• Title/Summary/Keyword: Multi Effect

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A Study on the Factors to Customers Attitude for the Goods and Service Introduced in Review UGC (체험형 1인 미디어콘텐츠에서 소개하는 상품에 대한 소비자 태도 영향요인 연구)

  • Son, Jaeyoung
    • 지역과문화
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    • v.7 no.2
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    • pp.155-172
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    • 2020
  • This study analyzed the factors to customer attitude on the goods and service introduced in UGC(User Generated Contents) and explored the difference between Korean and Chinese customers. For the first research question, the hypothetical factors were selected through literature review, the area of which are media consumption, social media and effect of advertising. In this study examined 4 independent variables: information, reliability, BJ attractiveness and customer innovation. Methodologies are confirmatory factor analysis, correlation analysis and multi regression. Result showed that reliability, BJ attractiveness and customer innovation are statistically significant. According to the β value, the biggest one is customer innovation, the second one is BJ attractiveness and the third one is reliability. The influence of information on customer attitude is not statistically significant. The result is well-aligned with the prior studies. The information factor's influence, however, is disputable because some prior studies shows that it is not significant when the research samples are recently developed channel such as mobile or social media commerce platforms. It is necessary to identify the root causes why the information factor is not significant in some research cases. For the second research question, this study used independent t-test between Korean and Chinese customers. The result shows that the difference in reliability, BJ attractiveness and attitude are stastically significant, and the ratings of Chinese customers are higher. This result caused by the difference of media commerce environment between Korea and China. Information and customer innovation didn't show significant difference.

Anti-atopic dermatitis effects of Parasenecio auriculatus via simultaneous inhibition of multiple inflammatory pathways

  • Kwon, Yujin;Cho, Su-Yeon;Kwon, Jaeyoung;Hwang, Min;Hwang, Hoseong;Kang, Yoon Jin;Lee, Hyeon-Seong;Kim, Jiyoon;Kim, Won Kyu
    • BMB Reports
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    • v.55 no.6
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    • pp.275-280
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    • 2022
  • The treatment of atopic dermatitis (AD) is challenging due to its complex etiology. From epidermal disruption to chronic inflammation, various cells and inflammatory pathways contribute to the progression of AD. As with immunosuppressants, general inhibition of inflammatory pathways can be effective, but this approach is not suitable for long-term treatment due to its side effects. This study aimed to identify a plant extract (PE) with anti-inflammatory effects on multiple cell types involved in AD development and provide relevant mechanistic evidence. Degranulation was measured in RBL-2H3 cells to screen 30 PEs native to South Korea. To investigate the anti-inflammatory effects of Parasenecio auriculatus var. matsumurana Nakai extract (PAE) in AD, production of cytokines and nitric oxide, activation status of FcεRI and TLR4 signaling, cell-cell junction, and cell viability were evaluated using qRT-PCR, western blotting, confocal microscopy, Griess system, and an MTT assay in RBL-2H3, HEK293, RAW264.7, and HaCaT cells. For in vivo experiments, a DNCBinduced AD mouse model was constructed, and hematoxylin and eosin, periodic acid-Schiff, toluidine blue, and F4/80-staining were performed. The chemical constituents of PAE were analyzed by HPLC-MS. By measuring the anti-degranulation effects of 30 PEs in RBL-2H3 cells, we found that Paeonia lactiflora Pall., PA, and Rehmannia glutinosa (Gaertn.) Libosch. ex Steud. show an inhibitory activity of more than 50%. Of these, PAE most dramatically and consistently suppressed cytokine expression, including IL-4, IL-9, IL-13, and TNF-α. PAE potently inhibited FcεRI signaling, which mechanistically supports its basophil-stabilizing effects, and PAE downregulated cytokines and NO production in macrophages via perturbation of toll-like receptor signaling. Moreover, PAE suppressed cytokine production in keratinocytes and upregulated the expression of tight junction molecules ZO-1 and occludin. In a DNCB-induced AD mouse model, the topical application of PAE significantly improved atopic index scores, immune cell infiltration, cytokine expression, abnormal activation of signaling molecules in FcεRI and TLR signaling, and damaged skin structure compared with dexamethasone. The anti-inflammatory effect of PAE was mainly due to integerrimine. Our findings suggest that PAE could potently inhibit multi-inflammatory cells involved in AD development, synergistically block the propagation of inflammatory responses, and thus alleviate AD symptoms.

The Effects of Self-Sit-to-Stand Training Using Multi-Sensory Feedback Device on Balance Ability and Sit-to-Stand Ability in Hemiplegic Stroke Patients (다중감각 되먹임 장치를 이용한 자가 일어서기 훈련이 편마비 환자의 균형능력과 일어서기 동작 수행능력에 미치는 영향)

  • Min, Jun-Ki;Choi, Won-Jae;Jung, Jihye;Lee, Seung-Won
    • PNF and Movement
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    • v.20 no.2
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    • pp.157-166
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    • 2022
  • Purpose: The aim of this research was to investigate the effects of self-sit-to-stand training on balance ability and sit-to-stand ability in hemiplegic stroke patients using a multisensory feedback device. Methods: A total of 19 stroke patients participated in this study, and they were divided into two groups: 10 underwent self-sit-to-stand training using a multisensory feedback device, and 9 underwent sit-to-stand training with a physical therapist. In both groups, sit-to-stand training was performed for 30 min, 3 times a week, for 6 weeks. The subjects also underwent physical therapy twice a day for 30 min, 10 times a week, for a total of 60 sessions. Balance ability was evaluated using the AFA-50 and Berg Balance Scale. Sit-to-stand ability was evaluated using the five times sit-to-stand test. Results: Sway length, pressure, and total pressure all significantly increased in both groups, and there was no difference between the two groups. The Berg Balance Scale results showed that balance ability significantly increased in both groups, and there was no difference between the two groups. The five times sit-to-stand test results showed that sit-to-stand ability significantly increased in both groups, and there was no difference between the two groups. It was found that the self-sit-to-stand training using a multisensory feedback device had a positive effect on balance control and sit-to-stand ability. When the two groups were compared, no difference in balance ability or sit-to-stand ability was observed. Conclusion: The findings of this study indicate that self-sit-to-stand training using a multisensory feedback device is as effective as sit-to-stand training with a physical therapist. Hence, self-sit-to-stand training using a multisensory feedback device could be an effective home-based exercise protocol for hemiplegic stroke patients to improve their balance and sit-to-stand abilities.

Numerical Study of Heat Flux and BOG in C-Type Liquefied Hydrogen Tank under Sloshing Excitation at the Saturated State (포화상태에 놓인 C-Type 액체수소 탱크의 슬로싱이 열 유속과 BOG에 미치는 변화의 수치적 분석)

  • Lee, Jin-Ho;Hwang, Se-Yun;Lee, Sung-Je;Lee, Jang Hyun
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.35 no.5
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    • pp.299-308
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    • 2022
  • This study was conducted to predict the tendency for heat exchange and boil-off gas (BOG) in a liquefied hydrogen tank under sloshing excitation. First, athe fluid domain excited by sloshing was modeled using a multiphase-thermal flow domain in which liquid hydrogen and hydrogen gas are in the saturated state. Both the the volume of fluid (VOF) and Eulerian-based multi-phase flow methods were applied to validate the accuracy of the pressure prediction. Second, it was indirectly shown that the fluid velocity prediction could be accurate by comparing the free surface and impact pressure from the computational fluid dynamics with those from the experimental results. Thereafter, the heat ingress from the external convective heat flux was reflected on the outer surfaces of the hydrogen tank. Eulerian-based multiphase-heat flow analysis was performed for a two-dimensional Type-C cylindrical hydrogen tank under rotational sloshing motion, and an inflation technique was applied to transform the fluid domain into a computational grid model. The heat exchange and heat flux in the hydrogen liquid-gas mixture were calculated throughout the analysis,, whereas the mass transfer and vaporization models were excluded to account for the pure heat exchange between the liquid and gas in the saturated state. In addition, forced convective heat transfer by sloshing on the inner wall of the tank was not reflected so that the heat exchange in the multiphase flow of liquid and gas could only be considered. Finally, the effect of sloshing on the amount of heat exchange between liquid and gas hydrogen was discussed. Considering the heat ingress into liquid hydrogen according to the presence/absence of a sloshing excitation, the amount of heat flux and BOG were discussed for each filling ratio.

Analysis of the Effect of Intralesional Steroid Injection on the Voice During Laryngeal Microsurgery (후두 미세수술 중 병변 내 스테로이드 주입이 음성에 미치는 효과 분석)

  • Jae Seon, Park;Hyun Seok, Kang;In Buhm, Lee;Sung Min, Jin;Sang Hyuk, Lee
    • Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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    • v.33 no.3
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    • pp.166-171
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    • 2022
  • Background and Objectives Vocal fold (VF) scar is known to be the most common cause of dysphonia after laryngeal microsurgery (LMS). Steroids reduce postoperative scar formation by inhibiting inflammation and collagen deposition. However, the clinical evidence of whether steroids are helpful in reducing VF scar formation after LMS is still lacking. The purpose of this study is to determine whether intralesional VF steroid injection after LMS helps to reduce postoperative scar formation and voice quality. Materials and Method This study was conducted on 80 patients who underwent LMS for VF polyp, Reinke's edema, and leukoplakia. Among them, 40 patients who underwent VF steroid injection after LMS were set as the injection group, and patients who had similar sex, age, and lesion size and who underwent LMS alone were set as the control group. In each group, stroboscopy, multi-dimensional voice program, Aerophone II, and voice handicap index (VHI) were performed before and 1 month after surgery, and the results were statistically analyzed. Results There were no statistically significant differences in the distribution of sex, age, symptom duration, occupation and smoking status between each group. Both groups consisted of VF polyp (n=21), Reinke's edema (n=11), and leukoplakia (n=9). On stroboscopy, the lesion disappeared after surgery, and the amplitude and mucosal wave were symmetrical on both sides of the VFs in all patients. Acoustic parameters and VHI significantly improved after surgery in all patients. However, there was no significant difference between the injection and control group in most of the results. Conclusion There was no significant difference in the results of stroboscopy, acoustic, aerodynamic, and subjective evaluation before and after surgery in the injection group and the control group.

Governance Strategy for Marine Microplastic Risk Assessment based on Ecosystem Protection (해양생태계 보호 기반의 해양 미세플라스틱 위해성평가 전략)

  • Jee-Hyun Jung;Won Joon Shim;Moonkoo Kim
    • Journal of Marine Life Science
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    • v.8 no.1
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    • pp.87-92
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    • 2023
  • Microplastic particles are ubiquitous in the environment and not standardized particles of size, shape, or type. Therefore, it is very limited to establish a risk assessment framework that accurately evaluated and manage the multi-dimension of marine environment including seawater and sediment based on toxic data. In the study, we review the characteristics and effects of marine environmental microplastic and suggest risk assessment framework (draft) based on the distribution and impact of marine environmental microplastics. Although, the characteristics of environmental microplastic are very widely but the most abundant toxic data are concentrated on unique shape and type, and there are also large gaps of test organism between laboratory-exposed organisms and resident species. Great limitations with respect to toxicity data quality also exist for traditional effect assessment methods, which in reliability of the resulting risk characterizations. However, considering the fact that the international community's movement on microplastics management is gradually strengthening and the pollution level of microplastics in marine environment is increasing, further research on environmental relevant risk assessment technique should be proposed based on the characteristics of microplastics in the marine environment.

The Moderating Effect of Gender in the Relationship between Physical Education and Adolescents' Internalizing and Externalizing Problem Behaviors: Using Multi-level Growth Modeling (체육시간과 청소년의 외현화·내재화 문제와의 관계에서 성별의 조절효과: 다층성장모형의 적용)

  • Taekho Lee;Seokyoung Lee;Yoonsun Han
    • Korean Journal of Culture and Social Issue
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    • v.21 no.2
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    • pp.131-158
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    • 2015
  • This study examined the relationship between physical education and externalizing(aggression) and internalizing(depression, social withdrawal) problem behaviors among adolescents. The moderating role of gender and time in the association between physical education and problem behavior was also identified. This study used data from the second, third, and fourth waves of the middle school student cohort (N=2,133, N=2,151, N=1,979) of the Korean Children-Youth Panel Survey(KCYPS). Main analyses involved multilevel growth model with interaction terms. The dependent variables were aggression, depression, and social withdrawal. The independent variables were gender and physical education (exercise hours) at school. The control variables were abuse, school-adjustment, annual household income and parents' highest level of education. The major longitudinal findings of this study are as follows: First, there was significant change according to the passage of time only in aggression among externalizing and internalizing problems. Second, gender differences exist in aggression and depression. Third, exercise hours of physical education had a negative relationship with internalizing problems. Fourth, there were no gender differences over time in both externalizing and internalizing problems. Fifth, the interaction between exercise hours of physical education and time was statistically significant for social withdrawal. Sixth, the interaction between exercise hours of physical education and gender was statistically significant for depression. The results of this study may become an academic basis for suggesting policy directions that promote increased exercise hours in physical education classes at school.

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Lateral Earth Pressures Acting on Anchored Diaphragm Walls and Deformation Behavior of Walls during Excavation (지하굴착시 앵커지지 지중연속벽에 작용하는 측방토압 및 벽체의 변형거동)

  • Hong, Won-Pyo;Lee, Moon-Ku;Lee, Jae-Ho;Yun, Jung-Mann
    • Journal of the Korean Geotechnical Society
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    • v.23 no.5
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    • pp.77-88
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    • 2007
  • Lateral earth pressure and horizontal displacement of the diaphragm walls constructed in multi-soil layers were analyzed by the field instrumentation from six building construction sites in urban area. The distribution of the developed earth pressure of the anchored diaphragm walls during excavation shows approximately a trapezoid diagram. The maximum earth pressure of anchored diaphragm walls corresponds to $0.45{\gamma}H$ and the earth pressure acts at the upper part of the walls. The maximum earth pressure is two times larger than the empirical earth pressure of flexible walls in sands suggested by Terzaghi and Peck(1967), Tschebotarioff(1973), and Hong and Yun(1995a). The horizontal displacement of diaphragm walls is closely related with supporting systems such as struts, anchors, and so on. The horizontal displacement of anchored walls shows less than 0.1 percent of the excavated depth, and the horizontal displacement of strutted walls shows less than 0.25 percent of the excavated depth. Therefore, the restraining effect of horizontal displacement to the anchored diaphragm walls is larger than the strutted diaphragm walls. In addition, since the horizontal displacement of the diaphragm walls is lower than the criterion, $\delta=0.25%H$, used for control the anchored retention wall using soilder piles, the safety of excavation sites applied with the diaphragm walls is pretty excellent.

The Mediating Effects of Depression on Loneliness and Suicidal Ideation in Elderly Living Alone with Diabetes Mellitus: A Secondary Data Analysis (독거 당뇨병 노인의 외로움이 자살사고에 미치는 영향에 대한 우울의 매개효과 검증: 2차 자료 분석)

  • Moonhee Gang;Yujin Ahn
    • Journal of Industrial Convergence
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    • v.21 no.5
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    • pp.51-58
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    • 2023
  • The purpose of this study is to analyze suicidal ideation of elderly people with diabetes living alone and to investigate the relationship between suicidal ideation, loneliness, and depression. This study was conducted through secondary data analysis using total survey data for the elderly living alone in O province. The subjects of this study were 466 elderly people who were diagnosed with diabetes among the elderly living alone. The data of this study were analyzed using descriptive statistics, t-test, Pearson's correlation coefficients, multi-linear regression analysis, and the three-step mediating effect verification procedure of Baron & Kenny using the SPSS 26.0 program. The average loneliness score and average depression score of the subjects were 4.52±3.30 and 4.88±4.03, respectively, and 27.3% of the subjects said they had a suicidal ideation. The subject's loneliness (β=.20, p=.005) and depression (β=.30, p<.001) was found to be a significant factor in predicting suicide ideation. In addition, depression was found to be partially mediated in the relationship between loneliness and suicidal ideation. Through the results of this study, loneliness and depression were found to be important factors related to suicidal ideation in the elderly with diabetes living alone. In addition, in order to improve suicidal ideation in the elderly with diabetes living alone, intervention to lower the level of loneliness and depression is necessary.

Family-Friendly Community Characteristics and Life Satisfaction of Working Mothers with Elementary School-Age Children: Mediation Effects of Work-Family Conflict and Facilitation (가족친화적 지역사회 특성과 초등학령기 자녀를 둔 취업모의 삶의 만족도 : 일-가족 갈등 및 촉진의 매개효과)

  • Park, In-Sook
    • Journal of Family Resource Management and Policy Review
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    • v.27 no.2
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    • pp.1-17
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    • 2023
  • This study examined the relationship between family-friendly community characteristics and the life satisfaction of working mothers with elementary school children, and investigated whether the relationship was mediated by work-family conflict and facilitation of working mothers. For the analysis, the study used the response data of 627 working mothers from the 11th wave of the Panel Study on Korean Children (PSKC, 2019) and multi-mediation effect analyses were conducted using PROCESS. The main results are as follows. First, the higher neighbor support, the higher the work-family facilitation, which significantly increased life satisfaction. Second, the appropriateness of parenting environment and community service infrastructure satisfaction showed significant indirect effects with life satisfaction through increasing work-family facilitation and lowering work-family conflict. Moreover, the appropriateness of parenting environment was positively related with life satisfaction and it was a only variable that was directly associated with life satisfaction. On the other hand, the convenient access to community service infrastructure was found to lower work-family facilitation and lower life satisfaction, confirming the need for follow-up studies. This study shows that the family-friendly characteristics of the community are important for working mothers with elementary school-age children and provides empirical evidence to improve the family-friendly community characteristics.