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A Multi-detection Fluorescence Dye with 5-ALA and ICG Using Modified Light Emitting Diodes

  • Yoon, Kicheol;Kim, Eunji;Kim, Kwanggi;Lee, Seunghoon;Yoo, Heon
    • Current Optics and Photonics
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    • v.3 no.3
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    • pp.256-262
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    • 2019
  • Extensive tumor resection accompanied by radiotherapy and chemotherapy is the standard of care for malignant gliomas. However, there is a significant obstacle to the complete resection of the tumor due to the difficulty of distinguishing tumor and normal brain tissue with a conventional surgical microscope. Recently, multiple studies have shown the possibility of fluorescence-guided surgery in malignant gliomas. The most used fluorescence dyes for brain tumor surgery are 5-aminolevulinic acid (5-ALA) and indocyanine green (ICG). In this paper, a new fluorescence guided operation system, which can detect both 5-ALA and ICG fluorescent images simultaneously, is presented. This operation system consists of light emitting diodes (LEDs) which emits 410 nm and 740 nm wavelengths. We have performed experiments on rats in order to verify the operation of the newly developed operation system. Oral administration and imaging were performed to observe the fluorescence of 5-ALA and ICG fluorescence in rats. When LEDs at wavelengths of 410 nm and 740 nm were irradiated on rats, 628 nm wavelength with a violet fluorescence color and 825 nm wavelength with a red fluorescence color were expressed in 5-ALA and ICG fluorescent material, respectively, thus we were able to distinguish the tumor tissues easily. Previously, due to the poor resolution of the conventional surgical microscope and the fact that the color of the vein is similar to that of the tumor, the tumor resection margin was not easy to observe, thus increasing the likelihood for cancer recurrence. However, when the tumor is observed through the fluorescence guided operation system, it is possible to easily distinguish the color with the naked eye and it can be completely removed. Therefore, it is expected that surgical removal of cancerous tumors will be possible and surgical applications and surgical microscopes for cancer tumor removal surgery will be promising in the future.

Adaptive Convolution Filter-Based 3D Plane Reconstruction for Low-Power LiDAR Sensor Systems (저전력 LiDAR 시스템을 위한 Adaptive Convolution Filter에 기반한 3D 공간 구성)

  • Chong, Taewon;Park, Daejin
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.25 no.10
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    • pp.1416-1426
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    • 2021
  • In the case of a scanning type multi-channel LiDAR sensor, the distance error called a walk error may occur due to a difference in received signal power. This work error causes different distance values to be output for the same object when scanning the surrounding environment based on multiple LiDAR sensors. For minimizing walk error in overlapping regions when scanning all directions using multiple sensors, to calibrate distance for each channels using convolution on external system. Four sensors were placed in the center of 6×6 m environment and scanned around. As a result of applying the proposed filtering method, the distance error could be improved by about 68% from average of 0.5125 m to 0.16 m, and the standard deviation could be improved by about 48% from average of 0.0591 to 0.030675.

A Review of Open Modeling Platform Towards Integrated Water Environmental Management (통합 물환경 관리를 위한 개방형 모델링 플랫폼 고찰)

  • Lee, Sunghack;Shin, Changmin;Lee, Yongseok;Cho, Jaepil
    • Journal of Korean Society on Water Environment
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    • v.36 no.6
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    • pp.636-650
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    • 2020
  • A modeling system that can consider the overall water environment and be used to integrate hydrology, water quality, and aquatic ecosystem on a watershed scale is essential to support decision-making in integrated water resources management (IWRM). In adapting imported models for evaluating the unique water environment in Korea, a platform perspective is becoming increasingly important. In this study, a modeling platform is defined as an ecosystem that continuously grows and provides sustainable values through voluntary participation- and interaction-of all stakeholders- not only experts related to model development, but also model users and decision-makers. We assessed the conceptual values provided by the IWRM modeling platform in terms of openness, transparency, scalability, and sustainability. I We also reviewed the technical aspects of functional and spatial integrations in terms of socio-economic factors and user-centered multi-scale climate-forecast information. Based on those conceptual and technical aspects, we evaluated potential modeling platforms such as Source, FREEWAT, Object Modeling System (OMS), OpenMI, Community Surface-Dynamics Modeling System (CSDMS), and HydroShare. Among them, CSDMS most closely approached the values suggested in model development and offered a basic standard for easy integration of existing models using different program languages. HydroShare showed potential for sharing modeling results with the transparency expected by model user-s. Therefore, we believe that can be used as a reference in development of a modeling platform appropriate for managing the unique integrated water environment in Korea.

Proposal of the development plan for the ROK military data strategy and shared data model through the US military case study (미군 사례 고찰을 통한 한국군 데이터 전략 및 공유 데이터 모델 개발방안 제안)

  • Lee, Hak-rae;Kim, Wan-ju;Lim, Jae-sung
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.25 no.6
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    • pp.757-765
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    • 2021
  • To carry out multi-domain operations included in the U.S. Department of Defense's national security strategy in 2018, timely data sharing between C4I systems is critical. Several studies of the Korean military have also raised the problems of interface and standardization between C4I systems, and it is necessary to establish a new plan to solve this problem. In this study, a solution to the problem was derived through case analysis that the U.S. Department of Defense has been pursuing for about 20 years to implement the data strategy after establishing the data strategy in 2003. and by establishing a data strategy suitable for the ROK military C4I system operating environment, developing a data model, selecting a standard for data sharing, and proposing a shared data development procedure, we intend to improve the data sharing capability between ROK military C4I systems.

Cross Mapping of Standardized Nursing Diagnoses and Problems with NANDA-I in 4 Tertiary Hospitals (표준화된 간호진단 및 문제와 NANDA-I 교차분석: 4개 상급종합병원 사례를 중심으로)

  • Song, Mi Ra;Shim, So Yun;Kim, Dae Sung;Lee, Kyung Soon;Lee, Yu Na;Won, Mi Suk
    • Journal of Korean Clinical Nursing Research
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    • v.26 no.3
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    • pp.374-384
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    • 2020
  • Purpose: To explore the scope and method of applying standardized nursing terminologies to nursing diagnosis and problems used in nursing practice. Methods: A descriptive study was done with a retrospective analysis of the nursing records of 141,420 patients that were hospitalized in 4 tertiary hospitals. The nursing diagnosis and problems collected from the records were standardized, and the standardized nursing diagnosis and problems cross mapped with NANDA-I, confirmed in a nursing focus group. Results: 65 (67.7%) of the 96 standardized nursing diagnosis and problems were equal with NANDA-I and included in the 10 domains of NANDA-I. Among 86 nursing diagnosis and problems excluded from the cross mapping with NANDA-I, the 63 terms (73.3%) related to surgery/procedure were the most common. Conclusion: It is meaningful that multi-tertiary hospital nursing diagnosis and problems were standardized and cross mapping with standard nursing terminologies was performed. As for the method of applying standardized nursing terminologies in nursing practice, it is appropriate to use several standardized nursing terminologies complementarily.

A novel amnion-chorion allograft membrane combined with a coronally advanced flap: a minimally invasive surgical therapy to regenerate interdental papillary soft tissue recession - a six-month postoperative image analysis-based clinical trial

  • Pitale, Unnati;Pal, Pritish Chandra;Boyapati, Ramanarayana;Bali, Ashish;Varma, Manish;Khetarpal, Shaleen
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.47 no.6
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    • pp.438-444
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    • 2021
  • Objectives: Loss of the interdental papilla is multi-factorial and creates a multitude of problems. Autogenous connective tissue/biomaterial-based regeneration has been attempted for decades to reconstitute the black space created due to the loss of papilla. The aim of this present study was to regenerate papillary recession defects using an amnion-chorion membrane (ACM) allograft and to evaluate the clinical outcome up to six months postoperatively. Materials and Methods: Twenty patients with 25 Nordland and Tarnow's Class I/II interdental papillary recession defects were treated with ACM and coronal advancement of the gingivo-papillary unit via a semilunar incision on the labial aspect followed by a sulcular incision in the area of interest. A photographic image analysis was carried out using the GNU Image Manipulation software program from the baseline to three and six months postoperatively. The black triangle height (BTH) and the black triangle width (BTW) were calculated using the pixel size and were then converted into millimeters. The mean and standard deviation values were determined at baseline and then again at three and six months postoperatively. The probability values (P<0.05 and P≤0.01) were considered statistically significant and highly significant, respectively. An analysis of variance and post hoc Bonferroni test were carried out to compare the mean values. Results: Our evaluation of the BTH and BTW showed a statistically and highly significant difference from the baseline until both three and six months postoperatively (P=0.01). A post hoc Bonferroni test disclosed a statistically significant variance from the baseline until three and six months postoperatively (P<0.05) and a non-significant difference from three to six months after the procedure (P≥0.05). Conclusion: An ACM allograft in conjunction with a coronally advanced flap could be a suitable minimally invasive alternative for papillary regeneration.

Linear interpolation and Machine Learning Methods for Gas Leakage Prediction Base on Multi-source Data Integration (다중소스 데이터 융합 기반의 가스 누출 예측을 위한 선형 보간 및 머신러닝 기법)

  • Dashdondov, Khongorzul;Jo, Kyuri;Kim, Mi-Hye
    • Journal of the Korea Convergence Society
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    • v.13 no.3
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    • pp.33-41
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    • 2022
  • In this article, we proposed to predict natural gas (NG) leakage levels through feature selection based on a factor analysis (FA) of the integrating the Korean Meteorological Agency data and natural gas leakage data for considering complex factors. The paper has been divided into three modules. First, we filled missing data based on the linear interpolation method on the integrated data set, and selected essential features using FA with OrdinalEncoder (OE)-based normalization. The dataset is labeled by K-means clustering. The final module uses four algorithms, K-nearest neighbors (KNN), decision tree (DT), random forest (RF), Naive Bayes (NB), to predict gas leakage levels. The proposed method is evaluated by the accuracy, area under the ROC curve (AUC), and mean standard error (MSE). The test results indicate that the OrdinalEncoder-Factor analysis (OE-F)-based classification method has improved successfully. Moreover, OE-F-based KNN (OE-F-KNN) showed the best performance by giving 95.20% accuracy, an AUC of 96.13%, and an MSE of 0.031.

Development of an optimized model to compute the undrained shaft friction adhesion factor of bored piles

  • Alzabeebee, Saif;Zuhaira, Ali Adel;Al-Hamd, Rwayda Kh. S.
    • Geomechanics and Engineering
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    • v.28 no.4
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    • pp.397-404
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    • 2022
  • Accurate prediction of the undrained shaft resistance is essential for robust design of bored piles in undrained condition. The undrained shaft resistance is calculated using the undrained adhesion factor multiplied by the undrained cohesion of the soil. However, the available correlations to predict the undrained adhesion factor have been developed using simple regression techniques and the accuracy of these correlations has not been thoroughly assessed in previous studies. The lack of the assessment of these correlations made it difficult for geotechnical engineers to select the most accurate correlation in routine designs. Furthermore, limited attempts have been made in previous studies to use advanced data mining techniques to develop simple and accurate correlation to predict the undrained adhesion factor. This research, therefore, has been conducted to fill these gaps in knowledge by developing novel and robust correlation to predict the undrained adhesion factor. The development of the new correlation has been conducted using the multi-objective evolutionary polynomial regression analysis. The new correlation outperformed the available empirical correlations, where the new correlation scored lower mean absolute error, mean square error, root mean square error and standard deviation of measured to predicted adhesion factor, and higher mean, a20-index and coefficient of correlation. The correlation also successfully showed the influence of the undrained cohesion and the effective stress on the adhesion factor. Hence, the new correlation enhances the design accuracy and can be used by practitioner geotechnical engineers to ensure optimized designs of bored piles in undrained conditions.

Influence of Health Promotion Environment and Job Stress on the Health-Related Quality of Life of Industrial Workers: A Study Based on an Ecological Model (산업장 근로자의 건강증진환경, 직무스트레스가 건강관련 삶의 질에 미치는 영향: 생태학적 모델에 기반하여)

  • Lim, Yumi;Shim, Moon Sook
    • Journal of Korean Public Health Nursing
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    • v.36 no.3
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    • pp.361-374
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    • 2022
  • Purpose: This study applies an ecological model to investigate individual and organizational levels to identify factors influencing the HRQOL of industrial employees. Methods: Totally, 133 industrial workers of a vehicle company were enrolled, who understood the purpose and consented to participate in the study. The collected data were analyzed by frequency, percentage, mean, standard deviation, independent t-test, one-way ANOVA, Scheffe Test and hierarchical regression analysis using the SPSS 20.0 program. Results: Hierarchical regression analysis showed that job Stress(β=-.44, p<.001), and hobbies(β=-.21, p=.013) were the major influencing factors of the Physical Component Summary of HRQOL, which had an additional explanatory power of 11.5%. The influencing factors for the Mental Component Summary of HRQOL were job stress(β=-.43, p<.001), and coronary artery disease(β=.17, p=.034) with an additional explanatory power of 13.5%. Conclusion: Results of this study, reveal that a multidimensional approach based on an ecological model is suitable as a health promotion intervention strategy to improve the HRQOL. We further propose developing a multi-dimensional health promotion program that consider the individual and organizational factors such as job stress, activation of in-house clubs, and assessing and managing of the risk of cerebral and cardiovascular diseases.

A Study on a space utilization plan for screening clinic in public health center by means of the prevention of respiratory infectious disease - Focused on a negative pressured tuberculosis exam room (호흡기 감염병 예방을 위한 보건소 상시 선별진료소 활용방안 연구 - 음압 결핵 검진실을 중심으로)

  • Yoon, Hyung Jin;Han, Su Ha
    • Journal of The Korea Institute of Healthcare Architecture
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    • v.27 no.4
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    • pp.51-60
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    • 2021
  • Purpose: Tuberculosis(TB) care unit in public health center should be carefully considered to be re-designed as an infection safety environment for both patient and healthcare workers. So, for the enhancement, this study analyses the facility requirements for co-using the screening clinic as a TB and other respiratory disease care unit. Methods: Not only screening clinic facility guidelines from "A Study for Standard Triage Design and Construction Document" but also the guidelines of TB care and related medical facility are reviewed; KDCA, CDC, ECDC and WHO as a TB care, and FGI and NHS for facility. The facility requirements are summarized space, approach, and mechanical requirement in order. By comparing the summary and screening clinic facility guidelines, supplementations are proposed for TB care unit setting. Results: The result of this study shows that both the space program and mechanical requirement of the screening clinic and that of TB care unit are almost identical and could be share, which include direct airflow or negative air pressure in an exam room. To increase functional and economical efficiency, however, it is necessary to consider a multi-functional negative pressured room, So care process may be re-designed based on a room type; face-to-face room or glass wall inbetween. Implications: The facility guidelines for TB care unit of a public health center should be developed to build a safe environment for infection control by reflecting its medical plan and budget.