• Development and Reproduction
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• v.16 no.1
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• pp.69-75
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• 2012

Hatching occurred in the time dependent manners and strictly controlled. Although, the hatching processes are under the control of muti-embryotrophic factors and the expressed G proteins of cell generate integrated activation, the knowledge which GPCRs are expressed during hatching stage embryos are very limited. In the present study, which G proteins are involved was examined during blastocyst development to the hatching stage. The early-, expanded-, and lobe-stage blastocysts were treated with various $G_{\alpha}$ activators and H series inhibitors, and examined developmental patterns. Pertusis toxin (PTX) improved the hatching rate of the early-stage blastocyst and lobe-formed embryos. Cholera toxin (CTX) suppressed the hatching of the early-stage blastocyst and expanded embryos. The effects of toxins on hatching and embryo development were changed by the H7 and H8. These results mean that PTX mediated GPCRs activation is signaling generator in the nick or pore formation in the ZP. In addition, PTX mediated GPCR activation induces the locomotion of trophectoderm for the escaping. CTX mediate GPCRs activation is the cause of suppression of hatching processes. Based on these data, it is suggested that various GPCRs are expressed in the periimplantation stage embryos and the integration of the multiple signals decoding of various signals in a spatial and temporal manner regulate the hatching process.

• Human Ecology Research
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• v.53 no.3
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• pp.331-339
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• 2015

This study investigates the effects of parental abuse and neglect on school life adjustment mediated by self-esteem in adolescents. Participants consisted of 2,259 middle school students from the Korean Children and Youth Panel Study 2012. Secondary questionnaire data on parental abuse and neglect, self-esteem, and school life adjustment are used for this study. Data were analyzed using descriptive analysis, Cronbach's a, Pearson's correlation analysis and multiple regression analysis. Baron and Kenny's method determined the mediation effect. SPSS ver 18.0 was adopted. The results were as follows. First, parental abuse and neglect were negatively correlated with the adolescent school life adjustment; however self-esteem was positively correlated with adolescent school life adjustment. Second, the results of the regression analysis revealed that adolescent school life adjustment was influenced both directly and indirectly; parental abuse had a direct effect on adolescents' school life adjustment and also had an indirect effect on mediated by self-esteem. Parental neglect had a direct effect on adolescent school life adjustment and had an indirect effect on adolescent school life adjustment mediated by self-esteem. The results indicated that self-esteem plays a crucial variable in the relationship of parental abuse and the school life adjustment. Also, self-esteem plays a crucial variable in the relationship between parental neglect and school life adjustment.

• Journal of Distribution Science
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• v.20 no.7
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• pp.97-105
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• 2022

Purpose: This study aims to analyze and prove the effect of logistic capability and Total Quality Management practices on Micro, Small and Medium Enterprises (SME) performance directly or mediated by non-financial performance. Research design, data and methodology: This study tested the hypothesis using Hierarchical multiple regression analysis, the method of data collection in this study was using questionnaire, the sampling technique was purposive sampling technique, with SME that has been established for more than 5 years and manufacturing. The data analyzed were 180 respondents using SPSS 25. Results: The findings showed that logistic capability has direct and indirect effects on SME financial performance and has a positive effect on SME financial performance mediated by non-financial performance. While the total quality management practices have a positive effect on SME financial performance mediated by non-financial performance. Thus, companies can achieve maximum financial performance if they invest in developing employee knowledge and concerning on non-financial actions, such as employee satisfaction, innovation and proactively seeking market opportunities. Conclusions: In conclusion, one of the main factors that companies need to consider to improve financial performance is non-financial performance in mediating the effect of logistic capability and TQM practices on the financial performance of SMEs.

• Journal of Ginseng Research
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• v.47 no.5
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• pp.615-621
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• 2023

Korean Red Ginseng (KRG) plays a key role in heme oxygenase (HO)-1 induction under physical and moderate oxidative stress conditions. The transient and mild induction of HO-1 is beneficial for cell protection, mitochondrial function, regeneration, and intercellular communication. However, chronic HO-1 overexpression is detrimental in severely injured regions. Thus, in a chronic pathological state, diminishing HO-1-mediated ferroptosis is beneficial for a therapeutic approach. The molecular mechanisms by which KRG protects various cell types in the central nervous system have not yet been established, especially in terms of HO-1-mediated mitochondrial functions. Therefore, in this review, we discuss the multiple roles of KRG in the regulation of astrocytic HO-1 under pathophysiological conditions. More specifically, we discuss the role of the KRG-mediated astrocytic HO-1 pathway in regulating mitochondrial functions in acute and chronic neurodegenerative diseases as well as physiological conditions.

• Journal of the Korean Home Economics Association
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• v.40 no.10
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• pp.65-76
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• 2002

The purpose of this study win to examine the relation between level of income, perceived parental behaviors, and ego-identity of school-aged children. The subjects were 356 children in the 6th grade selected from six elementary schools in Seoul and Keunggi-Do. The subjects were asked to complete the questionnaire on ego-identity and perceived parental behaviors. The data was analyzed by Mean, SD, Cronbach's α, Pearson's correlation and Multiple Regression. The major findings were as follows : 1. The level of income(antecedent variable) was significantly related with perceived parental behavior(mediator) and ego-identity of school-aged children(dependent variable). 2. The effects of level of income on ego-identity of school-aged children became lower after control of the effects of perceived parental behaviors. In other words, perceived parental behaviors partially mediated the effects of level of income on ego-identity of school-aged children.

• Research in Community and Public Health Nursing
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• v.31 no.1
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• pp.24-33
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• 2020

Purpose: The purpose of this study was to examine the mediating effect of self-esteem and social support on the relationship between anxiety and health-related quality of life (HRQoL) in the elderly. Methods: The Korea adult psycho-social anxiety survey data were collected from August to September 2015 by the Korea Institute for Health. The subjects were 1,035 elderly people who were aged 65 or older at the time of the data survey. The data were analyzed by t-test, chi-square, Pearson correlation coefficient, and parallel redundant mediated model for PROCESS macro using SPSS 23.0. Results: They scored an average of 37.93±7.58 for anxiety, 28.59±3.45 for self-esteem, 17.25±4.11 for social support, and 0.88±0.11 for HRQoL. The direct effect of anxiety on HRQoL and the indirect effect of anxiety mediated with self-esteem and social support about HRQoL were statistically significant. Conclusion: These results indicate that in order to increase the HRQoL of the elderly, it is necessary to develop an intervention program that focuses not only on reducing anxiety but also on improving self-esteem and social support.

• Journal of Families and Better Life
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• v.30 no.2
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• pp.1-10
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• 2012

This study focused on the relationships among emotionality, eating behavior problems, and behavior problems in a sample of 185 four- to five-year-old children attending kindergarten or a day care center in Seoul. The values were all measured by their teachers. The collected data were analyzed using simple regression and hierarchical multiple regression. The main results of this study were as follows. First, children's positive and negative emotionality each exerted negative and positive effects on their internalizing behavior problems. Second, children's positive emotionality had a negative influence on their eating behavior problems. On the other hand, children's negative emotionality had a positive influence on eating behavior problems. Finally, effect of children's positive emotionality on their eating behavior problems was partially mediated by internalizing behavior problems. On the other hand, the effect of children's negative emotionality on their eating behavior problems was totally mediated by their internalizing behavior problems.

• Korean Journal of Human Ecology
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• v.20 no.4
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• pp.789-800
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• 2011

This study examined the relationships among principals' transformational leadership, collective efficacy and efficacy of teachers based on the survey data from 196 teachers working in day care centers in the Incheon and Gyeonggi-do areas. These valuables were all measured by teachers. The collected data were analyzed by Simple Regression and Hierarchical Multiple Regression. The main results of this study were as follows. First, principals' transformational leadership had positive effects on collective efficacy and efficacy of teachers. Second, collective efficacy of teachers had a positive influence on efficacy of teachers. Finally, the effects of principals' leadership on efficacy of teachers was totally mediated by collective efficacy of teachers. Most importantly, the collective efficacy of teachers totally mediated the positive relation between principals' leadership and the individual efficacy of teachers.

• Journal of Ginseng Research
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• v.46 no.3
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• pp.444-453
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• 2022

Background: Compound K (CK) is among the protopanaxadiol (PPD)-type ginsenoside group, which produces multiple pharmacological effects. Herein, we examined the effects of CK on muscle atrophy under hyperlipidemic conditions along with its pro-myogenic effects. Further, the molecular pathways underlying the effects of CK on skeletal muscle have been justified. Methods: C2C12 myotubes were treated with palmitate and CK. C2C12 myoblasts were differentiated using CK for 4-5 days. For the in vivo experiments, CK was administered to mice fed on a high-fat diet for 8 weeks. The protein expression levels were analyzed using western blotting analysis. Target protein suppression was performed using small interfering (si) RNA transfection. Histological examination was performed using Jenner-Giemsa and H&E staining techniques. Results: CK treatment attenuated ER stress markers, such as eIF2a phosphorylation and CHOP expression and impaired myotube formation in palmitate-treated C2C12 myotubes and skeletal muscle of mice fed on HFD. CK treatment augmented AMPK along with autophagy markers in skeletal muscle cells in vitro and in vivo experiments. AMPK siRNA or 3-MA, an autophagy inhibitor, abrogated the impacts of CK in C2C12 myotubes. CK treatment augmented p38 and Akt phosphorylation, leading to an enhancement of C2C12 myogenesis. However, AMPK siRNA abolished the effects of CK in C2C12 myoblasts. Conclusion: These findings denote that CK prevents lipid-induced skeletal muscle apoptosis via AMPK/autophagy-mediated attenuation of ER stress and induction of myoblast differentiation. Therefore, we may suggest the use of CK as a potential therapeutic approach for treating muscle-wasting conditions associated with obesity.

• Korean Journal of Child Studies
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• v.26 no.1
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• pp.217-228
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• 2005

The present study explored relationships between self-esteem, general self-efficacy and creative personality. The responses of 113 university students on self-esteem, general self-efficacy, and creative personality scales were collected and analyzed by Cronbach a tests, Pearson correlations and multiple regression analysis. The results showed that, first, there were significant positive relationships between self-esteem, general self-efficacy and creative personality. Second, the effects of self-esteem on creative personality were mediated by general self-efficacy. Finally, multiple regression analysis demonstrated that self-regulation and self-confidence among the sub-factors of general self-efficacy were good predictors of the creative personality. From these results we conclude that it is important to improve general self-efficacy in order to develop creative personality.