• Journal of Digestive Cancer Research
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• 제12권1호
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• pp.44-47
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• 2024

Malignant melanomas, which are rarely found in the Asian population, are malignant tumors or melanocytes that manifest in the skin mucosa. Malignant melanomas of the anorectum are very rare and account for approximately 1% of all malignant melanomas in the Asian population. Here, we present a rare case presenting a malignant melanoma of the anorectum. An 85-year-old woman visited the hospital with bloody stools and an anal mass. Sigmoidoscopy revealed a black mass protruding from the anus, and the scope was able to penetrate the anorectal mass. Close-up endoscopy revealed black moles of different sizes scattered across the rectal mucosa. PET-CT indicated multiple FDG uptakes in the liver, indicating multiple metastases. Pathologic examination led to the detection of malignant melanocytes with dark brown deposits. The patient's immunohistochemical markers were positive for melanin-A antibodies and HMB-45, indicating a malignant melanoma. As there was no evidence of malignant melanomas on the skin, the patient was diagnosed with primary malignant anorectal melanoma with liver metastases.

• Journal of Chest Surgery
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• 제36권11호
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• pp.866-869
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• 2003

식도암 환자에서 동시에 일차성 폐암이 발견되는 빈도는 2% 미만에 불과하며, 특히 두 질환 모두 예후가 나쁨으로 인해서 환자들이 근치적 절제술을 받을 기회를 놓치게 되는 경우가 많다. 그러나 환자를 신중히 선택한다면 폐와 식도의 중복암을 동시에 절제함으로써 좋은 결과를 가져올 수 있다고 생각한다. 저자들은 최근 식도와 폐의 일차성 중복암 환자 1예를 경험하였고, 쌍폐엽절제술과 Ivor Lewis 술식으로 일차성 근치적 절제술을 시행하여 좋은 결과를 얻었기에 국내 문헌상으로는 최초로 이를 보고하는 바이다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5401-5406
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• 2015

Background: Brain metastases are the most common intra-cranial neoplasms. The incidence is on a rise due to advanced imaging techniques. Aims: The objective of the study was to analyse the clinical and demographic profile of patients with brain metastases from primary solid tumors. Materials and Methods: This is a retrospective single institutional study covering 130 consecutive patients with brain metastases from January 2007 to August 2014. Results: Some 64.6% of the patients were females. The majority were in the sixth decade of life. The site of the primary tumor was the lungs in 50.8% of the cases. The overall median time from the diagnosis of the primary malignancy to detection of brain metastases was 21.4 months. Survival was found to be significantly improved in patients with solitary brain lesions when compared to patients with multiple brain metastases, and in patients undergoing surgical excision with or without cranial irradiation when compared to whole brain irradiation alone. The majority of the cases belonged to the recursive partitioning analysis class II group. Whole brain radiation therapy was delivered to 79% of the patients. Conclusions: Most of the patients with brain metastases in the study belonged to recursive partitioning analysis classes II or III, and hence had poor prognosis. Most of the patients in the Indian context either do not satisfy the indications for surgical excision or are incapable of bearing the high cost associated with stereotactic radiosurgery. Treatment should be tailored on an individual basis to all these patients.

• Journal of Chest Surgery
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• 제54권5호
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• pp.422-424
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• 2021

Malignant peripheral nerve sheath tumors are rare sarcomas of the heart. Herein, we report the case of a 24-year-old man who complained of dyspnea, cough, and upper left back pain. He was found to have multiple primary heart tumors obstructing the right superior pulmonary vein in the left atrium, which were diagnosed as malignant peripheral nerve sheath tumors. The patient underwent successful resection of the tumors and immunohistochemistry was utilized for diagnosis.

• Journal of Chest Surgery
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• 제37권11호
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• pp.942-945
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• 2004

원발성폐지방육종은 극히 드문 질환일 뿐만 아니라, 국소재발이 빈번하고 발병 초기에 원격전이가 발생하여 예후가 불량한 질환이다. 지방육종의 치료를 위해서는 수술적인 절제가 우선적이나, 완전히 절제를 못하였을 경우 지방육종이 국소적으로 재발하게 되고 상당히 빠른 속도로 자라게 된다. 저자들은 원발성폐지방육종을 완전 절제하여 10개월 간 재발 및 전이가 없는 예를 경험하였기에 보고하는 바이다.

• 대한종양외과학회지
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• 제14권2호
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• pp.83-88
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• 2018

Purpose: Double primary colorectal cancer (CRC) and gastric cancer (GC) represent the most common multiple primary malignant tumors (MPMT) in Korea. The recognition and screening of hidden malignancies other than the primary cancer are critical. This study aimed to investigate the clinicopathologic characteristics and survival rates in patients with synchronous or metachronous double primary CRC and GC. Methods: Between January 1994 and May 2018, 11,050 patients were diagnosed with CRC (n=5,454) or GC (n=5,596) at Gil Medical Center. MPMT and metastatic malignant tumors were excluded from this study. A total of 103 patients with double primary CRC and GC were divided into two groups: the synchronous group (n=40) and the metachronous group (n=63). The incidence, clinicopathologic characteristics, and survival rate of the two groups were analyzed. Results: The incidence of synchronous and metachronous double primary CRC and GC was 0.93%. Double primary CRC and GC commonly occurred in male patients aged over 60 years with low comorbidities and minimal previous cancer history. There were significant differences between the synchronous and metachronous groups in terms of age, morbidity, and overall survival. Metachronous group patients were 6 years younger on average (P=0.009), had low comorbidities (P=0.008), and showed a higher 5-year overall survival rate (94.8% and 61.3%, P<0.001) in contrast to synchronous group. Conclusion: When primary cancer (CRC or GC) is detected, it is important to be aware of the possibility of the second primary cancer (GC or CRC) development at that time or during follow-up to achieve early detection and better prognosis.

• Journal of Gastric Cancer
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• 제14권3호
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• pp.215-219
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• 2014

Distant metastasis from papillary thyroid carcinoma (PTC), particularly from papillary thyroid microcarcinoma, is rare. We present a case of perigastric lymph node metastasis from PTC in a patient with early gastric cancer and breast cancer. During post-surgical follow-up for breast cancer, a 56-year-old woman was diagnosed incidentally with early gastric cancer and synchronous left thyroid cancer. Therefore, laparoscopic distal gastrectomy with lymph node dissection and left thyroidectomy were performed. On the basis of the pathologic findings of the surgical specimens, the patient was diagnosed to have papillary thyroid microcarcinoma with perigastric lymph node metastasis and early gastric cancer with mucosal invasion. Finally, on the basis of immunohistochemical staining with galectin-3, the diagnosis of perigastric lymph node metastasis from PTC was made. When a patient has multiple primary malignancies with lymph node metastasis, careful pathologic examination of the surgical specimen is necessary; immunohistochemical staining may be helpful in determining the primary origin of lymph node metastasis.

• 대한두개안면성형외과학회지
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• 제25권2호
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• pp.90-94
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• 2024

Primary cutaneous mucinous carcinoma (PCMC) is a rare malignancy of the sweat glands that most commonly affects the periorbital area. It is characterized by slow growth over a prolonged period, and its morphology can be easily confused with a benign tumor, such as an epidermal cyst. Consequently, many patients experience recurrence after undergoing multiple resections. However, there are few reports concerning the surgical management of PCMC. We present two cases of PCMC originating in the periorbital area. The first case involved a 76-year-old man with a mass measuring 3.0×1.5 cm that had been increasing in size. The second case was a 61-year-old man with two masses, each measuring 1.0×1.0 cm, that were also growing. Both patients underwent wide excision with a 5-mm safety margin, which was determined based on the widest view of the cross-section of the mass on the magnetic resonance imaging. Subsequently, based on the intraoperative frozen biopsy results, both patients underwent additional excision with a 5-mm safety margin in only one direction. This report shows that, when determining the surgical margin of PCMC in periorbital area, employing imaging modalities and intraoperative frozen biopsies can be helpful for narrowing the surgical margin.

• 대한두경부종양학회지
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• 제11권2호
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• pp.173-177
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• 1995

Multiple primary malignant neoplasms occur relatively frequently today and are important especially in the head and neck area for they usually carry a bad prognosis. Detection of a synchronous primary tumor at the time of initial work-up is crucial both for management and final outcome. The first case was a T1 hypopharyngeal cancer with a mid-esophageal second primary who complained of a huge neck node. The second case was a T3 hypopharyngeal cancer who was initially seen by the chest surgeons for a large lower esophageal tumor. The third case was a patient previously operated for stomach adenocarcinoma three years ago, who had newly developed symptoms like dysphagia and hoarseness, and was diagnosed as hypopharyngeal T3 with oropharyngeal second primary cancer. Three cases were all heavy smokers and had histories of heavy alcohol consumption. They were all treated at the same sitting by en-block resection of the involved organs and postoperative radiation therapy. The authors have recently experienced 3 cases of synchronous second primary cancers in association with hypopharyngeal cancer and a report is made.

• 대한영상의학회지
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• 제81권5호
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• pp.1109-1120
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• 2020

흉막의 종괴는 다양한 양성과 악성 종양이 있고 종양은 아니지만 종양 같은 질환들에 의해 발생한다. 일차 흉막 종양에는 고립섬유종양, 악성중피종, 그리고 원발성 흉막 비호지킨 림프종이 있다. 흉막에 발생하는 가장 흔한 종양은 전이성 질환이며, 림프종, 백혈병, 다발성 골수종 등의 혈액 종양을 가진 환자에서 드물게 나타난다. 흉수는 주로 흉막의 악성 질환과 연관이 있다. 드물지만 흉막 종양이 만성 농흉에서 생길 수 있으며, 그중 가장 흔한 것은 비호지킨 림프종이다(농흉과 연관된 림프종). 종양이 아닌 흉막 종괴로는 다양한 양성 질환에서 보일 수 있으며, 여기에는 결핵, 석면 흉막판, 그리고 흉막 유리체가 포함된다. 이 임상화보에서 저자들은 흉막의 다양한 양성과 악성 종양 및 종양성 질환들에 대한 특징적인 전산화단층촬영 소견에 대해 알아보고자 한다.