• Nuclear Engineering and Technology
• /
• 제55권10호
• /
• pp.3844-3853
• /
• 2023

Although radiation and chemotherapy methods for cancer therapy have advanced significantly, surgical resection is still recommended for most cancers. Therefore, intraoperative imaging studies have emerged as a surgical tool for identifying tumor margins. Intraoperative imaging has been examined using conventional imaging devices, such as optical near-infrared probes, gamma probes, and ultrasound devices. However, each modality has its limitations, such as depth penetration and spatial resolution. To overcome these limitations, hybrid imaging modalities and tracer studies are being developed. In a previous study, a multi-modal laparoscope with silicon photo-multiplier (SiPM)-based gamma detection acquired a 1 s interval gamma image. However, improvements in the near-infrared fluorophore (NIRF) signal intensity and gamma image central defects are needed to further evaluate the usefulness of multi-modal systems. In this study, an attempt was made to change the NIRF image acquisition method and the SiPM-based gamma detector to improve the source detection ability and reduce the image acquisition time. The performance of the multi-modal system using a complementary metal oxide semiconductor and modified SiPM gamma detector was evaluated in a phantom test. In future studies, a multi-modal system will be further optimized for pilot preclinical studies.

• Journal of Chest Surgery
• /
• 제33권5호
• /
• pp.432-435
• /
• 2000

We report a case of primary undifferentiated cardiac sarcoma. The tumor originated from the left atrial free wall with multi-organ metastases, e.g., lung, and adrenal gland. The patient gradually grew worse with dyspnea and hemoptysis because of the obstructed left atrial outflow. Surgical resection of the left atrial sarcoma was undertaken to save the patient's life, followed by chemotherapy and brain irradiation as adjuvant therapy. The prognosis of cardiac sarcoma with metastases is very poor. However, in patients with hemodynamic instability, surgical intervention could be a therapeutic modality as palliation.

• Molecules and Cells
• /
• 제25권4호
• /
• pp.462-466
• /
• 2008

Adenoviruses are the most commonly used gene-delivery vectors due to the efficiency of their in vivo gene transfer. Since 1993, about 300 protocols using an adenoviral vector have been performed, although they have yet to be proven effective in clinical trials. The adenovirus-based vector has been continuously improved by modification of the adenoviral genome and capsid, and novel adenovirus-delivery systems, such as the carrier-cell delivery system, have been recently proposed. Adenovirus-based cancer gene therapy is fast becoming one component of a multi-modality treatment approach to advanced cancer, along with surgery, radiotherapy, and chemotherapy.

• 한국멀티미디어학회논문지
• /
• 제15권3호
• /
• pp.291-298
• /
• 2012

일반적인 ATR시스템에서는 대부분 FLIR센서에 의존하여 영상을 획득하나, 표적의 경계가 모호한 경우 견실한 표적 분할을 보장할 수 없는 한계점이 있다. 이에 본 논문은 FLIR과 CCD센서를 통해 획득된 영상에 대한 적응적 가중치 기반의 융합 방법을 제안함으로써 보다 정확한 표적 분할 성능을 재현한다. 융합을 위한 FLIR영상의 가중치는 모호한 경계를 구분하기 위한 bi-modality 척도와 표적 경계와의 거리를 통해 결정되고, CCD영상의 가중치는 표적과 배경의 질감차이를 나타내는 질감 척도와 거리 척도를 통해 도출된다. 제안 방법의 타당성 검증을 위하여 다양한 환경에서 획득된 표적 영상에 대한 제안 방법과 단일 센서 기반의 표적 분할의 성능 비교를 수행하였다.

• Journal of Korean Neurosurgical Society
• /
• 제45권6호
• /
• pp.378-380
• /
• 2009

Osteoporotic patients who undergo percutaneous vertebroplasty (PVP) have the risk of a repeated collapse of their adjacent vertebral body due to alteration of load transfer into the adjacent vertebral body. The authors have experienced a rare case of repeated osteoporotic vertebral compression fractures (VCF) resulting in extreme multi-level PVP. A 74-year-old female developed severe back pain after slipping down one month ago. Her X-ray and MR images indicated a T11 VCF. She underwent successful PVP with polymethylmethacrylate (PMMA). Two weeks later, she returned to our hospital due to a similar back pain. Repeated X-ray and MR images showed an adjacent VCF on T12. A retrial of PVP was performed on T12, which provided immediate pain relief. Since then, repeated collapses of the vertebral body occurred 12 times in 13 levels within a 24-month period. Each time the woman was admitted to our hospital, she was diagnosed of newly developed VCFs and underwent repeated PVPs with PMMA, which finally eased back pain. Based on our experience with this patient, repeated multiple PVP is not dangerous because its few and minor complications. Therefore, repeated PVP can serve as an effective treatment modality for extreme-multi level VCFs.

• 정보과학회 컴퓨팅의 실제 논문지
• /
• 제23권6호
• /
• pp.386-391
• /
• 2017

본 논문에서는 실생활에서 수집한 웨어러블 센서 데이터에서 사용자의 체험 기반 감정 태그정보를 자동으로 부여하는 시스템을 제안한다. 사용자 본인의 감정과 사용자가 보고 듣는 정보를 종합적으로 고려하여 네 가지의 감정 태그를 정의한다. 직접 수집한 웨어러블 센서 데이터를 중심으로 기존 감성컴퓨팅 연구를 통해 알려진 보조 정보를 결합하여, 다중 센서 데이터를 입력으로 하고 감정 태그를 구분하는 머신러닝 기반 분류 시스템을 학습하였다. 다중 모달리티 기반 감정 태깅 시스템의 유용성을 보이기 위해, 기존의 단일 모달리티 기반의 감정 인식 접근법과의 정량적, 정성적 비교를 한다.

• 한국게임학회 논문지
• /
• 제12권6호
• /
• pp.25-32
• /
• 2012

디지털 기술의 발달로 탄생하게 된 디지털방송은 기존 영상 중심의 방송 콘텐츠뿐만 아니라 게임, 날씨정보, 증권거래 등의 다양한 데이터방송 서비스 (디지털TV 상에 운용되는 응용소프트웨어)를 서비스하는 멀티 엔터테인먼트 플랫폼으로 발전하고 있다. 하지만 게임을 포함한 대부분의 데이터방송 서비스들이 리모컨 조작의 불편함과 시청자의 한정적인 시간을 대상으로 방송 콘텐츠와의 경쟁으로 인해 성공적인 효과를 거두지 못하고 있다. 본 논문은 디지털TV가 게임 플랫폼으로 발전하기 위한 전제 조건인 데이터방송 서비스의 활성화 문제를 해결하기 위해서 데이터방송 서비스 경험자를 대상으로 인터뷰 형식의 설문조사를 수행하여 데이터방송 서비스 이용의 저해 요인을 분석하고 이를 바탕으로 시청자의 시청활동을 저해하지 않고 방송 콘텐츠와의 경쟁도를 낮추는 데이터방송 서비스 기획 가이드라인을 제안하였다.

• Journal of Periodontal and Implant Science
• /
• 제53권3호
• /
• pp.173-183
• /
• 2023

Purpose: Treatment for periodontitis has evolved over the years as new technologies have become available. Currently, lasers seem attractive as a treatment modality, but their effectiveness needs to be verified. The purpose of this project was to evaluate Laser Assisted New Attachment Procedure^® (LANAP^®) surgery as a single treatment modality. Methods: As part of a mandatory training program for periodontists and other dentists, 22 consecutive patients diagnosed with moderate to severe periodontitis (probing depth [PD] up to 11 mm) were treated with the LANAP^® surgical approach using a 1064-nm Nd:YAG laser as part of a multi-step protocol. Following single-session active therapy, they were entered into a maintenance program. Their clinical status was re-evaluated at 12-18 months following surgery. Results: All 22 patients completed the 12- to 18-month follow-up. PD, clinical attachment level, and furcation (FURC) showed substantial improvement. Recession was minimal (mean, 0.1 mm), while 93.5% of PD measurements were 3 mm or less at re-evaluation. Furthermore, 40% of grade 2 FURC closed clinically. Conclusions: Within the limits of this case series, LANAP^® was found to be an effective, minimally invasive, laser surgical therapy for moderate to advanced periodontitis.

• 대한의용생체공학회:의공학회지
• /
• 제28권1호
• /
• pp.117-126
• /
• 2007

In this paper, we propose an early rehabilitation training system for the improvement of postural balance with multi-modality on a tilting bed. The integration of the visual, somatosensory and vestibular functions is significant to for maintaining the postural control of the human body. However, conventional rehabilitation systems do not provide multi-modality to trainees. We analyzed the characterization of postural control at different tilt angles of an early rehabilitation training system, which consists of a tilting bed, a visual feedback, a computer interface, a computer, and a force plate. The software that we developed for the system consists of the training programs and the analysis programs. To evaluate the characterization of postural control, we conducted the first evaluation before the beginning of the training. In the following four weeks, 12 healthy young and 5 healthy elderly subjects were trained to improve postural control using the training programs with the tilting bed. After four weeks of training, we conducted the second evaluation. The analysis programs assess (center of pressure) COP moving time, COP maintaining time, and mean absolute deviation of the trace before and after training at different tilt angles on the bed. After 4 weeks, the COP moving time was reduced, the COP maintaining time was lengthened, and the mean absolute deviation of the trace was lowered through the repeated use of vertical, horizontal, dynamic circle movement training programs. These results show that this system improves postural balance and could be applied to clinical use as an effective training system.

• Journal of Korean Neurosurgical Society
• /
• 제29권1호
• /
• pp.44-50
• /
• 2000

Objective : A few anecdotal cases of mesenchyme-derived tumors which grow into a cranial cavity have been reported that disclosed a dismal prognosis, due to their critical location, aggressive biological behavior, and high rate of surgical morbidity. The aim of this study is to search clinical factors related to these tumors. Methods : Eight patients who underwent surgical removal of intracranial mesenchymal tumors between January 1993 and December 1997 were studied retrospectively. The tumors included are three chordomas, two chondrosarcomas, two rhabdomyosarcomas, and one hemangiopericytoma. Authors compared clinical features, treatment, and results of our cases with reported cases. The mean follow-up period was 20.5 months. Results : All cases showed nonspecific, location-related clinical findings and arose from sphenopetroclival region. Single stage operation was performed in 4 cases, and skull base approaches in 3 cases. Adjuvant therapies were done in 2 cases. Recurrence was seen in 3 cases(37.5%), and 3 patients died. Interdisciplinary approach with otologic surgeon was done in 2 cases. Conclusion : Recent advancement of refined tactics has made these tumors amenable and provides prolongation of progression-free survival. These are modified skull base approaches, multi-modality treatment options, and inter-disciplinary team approaches. Good results may be expected for these mesenchymal tumors by aggressive resection and adjuvant therapies according to their biological nature.