• Journal of Veterinary Science
• /
• v.21 no.5
• /
• pp.72.1-72.10
• /
• 2020

Background: Fenbendazole, a dewormer drug, is used widely in the clinical treatment of parasite infections in animals. Recent studies have shown that fenbendazole has substantial effects on tumor growth, immune responses, and inflammatory responses, suggesting that fenbendazole is a pluripotent drug. Nevertheless, the antiviral effects have not been reported. Fenbendazole can disrupt microtubules, which are essential for multiple viruses infections, suggesting that fenbendazole might have antiviral effects. Objectives: This study examined whether fenbendazole could inhibit bovine herpesvirus 1 (BoHV-1) productive infection in cell cultures. Methods: The effects of fenbendazole on viral production, transcription of the immediate early (IE) genes, viron-associated protein expression, and the cellular signaling PLC-γ1/Akt pathway were assessed using distinct methods. Results: Fenbendazole could inhibit BoHV-1 productive infections significantly in MDBK cells in a dose-dependent manner. A time-of-addition assay indicated that fenbendazole affected both the early and late stages in the virus replication cycles. The transcription of IE genes, including BoHV-1 infected cell protein 0 (bICP0), bICP4, and bICP22, as well as the synthesis of viron-associated proteins, were disrupted differentially by the fenbendazole treatment. The treatment did not affect the cellular signaling pathway of PLC-γ1/Akt, a known cascade playing important roles in virus infection. Conclusions: Overall, fenbendazole has antiviral effects on BoHV-1 replication.

• Journal of the Korean Society for Precision Engineering
• /
• v.22 no.10 s.175
• /
• pp.107-113
• /
• 2005

This paper presents a method to reduce errors in registration, which is used in transformation coordinate system of the multiple measuring data. In general, the ICP algorithms and feature-based approaches are used for registration. In order to measure wrap-around object, it is necessary to change the scanning direction or set-up of the object. A fixture is made to reduce registration errors caused by inaccurate center point of tooling balls, providing the more accurate registration method. And, the motorized fixture controls rotation and tilting to get precise the measuring data and registration. The proposed motorized fixture and registration method have advantages in accurate registration and precise measurement, compared with the conventional methods.

• Korean Journal of Pharmacognosy
• /
• v.43 no.1
• /
• pp.16-21
• /
• 2012

The characteristics of decoction water are important for the extraction of herbal drugs. In this study, the relationship between the characteristics of water and extraction efficiency of bioactive compounds from Corydalis tuber was investigated. Six different types of decoction water, including three types of mineral water from Jeju Island and three types of bottled water sold in market, were used as decoction water for the extraction of bioactive compounds from Corydalis tuber. The contents of minerals in six types of water were analyzed by ICP-AES and ICP-MS; the contents of extracted bioactive compounds were analyzed by HPLC. Multivariate analysis of variance was used to analyze the differences in total extraction and bioactive compounds extracted with six types of water. Multiple factor analysis was used to analyze the relationship among the pH, content of mineral, anion, total extractions and content of bioactive components as factors. There was a significant difference among the six types of water in the total extracts and the bioactive compounds. The results proved that the content of extracted compounds from Corydalis tuber was influenced by the types of decoction water.

• Proceedings of the Korean Institute of Surface Engineering Conference
• /
• 2007.04a
• /
• pp.87-88
• /
• 2007

나노 다결정 실리콘 박막 증착을 하기 위해서 현재 정전결합플라즈마(CCP, Capacitively Coupled Plasma)를 이용한 PECVD(Plasma Enhanced Chemical Vapor Deposition) 공정에 관한 여구가 활발히 이루어지고 있다. 유도결합플라즈마는(ICP, Inductively Coupled Plasma) 정전결합플라즈마보다 플라즈마 밀도가 높고 파워전달 효율이 좋은 것으로 알려져 있으나 대면적가 어려워 기판이 큰 TFT-LCD로는 많이 연구되고 있지 않다. 본 연구는 유도결합플라즈마를 위해 내장형 multiple U-type 선형 안테나를 이용하여 나노 다결정 실리콘 박막을 증착하여 그 특성을 분석하였다.

• Journal of Society of Preventive Korean Medicine
• /
• v.17 no.3
• /
• pp.177-185
• /
• 2013

Objective : Eucommiae Cortex is bark of Eucommia ulmoides Oliver, a deciduous tree native to China. Today, teas or herbal drugs made from E. ulmoides leaves are widely consumed as a healthy food especially in Eastern Asia including Japan, China and Korea. This study was aimed to verify the extraction efficiency of bioactive compounds from Eucommiae Cortex depending on characteristics of decoction water. Method : Six types of decoction water with various origin were prepared and the contents of minerals in water were analyzed by ICP-AES and ICP-MS. The contents of extracted bioactive compounds were analyzed by HPLC and the relationship between mineral contents and extracted bioactive compounds in the decoction water were analysed by multiple factor analysis. The decoction waters could be classified in three groups by hierarchical cluster analysis. Result : Extracted amounts of compounds in Eucommiae Cortex showed a positive relationship with Na, Si, K concentration in decoction water, while a negative relationship with Ca, Mg concentration. Conclusion : The study proved that the minerals in water influenced the extraction efficiency of bioactive compounds from Eucommiae Cortex.

• Proceedings of the IEEK Conference
• /
• 2005.11a
• /
• pp.1007-1010
• /
• 2005

This paper presents a fingerprint image registration method. In the fingerprint system, the insufficiency of mutual information between a template and a query fingerprint is one of major factors to deteriorate recognition performance. To overcome this problem, we need to register multiple impressions and integrate their information. Our method matches the ridges from multiple impressions recursively and then registers the impressions to minimize the registration error calculated from the Distance map. Our method use regularized TPS model as the transformation model to compensate for the plastic deformation. We compare our method with 3 prior arts (ICP, Distance Map, Ross's method). Our registration error and its' variance is the smallest and also the average registration error is below 3 pixels.

• Journal of the Korean Vacuum Society
• /
• v.15 no.3
• /
• pp.241-245
• /
• 2006

In this study, the characteristics of large area internal linear ICP sources of 1020mm X 920mm(substrate area is 880 X 660mm) were investigated using two different types of antenna, that is, a conventional serpentine-type antenna and a newly developed multiple U-type antenna. The multiple antenna showed a higher plasma density, a higher radical density, and more plasma stability compared to the serpentine-type antenna, and it appeared from the higher inductively coupling and less standing wave effect compared to the serpentine-type antenna. Using the multiple U-type antenna, the plasma density of $2\times10^{11}/cm^3$ with the plasma uniformity of 4% could be obtained using 15mTorr Ar and 5000W of RF power.

• Economic and Environmental Geology
• /
• v.56 no.2
• /
• pp.115-123
• /
• 2023

We introduce a new 'image-mapping' in-situ U-Pb dating method using LA-ICP-MS, proposed by Drost et al. (2018), and show the characteristics and usability of this method through several examples of absolute age results determined by first applying it to samples from the Joseon Supergroup of the Early Paleozoic Era in Korea. Unlike the previous in-situ spot analysis, this in-situ U-Pb dating method for carbonate minerals can determine the absolute age with high reliability by applying the 'image-mapping' method of micro-sized domains based on micro-textural observation, as well as determine the absolute age of multiple geological 'events' that occurred after deposition. This was confirmed in the case of determining the syn-depositional age and the multiple post-depositional ages from carbonate minerals of the Makgol and the Daegi Formations. Therefore, if the 'image-mapping' in-situ U-Pb dating method is applied to determine the absolute age of various types of carbonate minerals that exist in various geological environments throughout the geologic era, it will be possible to secure new geological age information.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.13 no.1
• /
• pp.11-19
• /
• 2015

The production of nuclear fuel cladding tube is expected to increase with the nuclear power plant expansion. Zirconium(Zr) scrap that is generated during manufacturing is also expected to increase. Zr electrorefining experiment was carried out in the fluoride salt of LiF-KF-ZrF₄ using multiple electrode for scale up and improving throughput Zr electrorefiner develop-ment. The Zr reduction peak observed at-0.8 V(vs.Ni). Polarization behavior showed that the amount of applied current increases because of decreasing cell resistance as the number of cathode increases. Experimental results showed the highest recovery rate about 98% at lowest current density of 25.64 mA/cm² using 6 electrodes. XRD and TG analysis result show that pure Zr was recovered 99.92% and ICP analysis shows that lower impurity content than conventional impurity content of the Anode(97.8%). Electrorefining consumes energy about 7.15 kWh/kg less than 39.7% compared to the Kroll process using 6 electrode width of 20 mm and height of 65 mm. Because of increasing cell efficiency and recovery rate, using multiple cathode is determined as an efficient technique for scale up electrorefining Zr scrap.

• Journal of the Institute of Electronics Engineers of Korea CI
• /
• v.41 no.2
• /
• pp.137-148
• /
• 2004

In this paper, we propose a new camera calibration method for rotating multi-view cameras to generate image-based panoramic 3D Virtual Environment. Since calibration accuracy worsens with an increase in distance between camera and calibration pattern, conventional camera calibration algorithms are not proper for panoramic 3D VE generation. To remedy the problem, a geometric relationship among all lenses of a multi-view camera is used for intra-camera calibration. Another geometric relationship among multiple cameras is used for inter-camera calibration. First camera parameters for all lenses of each multi-view camera we obtained by applying Tsai's algorithm. In intra-camera calibration, the extrinsic parameters are compensated by iteratively reducing discrepancy between estimated and actual distances. Estimated distances are calculated using extrinsic parameters for every lens. Inter-camera calibration arranges multiple cameras in a geometric relationship. It exploits Iterative Closet Point (ICP) algorithm using back-projected 3D point clouds. Finally, by repeatedly applying intra/inter-camera calibration to all lenses of rotating multi-view cameras, we can obtain improved extrinsic parameters at every rotated position for a middle-range distance. Consequently, the proposed method can be applied to stitching of 3D point cloud for panoramic 3D VE generation. Moreover, it may be adopted in various 3D AR applications.