• Journal of Periodontal and Implant Science
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• v.27 no.2
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• pp.425-441
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• 1997

The neuropeptide substance P(SP) has been implicated in the mediation of inflammation and immune-mediated disease such as arthritis. Recently, it was reported that SP was markedly increased around the blood vessels in inflamed gingiva as well as in close association with the inflammatory cell infiltrate. These results support that SP may contribute to the pathophysiology of neuronal inflammation in human periodontal tissues. SP may regulate inflammatory/immune responses by stimulating the proliferation of human T cells, differentiation and antibody-secreting potential of B cells, macrophage respiratory burst, connective tissue proliferation, and the secretion of cytokines from monocytes and T cells. Here, I studied potential role of SP as a costimulatory chemical signal in inflammatory/immune responses, by determining the released proinflammatory cytokines such as $MIP-1{\alpha}$, $IL-1{\beta}$, and IL-6 from culture supernatants of homogeneous immune cell lines. Serum free cell supernatants were concentrated with TCA precipitation, fractionated with SDS-PAGE, and subjected into western blot analysis. Among 15 cell lines tested, macrophage/monocyte cell line RAW264.7 and WRl9m.1 showed the highest level of induction of $MIP-1{\alpha}$ when stimulated with LPS. Discrete IL-6 bands with multiple forms of molecular mass were detected from supernatants of B cell lines A20(32kDa), Daudi(32, 35kDa), and SKW6.4(29kDa), which were expressed constitutively. $IL-1{\beta}$ could not be detected by the method of western blot analysis from supernatants of all cell lines tested except RAW264.7, WRl9m.1, and erythroid cell line K562 which showed the least amount of $IL-{\beta}$ secretion. SP $10^{-9}M$ with suboptimal dose of LPS treatment showed synergistic induction of $MIP-1{\alpha}$ release from RAW264.7 or WR19m.1, and also IL-6 release from A20, but this synergism is not the case in costimulation of RAW264.7 or WRl9m.1 with SP $10^{-9}M$ and TPA. Although treatment of T cell line CTLL-R8 with SP $10^{-7}M$ or PHA+TPA induced modest level of $MIP-1{\alpha}$ secretion, synergism was not observed when they are applied together. These findings all together suggest the possibility of a regulatory role of SP in inflammatory/immune reaction through differential modulation of bioactivities of other chemical cosignals.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.4
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• pp.452-462
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• 2020

This study analyzed the impact of resilience on the job satisfaction of middle-aged employees and the meditating effect of retirement attitude. The survey was administered to 468 regular workers aged 40 or older in Seoul and the surrounding metropolitan area. This study utilized SPSS 19.0 statistical program, and multiple regression and mediated effect analyses were applied with descriptive statistics, reliability and validity of measurement tools to analyze differences between correlations and groups. First, male workers had higher self-regulation ability and job satisfaction than women. Female workers had higher old age rest than male ones. The higher the educational background, the higher the recognition of retirement as a new beginning, The longer the working years, the higher the self-regulation ability and job satisfaction. The higher the household income, the higher the positiveness. Second, the Resilience had a positive effect on job satisfaction. Third, resilience had had a negative impact on the forced frustration and a positive influence on the new beginning of retirement attitudes. Fourth, the forced frustration and new beginning showed mediating effects of resilience and job satisfaction. The study results confirmed the importance of resilience and demonstrated the need for measures to enhance resilience in order to reduce anxiety about retirement and increase job satisfaction.

• The Journal of Industrial Distribution & Business
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• v.8 no.5
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• pp.95-109
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• 2017

Purpose - The purpose of this study is to classify the quality factors of coffee shop customers with the service quality based on the SERVQUAL, selection attributes, and service qualities used in previous studies. The path structure of coffee shops' quality factors → customer satisfaction → trust → behavioral intention was analyzed in order to confirm the system of coffee shops' quality factors. Research design, data, and methodology - The survey of was conducted with college students of Kangwon University. A total of 250 questionnaires were distributed, with 232 collected. Of them, Excluding 36 respondents' because of incomplete answers and missing values, 196 responses were used in the final analysis. Empirical analysis was made through factor analysis, correlation analysis, multiple regression analysis, simple regression analysis and mediating regression analysis by using Statistics Package SPSS 19.0. Results - The results are as follows: Firstly, coffee shops' quality factors were classified into seven categories like service encounter quality, product quality, cleanliness, overall interior, purchase quality, convenience, and aesthetics. Secondly, service encounter quality, product quality, purchase quality, and aesthetics had a positive effect on customer satisfaction, respectively. Thirdly, it showed that service encounter quality, product quality, overall interior, purchase quality, and aesthetics had a positive effect on trust, respectively. Fourthly, customer satisfaction had a positive effect on behavioral intention. Lastly, after verifying the effect relations of trust between customer satisfaction about coffee shop and behavioral intention, customer satisfaction has a positive effect on trust and trust has a positive effect on behavioral intention. On the other hand, trust did not have a mediating effect between customer satisfaction and behavioral intention. But, cleanliness, convenience, and overall interior did not have a positive effect on customer satisfaction. Conclusions - Coffee shop consumers put importance on price, discount systems, taste, and freshness, but more on courteous and kind services of coffee shop staff or comfortable and calming atmosphere of inner space. Thereby, coffee shop marketers need to take factors like service encounter quality and aesthetics into more consideration. In addition, customer satisfaction has an effect on trust, while trust on behavioral intention, even though trust is not mediated between customer satisfaction and behavior intention.

• Journal of the Korean Home Economics Association
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• v.43 no.5 s.207
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• pp.131-147
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• 2005

The purpose of this study was to provide a better understanding of foreign-born Korean children's early school adjustment in the U.S. The interaction between the foreign-born Korean children in the U.S. and several of the children's microsystems, including family, school, and peer was assessed to meet this purpose. The study subjects were 43 foreign-bom Korean children who were sampled from Korean Sunday Language schools and who attended local schools in the Boston area, MA, USA. Quantitative analysis was conducted to identify which variables of interest predicted the early adjustment of this group of children. Furthermore, in-depth interviews were conducted with mothers of the children from the top and bottom groups 1) the most successful (in the top quartile) and 2) the least successful adjustment groups (in the bottom quartile) sorted by scores on the Peabody Picture Vocabulary Test-Revised (PPVT-R). The interview results were analyzed to elicit maternal perceptions/beliefs on education, in general, and those of home-school relationships, in specific. Several conclusions can be drawn from both the quantitative and qualitative analyses. The results of multiple regression and path analysis showed that the children's language development predicted their adjustment, but the effects of the other two variables, peer relationships and school experiences, on the adjustment of children, were mediated through the children's language. Moreover, common themes and patterns in the responses to a series of open-ended questions emerged from the interviews with the two groups of mothers. The two mothers of the least successful group were concerned about their children's future and school success, but thev did not show anv responsive attitudes toward achieving this goal. By contrast, the mothers from the most successful group were self-determined with regard to their children's education and had strong beliefs and values on how to raise their children in the new culture. The implications were discussed.

• Management & Information Systems Review
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• v.33 no.4
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• pp.99-118
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• 2014

Using the theory of attribution, this study investigates the determinants if controllability and explores underlying dimensions of online information credibility, and then investigates if the credibility of online information influences the users' intention to use the online information for evaluating or judging the involved products. Moreover, as a research attempt to investigate the impacts of online information credibility, this study examines whether the main effect of perceived online information credibility on the intention of using online information to make a decision of purchase is mediated by both perceived risk and perceived usefulness. A total of 287 survey forms were collected from online consumers. We examined reliability by exploring internal consistency of the multiple item scales in the overall sample. Convergent and discriminant validity were also examined for evidence of construct validity. Then, PLS technique was employed to test the research model. As a result of analyzing data from a dataset of 287 responses via PLS technique, it is found that (1) both sources (controllability and stability) of perceived credibility are significantly associated with both perceived risk and perceived usefulness, and (2) perceived risk as well as perceived usefulness partially mediate the link between the two sources of credibility and intention to use. The findings of this study also suggest that the two dimensions of online information credibility influence information recipient's intention to use. Moreover, the online information including descriptions about controllability and stability can trigger potential consumers to perceive risk about consumption of the informed products and services. Therefore, providing online information with highly described controllability and stability can increase not only the credibility of the online information itself, but also the intention to use the online information through perceived risk and usefulness.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.10
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• pp.341-350
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• 2019

The aim of this study was to establish research hypotheses and conduct empirical analysis to clarify the relationship between self-leadership, self-efficacy, job satisfaction, and job performance of researchers in the energy and environment fields. Data were extracted from questionnaires returned by 165 researchers in the field of energy environment among 200 questionnaires collected for approximately three weeks. The reliability, frequency, descriptive statistics, correlation analysis, multiple regression analysis, and sobel-test were examined using the SPSS 22.0 statistical program. The self-leadership of the researcher has a positive (+) effect on self-efficacy, job satisfaction, and job performance, and the researcher's self-efficacy has a positive (+) influence on both job satisfaction and job performance. In addition, the self-efficacy and job satisfaction mediated the relationship between self-leadership, and job performance. Therefore, to improve the job performance of the researchers, it is important to establish a system for the human resource management of the affiliated institutions and revitalize the education for the self-leadership and self-efficacy improvement. In addition, it is necessary to provide an appropriate compensation system to satisfy the researchers' enjoyment, satisfaction and trust in their jobs. In particular, because self-efficacy is a very important factor for job performance, it is important to prepare an institutional strategy for strengthening the self-efficacy of researchers.

• 한국노년학
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• v.38 no.4
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• pp.905-922
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• 2018

The purpose of this study was to examine the mediating effects of generativity and ego-integration on the relationship between leisure activity experience and life satisfaction after retirement, and to clarify the structural relationship between variables. In this study, SPSS for window 21.0 program r and AMOS 18.0 were used. First, correlation analysis was performed among the main variables to investigate the relationship between variables. Next, confirmatory factor analysis and fit of hypothesis model were confirmed. Finally, the bootstrapping procedure was conducted to verify the significance of the indirect effect. The main results of this study are as follows. First, leisure activity experience, life satisfaction, generativity and ego-integration were statistically correlated. Second, in the research model, there was a double-mediated effect of the generativity and ego-integration in the married couple's leisure experience and life satisfaction after retirement. The indirect effect that affects life satisfaction was found to be greater through mediation. This study has limitations in collecting data on retirees who have retirement experience or retired husbands who have. The reason for this is that there is a difference in the sense of life satisfaction between the couple and their spouse, and the significance of the path between the variables may also differ. Therefore, the follow-up study suggests the necessity of analyzing only the couple.

• The Journal of the Korea Contents Association
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• v.21 no.5
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• pp.384-397
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• 2021

This study seeks to dertermine the influence and mediating effect of work environments among counselors at National Protection Agencies for Elderly(NPAE), who are conducting elderly abuse prevention service when domestic and facility abuse is augmenting due to social distancing as a result of COVID-19, on turnover intention. This study ultimately applied the analysis of 290 replies to surveys that were distributed to 306 workers at a total of 34 National Protection Agencies for Elderly(NPAE). The nationwide investigation was carrid out from 1st July until 30th July, 2020. SPSS 23.0 was used for the analysis and the Sobel-Test was conducted to verify the multiple regression analysis and significance. This was for the confirmation of descriptive statistics, correlation analysis and mediation effect so that the influence and relationships of variables could be verified. The results are as follows. First the job stress of counselors in the NPAE had a positive effect on turnover intention. Second, the work environment of the NPAE was found to have a negative influence on turnover intention. Third, the work environment played a significant partially mediating role in the relation between the job stress and turnover intention among the counselors. Based on such research results, policy and practical implications to reduce the stress, improve the work environment and reduce turnover of counselors in the NPAE were presented.

• Korean Journal of Culture and Social Issue
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• v.26 no.3
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• pp.145-166
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• 2020

The present study examines whether fear of negative evaluation, social comparison and self-criticism mediate the relationship between insecure attachment and career indecision. Participants are 401 unemployed people in their 20s who have never had a job. The major findings of this study are as follows. First, correlation analysis indicates that both anxious attachment and avoidant attachment are positively related to fear of negative evaluation and self-criticism. Also, anxious attachment is positively correlated with social comparison, whereas avoidant attachment is negatively correlated with it. Second, both insecure attachments have significant positive correlation with career indecision. Third, it shows the respective unique mechanisms by which each of the two insecure attachment forms are related to career indecision are distinctive: Specifically, The linkage between anxious attachment and career indecision is partially mediated by self-criticism and social comparison, whereas avoidant attachment is indirectly related to career indecision through a full mediation of self-criticism and social comparison. Implications and limitations of this study are discussed.

• Journal of Ginseng Research
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• v.46 no.6
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• pp.759-770
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• 2022

Background: Aerobic cellular respiration provides chemical energy, adenosine triphosphate (ATP), to maintain multiple cellular functions. Sirtuin 1 (SIRT1) can deacetylate peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) to promote mitochondrial biosynthesis. Targeting energy metabolism is a potential strategy for the prevention and treatment of various diseases, such as cardiac and neurological disorders. Ginsenosides, one of the major bioactive constituents of Panax ginseng, have been extensively used due to their diverse beneficial effects on healthy subjects and patients with different diseases. However, the underlying molecular mechanisms of total ginsenosides (GS) on energy metabolism remain unclear. Methods: In this study, oxygen consumption rate, ATP production, mitochondrial biosynthesis, glucose metabolism, and SIRT1-PGC-1α pathways in untreated and GS-treated different cells, fly, and mouse models were investigated. Results: GS pretreatment enhanced mitochondrial respiration capacity and ATP production in aerobic respiration-dominated cardiomyocytes and neurons, and promoted tricarboxylic acid metabolism in cardiomyocytes. Moreover, GS clearly enhanced NAD⁺-dependent SIRT1 activation to increase mitochondrial biosynthesis in cardiomyocytes and neurons, which was completely abrogated by nicotinamide. Importantly, ginsenoside monomers, such as Rg1, Re, Rf, Rb1, Rc, Rh1, Rb2, and Rb3, were found to activate SIRT1 and promote energy metabolism. Conclusion: This study may provide new insights into the extensive application of ginseng for cardiac and neurological protection in healthy subjects and patients.