• Journal of the Korea Computer Graphics Society
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• v.29 no.3
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• pp.127-135
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• 2023

Accurate segmentation of histopathology whole slide images (WSIs) is a crucial task for disease diagnosis and treatment planning. However, conventional automated segmentation algorithms may not always be applicable to WSI segmentation due to their large size and variations in tissue appearance, staining, and imaging conditions. Recent advances in interactive segmentation, which combines human expertise with algorithms, have shown promise to improve efficiency and accuracy in WSI segmentation but also presented us with challenging issues. In this paper, we propose a novel interactive segmentation method, ZoomISEG, that leverages multi-resolution WSIs. We demonstrate the efficacy and performance of the proposed method via comparison with conventional single-scale methods and an ablation study. The results confirm that the proposed method can reduce human interaction while achieving accuracy comparable to that of the brute-force approach using the highest-resolution data.

• Genomics & Informatics
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• v.21 no.3
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• pp.42.1-42.23
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• 2023

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, one of the most deadly infections in humans. The emergence of multidrug-resistant and extensively drug-resistant Mtb strains presents a global challenge. Mtb has shown resistance to many frontline antibiotics, including rifampicin, kanamycin, isoniazid, and capreomycin. The only licensed vaccine, Bacille Calmette-Guerin, does not efficiently protect against adult pulmonary tuberculosis. Therefore, it is urgently necessary to develop new vaccines to prevent infections caused by these strains. We used a subtractive proteomics approach on 23 virulent Mtb strains and identified a conserved membrane protein (MmpL4, NP_214964.1) as both a potential drug target and vaccine candidate. MmpL4 is a non-homologous essential protein in the host and is involved in the pathogen-specific pathway. Furthermore, MmpL4 shows no homology with anti-targets and has limited homology to human gut microflora, potentially reducing the likelihood of adverse effects and cross-reactivity if therapeutics specific to this protein are developed. Subsequently, we constructed a highly soluble, safe, antigenic, and stable multi-subunit vaccine from the MmpL4 protein using immunoinformatics. Molecular dynamics simulations revealed the stability of the vaccine-bound Tolllike receptor-4 complex on a nanosecond scale, and immune simulations indicated strong primary and secondary immune responses in the host. Therefore, our study identifies a new target that could expedite the design of effective therapeutics, and the designed vaccine should be validated. Future directions include an extensive molecular interaction analysis, in silico cloning, wet-lab experiments, and evaluation and comparison of the designed candidate as both a DNA vaccine and protein vaccine.

• Proceedings of the Materials Research Society of Korea Conference
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• 2012.05a
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• pp.72-72
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• 2012

Lithium rechargeable batteries have been widely used as key power sources for portable devices for the last couple of decades. Their high energy density and power have allowed the proliferation of ever more complex portable devices such as cellular phones, laptops and PDA's. For larger scale applications, such as batteries in plug-in hybrid electric vehicles (PHEV) or power tools, higher standards of the battery, especially in term of the rate (power) capability and energy density, are required. In PHEV, the materials in the rechargeable battery must be able to charge and discharge (power capability) with sufficient speed to take advantage of regenerative braking and give the desirable power to accelerate the car. The driving mileage of the electric car is simply a function of the energy density of the batteries. Since the successful launch of recent Ni-MH (Nickel Metal Hydride)-based HEVs (Hybrid Electric Vehicles) in the market, there has been intense demand for the high power-capable Li battery with higher energy density and reduced cost to make HEV vehicles more efficient and reduce emissions. However, current Li rechargeable battery technology has to improve significantly to meet the requirements for HEV applications not to mention PHEV. In an effort to design and develop an advanced electrode material with high power and energy for Li rechargeable batteries, we approached to this in two different length scales - Atomic and Nano engineering of materials. In the atomic design of electrode materials, we have combined theoretical investigation using ab initio calculations with experimental realization. Based on fundamental understanding on Li diffusion, polaronic conduction, operating potential, electronic structure and atomic bonding nature of electrode materials by theoretical calculations, we could identify and define the problems of existing electrode materials, suggest possible strategy and experimentally improve the electrochemical property. This approach often leads to a design of completely new compounds with new crystal structures. In this seminar, I will talk about two examples of electrode material study under this approach; $LiNi_{0.5}Mn_{0.5}O_2$ based layered materials and olivine based multi-component systems. In the other scale of approach; nano engineering; the morphology of electrode materials are controlled in nano scales to explore new electrochemical properties arising from the limited length scales and nano scale electrode architecture. Power, energy and cycle stability are demonstrated to be sensitively affected by electrode architecture in nano scales. This part of story will be only given summarized in the talk.

• Journal of Electrical Engineering and Technology
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• v.10 no.2
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• pp.474-486
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• 2015

This paper proposes a multi-objective optimal placement method of Phasor Measurement Units (PMUs) in large electric transmission systems. It is proposed for minimizing the number of PMUs for complete system observability and maximizing measurement redundancy of the buses, simultaneously. The measurement redundancy of the bus indicates that number of times a bus is able to monitor more than once by PMUs set. A high level of measurement redundancy can maximize the system observability and it is required for a reliable power system state estimation. Therefore, simultaneous optimizations of the two conflicting objectives are performed using a binary coded firefly algorithm. The complete observability of the power system is first prepared and then, single line loss contingency condition is added to the main model. The practical measurement limitation of PMUs is also considered. The efficiency of the proposed method is validated on IEEE 14, 30, 57 and 118 bus test systems and a real and large- scale Polish 2383 bus system. The valuable approach of firefly algorithm is demonstrated in finding the optimal number of PMUs and their locations by comparing its performance with earlier works.

• The Korean Journal of Applied Statistics
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• v.22 no.3
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• pp.499-513
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• 2009

An economic signal in the real world usually reflects complex phenomena. One may have difficulty both extracting and interpreting information embedded in such a signal. A natural way to reduce complexity is to decompose the original signal into several simple components, and then analyze each component. Spectral analysis (Priestley, 1981) provides a tool to analyze such signals under the assumption that the time series is stationary. However when the signal is subject to non-stationary and nonlinear characteristics such as amplitude and frequency modulation along time scale, spectral analysis is not suitable. Huang et al. (1998b, 1999) proposed a data-adaptive decomposition method called empirical mode decomposition and then applied Hilbert spectral analysis to decomposed signals called intrinsic mode function. Huang et al. (1998b, 1999) named this two step procedure the Hilbert-Huang transform(HHT). Because of its robustness in the presence of nonlinearity and non-stationarity, HHT has been used in various fields. In this paper, we discuss the applications of the HHT and demonstrate its promising potential for non-stationary financial time series data provided through a Korean stock price index.

• Journal of Ocean Engineering and Technology
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• v.20 no.4 s.71
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• pp.83-90
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• 2006

Recently, as the technology of utilization for the ocean space is being advanced, floating structures are asked for being mare and mare huge-scale. A very large floating structure(VLFS) is considered as a flexible structure, because of a quite large length-to-breadth ratio and its geometrical flexibility. The main object of this study is to develop an accurate and convenient method on the hydroelastic response analysis of very large offshore structures on the real sea states. The numerical approach for the hydorelastic responses is based on the combination of the three dimensional source distribution methods, the dynamic response analysis method and the spectral analysis method. A model is considered as many rigid bodies connected elastic beam elements. The calculated results shaw good agreement with the experimental and calculated ones by Ohta.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.4
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• pp.1884-1903
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• 2019

Device-to-Device (D2D) communications can provide proximity based services in the future 5G cellular networks. It allows short range communication in a limited area with the advantages of power saving, high data rate and traffic offloading. However, D2D communications may reuse the licensed channels with cellular communications and potentially result in critical interferences to nearby devices. To control the interference and improve network throughput in overlaid D2D cellular networks, a novel channel assignment approach is proposed in this paper. First, we characterize the performance of devices by using Poisson point process model. Then, we convert the throughput maximization problem into an optimal spectrum allocation problem with signal to interference plus noise ratio constraints and solve it, i.e., assigning appropriate fractions of channels to cellular communications and D2D communications. In order to mitigate the interferences between D2D devices, a cluster-based multi-channel assignment algorithm is proposed. The algorithm first cluster D2D communications into clusters to reduce the problem scale. After that, a multi-channel assignment algorithm is proposed to mitigate critical interferences among nearby devices for each D2D cluster individually. The simulation analysis conforms that the proposed algorithm can greatly increase system throughput.

• Journal of the Earthquake Engineering Society of Korea
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• v.11 no.4
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• pp.25-31
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• 2007

For areas such as the Korean Peninsula, which have moderate seismic activity but no available records of strong ground motion, synthetic seismograms can be used to evaluate ground motion without waiting for a strong earthquake. Such seismograms represent the estimated ground motions expected from a set of possible earthquake scenarios. Local site effects are especially important in assessing the seismic hazard and possible ground motion scenarios for a specific fault. The earthquake source and rupture dynamics can be described as a two-step process of rupture initiation and front propagation controlled by a frictional sliding mechanism. The seismic wavefield propagates through heterogeneous geological media and finally undergoes near-surface modulations such as amplification or deamplification. This is a complex system in which various scales of physical phenomena are integrated. A unified approach incorporates multi-scale problems of dynamic rupture, radiated wave propagation, and site effects into an all-in-one model using a three-dimensional, fourth-order, staggered-grid, finite-difference method. The method explains strong ground motions as products of complex systems that can be modified according to a variety of fine-scale rupture scenarios and friction models. A series of such deterministic earthquake scenarios can shed light on the kind of damage that would result and where it would be located.

• Journal of the Korean Institute of Educational Facilities
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• v.26 no.5
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• pp.25-36
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• 2019

School gymnasium is a multi-purpose large space building for various events and physical education activities, and is a facility that requires an approach to the desirable structural design, besides mechanical problems of structure against loads. For the integrated structure design concerning the architectural features, the major considerations of gymnasium planning that are the internal and external shape of the gymnasium, the space scale with structure members, the structural efficiency by members weight reduction and openness of the gymnasium space will have to take into account in the structural planning. From this point of view, the several cases of the school gymnasium were investigated and the parametric analyses were performed to the models using the various structural system. The parameters were the composition elements of structure system that are profile of structure, rigidity of member, connection and anchorage and stability. At the result, It was presented that the profile of structure member was the most influential factor to structural efficiency and the effect of the form and space of gymnasium. Also the design informations of structure design having the various feature of form and space were presented for the initial gymnasium planning.

• Computers and Concrete
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• v.33 no.5
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• pp.545-557
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• 2024

A real-case incident occurred where a 9-meter-high segment of a pre-fabricated concrete separation wall unexpectedly collapsed. This collapse was triggered by improperly depositing excavated soil against the wall's back, a condition for which the wall segments were not designed to withstand lateral earth pressure, leading to a flexural failure. The event's analysis, integrating technical data and observational insights, revealed that internal forces at the time of failure significantly exceeded the wall's capacity per standard design. The Lattice Discrete Particle Model (LDPM) further replicates the collapse mechanism. Our approach involved defining various parameter sets to replicate the concrete's mechanical response, consistent with the tested compressive strength. Subsequent stages included calibrating these parameters across different scales and conducting full-scale simulations. These simulations carried out with various parameter sets, were thoroughly analyzed to identify the most representative failure mechanism. We developed an equation from this analysis that quickly correlates the parameters to the wall's load-carry capacity, aligned with the simulation. Additionally, our study examined the wall's post-peak behavior, extending up to the point of collapse. This aspect of the analysis was essential for preventing failure, providing crucial time for intervention, and potentially averting a disaster. However, the reinforced concrete residual state is far from being fully understood. While it's impractical for engineers to depend on the residual state of structural elements during the design phase, comprehending this state is essential for effective response and mitigation strategies after initial failure occurs.