• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 C
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• pp.1315-1316
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• 2006

Microarray-based DNA chips provide an architecture for multi-analyte sensing. In this paper, we report a new approach for DNA chip microarray fabrication. Multifunctional DNA chip microarray was made by immobilizing many kinds of biomaterials on transducers (particles). DNA chip microarray was prepared by randomly distributing a mixture of the particles on a chip pattern containing thousands of m-scale sites. The particles occupied a different sites from site to site. The particles were arranged on the chip pattern by the random fluidic self-assembly (RFSA) method, using a hydrophobic interaction for assembly.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 추계학술대회 논문집 전기물성,응용부문
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• pp.271-274
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• 2004

Microarray-based DNA chips provide an architecture for multi-analyte sensing. In this paper, we report a new approach for DNA chip microarray fabrication. Multifunctional DNA chip microarray was made by immobilizing many kinds of biomaterials on transducers (particles). DNA chip microarray was prepared by randomly distributing a mixture of the particles on a chip pattern containing thousands of m-scale sites. The particles occupied a different sites from site to site. The particles were arranged on the chip pattern by the random fluidic self-assembly (RFSA) method, using a hydrophobic interaction for assembly.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2004년도 추계학술대회 논문집 Vol.17
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• pp.472-475
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• 2004

Microarray-based DNA chips provide an architecture for multi-analyte sensing. In this paper, we report a new approach for DNA chip microarray fabrication. Multifunctional DNA chip microarray was made by immobilizing many kinds of biomaterials on transducers (particles). DNA chip microarray was prepared by randomly distributing a mixture of the particles on a chip pattern containing thousands of m-scale sites. The particles occupied a different sites from site to site. The particles were arranged on the chip pattern by the random fluidic self-assembly (RFSA) method, using a hydrophobic interaction for assembly.

• Interaction and multiscale mechanics
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• 제5권2호
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• pp.115-129
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• 2012

Nanowires (NWs) have attracted intensive researches owing to the broad applications that arise from their remarkable properties. Over the last decade, immense numerical studies have been conducted for the numerical investigation of mechanical properties of NWs. Among these numerical simulations, the molecular dynamics (MD) plays a key role. Herein we present a brief review on the current state of the MD investigation of nanowires. Emphasis will be placed on the FCC metal NWs, especially the Cu NWs. MD investigations of perfect NWs' mechanical properties under different deformation conditions including tension, compression, torsion and bending are firstly revisited. Following in succession, the studies for defected NWs including the defects of twin boundaries (TBs) and pre-existing defects are discussed. The different deformation mechanism incurred by the presentation of defects is explored and discussed. This review reveals that the numerical simulation is an important tool to investigate the properties of NWs. However, the substantial gaps between the experimental measurements and MD results suggest the urgent need of multi-scale simulation technique.

• Genomics & Informatics
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• 제21권3호
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• pp.42.1-42.23
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• 2023

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, one of the most deadly infections in humans. The emergence of multidrug-resistant and extensively drug-resistant Mtb strains presents a global challenge. Mtb has shown resistance to many frontline antibiotics, including rifampicin, kanamycin, isoniazid, and capreomycin. The only licensed vaccine, Bacille Calmette-Guerin, does not efficiently protect against adult pulmonary tuberculosis. Therefore, it is urgently necessary to develop new vaccines to prevent infections caused by these strains. We used a subtractive proteomics approach on 23 virulent Mtb strains and identified a conserved membrane protein (MmpL4, NP_214964.1) as both a potential drug target and vaccine candidate. MmpL4 is a non-homologous essential protein in the host and is involved in the pathogen-specific pathway. Furthermore, MmpL4 shows no homology with anti-targets and has limited homology to human gut microflora, potentially reducing the likelihood of adverse effects and cross-reactivity if therapeutics specific to this protein are developed. Subsequently, we constructed a highly soluble, safe, antigenic, and stable multi-subunit vaccine from the MmpL4 protein using immunoinformatics. Molecular dynamics simulations revealed the stability of the vaccine-bound Tolllike receptor-4 complex on a nanosecond scale, and immune simulations indicated strong primary and secondary immune responses in the host. Therefore, our study identifies a new target that could expedite the design of effective therapeutics, and the designed vaccine should be validated. Future directions include an extensive molecular interaction analysis, in silico cloning, wet-lab experiments, and evaluation and comparison of the designed candidate as both a DNA vaccine and protein vaccine.

• Geomechanics and Engineering
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• 제38권6호
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• pp.553-569
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• 2024

In recent tunneling projects, encounters with multi-layered strata have become more frequent as the desired scale of tunneling increases. Despite substantial practical experience, the design of large-diameter shield-driven tunnels often simplifies the surrounding ground as uniform, overlooking the complexities introduced by non-uniform geotechnical factors. This study comparatively analyzed the influence of design factors, particularly segment stiffness and joint parameters, on segmental lining behavior in layered ground conditions using numerical methods. A comprehensive parametric study revealed the significant impact of deformative interaction between the lining and the soft top soil layer on overall tunnel behavior. Permitting lining deformation in the soft soil layer effectively mitigated the induced internal forces but resulted in considerable tunnel lining convergence, adopting a peanut-shaped appearance. From a practical design perspective, application of a soft segment with lower stiffness near the stiff soil layer is an economically advantageous approach, alleviating internal forces within an acceptable convergence level. Notably, around the interfaces between soil layers with different stiffnesses, the induced internal forces in the lining were minimized based on joint rotational stiffness and location. This indicates the possibility of achieving an optimal design for segmental lining joints under layered ground conditions. Additionally, a preliminary design method was proposed, which sequentially optimizes parameters for joints located near soil layer interfaces. Subsequently, a specialized design based on the proposed method for complex multi-layered strata was compared with a conventional design. The results confirmed that the internal force was effectively relieved at an allowable lining deflection level.

• 감성과학
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• 제24권4호
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• pp.139-148
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• 2021

본 연구의 목적은 뇌성마비 아동에게 다감각스토리텔링에 기반한 활동중심중재를 적용하고 사회적 상호작용에 미치는 영향에 대해 알아보는 것이다. 유사실험연구로 단일눈가림, 두 집단 사전-사후검사로 설계하였고, 경직형 뇌성마비로 진단받고, 대동작기능분류체계(GMFCS) I~III단계에 속하는 7~8세 아동 24명을 대상으로 하였다. 실험군과 대조군에 12명씩 무작위 배정하고 아동과 보호자는 집단이 어디에 속하는지 알 수 없도록 하였다. 집단별 프로그램은 회기당 60분, 주 2회, 8주간, 총 16회기 동안 진행되었고, 실험군은 다감각스토리텔링에 기반한 활동중심중재를 하였고, 대조군은 구조화된 신체활동을 실시하였다. 아동의 중재 전과 후에 사회적 상호작용의 변화정도를 확인하기 위해 또래관계기술척도를 사용하여 측정하였다. 수집된 자료는 SPSS 25.0 for windows (IBM Corp, USA) 프로그램을 이용하여 분석하였고, 통계적 검증을 위한 유의수준(α)은 0.05로 하였다. 실험군과 대조군의 또래관계기술의 집단 내 변화는 윌콕슨부호순위검정(Wilcoxon Signed-Rank test)으로 확인하고, 두 집단 간 변화량 차이의 비교는 맨휘트니검정(Mann-Whitney U test)으로 분석하였다. 연구결과 또래관계기술의 집단 내 변화에서 또래관계기술의 전체 값과 하위평가의 협동과 공감영역에서 실험군과 대조군 모두 유의한 차이가 있었고, 주도성 영역에서는 실험군은 유의한 차이를 나타냈으나 대조군은 유의한 차이가 없었다. 두 집단 간 변화량 차이에서 또래관계기술의 하위평가의 주도성영역과 전체 값에서 유의한 차이를 나타냈고, 협동과 공감 영역에서는 유의한 차이가 없었다. 본 연구에서는 뇌성마비 아동을 대상으로 다감각스토리텔링에 기반한 활동중심중재를 적용하여 또래관계기술에 유의한 향상을 확인하였다. 다감각스토리텔링에 기반한 활동중심중재는 뇌성마비 아동의 사회적 상호작용에 효과적인 중재방법으로 제안할 수 있다.

• Advances in Computational Design
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• 제3권4호
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• pp.339-366
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• 2018

Parametric design systems serve as powerful assistive tools in the design process by providing a flexible approach for the generation of a vast number of design alternatives. However, contemporary parametric design systems focus primarily on low-level engineering and structural forms, without an explicit means to also take into account high-level, cognitively motivated people-centred design goals. We present a precedent-based parametric design method that integrates people-centred design "precedents" rooted in empirical evidence directly within state of the art parametric design systems. As a use-case, we illustrate the general method in the context of an empirical study focusing on the multi-modal analysis of wayfinding behaviour in two large-scale healthcare environments. With this use-case, we demonstrate the manner in which: (1). a range of empirically established design precedents -e.g., pertaining to visibility and navigation- may be articulated as design constraints to be embedded directly within state of the art parametric design tools (e.g., Grasshopper); and (2). embedded design precedents lead to the (parametric) generation of a number of morphologies that satisfy people-centred design criteria (in this case, pertaining to wayfinding). Our research presents an exemplar for the integration of cognitively motivated design goals with parametric design-space exploration methods. We posit that this opens-up a range of technological challenges for the engineering and development of next-generation computer aided architecture design systems.

• 대한기계학회논문집B
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• 제25권12호
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• pp.1887-1897
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• 2001

Korea Atomic Energy Research Institute (KAERI) launched an intermediate scale steam explosion experiment named "Test for Real Corium Interaction with water (TROI)" using reactor material to investigate whether the molten reactor material would lead to energetic steam explosion when interacted wish cold water at low pressure. The melt-water interaction experiment is performed in a pressure vessel with the multi-dimensional fuel and water pool geometry. The novel concept of cold crucible technology, where powder of the reactor material in a water-cooled cafe is heated by high frequency induction, is firstly implemented for the generation of molten fuel. In this paper, the lest facility and cold crucible technology are introduced and the results or the first series of tests were discussed. The 5 kg of molten ZrO$_2$jet was poured into the 67cm deep water pool at 30 ∼ 95 $\^{C}$. Either spontaneous steam explosions or quenching was observed. The morphology of debris and pressure wave profiles clearly indicate the differences between the two cases.

• 한국정보처리학회논문지
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• 제6권1호
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• pp.57-65
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• 1999

규모가 크고 복잡하며, 사용자와 상호 작용하는 시뮬레이션은 처리되는 메시지 수가 매우 많으므로 메시지의 순차적 시뮬레이션이 더 효율적이라 생각할 수 있다. 또한 사용자가 많은 훈련용 시뮬레이션은 지역적으로 분산되고 사용자의 추가 요구 사항의 증가로 시스템의 운용 및 유지보수 비용이 많이 든다. 따라서 시뮬레이션에 웹 기술의 적용은 이러한 문제를 해결할 수 있는 하나의 방법이 될 수 있다. 하지만 웹의 동적인 환경은 분산 처리되는 사건들의 인과성 오류를 유발 할 수 있다. 따라서 본 논문에서는 분산 처리되는 시뮬레이션 서버와 웹 브라우저의 클라이언트 사이에 상호작용을 위한 클라이언트-서버 모델을 제시하고 구현하였으며, 구현에는 웹 기술에 적합한 자바와 자바 분산 객체 모델을 사용하였다. 제시된 모델에 의한 실험결과 인터넷의 동적인 환경에 분산 시뮬레이션이 정확하게 수행되었음을 확인할 수 있었다.