total of eleven clinics in Seoul. The period of data collection was from February 28, 1995 to May 2, 1995. Data were collected through an interview with a structured packet and the physiological data. The tools used in this study were the Visual Analogue Scale-Fatigue developed by Lee et al(1990) and translated by Lee(1991), the fatigue interview schedule developed by this researcher, Zung's self rating depression scale(Zung, 1965), the self-efficacy scale developed by Sherer et al(1982) and the Norbeck Social Support Questionnaire(NSSQ) translated by Oh(1984). The collected data were analyzed using descriptive statistics(mean, standard deviation, frequency, range), Pearson correlation coefficients and Stepwise multiple regression. The results were as follows ; 1. Characteristics of Fatigue of hemodialysis patients : 1) 79 of 101 hemodialysis patients complained fatigue. 2) The mean fatigue score as measured by the VAS-F was 36.2mm. 3) The mean duration of fatigue was 2.9 hours 2. Characteristics of fatigue related factors : 1) The physiologic factor which included Hgb, Hct, BUN, creatinine, potassium and interdialytic weight gain deviated from normal range. 2) The psychological factor which included depression and self-efficacy was about the same level as for patients with other chronic diseases. 3) The environmental factor which included social support had wide variation. 3. The relationship between fatigue and related factors : 1) Interdialytic weight gain in the physiologica factor was the only valuable with fatigue （p＜.05） 2) The relationship between fatigue and the psychological factor of depression showed a positive and strong correlation（p＜.05）. According to the findings of this study, fatigue was highly correlated with the depression. This indicates that nurses should try to assess and control psychological factors when patients complain of fatigue rather than just considering physiological factors. Nursing has to develop effective nursing interventions to reduce fatigue in patients with chronic diseases using the relationship between fatigue and physiological, psychological and environmental factors.

• Tuberculosis and Respiratory Diseases
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• v.42 no.1
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• pp.99-104
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• 1995

Most cases of eosinophilic pneumonia reported previously have followed a chronic course. The case presented here was acute in onset, suggesting a acute eosinophilic pneumonia. A model of criteria for acute and chronic eosinophilic pneumonia was made by Umeki in 1992. A previously healthy young man presented with cough, sputum, fever, and multiple small nodules on the chest radiograph. We confirmed eosinophilic pneumonia with bronchoalveolar lavage analysis and transbronchial lung biopsy. This case examplifies the recently descrived acute eosinophilic pneumonia.