• 대한전기학회:학술대회논문집
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• 대한전기학회 2002년도 추계학술대회 논문집 전기물성,응용부문
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• pp.156-158
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• 2002

Reduction of on-resistance($R_{on}$) in high voltage devices is of critical importance for the power consumption of the device. $R_{on}$ decreases with increase of the doping concentration of the drift region. However, breakdown voltage(BV) decreaes also with increase of doping concentration. In this report, a multi-resurf LDMOS[1] strcuture is proposed to reduce the $R_{on}$ which allows no degradation in BV. The on-and off-state characteristics of the proposed structure are simulated using the two-dimensional devices simulator ATLAS and compared with those from the conventional structure.

• 한국정보전자통신기술학회논문지
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• 제9권2호
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• pp.196-204
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• 2016

세계보건기구협회에의 통계에 따르면 심장 혈관 질환의 발병률이 가장 높은 것으로 알려져 있다. CTA영상을 사용하여 관상동맥 및 대동맥 질환을 치료 및 검사할 수 있다. 혈관을 3차원으로 복원하는 과정이 의사의 숙련도에 따라 결과가 상이하며 복원 시간이 길다는 단점이 있으며 이를 극복하고자 자동으로 정확한 혈관을 추출하는 연구들이 진행되어 왔다. 본 논문에서는 자동 및 반자동 분할 기법인 Region Competition, Geodesic Active Contour(GAC), Multi-atlas based segmentation, Active Shape Model(ASM) 알고리즘을 CTA영상에 적용하여 대동맥 기부를 추출하였으며 하우스도르프 거리, 볼륨, 영상처리속도, 사용자 관여 여부, 그리고 관상동맥 심문 검출률을 비교 및 분석하였다. 추출된 3차원 대동맥 모델 중 가장 높은 정확도를 나타낸 알고리즘은 GAC인 반면 사용자 관여가 가장 높았기 때문에 실제 시술에 적용하기 위해서는 자동 분할 알고리즘 개선이 필요하다

• 한국전기전자재료학회논문지
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• 제19권9호
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• pp.813-817
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• 2006

In this paper, we analyzed the breakdown voltage and on-resistance of the multi-RESURF SOI LDMOSFET as a function of epi-layer concentration. P-/n-epi layer thickness and doping concentration of the proposed structure are varied from $2{\sim}5{\mu}m\;and\;1\{times}10^{15}/cm^{3}^{\sim}9\{times}10^{15}/cm^{3}$ to find optimum breakdown voltage and on-resistance of the proposed structure. The maximum breakdown voltage of the proposed structure is $224\;V\;at\;R_{on}=0.2{\Omega}-mon^{2}\;with\;P_{epi}=3\{times}10^{15}/cm^{3},\;N_{epi}=7\{times}10^{15}/cm^{3}\;and\;L_{epi}=10{\mu}m$. Characteristics of the device are verified by two-dimensional process simulator ATHENA and device simulator ATLAS.

• 한국태양에너지학회 논문집
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• 제35권2호
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• pp.1-10
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• 2015

Promising onshore wind farm sites in Gangwon province of Korea were investigated in this study. Gangwon province was divided into twenty five simulation regions and a commercial program based on Reynolds averaged Navier-Stokes equation was used to find out wind resource maps of the regions. The national wind atlas with a period 2007-2009 developed by Korea institute of energy research was used as climatologies. The wind resource maps were combined to construct a wind resource map of Gangwon province with a horizontal spatial resolution of 100m. In addition to the wind resource, national environmental zoning map, distance from substation, residence and automobile road, Beakdudaegan mountain range, terrain slope, airport and military reservation district were considered to find out promising wind farm sites. A commercial wind farm design program was used to find out developable wind farm capacities in promising wind farm site with and without excluding environmental protection regions. The total wind farm capacities with and without excluding the protection regions were estimated to be 46MW and 598MW, respectively, when a 2MW commercial wind turbine was employed.

• JSTS:Journal of Semiconductor Technology and Science
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• 제5권3호
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• pp.195-203
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• 2005

Recently, a novel multi-bit nonvolatile memory based on double gate (DG) MOSFET is proposed to overcome the short channel effects and to increase the memory density. We need more complex voltage schemes for DG MOSFET devices. In view of peripheral circuits driving memory cells, one should consider various voltage sources used for several operations. It is one of the key issues to minimize the number of voltage sources. This criterion needs more caution in considering a DG nonvolatile memory cell that inevitably requires more number of events for voltage sources. Therefore figuring out the permissible range of operating bias should be preceded for reliable operation. We found that reliable operation largely depends on the depletion conditions of the silicon channel according to charge amount stored in the floating gates and the negative control gate voltages applied for read operation. We used Silvaco Atlas, a 2D numerical simulation tool as the device simulator.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2023년도 춘계학술발표대회
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• pp.490-492
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• 2023

시퀀싱(sequencing) 기술의 발달로 다양한 오믹스(omics) 데이터의 축적과 인공 지능 기술의 발달로 인하여 다양한 드라이버 유전자 분류기법이 제안되어왔다. 최근에는 암 데이터가 대용량으로 축적되며 기계 학습 기반의 다양한 기법들이 활발히 제안되었다. 특히 다양한 오믹스 데이터를 결합한 고차원 데이터에서 높은 정확도를 확보하기 위한 시도가 활발히 이루어지고 있다. 본 논문에서는 멀티 오믹스와 네트워크 관련 특징을 기반으로 암의 증식 및 발생에 중요한 역할을 하는 드라이버 유전자를 분류하는 딥러닝 모델을 제시한다. 또한 The Cancer Genome Atlas(TCGA) 데이터를 통해서 모델 학습 후 기존 통계 및 머신러닝 기반 기법과 비교하여 성능이 개선되었음을 확인하였다.

• IMMUNE NETWORK
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• 제21권4호
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• pp.31.1-31.16
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• 2021

Gastric cancer (GC) is the fourth most common cause of cancer-related death globally. The classification of advanced GC (AGC) according to molecular features has recently led to effective personalized cancer therapy for some patients. Specifically, AGC patients whose tumor cells express high levels of human epidermal growth factor receptor 2 (HER2) can now benefit from trastuzumab, a humanized monoclonal Ab that targets HER2. However, patients with HER2^negative AGC receive limited clinical benefit from this treatment. To identify potential immune therapeutic targets in HER2^negative AGC, we obtained 40 fresh AGC specimens immediately after surgical resections and subjected the CD45⁺ immune cells in the tumor microenvironment to multi-channel/multi-panel flow cytometry analysis. Here, we report that HER2 negativity associated with reduced overall survival (OS) and greater tumor infiltration with neutrophils and non-classical monocytes. The potential pro-tumoral activities of these cell types were confirmed by the fact that high expression of neutrophil or non-classical monocyte signature genes in the gastrointestinal tumors in The Cancer Genome Atlas, Genotype-Tissue Expression and Gene Expression Omnibus databases associated with worse OS on Kaplan-Meir plots relative to tumors with low expression of these signature genes. Moreover, advanced stage disease in the AGCs of our patients associated with greater tumor frequencies of neutrophils and non-classical monocytes than early stage disease. Thus, our study suggests that these 2 myeloid populations may serve as novel therapeutic targets for HER2^negative AGC.

• 천문학회보
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• 제36권2호
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• pp.65-65
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• 2011

Early-type galaxies represent the end point of galaxy evolution and, despite pervasive residual star formation, are generally considered "red and dead", that is composed exclusively of old stars with no star formation. Here, their molecular gas content is constrained and discussed in relation to their evolution, supporting the continuing importance of minor mergers and/or cold gas accretion. First, as part of the Atlas3D survey, the first complete, large, volume-limited survey of CO in normal early-type galaxies is presented. At least of 23% of local early-types possess a substantial amount of molecular gas, the necessary ingredient for star formation, independent of mass and environment but dependent on the specific stellar angular momentum. Second, using CO synthesis imaging, the extent of the molecular gas is constrained and a variety of morphologies is revealed. The kinematics of the molecular gas and stars are often misaligned, implying an external gas origin in over a third of all systems, more than half in the field, while external gas accretion must be shot down in clusters. Third, many objects appear to be in the process of forming regular kpc-size decoupled disks, and a star formation sequence can be sketched by piecing together multi-wavelength information on the molecular gas, current star formation, and young stars. Fourth, early-type galaxies do not seem to systematically obey all our usual prejudices regarding star formation (e.g. Schmidt-Kennicutt law, far infrared-radio continuum correlation), suggesting a greater diversity in star formation processes than observed in disk galaxies and the possibility of "morphological quenching". Lastly, a first step toward constraining the physical properties of the molecular gas is taken, by modeling the line ratios of density- and opacity-sensitive molecules in a few objects. Taken together, these observations argue for the continuing importance of (minor) mergers and cold gas accretion in local early-types, and they provide a much greater understanding of the gas cycle in the galaxies harbouring most of the stellar mass. In the future, better dust masses and dust-to-gas mass ratios from Herschel should allow to place entirely independent constraints on the gas supply, while spatially-resolved high-density molecular gas tracers observed with ALMA will probe the interstellar medium and star formation laws locally in a regime entirely different from that normally probed in spiral galaxies.

• 한국임상수의학회지
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• 제26권5호
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• pp.490-494
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• 2009

A 2-year-old Maltese and a 5-month-old Yorkshire terrier were presented with ataxia. Tetraparesis was observed in a 9-year -old Yorkshire terrier. The localizations of the lesions suggested brain or cervical spinal cord by the neurological examination, and the following images was achieved: radiography, axial images of computed tomography (CT), reconstruction image of CT such as multi-planar reformation(MPR) and 3-dimensional(3D) reconstruction and magnetic resonance imaging (MRI). On radiography, the misalignment between atlas (C1) and axis (C2), absent dens of axis, and increased space between the dorsal arch of C1 and spinous process of C2 were found. The discontinuation between dens and body of C2 was identified through axial CT images, and the fragmentation of dens separated from axis was observed through MPR and 3D image in all case. The hyperintense lesions and the spinal cord compression on T2-weighted MR images were represented in a dog with tetraparesis, the others represented only spinal cord compression. Three dogs were diagnosed as atlantoaxial instability (AAI) by dens fracture of C2. The dog with tetraparesis was euthanized due to guarded prognosis. The others were recovered completely. It is difficult to differentiate dens fracture of C2 from abnormal dens such as agenesis and hypoplasia. We thought that CT is very useful to evaluate the dens of C2 and differentiate the causes of AAI, and the reconstruction images of CT such as MPR and 3D make the translation of the fragmented dens or axis of AAI more precisely evaluate.