• Journal of health informatics and statistics
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• 제43권4호
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• pp.329-335
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• 2018

Objectives: In recent years, there has been an increased need for a way to extract desired information from multiple medical literatures at once. This study was conducted to confirm the usefulness of unstructured data analysis using previously published medical literatures to search for new indications. Methods: The new indications were searched through text mining, network analysis, and topic modeling analysis using 5,057 articles of atorvastatin, a treatment for hyperlipidemia, from 1990 to 2017. Results: The extracted keywords was 273. In the frequency of text mining and network analysis, the existing indications of atorvastatin were extracted in top level. The novel indications by Term Frequency-Inverse Document Frequency (TF-IDF) were atrial fibrillation, heart failure, breast cancer, rheumatoid arthritis, combined hyperlipidemia, arrhythmias, multiple sclerosis, non-alcoholic fatty liver disease, contrast-induced acute kidney injury and prostate cancer. Conclusions: Unstructured data analysis for discovering new indications from massive medical literature is expected to be used in drug repositioning industries.

• Child Health Nursing Research
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• 제26권4호
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• pp.393-401
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• 2020

Purpose: This pilot study aimed to describe children's social contact patterns and to analyze factors related to their social contacts. Methods: The participants were 30 children aged ≥13 months to <7 years, whose teachers at childcare centers and parents at home were asked to maintain diaries of their social contacts prospectively for 24 hours. Data were collected from November 30, 2018, to January 7, 2019. Results: The 30 participating children were in contact with 363 persons in a 24-hours period (mean, 12.1±9.1). The number of contacts showed significant relationships with day of the week (p<.001), number of family members/cohabitants (p=.015), area of residence (p=.003), and type of housing (p=.002). A multiple regression model showed significantly higher numbers of contacts on weekdays (B=10.64, p=.010). Physical versus non-physical types of contact showed significant differences in terms of duration, location, and frequency (p<.001). The duration of contacts showed significant relationships with their location and frequency (p<.001), while the frequency of contacts was significantly related to their location (p<.001). Conclusion: This is the first survey describing the characteristics of Korean preschool children's social contacts. Further large-scale social contact studies of children should be conducted.

• 한국치위생학회지
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• 제20권2호
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• pp.129-137
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• 2020

Objectives: Using the annual data from the 2016 Korean Health Panel, this study aims to identify the factors that affect the dental utilization and expenditure of patients with chronic diseases, and to provide basic data to explain the inequality gap in dental utilization. Methods: The dental utilization and expenditure of 3,557 patients with chronic diseases were analyzedfor frequency using the SPSS Windows version 23.0 (SPSS Inc. IL, USA). Analysis of the factors that affect dental utilization and expenditure were performed using a multiple regression analysis. The level of statistical significance was 0.05. Results: The frequency of dental utilization in patients with chronic diseases was high for subjects who were younger than 65 years and those whose education level was below high school. The frequency of dental utilization was relatively lower for subjects who did not have disabilities and those with healthier subjective health status. The dental expenditure of patients with chronic diseases was higher in subjects who were younger than 65 years and those with greater household income. Conclusions: The above findings suggest that a plan is needed to control dental utilization by efficiently managing chronic diseases, and that a policy-based plan is needed to devise ways to supplement the uninsured medical expenses of dental care.

• 치위생과학회지
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• 제12권6호
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• pp.583-590
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• 2012

본 연구는 경제적 스트레스와 상태 특성불안이 치주질환에 미치는 영향을 파악하여 치주질환의 예방과 발생 및 진행 정도를 미연에 방지할 수 있는 방안을 마련하기 위하여 실시되었다. 연구대상은 일부 지역 치과의원에 내원한 40~50대 성인남녀 총 326명을 대상으로 하여 구조화된 설문지와 치주상태를 측정하여 조사 분석하였다. 수집된 자료는 IBM SPSS ver. 19.0 통계프로그램(IBM Co., Armonk, NY, USA)을 이용하여 빈도와 백분율, t-test (검증), One way ANOVA (일원배치 분산분석), Multiple regression Analysis (다중회귀분석)을 실시하여 분석결과는 다음과 같다. 1. 경제적 스트레스는 치은염 지수의 고($1.12{\pm}0.72$), 중($0.85{\pm}0.62$), 저($0.88{\pm}0.62$)에 따라 통계적으로 유의한 차이를 보였다(p<0.01). 2. 상태 특성불안은 치은염 지수(p<0.001)의 고($1.16{\pm}0.71$), 중($0.81{\pm}0.63$), 저($0.86{\pm}0.60$), 치주낭 깊이(p<0.05)의 고($3.86{\pm}1.12$), 중($3.44{\pm}1.07$), 저($3.57{\pm}1.01$), 임상적 부착소실(p<0.05)의 고($3.86{\pm}1.12$), 중($3.44{\pm}1.07$), 저($3.57{\pm}1.01$)에 따라 통계적으로 유의한 차이를 보였다. 3. 치은염 지수에 영향을 미치는 요인으로 경제적 스트레스($\beta$=0.052, p<0.01)가 높을수록, 상태 특성불안($\beta$=0.052, p<0.01)이 높을수록 영향을 미치는 것으로 조사되었다. 이상의 연구결과에서 치과의료기관은 치주질환으로 힘들어 하는 환자에게 경제적 스트레스와 상태 특성불안이 치주질환에 영향을 미친다는 사실을 인식시킬 필요가 있으며 이에 따른 치주질환의 예방과 발생 및 진행 정도를 방지할 수 있는 스트레스 관리능력배양을 위한 교육프로그램 개발이 마련되어야 할 것이다.

• 한국치위생학회지
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• 제17권6호
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• pp.1109-1119
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• 2017

Objectives: The purpose of this study is to evaluate the relationship between socioeconomic characteristics and prevalence of periodontal disease in a representative sample of Korean adults older than age 20. Methods: Data of 3,837 adults were collected by the six Korean National Health and Nutrition Examination Survey, which was conducted in 2015. Socioeconomic, demographic, and oral health-related behavior data were collected as independent variables. We determined frequencies, percentage, and determining statistical significance using multiple regression analysis. Results: Prevalence of periodontal diseases showed statistically significant difference in accordance with sex, age, socioeconomic and demographical characteristics and oral health-related behavior. It was confirmed that the prevalence of periodontal diseases was increased in the lower educational level and income (OR, 1.478 and 1.520) after adjusting for conditions such as age, sex, recent dental check-ups, visiting dental clinic, tooth brushing frequency, use of self-care devices. Conclusions: The prevalence of periodontal disease was related with socioeconomic factors in Korean adults. Therefore, differentiated oral health service policies and dental health education among adults with lower education and income is required in order to reduce the prevalence of periodontal disease.

• 한국치위생학회지
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• 제17권6호
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• pp.1121-1134
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• 2017

Objectives: The purpose of this study is to analyze the factors affecting the self-perceived halitosis of adults and to utilize them as basic data for the development of prevention and management program to reduce of self-perceived halitosis. Methods: A questionnaire survey of 301 adults in their 20s and 50s living in Gwangju and Jeonnam selected by convenience sampling from July 1, 2017 to August 31, 2017 was conducted to investigate oral health status and behavior, fatigue and perceived stress. Statistical analysis was performed using frequency analysis, independent t-test, one way ANOVA, Pearson's correlation analysis, and multiple regression analysis. Results: The degree of self-perceived halitosis was higher in married (2.51) and unemployed (2.71), with tongue brushing (2.68), intention to participate in halitosis education (2.57), taking medication (2.73), coated tongue (2.82) and there was both otolaryngology and gastrointestinal disease (2.72) and periodontal disease (2.89) (p<0.05). Fatigue (${\beta}=0.237$), periodontal disease (${\beta}=0.196$), and coated tongue (${\beta}=0.237$) affect the self-perceived halitosis (p<0.001). Conclusions: The self-perceived halitosis in adults was correlated with fatigue and perceived stress. Also fatigue, periodontal disease, coated tongue factors were analyzed as factors influencing self-perceived halitosis. Additional studies such as prevention and management of periodontal disease and coated tongue, which is a factor of self-perceived halitosis in adults, and development of programs to reduce self-perceived halitosis for fatigue management, which is an external factor, are necessary.

• Journal of Photoscience
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• 제9권2호
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• pp.182-185
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• 2002

There are 3 UV DNA repair endonuclease activities in mammalian cells that cleave UV -irradiated DNA. Interestingly, mammalian UV endonuclease III with MW of 26.7kD has a lyase activity on AP sites. It also cleaves the phosphodiester bond within a cyclobutane pyrimidine dimer. Genomic analysis of human repair endonuclease III gene revealed that this gene has 100% sequence identity with ribosomal protein S3 (rpS3). Therefore, rpS3 seems to function both in translation and in DNA repair. This gene of about 6.1 kb contains 6 introns and 7 exons, and the first and fifth introns of human rpS3 gene contain functional U15 small nucleolar (sno) RNAs which appear to be involved in ribosome assembly. It is to be noted that the column profile of the endonuclease activity of rpS3 appears to be altered in Xeroderma Pigmentosum (XP) group D cells compared to normal cells indicating that this protein is involved in XP disease as well. XP is a human disease characterized by high sensitivity of skin by UV- or sun-light irradiation and by high frequency of developing skin cancers. We also report here that rpS3 protein is involved in other cellular functions.

• 기본간호학회지
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• 제23권2호
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• pp.136-148
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• 2016

Purpose: This study was done to investigate the level of nursing students' awareness, attitude, safety climate, and performance of infection control, and to identify factors influencing performance. Methods: The sample consisted of 239 nursing students from 5 nursing schools. Data were collected from November 15 to December 11, 2013 and analyzed by frequency, t-test, ANOVA, Pearson correlation coefficients, and multiple stepwise regression with SPSS/WIN 21.0. Results: Of the participants, 216 (90.4%) had experienced contact with infectious diseases. The performance of personal hygiene was scored the highest followed by standard precautions, transmission precautions, and vaccination. There were significant correlations between awareness, attitude, safety-climate and performance. Awareness, safety-climate, attitude, contents of infection control education, and direct exposure to infectious disease collectively explained 30% of the variance in performance, and awareness was the most influential factor. Conclusion: The results indicate that performance of infection control by nursing students can be increased if awareness, safety climate, attitude, and contents of infection control education are improved, and exposure to infectious disease is decreased. These findings can be utilized to improve performance by developing education programs for infection control.

• 한국직업건강간호학회지
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• 제28권1호
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• pp.44-52
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• 2019

Purpose: This study aimed to identify the level of health problems and the factors that affect health problems for concrete mixer truck divers. Methods: The questionnaires were administered to 111 drivers in 6 Remicon workplaces located in D city and 7 Remicon workplaces located in K city from September 10 to 28, 2018. A total of 111 questionnaires were collected and 106 were used, excluding 5 incomplete ones. Data were analyzed with frequency, percentage, $x^2$ test, multiple logistic regression analysis by SPSS/WIN 23.0. Results: The factors affecting subjective health were eating habits, sleeping hours and drinking conditions. The factors that affected chronic diseases were age, eating habits, sleep hours, and drinking conditions. The factors influencing musculoskeletal complaints were work experience, eating habits, and sleep hours. Conclusion: The major influencing factors of health problems were eating habits, sleeping hours. This study suggests that it is necessary to run a systematic health care program for the desirable health behaviors in the communities and industrial fields.

• Physical Therapy Rehabilitation Science
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• 제11권4호
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• pp.535-545
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• 2022

Objective: This study was conducted to identify predictive factors of physical activity in total hip arthroplasty patients, and to provide basic data for the developing physical activity promotion program for total hip arthroplasty patients. Design: Descriptive correlational research. Methods: Data were collected from August 2017 to May 2018. Surveys were distributed to 60 patients in a G university hospital located at J city, Gyeongsangnam-do. Data were analyzed by frequency, mean, standard deviation, t-test, ANOVA, Pearson's correlation coefficient, multiple regression analysis using SPSS 24 Win program. Results: The variables affecting the 4-week physical activity after discharge were age (β=.07), residence after discharge (β=-.22), cerebrovascular disease (β=-.13), mental and behavioural disease (β=-.11), taking antibiotic (β=-.26), walking ability (β=.41), nutritional status (β=.25), depression (β=.05). The eight variables accounted for 39.4% in the 4-week physical activity (F=4.49 p=.001). The variables affecting the 8-week physical activity after discharge were age (β=.06), waking ability (β=.34), nutritional status (β=.20), exercise self-efficacy (β=.05), depression (β=-.05). The six variables accounted for 28.0% in the 8-week physical activity (F=4.58, p<.001). Conclusions: The walking ability in discharge important to improve the physical activity, there is a need to develop an program to improve walking ability before discharge, in total hip arthroplasty. There is a need to develop a physical activity program to consistently participate in a community.