• Asian Pacific Journal of Cancer Prevention
• /
• 제14권2호
• /
• pp.765-768
• /
• 2013

Background and Aims: Prostate cancer is the most commonly diagnosed cancer in males in many populations. Metformin is the most widely used anti-diabetic drug in the world, and there is increasing evidence of a potential efficacy of this agent as an anti-cancer drug. Metformin inhibits the proliferation of a range of cancer cells including prostate, colon, breast, ovarian, and glioma lines. MicroRNAs (miRNAs) are a class of small, non-coding, single-stranded RNAs that downregulate gene expression. We aimed to evaluate the effects of metformin treatment on changes in miRNA expression in PC-3 cells, and possible associations with biological behaviour. Materials and Methods: Average cell viability and cytotoxic effects of metformin were investigated at 24 hour intervals for three days using the xCELLigence system. The $IC_{50}$ dose of metformin in the PC-3 cells was found to be 5 mM. RNA samples were used for analysis using custom multi-species microarrays containing 1209 probes covering 1221 human mature microRNAs present in miRBase 16.0 database. Results: Among the human miRNAs investigated by the arrays, 10 miRNAs were up-regulated and 12 miRNAs were down-regulated in the metformin-treated group as compared to the control group. In conclusion, expression changes in miRNAs of miR-146a, miR-100, miR-425, miR-193a-3p and, miR-106b in metformin-treated cells may be important. This study may emphasize a new role of metformin on the regulation of miRNAs in prostate cancer.

• 한국농촌건축학회논문집
• /
• 제6권2호
• /
• pp.1-10
• /
• 2004

The purpose of this study is to clarify the actual condition of the layout and floor planning of elementary schools for the 7th education curriculum. This article discuses about the basic characteristics of the plan composition and the outdoor spaces of 35 elementary schools in Gyeongnam prefecture. The results of this study are summarized as follows; 1) To respond to the 7th educational curriculum, unit classrooms need to be expanded or space for a multi-purpose room needs to be secured to serve the following purposes: the operation of educational program by the level and offering of unified Subjects. overall, elementary schools need to seek ways to deal with problems associated with space composition, types of classrooms, and changes in the number of classrooms so that the 7th Educational curriculum can be carried out smoothly. 2) Different from the past, various plan types are available nowadays. Even in case of schools with the same class size, their areas were different by 130 percentages or higher. Therefore, practicality needs to be more focused than facility standards in order for the school to cope with changes in future educational environment. 3) When designing the elementary school in the future, more space needs to be assigned for learning by expanding facilities - special purpose classrooms and supporting facilities - to accommodate students' various learning activities. In addition, faculty facilities need to be rearranged to promote research and development as well as to ensure the operation of the educational program. And, resident facilities that consider the close connection with the local community need to be rearranged in an efficient manner as well.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제7권12호
• /
• pp.2957-2986
• /
• 2013

The traditional approach of fixed spectrum allocation to licensed networks has resulted in spectrum underutilisation. Cognitive radio technology is envisioned as a promising solution that can be used to resolve the ineffectiveness of the fixed spectrum allocation policy by accessing the underutilised spectrum of existing technologies opportunistically. The implementation of cognitive radio networks (CRNs) faces distinct challenges due to the fact that two systems (i.e., cognitive radio (CR) and primary users (PUs)) with conflicting interests interact with each other. Specially, in self-organised systems such as ad-hoc CRNs (AHCRNs), the coordination of spectrum access introduces challenges to researchers due to rapid utilisation changes in the available spectrum, as well as the multi-hop nature of ad-hoc networks, which creates additional challenges in the analysis of resource allocation (e.g., power control, channel and rate allocation). Instead, game theory has been adopted as a powerful mathematical tool in analysing and modelling the interaction processes of AHCRNs. In this survey, we first review the most fundamental concepts and architectures of CRNs and AHCRNs. We then introduce the concepts of game theory, utility function, Nash equilibrium and pricing techniques. Finally, we survey the recent literature on the game theoretic analysis of AHCRNs, highlighting its applicability to the physical layer PHY, the MAC layer and the network layer.

• 공학교육연구
• /
• 제5권2호
• /
• pp.42-53
• /
• 2002

열린 캠퍼스로 21세기를 맞이하기 위하여 정보기술의 미래사회에서의 위치와 역할을 점검하였다. 향후 30년간은 정보기술이 산업전반을 이끌어 갈 것으로 예측하고 있는 즈음에 정보기술교육의 한 축을 담당하고 있는 전자계열학과의 IT인력양성시스템은 어떻게 구축하여야 하는가에 초점을 두었다. 다양한 학년제와 학기제의 교육시스템이 어떻게 산업체의 요구를 유연하게 수용하고 경쟁력 있는 인력을 양성할 수 있는가 하는 문제는 시대적으로 평생교육과 연계되어야 할 것이다. 평생직업사회의 열린 교육은 구체적으로 어떻게 하여 구현할 것인가의 문제 또한 매우 중요한 요소이다. 이 연구는 센터(연구소)를 기반으로 하는 모듈형 다학기제 교육시스템의 구체적인 실현을 위한 전문대학 IT계열학과와 학교간의 조직을 중심으로 고찰하였으며, 원격(가상)교육은 열린 교육 시스템과 어떠한 관계인가를 제시함으로써 시대에 부응하는 교육시스템 개발의 한 방향을 제시하였다. 특히 '정보매체학습센터'를 예시하여 가상교육과 산학 및 평생교육시스템이 어떠한 연계를 이를 수 있는가를 제시하였다.

• 한국실내디자인학회논문집
• /
• 제21권6호
• /
• pp.271-279
• /
• 2012

Among the community-based cultural facilities, public libraries are places for social and educational purpose that improve the education of the resident, the expansion of the basic cultural education, communication between the members of society, and the accumulations and preservations of the culture. Public libraries should be a local cultural facility that expresses the value of a community. This study aims to analyze the design expression of publicness in a public branch library as a community-based cultural space through the study of branch library in the U.S. This study focused on the most future-oriented and innovative Ten New Landmark Libraries in the United States selected by Library Journal magazine in 2011. Among the selected libraries, three branch libraries which belongs Arizona Maricopa County were included in the study. The results of this study are as follows. First, the sites of the branch libraries vary geographically, but the libraries increase accessibility are caused by unique appearances and design concept of intellectual interest. Second, the floor plan shows the separation of meeting rooms and faculty space from the public space and has visual and spatial open space by high ceiling of the reading room. Third, multi-functional public space for residents are meeting rooms, the external patios for reading, galleries, cafes, libraries-shops which provides a variety of cultural programs, activities, and the opportunity to socialize neighbors. Fourth, branch Libraries have unique designs that harmonizes with nearby places to reflect locality, giving the locals a sense of pride in their community. Fifth, concrete brick and metal panel were used as finishing material for the practicality of maintenance. In particular, transparent glass envelope allows the locals to stay for long time due to openness and brightness of space.

• Smart Structures and Systems
• /
• 제26권3호
• /
• pp.331-343
• /
• 2020

In this paper, based on the CPT, motion equations for a sandwich plate containing a core and two integrated face-sheets have derived. The structure rests on the Visco-Pasternak foundation, which includes normal and shear modules. The piezo-magnetic core is made of CoFe₂O₄ and also is subjected to 3D magnetic potential. Two face sheets at top and bottom of the core are under electrical fields. Also, in order to obtain more accuracy, the effect of flexoelectricity has took into account at face sheets' relations in this work. Flexoelectricity is a property of all insulators whereby they polarize when subject to an inhomogeneous deformation. This property plays a crucial role in small-scale rather than macro scale. Employing CPT, Hamilton's principle, flexoelectricity considerations, the governing equations are derived and then solved analytically. By present work a detailed numerical study is obtained based on Piezoelectricity, Flexoelectricity and modified couple stress theories to indicate the significant effect of length scale parameter, shear correction factor, aspect and thickness ratios and boundary conditions on natural frequency of sandwich plates. Also, the figures show that there is an excellent agreement between present study and previous researches. These finding can be used for automotive industries, aircrafts, marine vessels and building industries.

• Journal of Electrical Engineering and Technology
• /
• 제5권2호
• /
• pp.179-190
• /
• 2010

This paper describes a new stochastic heuristic algorithm in engineering problem optimization especially in power system applications. An improved particle swarm optimization (PSO) called adaptive particle swarm optimization (APSO), mixed with simulated annealing (SA), is introduced and referred to as APSO-SA. This algorithm uses a novel PSO algorithm (APSO) to increase the convergence rate and incorporate the ability of SA to avoid being trapped in a local optimum. The APSO-SA algorithm efficiency is verified using some benchmark functions. This paper presents the application of APSO-SA to find the optimal location, type and size of flexible AC transmission system devices. Two types of FACTS devices, the thyristor controlled series capacitor (TCSC) and the static VAR compensator (SVC), are considered. The main objectives of the presented method are increasing the voltage stability index and over load factor, decreasing the cost of investment and total real power losses in the power system. In this regard, two cases are considered: single-type devices (same type of FACTS devices) and multi-type devices (combination of TCSC, SVC). Using the proposed method, the locations, type and sizes of FACTS devices are obtained to reach the optimal objective function. The APSO-SA is used to solve the above non.linear programming optimization problem for better accuracy and fast convergence and its results are compared with results of conventional PSO. The presented method expands the search space, improves performance and accelerates to the speed convergence, in comparison with the conventional PSO algorithm. The optimization results are compared with the standard PSO method. This comparison confirms the efficiency and validity of the proposed method. The proposed approach is examined and tested on IEEE 14 bus systems by MATLAB software. Numerical results demonstrate that the APSO-SA is fast and has a much lower computational cost.

• Journal of Information Science Theory and Practice
• /
• 제7권4호
• /
• pp.56-64
• /
• 2019

Planting intercropping in rubber plantations is another alternative for generating more income for farmers. However, farmers still lack the knowledge of choosing plants. In addition, information for decision making comes from many sources and is knowledge accumulated by the expert. Therefore, this research aims to create a decision support system for growing rubber trees for individual farmers. It aims to get the highest income and the lowest cost by using semantic web technology so that farmers can access knowledge at all times and reduce the risk of growing crops, and also support the decision supporting system (DSS) to be more intelligent. The integrated intercropping ontology and rule are a part of the decision-making process for selecting plants that is suitable for individual rubber plots. A list of suitable plants is important for decision variables in the allocation of planting areas for each type of plant for multiple purposes. This article presents designing and developing the intercropping ontology for DSS which defines a class based on the principle of intercropping in rubber plantations. It is grouped according to the characteristics and condition of the area of the farmer as a concept of the rubber plantation. It consists of the age of rubber tree, spacing between rows of rubber trees, and water sources for use in agriculture and soil group, including slope, drainage, depth of soil, etc. The use of ontology for recommended plants suitable for individual farmers makes a contribution to the knowledge management field. Besides being useful in DSS by offering options with accuracy, it also reduces the complexity of the problem by reducing decision variables and condition variables in the multi-objective optimization model of DSS.

• 한국문헌정보학회지
• /
• 제49권4호
• /
• pp.241-264
• /
• 2015

Bibliometric analysis for research performance evaluation can generate erroneous assessments for various reasons. Application of the same evaluation metric to different domains, for instance, can produce unfair evaluation results, while analysis based on incomplete data can lead to incorrect conclusions. This study examines bibliometric data of library and information science (LIS) research in Korea to investigate whether research performance should be evaluated in a uniform manner in multi-disciplinary fields such as LIS and how data incompleteness can affect the bibliometric assessment outcomes. The initial analysis of our study data, which consisted of 4,350 citations to 1,986 domestic papers published between 2001 and 2010 by 163 LIS faculty members in Korea, showed an anomalous citation pattern caused by data incompleteness, which was addressed via data projection based on past citation trends. The subsequent analysis of augmented study data revealed ample evidence of bibliometric pattern differences across subject areas. In addition to highlighting the need for a subject-specific assessment of research performance, the study demonstrated the importance of rigorous analysis and careful interpretation of bibliometric data by identifying and compensating for deficiencies in the data source, examining per capita as well as overall statistics, and considering various facets of research in order to interpret what the numbers reflect rather than merely taking them at face value as quantitative measures of research performance.

• 한국식품영양학회지
• /
• 제34권4호
• /
• pp.372-380
• /
• 2021

In this study, data from the 7th (2016~2018) and 8th (2019) Korea National Health and Nutrition Examination Surveys were used, which included 5,325 subjects. Health behavior, dietary and nutrient intake status, physical measurement and biochemical characteristics, and risk factors for elderly related chronic diseases were classified and analyzed according to the changing composition of single households and other households in the current society. As a result, the ratio of current smokers and drinkers in young adult single households, walking less than 30 minutes per day, subjective health status was poor, breakfast rate less than three times per week, eating out frequency more than once a day, lipid intake ratio to total calories, saturation fatty acid intake were significantly higher. In addition, waist circumference, and diastolic blood pressure were significantly higher. However, dietary fiber intake level was significantly lower. The results for hypertension, which is the representative chronic disease that causes old age-related chronic diseases, were significantly higher in single households (ORs=1.400 (95% CI: 1.095, 1.791), p=0.007). Although young adults may not have showed particularly serious health problems yet, education is believed as important to recognize and prevent age-related disease risk factors.