• Journal of the Society of Cosmetic Scientists of Korea
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• v.32 no.4 s.59
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• pp.209-217
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• 2006

Emulsion is a dispersion system among liquids which are not miscible together. There are numerous cosmetic raw materials which have different physicochemical properties. Therefore, emulsion technology is very useful in cosmetics. With the development of emulsifier, several emulsification technologies have been developed. Since HLB method by Griffin in 1950's, PIT method, gel method, and D-phase methods, etc, have been developed. Recently, the application of natural emulsifier and polymeric emulsifier increases in cosmetics in order to achieve enhanced safety and biocompatibility. Besides nano-emulsion, multiple-emulsion, liquid crystal emulsion, and Pickering emulsion have been developed and applied as means of differentiating appearance and texture of products and achieving enhanced delivery of active ingredients. Meanwhile, the application studies of nano-dispersed structural system such as liposome or cubosome are on progress. Liposome is a bi- or multi-lamella layer dispersion system composed of amhiphilic molecules - phospholipids which are main components of plasma membrane. Cubosome also is a nano-sized dispersion system composed of a specific molecule like glyceryl monoloeate derived from natural products. And it has a cubic bicontinuous structure in water due to its unique molecular structure. Incorporating compounds (active materials) into such nano-particles can increase biocompatibility and delivery efficiency of target compounds. Manufacturing process and application of cosmetic emulsions and nano-particles are briefly introduced in this paper.

• Journal of Life Science
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• v.23 no.3
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• pp.462-469
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• 2013

Withaferin A is a steroidal lactone purified from the Indian medicinal plant Withania somnifera. It exhibits a wide variety of activities, including anti-tumor, anti-inflammation, and immunomodulation properties. In this review, we focused on the anti-cancer effects of withaferin A. Withaferin A inhibits cell proliferation, metastasis, invasion, and angiogenesis in cancer cells. Furthermore, it sensitized irradiation, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-, and doxorubicin-mediated apoptosis. The results showed that multiple mechanisms were involved in withaferin A-mediated anti-cancer effects. First, withaferin A increased intracellular reactive oxygen species (ROS) production and induced ER stress- and mitochondria-mediated apoptosis. Second, withaferin A inhibited the signaling pathways (Jak/STAT, Akt, Notch, and c-Met), which are important in cell survival, proliferation, and metastasis. Third, it induced apoptosis and inhibited cancer cell migration through the up-regulation of prostate apoptosis protein-4 (Par-4). Finally, withaferin A up-regulated pro-apoptotic protein expression levels through the inhibition of proteasome activity. Our findings suggested that withaferin A is a potential, potent therapeutic agent.

• Korean journal of food and cookery science
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• v.17 no.5
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• pp.490-496
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• 2001

The purpose of this study was to investigate the effects of ingredients(spices and medicinal plants) on the physicochemical properties of Pyunyuk a Korean style-cooked pork. Pyunyuk samples were prepared by the following 5 cooking conditions: Control(pork, water), A(pork, water, soy sauce), B(pork, water, soy sauce, onion, ginger), C(pork, water, soy sauce, onion, ginger, licorice, cinnamon) and D(pork, water, soy sauce, onion, ginger, licorice, cinnamon, clove and chestunt inner skin(CIS). The contents of ash, crude protein in loin and shank Pyunyuk were not significantly different among Pyunyuk samples, but crude fat content of C, D were significantly lower than control, A and B(p＜0.05). In Hunter’s color values of Pyunyuk, the lightness(L) was decreased by the addition of multiple ingredients, whereas the redness was increased. In mechanical characteristics, the hardness of control was the highest among the samples(p ＜0.05). In sensory evaluation, sample D obtained the highest score in flavor, taste, hardness, cohesiveness, springiness, gumminess and overall acceptability(p<0.05), and it was most preferred by the panels. There were higher negative-correlations between mechanical hardness and sensory characteristics of flavor, taste, cohesiveness, gumminess, brittleness and overall acceptability. From these results, it could be concluded that Pyunyuk ingredients(herbs and medicinal plants) reduce the content of crude fat, increase the tenderness and improve the flavor and taste of pork during cooking.

• Journal of Conservation Science
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• v.26 no.4
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• pp.429-436
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• 2010

Dyestuffs extracted from fifteen kinds of natural dyeing materials were researched on their antimicrobial performance against 3 kinds of bacteria and 2 kinds of fungi in order to develop conservation/storage materials of traditional and natural dyed papers. The three types of mordants were evaluated by using the same method and then mixed with the dyestuffs to research their antimicrobial performance. With those results, dyed paper was made by mixing mordants with 9 kinds of dyestuffs with excellent antimicrobial performance. Among the dyed papers, Cotinus coggygria, Coptis chinensis, Phellodendri amurense, Rhus javanica and Acer ginnala multiple mordant papers were found to have an antibacterial quality against fungi, while, in the insect repellent experiment using termites, Coptis chinensis and Phellodendri amurense dyed papers were found to have insect repellent qualities. Also, with regard to the research result about the affect of dyeing paper on other materials like metal, Coptis chinensis have relatively stable qualities. Also, the three types of dyeed paper by Cotinus coggygria, Coptis chinensis and Phellodendri amurense, were found to have a tendency to remove harmful gases. Not only can these dyed papers be used for making storage box for cultural properties to prevent various organic artifacts from bio-damaging, but they can also be utilized as functional finishing materials in various spaces.

• Journal of Microbiology and Biotechnology
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• v.28 no.6
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• pp.1007-1021
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• 2018

Cancer represents one of the most significant threats to human health on a global scale. Hence, the development of effective cancer prevention strategies, as well as the discovery of novel therapeutic agents against cancer, is urgently required. In light of this challenge, this research aimed to evaluate the effects of several potent bioactive peptides and proteins contained in crocodile white blood cell extract (cWBC) against LU-1, LNCaP, PC-3, MCF-7, and CaCo-2 cancer cell lines. The results demonstrate that 25, 50, 100, and $200{\mu}g/ml$ cWBC exhibits a strong cytotoxic effect against all investigated cell lines ($IC_{50}$ $70.34-101.0{\mu}g/ml$), while showing no signs of cytotoxicity towards noncancerous Vero and HaCaT cells. Specifically, cWBC treatment caused a significant reduction in the cancerous cells' colony forming ability. A remarkable suppression of cancerous cell migration was observed after treatment with cWBC, indicating potent antimetastatic properties. The mechanism involved in the cancer cell cytotoxicity of cWBC may be related to apoptosis induction, as evidenced by typical apoptotic morphology features. Moreover, certain cWBC concentrations induced significant overproduction of ROS and significantly inhibited the $S-G_2/M$ transition in the cancer cell. The molecular mechanisms of cWBC in apoptosis induction were to decrease Bcl-2 and XIAP expression levels and increase the expression levels of caspase-3, caspase-8, and p53. These led to a decrease in the expression level of the cell cycle-associated gene cyclin-B1 and the arrest of cell population growth. Consequently, these findings demonstrate the prospect of the use of cWBC for cancer therapy.

• Restorative Dentistry and Endodontics
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• v.33 no.3
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• pp.213-223
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• 2008

The objective of this study was to compare dentin shear bond strength (DSBS) of dentin bonding agents (DBAs) cured with a plasma arc (PAC) light curing unit (LCU) and those cured with a light emitting diode (LED) LCU. Optical properties were also analyzed for Elipar freelight 2 (3M ESPE); LED LCU, Apollo 95E (DMT Systems); PAC LCU and VIP Junior (Bisco); Halogen LCU. The DBAs used for DSBS test were Scotchbond Multipurpose (3M ESPE), Singlebond 2 (3M ESPE) and Clearfil SE Bond (Kuraray). After DSBS testing, fractured specimens were analyzed for failure modes with SEM. The total irradiance and irradiance between 450 nm and 490 nm of the LCUs were different. LED LCU showed narrow spectral distribution around its peak at 462 nm whereas PAC and Halogen LCU showed a broad spectrum. There were no significant differences in mean shear bond strength among different LCUs (P > 0.05) but were significant differences among different DBAs (P < 0.001)

• Journal of the Korean Association of Geographic Information Studies
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• v.15 no.1
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• pp.87-98
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• 2012

A river boundary is defined as the intersection between a main stream of a river and the land. Mapping of the river boundary is important for the protection of the properties in river areas, the prevention of flooding and the monitoring of the topographic changes in river areas. However, the utilization of the ground surveying technologies is not efficient for the mapping of the river boundary due to the irregular surfaces of river zones and the dynamic changes of water level of a river stream. Recently, the spatial information data sets such as the airborne LiDAR and aerial images are widely used for coastal mapping due to the acquisition of the topographic information without human accessibility. Due to these advantages, this research proposes a semi-automatic method for mapping of the river boundary using the spatial information data set such as the airborne LiDAR and the aerial photographs. Multiple image processing technologies such as the image segmentation algorithm and the edge detection algorithm are applied for the generation of the 3D river boundary using the aerial photographs and airborne topographic LiDAR data. Check points determined by the experienced expert are used for the measurement of the horizontal and vertical accuracy of the generated 3D river boundary. Statistical results show that the generated river boundary has a high accuracy in horizontal and vertical direction.

• Journal of the Korea Concrete Institute
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• v.23 no.1
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• pp.3-12
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• 2011

The structural behavior of continuous reinforced concrete deep beams is mainly controlled by the mechanical relationships associated with the shear span-to-effective depth ratio, flexural reinforcement ratio, load and support conditions, and material properties. In this study, a simple indeterminate strut-tie model which reflects characteristics of the complicated structural behavior of the continuous deep beams is presented. In addition, the reaction and load distribution ratios defined as the fraction of load carried by an exterior support of continuous deep beam and the fraction of load transferred by a vertical truss mechanism, respectively, are proposed to help structural designers for the analysis and design of continuous reinforced concrete deep beams by using the strut-tie model approaches of current design codes. In the determination of the load distribution ratio, a concept of balanced shear reinforcement ratio requiring a simultaneous failure of inclined concrete strut and vertical steel tie is introduced to ensure a ductile shear failure of reinforced concrete deep beams, and the primary design variables including the shear span-to-effective depth ratio, flexural reinforcement ratio, and concrete compressive strength are implemented after thorough parametric numerical analyses. In the companion paper, the validity of the presented model and load distribution ratio was examined by applying them in the evaluation of the ultimate strength of multiple continuous reinforced concrete deep beams, which were tested to failure.

• Korean Journal of Construction Engineering and Management
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• v.17 no.5
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• pp.78-88
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• 2016

Recently BIM technology has been expanded for using in construction project. However its spread has been delayed than the initial expectations, due to the high-cost of BIM infrastructure development, the lack of regulations, the lack of process and so forth. In design phase, especially, collaboration based on BIM system has being a key factor for successful next generation building project. Through the analysis of current research trend about IT technologies, virtualization and BIM service, data exchange such as drawing, 3D model, object data, properties using cloud computing and virtual server system is defined as a most successful solution. In various industrial fields, cloud computing technology is utilized as a promising solution which can reduce time and cost of hardware infrastructure. Among the cloud computing technology, VDI is receiving a great deal of attention from it market as an essential part cloud computing. VDI enables to host multiple individual virtual machines by using hypervisor. It has an advantage to easy main device management. Therefore, this study implements a step-by-step user's DaaS by analyzing the desktop resource data of the workers from Pre-design phase to Schematic design, Design develop and Construction design phase. It also develops BIM environment based on test of BIM modeler and designers in architectural design firm. The goal of the study is to enable the cloud computing BIM server. It provides cost saving, high-performance quality of working environment and cooperation's convenience and high security when doing BIM work in small and medium sized architectural design firm.

• Korean Journal of Environment and Ecology
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• v.26 no.1
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• pp.82-90
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• 2012

In this study, we investigated the environmental factors and growth characteristics of Sasa borealis community inside a temperate deciduous forest and reviewed its effect on the lower vegetation and natural regeneration. The S. borealis community in the Jungsan-ri region of Jirisan National Park was chosen as the study area, and the vegetation and the environmental factors were investigated. The dominance value, height and foliage layer thickness were investigated as the growth characteristics of S. borealis in the area. As the environmental factors, we investigated the photosynthesis photon flux density (PPFD) of the shrub and ground layers as well as the chemical characteristics of the soil. Additionally, we investigated the flora on the ground layer of the area as well as the number and height of woody plants. The result showed that the height and foliage layer thickness of the S. borealis was closely related to the light conditions but the distribution was not determined simply by the effect of the environment or vegetation of the particular area. This may be deeply related with the unique survival strategy of S. borealis, a vegetably propagated plant, that it can extensively distributed on a heterogeneous resources environment in a forest as multiple culm are interconnected with each other through the rhizomes. The dense dominance and great height of S. borealis reduced the plant species diversity in the ground layer by decreasing the PPFD on the ground surface.