• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5543-5552
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• 2013

Colorectal cancer (CRC), a complex multi-step process involving progressive disruption of homeostatic mechanisms controlling intestinal epithelial proliferation/inflammation, differentiation, and programmed cell death, is the third most common malignant neoplasm worldwide. A number of promising targets such as inducible nitric acid (iNOS), cyclooxygenase (COX)-2, NF-E2-related factor 2 (Nrf2), $Wnt/{\beta}$-catenin, Notch and apoptotic signaling have been identified by researchers as useful targets to prevent or therapeutically inhibit colon cancer development. In this review article, we aimed to explore the current targets available to eliminate colon cancer with an update of dietary and non-nutritional compounds that could be of potential use for interaction with regulatory molecules to prevent CRC.

• 한국신재생에너지학회:학술대회논문집
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• 2011.11a
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• pp.42.1-42.1
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• 2011

NREL NWTC Deside codes are analyzed and introduced to develop the system performance simulation program for wind turbine generator systems. In this paper, The FAST performing multi-body and flexible body dynamics, control and the AeroDyn calculating aerodynamic forces with airfoil data and wind data are explained. Furthermore, initialization and process for transfer of aerodynamic force between AeroDyn and FAST at each time step are also introduced.

• Analytical Science and Technology
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• v.6 no.2
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• pp.231-238
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• 1993

The thermal behavior of binder in multi-layer actuator has an effect on the properties of actuator. Binder burn-out process and thermal degradation mechanism of PNN-PZT/Acrylic binder were analyzed by FTIR, DSC, TGA. Binder was burnt out by two step. In oxygen atomsphere, thermal degradation was activated and final residue was minimized to 5%.

• Journal of Electrical Engineering and information Science
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• v.3 no.3
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• pp.292-299
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• 1998

Placement of multiple dies on an MCM or high-performance VLSI substrate is a non-trivial task in which multiple criteria need to be considered simultaneously to obtain a true multi-objective optimization. Unfortunately, the exact physical attributes of a design are not known in the placement step until entire design process is carried out. When the performance issues are considered, crosstalk noise constraints in the form of net separation and via constraint become important. In this paper, for better performance and wirability estimation during placement for MCMs, several performance constraints are taken into account simultaneously. A graph-based wirability estimation along with the Genetic placement optimization technique is proposed to minimize crosstalk, crossing, wirelength and the number of layers. Our work is significant since it is the first attempt at bringing the crosstalk and other performance issues into the placement domain.

• Proceedings of the IEEK Conference
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• 2006.06a
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• pp.437-438
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• 2006

Virtual view synthesis is essential for 3DTV systems, which utilizes the motion parallax cue. In this paper, we propose a multi-step view synthesis algorithm to efficiently reconstruct an arbitrary view from limited number of known views of a 3D scene. We describe an efficient image rectification procedure which guarantees that an interpolation process produce valid views. This rectification method can deal with all possible camera motions. The idea consists of using a polar parameterization of the image around the epipole. Then, to generate intermediate views, we use an efficient dense disparity estimation algorithm considering features of stereo image pairs. Main concepts of the algorithm are based on the region dividing bidirectional pixel matching. The estimated disparities are used to synthesize intermediate view of stereo images. We use computer simulation to show the result of the proposed algorithm.

• Journal of the Korean Institute of Intelligent Systems
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• v.18 no.1
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• pp.133-138
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• 2008

In this paper, we propose a novel anchor shot detection system, named to MASD (Multi-phase Anchor Shot Detection), which is a core step of the preprocessing process for the news video analysis. The proposed system is composed of four modules and operates sequentially: 1) skin color detection module for reducing the candidate face regions; 2) face detection module for finding the key-frames with a facial data; 3) vector representation module for the key-frame images using a non-negative matrix factorization; 4) one class SVM module for determining the anchor shots using a support vector data description. Besides the qualitative analysis, our experiments validate that the proposed system shows not only the comparable accuracy to the recently developed methods, but also more faster detection rate than those of others.

• Bulletin of the Korean Chemical Society
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• v.34 no.8
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• pp.2348-2352
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• 2013

We report a simple electrochemical approach in fabricating multiple colored molybdenum (Mo) oxide bronzes on the surface of a Mo-quartz electrode. A three step electrochemical batch process consisting of linear sweep voltammetry and anodic oxidation followed by cathodic reduction in neutral $K_2SO_4$ electrolyte at different end potentials, viz. -0.62, -0.80 and -1.60 V (vs. $Hg/HgSO_4$) yielded red, blue and yellow colored bronzes. The samples produced were analyzed by XRD, EDS, and SIMS. The color variation was suggested to be associated with the cations intercalation into the oxide formed and the simultaneous structural changes that occurred during the cathodic reduction in neutral aqueous medium.

• Nuclear Engineering and Technology
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• v.39 no.4
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• pp.249-256
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• 2007

Light water reactors operated under supercritical pressure conditions have been selected as one of the promising future reactor concepts to be studied by the Generation IV International Forum. Whereas the steam cycle of such reactors can be derived from modem fossil fired power plants, the reactor itself, and in particular the reactor core, still need to be developed. Different core design concepts shall be described here to outline the strategy. A first option for near future applications is a pressurized water reactor with $380^{\circ}C$ core exit temperature, having a closed primary loop and achieving 2% pts. higher net efficiency and 24% higher specific turbine power than latest pressurized water reactors. More efficiency and turbine power can be gained from core exit temperatures around $500^{\circ}C$, which require a multi step heat up process in the core with intermediate coolant mixing, achieving up to 44% net efficiency. The paper summarizes different core and assembly design approaches which have been studied recently for such High Performance Light Water Reactors.

• Nuclear Engineering and Technology
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• v.42 no.4
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• pp.365-376
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• 2010

This paper summarizes the results of a Writing Group on the Extension of CFD codes to two-phase flow safety problems, which was created by the Group for Analysis and Management of Accidents of the Nuclear Energy Agency' Committee on the Safety of Nuclear Installations (NEA-CSNI). Two-phase CFD used for safety investigations may predict small scale flow processes, which are not seen by system thermalhydraulic codes. However, the two-phase CFD models are not as mature as those in the single phase CFD and potential users need some guidance for proper application. In this paper, a classification of various modelling approaches is proposed. Then, a general multi-step methodology for using two-phase-CFD is explained, including a preliminary identification of flow processes, a model selection, and a verification and validation process. A list of 26 nuclear reactor safety issues that could benefit from investigations at the CFD scale is identified. Then, a few issues are analyzed in more detail, and a preliminary state-of-the-art is proposed and the remaining gaps in the existing approaches are identified. Finally, guidelines for users are proposed.

• Molecules and Cells
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• v.44 no.8
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• pp.569-579
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• 2021

Cyclase-associated protein 2 (CAP2) has been addressed as a candidate biomarker in various cancer types. Previously, we have shown that CAP2 is expressed during multi-step hepatocarcinogenesis; however, its underlying mechanisms in liver cancer cells are not fully elucidated yet. Here, we demonstrated that endoplasmic reticulum (ER) stress induced CAP2 expression, and which promoted migration and invasion of liver cancer cells. We also found that the ER stress-induced CAP2 expression is mediated through activation of protein kinase C epsilon (PKCε) and the promotor binding of activating transcription factor 2 (ATF2). In addition, we further demonstrated that CAP2 expression promoted epithelial-mesenchymal transition (EMT) through activation of Rac1 and ERK. In conclusion, we suggest that ER stress induces CAP2 expression promoting EMT in liver cancer cells. Our results shed light on the novel functions of CAP2 in the metastatic process of liver cancer cells.