• Radiation Oncology Journal
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• 제30권3호
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• pp.132-139
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• 2012

Purpose: The purpose of this prospective multi-institutional study was to evaluate the nutritional status of patients undergoing radiotherapy (RT) for treatment of head and neck, lung, or gastrointestinal cancer. Materials and Methods: A total of 1,000 patients were enrolled in this study at seven different hospitals in Seoul, Korea between October 2009 and May 2010. The nutritional status of patients after receiving 3 weeks of RT was evaluated using subjective global assessment (SGA). The nutritional status of each patient was rated as well nourished (A), moderately malnourished (B), or severely malnourished (C). Results: The mean age of patients in this study was $59.4{\pm}11.9$ years, and the male to female ratio was 7:3. According to the SGA results, 60.8%, 34.5%, and 4.7% of patients were classified as A, B, or C, respectively. The following criteria were significantly associated with malnutrition (SGA B or C; p < 0.001): loss of subcutaneous fat or muscle wasting (odds ratio [OR], 11.473); increased metabolic demand/stress (OR, 8.688); ankle, sacral edema, or ascites (OR, 3.234); and weight loss ${\geq}5%$ (OR, 2.299). Conclusion: SGA was applied successfully to assess the nutritional status of most patients. The prevalence of malnutrition in a radiation oncology department was 39.2%. The results of this study serve as a basis for implementation of nutrition intervention to patients being treated at radiation oncology departments.

• Journal of Chest Surgery
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• 제41권4호
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• pp.463-468
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• 2008

Background: Descending necrotizing mediastinitis (DNM) is a life-threatening cervico-mediastinal infection extending from the oropharynx or periodontal space. We reviewed clinical outcomes of DNM patients that underwent surgical management. Material and Method: We analyzed the demographic and surgical data from 8 patients (6 males and 2 females) that underwent surgical management for DNM between August 2003 and August 2007. Result: The mean age was $56.6{\pm}12.3$ ($34{\sim}72$) years, Types of DNM were I (n=2), IIA (n=1), and IIB (n=5), based on the classification system of Endo et al. Four patients were septic at the time of operation. The infectious organism was identified in three cases and turned out to be Streptococcus. ICU stay was $24.3{\pm}17.9$ ($3{\sim}58$) days, and hospital stay was $49.1{\pm}33.8$ ($20{\sim}125$) days, There were two deaths (25%), both of which were due to multi-organ failure. Conclusion: Despite aggressive surgical drainage and appropriate medical management, DNM still had a high mortality rate, Early diagnosis and prompt surgical intervention are key to DNM management. In addition, transcervical drainage should be used in limited disease only.

• Journal of the Institute of Electronics Engineers of Korea SD
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• 제48권9호
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• pp.40-49
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• 2011

Integrating massive components and low-power policies have been actively investigated for system-on-chip designs. But in recent years, finding the optimal interconnection structure among heterogeneous components has emerged as a critical system design issue. Therefore, various simulation tools to model interconnection designs are being developed and performance evaluation of simulation is reflected in the real design. But most of the simulation environments employ traffic generation based on the mathematical probability functions, and such traffic generation cannot fully cover for various situations that may be occurred in the real system. Therefore, the demand for traffic pattern generation based on real applications is increasing. However, there have been few simulators that adopt application-specific traffic generators. This paper proposes a novel traffic generation method in simulating various interconnection structures for multi-processor system-on-chip design. The proposed traffic generation method can generate traffic patterns that can reflect the actual characteristics of the application and evaluate the performance of an interconnection structure under more realistic circumstance than traffic patterns using mathematical probability functions. By comparing the differences between the proposed method and the one based on mathematical probability functions, this paper shows advantages of the proposed traffic generation method.

• Asian-Australasian Journal of Animal Sciences
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• 제29권11호
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• pp.1530-1540
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• 2016

This study was conducted to estimate the genetic parameters of ${\beta}$-hydroxybutyrate (BHBA) and acetone concentration in milk by Fourier transform infrared spectroscopy along with test-day milk production traits including fat %, protein % and milk yield based on monthly samples of milk obtained as part of a routine milk recording program in Korea. Additionally, the feasibility of using such data in the official dairy cattle breeding system for selection of cows with low susceptibility of ketosis was evaluated. A total of 57,190 monthly test-day records for parities 1, 2, and 3 of 7,895 cows with pedigree information were collected from April 2012 to August 2014 from herds enrolled in the Korea Animal Improvement Association. Multi-trait random regression models were separately applied to estimate genetic parameters of test-day records for each parity. The model included fixed herd test-day effects, calving age and season effects, and random regressions for additive genetic and permanent environmental effects. Abundance of variation of acetone may provide a more sensitive indication of ketosis than many zero observations in concentration of milk BHBA. Heritabilities of milk BHBA levels ranged from 0.04 to 0.17 with a mean of 0.09 for the interval between 4 and 305 days in milk during three lactations. The average heritabilities for milk acetone concentration were 0.29, 0.29, and 0.22 for parities 1, 2, and 3, respectively. There was no clear genetic association of the concentration of two ketone bodies with three test-day milk production traits, even if some correlations among breeding values of the test-day records in this study were observed. These results suggest that genetic selection for low susceptibility of ketosis in early lactation is possible. Further, it is desirable for the breeding scheme of dairy cattle to include the records of milk acetone rather than the records of milk BHBA.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5773-5779
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• 2014

Background: Since cervical cancer can be prevented and controlled through human papillomavirus (HPV) vaccination, it is important to train health care providers and provide them with appropriate knowledge. This study aimed to understand the level of HPV related knowledge among medical students and correlates in Southwest China in order to address any potential gap in their knowledge base. Methods: We conducted a cross-sectional survey among medical students in six selected universities across Southwest China based on a pretested questionnaire regarding HPV infection, cervical cancer, and HPV vaccines. Results: We successfully surveyed 1, 878 medical students, of whom 32.1% were males and 67.9% were females. Their mean age was 20.8 (standard deviation: 1.3) years. 91.8% of them were ethnic Han Chinese, and 43.8% were students in clinical medicine. While 76.5% had heard of HPV only 48.8% knew that the prevention of cervical cancer was possible through HPV vaccination. Only 42.9% of the male and 49.2% of the female students correctly answered over 10 out of 22 questions on HPV related knowledge. Female students appeared to know more about HPV and HPV vaccination (OR: 1.39; 95% CI: 1.11-1.75). In addition, the student knowledge improved with the grade (p<0.001). University courses were the most selected source of knowledge about HPV vaccination (66.4%). 83.6% of males and 91.4% of females were willing to have more HPV related education by experts (p<0.001). Only 10.1% of the students acknowledged that people had asked for their advice regarding HPV vaccination. Conclusions: Our survey indicates that medical students from Southwest China have poor knowledge of HPV and HPV vaccination, but are willing to receive more relevant information. Targeted education should be incorporated into school courses to inform these future health care providers and ensure success of programs for cervical cancer control and prevention.

• Journal of Society of Preventive Korean Medicine
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• 제21권2호
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• pp.1-13
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• 2017

Objectives : This paper serves to explore current trends of systems biology in Traditional Chinese Medicine (TCM) and examine how it may influence the Traditional Korean medicine. Methods : Literature review method was collectively used to classify Introduction to systems biology, diagnosis and syndrome classification of systems biology in TCM perspective, physiotherapy including acupuncture, herbs and formula functions, TCM systems biology, and directions of academic development. Results : The term 'Systems biology' is coined as a combination of systems science and biology. It is a field of study that tries to understand living organism by establishing a theory based on an ideal model that analyzes and predicts the desired output with understanding of interrelationships and dynamics between variables. Systems biology has an integrated and multi-dimensional nature that observes the interaction among the elements constructing the network. The current state of systems biology in TCM is categorized into 4 parts: diagnosis and syndrome, physical therapy, herbs and formulas and academic development of TCM systems biology and its technology. Diagnosis and syndrome field is focusing on developing TCM into personalized medicine by clarifying Kidney yin deficiency patterns and metabolic differences among five patterns of diabetes and analyzing plasma metabolism and biomarkers of coronary heart disease patients. In the field of physical therapy such as acupuncture and moxibustion, researchers discovered the effect of stimulating acupoint ST40 on gene expression and the effects of acupuncture on treating functional dyspepsia and acute ischemic stroke. Herbs and formulas were analyzed with TCM network pharmacology. The therapeutic mechanisms of Si Wu Tang and its series formulas are explained by identifying potential active substances, targets and mechanism of action, including metabolic pathways of amino acid and fatty acid. For the academic development of TCM systems biology and its technology, it is necessary to integrate massive database, integrate pharmacokinetics and pharmacodynamics, as well as systems biology. It is also essential to establish a platform to maximize herbal treatment through accumulation of research data and diseases-specific, or drug-specific network combined with clinical experiences, and identify functions and roles of molecules in herbs and conduct animal-based studies within TCM frame. So far, few literature reviews exist for systems biology in traditional Korean medicine and they merely re-examine known efficacies of simple substances, herbs and formulas. For the future, it is necessary to identify specific mechanisms of working agents and targets to maximize the effects of traditional medicine modalities. Conclusions : Systems biology is widely accepted and studied in TCM and already advanced into a field known as 'TCM systems biology', which calls for the study of incorporating TCM and systems biology. It is time for traditional Korean medicine to acknowledge the importance of systems biology and present scientific basis of traditional medicine and establish the principles of diagnosis, prevention and treatment of diseases. By doing so, traditional Korean medicine would be innovated and further developed into a personalized medicine.

• Proceedings of the Korean Vacuum Society Conference
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• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
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• pp.431-432
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• 2012

In the era of 20 nm scaled semiconductor volume manufacturing, Microelectronics Manufacturing Engineering Education is presented in this paper. The purpose of microelectronic engineering education is to educate engineers to work in the semiconductor industry; it is therefore should be considered even before than technology development. Three Microelectronics Manufacturing Engineering related courses are introduced, and how undergraduate students acquired hands-on experience on Microelectronics fabrication and manufacturing. Conventionally employed wire bonding was recognized as not only an additional parasitic source in high-frequency mobile applications due to the increased inductance caused from the wiring loop, but also a huddle for minimizing IC packaging footprint. To alleviate the concerns, chip bumping technologies such as flip chip bumping and pillar bumping have been suggested as promising chip assembly methods to provide high-density interconnects and lower signal propagation delay [1,2]. Aluminum as metal interconnecting material over the decades in integrated circuits (ICs) manufacturing has been rapidly replaced with copper in majority IC products. A single copper metal layer with various test patterns of lines and vias and $400{\mu}m$ by $400{\mu}m$ interconnected pads are formed. Mask M1 allows metal interconnection patterns on 4" wafers with AZ1512 positive tone photoresist, and Cu/TiN/Ti layers are wet etched in two steps. We employed WPR, a thick patternable negative photoresist, manufactured by JSR Corp., which is specifically developed as dielectric material for multi- chip packaging (MCP) and package-on-package (PoP). Spin-coating at 1,000 rpm, i-line UV exposure, and 1 hour curing at $110^{\circ}C$ allows about $25{\mu}m$ thick passivation layer before performing wafer level soldering. Conventional Si3N4 passivation between Cu and WPR layer using plasma CVD can be an optional. To practice the board level flip chip assembly, individual students draw their own fan-outs of 40 rectangle pads using Eagle CAD, a free PCB artwork EDA. Individuals then transfer the test circuitry on a blank CCFL board followed by Cu etching and solder mask processes. Negative dry film resist (DFR), Accimage$^{(R)}$, manufactured by Kolon Industries, Inc., was used for solder resist for ball grid array (BGA). We demonstrated how Microelectronics Manufacturing Engineering education has been performed by presenting brief intermediate by-product from undergraduate and graduate students. Microelectronics Manufacturing Engineering, once again, is to educating engineers to actively work in the area of semiconductor manufacturing. Through one semester senior level hands-on laboratory course, participating students will have clearer understanding on microelectronics manufacturing and realized the importance of manufacturing yield in practice.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• 제48권8호
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• pp.555-563
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• 2020

Foward-swept wings are known to possess superior aerodynamic performance compared to the conventional straight wings. However major concerns regarding forward-swept wings include divergence at lower airspeeds which require careful consideration at the design stage. As an endeavor to overcome such drawbacks, aeroelastic tailoring is attempted. In order to find an optimal ply sequence, recursive aeroelastic analyses is conducted and one-dimensional beam analysis coupled with simple aerodynamics is used for the improved computational efficiency and modelling convenience. The analysis used in this paper, DYMORE and analytic formula, both use one-dimensional beam model for the structure. Cross-sectional analysis for multi-cell NACA0015 airfoil section is conducted using VABS and oblique function is used for the sweep angle. Throughout the present aeroelastic tailoring, the maximum divergence speed of 290.2m/s is achieved which is increased by approximately 43% than that for the conventional ply configuration.

• Ecology and Resilient Infrastructure
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• 제6권4호
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• pp.227-235
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• 2019

This study monitored Daecheong 1-bo, Daecheong-stream, which carried out the project in 2014, from 2015 to 2016. The technology applied to the stream was evaluated using Periphytic Algae to check contamination indicators and ecological health of the area with an integral river-bed protection using non-toxic materials. The water quality of the monitoring section was confirmed to be above the river environment standard (II), and it was confirmed that the Saproxenic taxa of the river bed protection were higher than the upper and downstream sections. The TDI, which is an index of attachment algae, was shown in the average 51.03 and 52.15 for the pilot project sections in 2015 and 2016, confirming that the index is of the "normal" grade. This is the other sections in the upstream and downstream sections showed higher than "bad", which is thought to have a positive effect on the habitat of the river ecosystem components, especially the microbial population in river bed protection.

• Journal of Sasang Constitutional Medicine
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• 제21권1호
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• pp.237-246
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• 2009

1. Objectives To compare the contents of heavy metals, residual pesticides and sulfur dioxide before/after decoction. 2. Methods The heavy metal contents before/after decoction were measured by Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES) and mercury analyzer. In order to analyze pesticides in 3 samples we used simultaneous multi-residue analysis of pesticides by GC/ECD, followed by GC/MSD analysis to confirm the identity of the detected pesticide in each sample. In addition, the contents of sulfur dioxide (SO2) were performed by Monier-Williams distillation method. 3. Results 1) The mean values of heavy metal contents (mg/kg) for the samples were as follows: Yuldahanso-tang (before decoction - Pb; 1.85, Cd; 0.148, As; 0.042 and Hg; 0.003, after decoction - Pb; 0.096, Cd; 0.006, As; 0.006 and Hg; 0.002), Chongsimyonja-tang (before decoction - Pb; 1.193, Cd; 0.094, As; 0.084 and Hg; 0.008, after decoction - Pb; 0.053, Cd; 0.007, As; 0.011 and Hg; not detected) and Taeyeumjowee-tang (before decoction - Pb; 0.878, Cd; 0.078, As; 0.302 and Hg; 0.004, after decoction - Pb; 0.079, Cd; 0.005, As; 0.006 and Hg; not dectcted). 2) Contents (mg/kg) of residual pesticides before/after decoction in all samples were not detected. 3) Contents (mg/kg) of sulfur dioxide (SO2) before decoction in Yuldahanso-tang, Chongsimyonja-tang and Taeyeumjowee-tang exhibited 6.1, 37.8, 31.5 and 19.7, respectively. However, contents of sulfur dioxide after decoction in all samples were not detected. 4. Conclusion These results will be used to establish a criterion of heavy metals, residual pesticides and sulfur dioxide.