• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.43 no.6
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• pp.407-414
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• 2017

Objectives: The study was designed to evaluate the efficacy of performing a second, repeat anterior maxillary distraction (AMD) to treat residual cleft maxillary hypoplasia. Materials and Methods: Five patients between the ages of 12 to 15 years with a history of AMD and with residual cleft maxillary hypoplasia were included in the study. Inclusion was irrespective of gender, type of cleft lip and palate, and the amount of advancement needed. Repeat AMD was executed in these patients 4 to 5 years after the primary AMD procedure to correct the cleft maxillary hypoplasia that had developed since the initial procedure. Orthopantomogram (OPG) and lateral cephalograms were taken for evaluation preoperatively, immediately after distraction, after consolidation, and one year postoperatively. The data obtained was tabulated and a Mann Whitney U-test was used for statistical comparisons. Results: At the time of presentation, a residual maxillary hypoplasia was observed with a well maintained distraction gap on the OPG which ruled out the occurrence of a relapse. Favorable movement of the segments without any resistance was seen in all patients. Mean maxillary advancement of 10.56 mm was achieved at repeat AMD. Statistically significant increases in midfacial length, SNA angle, and nasion perpendicular to point A distance was achieved (P=0.012, P=0.011, and P=0.012, respectively). Good profile was achieved for all patients. Minimal transient complications, for example anterior open bite and bleeding episodes, were managed. Conclusion: Addressing the problem of cleft maxillary hypoplasia at an early age (12-15 years) is beneficial for the child. Residual hypoplasia may develop in some patients, which may require additional corrective procedures. The results of our study show that AMD can be repeated when residual deformity develops with the previous procedure having no negative impact on the results of the repeat procedure.

• International Area Studies Review
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• v.22 no.4
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• pp.189-208
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• 2018

This study validates if this relationship results in differences of significance levels between first time and repeat visitors and analyzes if there exist any differences in the spatial characteristics of tourist attractions using Social Network Analysis(SNA) for the spacial attributes of movement network Focusing on Hwaseong city, South Korea. It is important for balanced development between tour sites in Hwaseong by enhancing the value of tourism resources and applying the concept of hub-and-spoke tourism development. Based on the analyzing the centrality of tourist movement networks, degree centrality, closeness centrality, and betweenness centrality all did not show much variation for 20 tourist attractions versus the top five. That is, the attractions that both first time and repeat visitors visit are concentrated in well-known, famous places. The authors hope that this study, which defines practical interactions among attractions based movement, will be used as practical data for developing tourist retention marketing strategies.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.11
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• pp.648-654
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• 2016

This paper investigates differences of tourism destination choices for sightseeing in Seoul between first-time visitors and repeat visitors. We constructed social network using secondary data from '2015 International Visitor Survey' and analyzed its density and centrality. Study results find that: (1) first-time and repeat visitors' tourism destinations are concentrated in areas located north of the Han river. The proximity of destinations suggests the positive effects resulting from the movement network. (2) As the result of degree centrality, closeness centrality, betweenness centrality, the highest ranking tourism destinations for both visitor groups are identical, but indexes of centralities in repeat visitors' destinations increase, including Shinchon/ Hongik University, Gangnam station, and Garosu-gil. Therefore, the roles of these destinations are becoming established as tourism hubs and are popular among younger visitors as well as attract repeat visitors. Results of this study will be a useful reference in developing and managing new tourism products.

• Korean Journal of Biological Psychiatry
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• v.23 no.4
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• pp.148-156
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• 2016

Objectives According to previous studies, the cannabinoid receptor 1 (CNR1) gene could be an important candidate gene for schizophrenia. Some studies have linked the (AAT)n trinucleotide repeat polymorphism in CNR1 gene with the risk of schizophrenia. Meanwhile, smooth pursuit eye movement (SPEM) has been regarded as one of the most consistent endophenotypes of schizophrenia. In this study, we investigated the association between the (AAT)n trinucleotide repeats in CNR1 gene and SPEM abnormality in Korean patients with schizophrenia. Methods We measured SPEM function in 167 Korean patients with schizophrenia (84 male, 83 female) and they were divided according to SPEM function into two groups, good and poor SPEM function groups. We also investigated allele frequencies of (AAT)n repeat polymorphisms on CNR1 gene in each group. A logistic regression analysis was performed to find the association between SPEM abnormality and the number of (AAT)n trinucleotide repeats. Results The natural logarithm value of signal/noise ratio (Ln S/N ratio) of the good SPEM function group was $4.34{\pm}0.29$ and that of the poor SPEM function group was $3.21{\pm}0.70$. In total, 7 types of trinucleotide repeats were identified, each containing 7, 10, 11, 12, 13, 14, and 15 repeats, respectively. In the patients with $(AAT)7$ allele, the distributions of the good and poor SPEM function groups were 18 (11.1%) and 19 (11.0%) respectively. In the patients with $(AAT)_{10}$ allele, $(AAT)_{11}$ allele, $(AAT)_{12}$ allele, $(AAT)_{13}$ allele, $(AAT)_{14}$ allele and $(AAT)_{15}$ allele, the distributions of good and poor SPEM function groups were 13 (8.0%) and 12 (7.0%), 4 (2.5%) and 6 (3.5%), 31 (19.8%) and 35 (20.3%), 51 (31.5%) and 51 (29.7%), 36 (22.2%) and 45 (26.2%), 9 (5.6%) and 4 (2.3%) respectively. As the number of (AAT) n repeat increased, there was no aggravation of abnormality of SPEM function. Conclusions There was no significant aggravation of SPEM abnormality along with the increase of number of (AAT)n trinucleotide repeats in the CNR1 gene in Korean patients with schizophrenia.

• Korean Journal of Digital Imaging in Medicine
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• v.12 no.1
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• pp.43-50
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• 2010

The representative study of Patellofemoral Joint Merchant method can show the view for inspection of the sulcus angle, congruence angle and diagnose whether there are the vertical fractures and recognize the degree of dislocation and patella subluxation. However, anatomical correlation about the degree of knee joint curvature changes during position adjustment and distortion of the image reduces reproducibility. In order to resolve these problems, Merchant method needs to use assisting device which reduces the occurrence of repeat projection and effectively to increase unification of examination and the consistency of the image. However, there are disadvantages for patients who take other examinations. For example, they have to change the position for every examination and it might cause the patient's discomfort and increase of examination time. In this study, we newly devised commercial assisting device which improves the reproducibility of the images and reduces inconvenience of patients movement. Further research should be taken to obtain a image without patient's movement and to reduce the time of the examination than existing method.

• Speech Sciences
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• v.15 no.3
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• pp.183-201
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• 2008

This study attempted to reveal the physiologic etiology or related factors associated with speech processing by comparing the compensation ability in speech motor control in children with and without articulation disorders. Subjects were 35 children with articulation disorder and 35 children without articulation disorder whose age ranged from 5 to 6 years. They were asked to rapidly repeat /$p^ha$/, /$t^ha$/, /$k^ha$/, /$p^hat^hak^ha$/ diadochokinetic movement while mandible was free and mandible was stabilized with bite block. The results showed that children with articulation disorder revealed significantly greater difference in elapsed time for diadochokinetic movement between mandible free and stabilized state compared to the without articulation disorder group. But the correlation between the percentage of consonants correct and the compensation ability in speech motor control in the articulation disorder group was irrelevant. These results point out to the fact that children with articulation disorder have poor compensation ability in speech motor control compared to the children without articulation disorder. On the other hand, the poor ability does not have any relation with the severity of articulation disorder. These results suggest either general or individual characteristics of children with articulation disorder.

• Journal of Life Science
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• v.28 no.2
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• pp.170-175
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• 2018

Parkinson's disease (PD) is the most common movement disorder and the second most common neurodegenerative disease after Alzheimer's disease. Approximately 5~10% of PD patients are familial PD cases. Leucine-rich repeat kinase 2 (LRRK2) has been known to be a causal gene of PD when it is mutated. LRRK2 contains the functional kinase and GTPase domains as well as leucine-rich repeat (LRR) and WD40 domains that are known to play critical roles for protein-protein interaction, suggesting that LRRK2-interacting proteins are important regulators for PD pathogenesis. In an effort to identify proteins interacting with LRRK2, we carried out co-immunoprecipitation of LRRK2 antibody using extracts of NIH3T3 cells that express LRRK2 at a relatively high level. The mass spectrometry analysis of a precipitated band revealed that the co-precipitated band was methionyl-tRNA synthetase (MRS), an ancient enzyme that transfers methionin to its cognate tRNA. The interaction of MRS with LRRK2 was confirmed again by co-immunoprecipitation of endogenous proteins and GST pull-down assays. However, LRRK2 did not phosphorylate recombinant MRS protein in in vitro kinase assays, and over-expression of LRRK2 or MRS did not affect the stability of its partner protein. Our data indicate that LRRK2 interacts with but does not phosphorylate MRS, and the stability of each partner is not affected by the other.

• Journal of IKEEE
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• v.25 no.3
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• pp.437-444
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• 2021

In this paper, we propose an autonomous driving algorithm that allows a robot to explore various terrains, and implement an application that can monitor the robot's movement path during terrain search. The implemented application consists of a status unit that indicates the position, direction, speed, and motion of the mobile robot, a map unit that displays terrain information obtained through terrain search, and a control unit that controls the movement of the mobile robot. In order to control the movement of the robot, only the start and stop of the search/return is commanded by the application, and all driving for the search is performed autonomously. The basic algorithm for terrain search uses an infrared sensor to check for obstacles in the order of left, front, right, and rear, and if there is no obstacle and the path traveled is a dead end, it returns to the previous position and moves in the other direction to continue the search. Repeat the process to explore the terrain.

• Design & Manufacturing
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• v.8 no.1
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• pp.35-39
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• 2014

Window roller housings are durable because high-quality source materials such as stainless steel is used in making them. After a series of precise structure analysis, their design is optimized. They are subject to repetitive driving tests of more 100,000 times, durability tests, impact resistance tests, corrosion tests and others. For a long time, gaps often occur in press molded products owing to serious squareness deformation and flatness deformation of them. Severe burrs in press molded products require frequent grinding, which leads to short life cycle and rough or unreliable movement of assembled roller housing, which, in turn, causes product defects. This study focuses on developing measures to resolve existing defects and to improve lifespan of dies by designing and making a window roller shearing die.

• Journal of Microbiology and Biotechnology
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• v.16 no.5
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• pp.771-777
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• 2006

A novel gene (agiA) required for adventurous gliding motility in Myxococcus xanthus has been identified. Null mutations in this gene caused defects in the gliding movement of isolated cells, suggesting that it belongs to one of the A-motility genes. The isolated agiA mutant cells neither glided nor produced slime trails on agar surface. However, agiA was different from other known A-motility genes in that the agiA mutant created in the $S^-$ mutant background glided in the swarm of cells, since other known A-motility mutants created in the $S^-$ mutant background do not move in the swarm of cells. The agiA mutant was also defective in fruiting body development. Sequence analysis predicted that agiA encodes a 787-amino-acid protein with eight tripeptide repeat motifs.