• Biomolecules & Therapeutics
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• 제10권4호
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• pp.258-267
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• 2002

In this study the general pharmacological profiles of AS6 on the central nervous system, cardiovascular and the other organs were investigated. The dosages given were 0, 250, 500 and 1000 mg/kg and drugs were orally administered. The animals used for this study were mice, rats and guinea pigs. Significant increases (p<0.01) in the charcoal transport capacity were observed at the high dose of 1000 mg/kg and significant increases in retardation of pain threshold were observed in the test using acetic acid in all dosed animals. However, AS6 showed no noticeable effects on general behavior, motor coordination, spontaneous locomotor activity, hexobarbital-induced sleep time, body temperature, analgesic activity in the test using hot plate method and anticonvulsant activity. Furthermore no noticeable effects were observed in cardiovascular functions in the isolated rat heart, contraction and relaxation of the smooth muscle in the isolated guinea ileum, gastric secretion and renal function.

• 국제학술발표논문집
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• The 6th International Conference on Construction Engineering and Project Management
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• pp.26-27
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• 2015

In the trend of globalization and location transfer of existing production bases is still characterized by an extremely unstable status between different countries and different regions. The results are negative impacts on cost, quality and speed of project implementation, especially automobile industry which is one of the most complex manufacturing sectors. In order to overcome problems from Global Standardization of Production Line and its Localization, it is highly required comprehensive coordination among design of production equipment, production technology, space and interfaces. It is necessary to set up standard of production equipment and building for parallel progress, in order to complete production line in shortest time for launching product. In addition, this standard should keep flexibility with consideration of local situation which means "Glocalization."

• The Journal of Korean Physical Therapy
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• 제24권2호
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• pp.151-156
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• 2012

Purpose: The purpose of this study was to investigate the adverse effects of sensorimotor function at the shoulder joint according to long-term cane usage in stroke patients without apraxic behavior, in terms of the presence of shoulder joint pain, accuracy of tracking task, proprioceptive joint position sense, and nine-hole pegboard. Methods: Nineteen stroke patients with long-term cane usage (cane usage group) and nineteen stroke patients without cane usage (non-cane usage group) were recruited. All subjects were tested in pain presence, a tracking task for visuomotor function, joint reposition, and nine-hole pegboard in the shoulder joint regarding the non-affected side. Results: In the accuracy index for tracking task and the nine-hole pegboard test, significant differences were observed between the cane usage group and the non-cane usage group. However, although a higher emergence of shoulder pain and a lower accuracy for joint reposition sense were detected in the cane usage group in comparison to the non-cane usage group, there were no significant differences between the two groups. Conclusion: Our findings suggest that long-term cane usage could induce to decrease in delicate movement and coordination in the non-affected upper arm in stroke patients. In addition, they could experience high frequency of shoulder pain and poor joint reposition sense. Therefore, careful evaluation and observation will be required concerning stroke patients with long-term cane usage.

• 한국전문물리치료학회지
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• 제24권2호
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• pp.58-65
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• 2017

Background: Children with cerebral palsy (CP) have impaired postural control, but critically require the control of stability. Consequently, therapeutic interventions for enhancing postural control in children with CP have undergone extensive research. One intervention is sensorimotor training (SMT) using a Flexi-bar, but this has not previously been studied with respect to targeting trunk control in children with CP. Objects: This study was conducted to determine the effect of SMT using a Flexi-bar on postural balance and gait performance in children with CP. Methods: Three children with ambulatory spastic diplegia (SD) participated in the SMT program by using a Flexi-bar for forty minutes per day, three times a week, for six weeks. Outcome variables included the pediatric balance scale (PBS), trunk control movement scale (TCMS), 10 meter walking test (10MWT), and 3-dimensional movement coordination measurement. Results: The SMT provided no statistically significant improvement in PBS, TCMS, 10MWT, or 3-dimensional movement coordination measurement. However, positive changes were observed in individual outcomes, as balance and trunk control movement were improved. Conclusion: SMT using a Flexi-bar may be considered by clinicians as a potential intervention for increasing postural balance and performance in children with SD. Future studies are necessary to confirm the efficacy of Flexi-bar exercise in improving the functional activity of subjects with SD.

• 한국전문물리치료학회지
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• 제13권1호
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• pp.54-60
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• 2006

This study aimed to compare movement patterns of shoulder joints between the right and left symmetry in stroke patients and control subjects. This study proposes use of the voluntary response index (VRI) calculated from quantitative analysis of surface electromyographic (sEMG) and motion data recorded during voluntary movement as a feeding task. The VRI is comprised of two numeric values, one derived from the total muscle activity recorded for the voluntary motor task (magnitude), and the other from the sEMG distribution across the recorded muscles with the similarity index (SI). Five stroke patients and five age-matched healthy controls were recruited. Feeding motion was performed using the provided spoon five times with rests taken on a chair in between tasks. EMG data were digitized and analyzed on the basis of the root mean square (RMS) envelope of activity. The average amplitude of responses was calculated. Responsiveness and clinically meaningful levels of discrimination between stroke patients and control for EMG magnitude and SI were determined. The similarity index of the results from two successive examinations of both sides apart for stroke patients and control subjects were .86 and .95 in motion analysis and .84 and .99 in electromyographic analysis. The SI of sEMG data and motion data was significantly correlated in stroke patients. The data suggest that SI is a sensitive program for comparing and analyzing the symmetry of muscle activity and motion in both sides. This analysis method has a clinical value in grading muscular activity and movement impairment after brain injury.

• 약학회지
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• 제50권6호
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• pp.429-435
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• 2006

The antidepressant effects of Cirsium japonicum compositae was investigated using open field test and forced swimming test. Total extract of Cirsium japonicum (CJ) was orally administered at dose of 20, 100, 300, 500 mg/kg bodyweight. Supplementation of CJ increased dose-dependently movement, rearing frequency and total turn angle in the center area of open field in mice. Treatment of Cirsium japonicum's extract (300 mg/kg, CJ) decreased immobile duration and increased mobile and strong mobile duration significantly; and it is comparable to that of imipramine and fluoxetine. These results indicate that CJ has antidepressant effect. Treatment of CJ did not induced any impairment in motor coordination and myorelaxation. These results indicate that the constituents or its complex of Cirsium japonicum could be a candidate of new antidepressant drug.

• 재활치료과학
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• 제5권2호
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• pp.23-33
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• 2016

목적: 본 연구는 노인의 인지기능과 상지기능의 관련성을 알아보고자 하며, 근거 자료들을 P.I.C.O. 방법에 따라 제시하였다. 연구방법: 2015년 11월부터 2016년 1월까지 연구를 진행하였으며 2000년 1월부터 2015년 10월까지 국외 학술지에 개재된 논문을 Medline과 PubMed를 통하여 검색하였다. 검색용어로는 elderly, dementia, Alzheimer's disease, Mild cognitive impairment, age-related, aging, cognitive, upper extremity function, hand function, hand-grip strength, grip force, complex motor function, bimanual, dexterity, UE performance, coordination을 사용하였다. 연구결과: 본 고찰에 포함된 총 8개의 연구 중 7개의 연구에서 상지기능이 노화에 따라 영향을 받는다는 것으로 나타났고, 1개의 연구에서는 노화에는 영향을 받지 않으나, 쥐기 힘 및 성별에 의해 물건조작능력에 영향을 받는 것으로 나타났다. 연구 분석 결과 노인 및 치매환자의 인지기능이 상지기능에 영향을 미치며 상호 관련성을 보였다. 결론: 본 연구는 노인을 대상으로 인지기능이 상지기능에 미치는 영향 및 관련성을 알아보고자 하였으며, 인지기능 정도에 따른 작업치료 적용 및 중재기법을 선택하는데 근거 자료로 활용될 수 있을 것으로 사료된다. 향후 국내 연구에서는 다양한 평가도구를 사용하고 질적 수준이 높은 연구들이 체계적으로 이루어져야 할 것이다.

• 인간행동과 음악연구
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• 제16권1호
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• pp.47-72
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• 2019

본 연구는 자폐스펙트럼장애(ASD) 아동의 운동조절을 평가하기 위해 리드믹 운동과제를 포함한 국외 실험연구를 고찰하고 분석하고자 하였다. 이를 위해 ASD로 진단받은 아동과 신경학적 손상이 없는 대조군(TD)을 대상으로 하고 리드믹 탭핑, 리드믹 운동, 동기화 등 운동조절 관련 변인을 포함하고 있는 국외 실험연구를 선정하였다. 총 10개의 연구가 최종 선정되었고, 해당 연구에 포함된 운동조절 관련 변인과 사용된 청각 자극, 측정 방법 등을 분석하였다. 또한 ASD 아동과 TD 아동의 리드믹 운동과제 수행력 차이를 확인하기 위해 메타분석을 실시하였다. 연구 결과, 리드믹 운동과제를 통해 운동조절을 평가할 때 목표된 변인은 다섯 가지로 운동 타이밍 조절, 타이밍 재산출, 양손 협응, 동기화, 대인 간 동기화가 포함되었고, 각 과제는 움직임의 정확도(accuracy)와 정밀도(precision)의 측면에서 분석됨을 알 수 있었다. 또한 리드믹 운동과제 수행력과 사회기술 지표의 상관관계가 보고됨을 확인할 수 있었다. 메타분석 결과, ASD 그룹은 청각 자극에 맞추어 움직이다가 자극이 소거된 후에도 동일한 움직임을 지속하는 타이밍 재산출 지표에 있어서는 TD 그룹과 유의한 차이가 없는 반면, 외부 자극(청각적 큐나타인)에 동기화하고 움직임을 일관적으로 조절하는 데 있어서는 유의하게 낮은 수행 수준을 보이는 것으로 나타났다. 이러한 연구 결과는 리드믹 운동과제가 음악치료 임상 현장에서 ASD 아동의 운동조절뿐만 아니라 사회기술을 평가하는 효과적인 방안이 될 수 있음을 시사한다.

• 인간행동과 음악연구
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• 제20권1호
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• pp.75-97
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• 2023

본 연구에서는 학령전기 자폐스펙트럼장애(ASD) 아동을 대상으로 인지-운동 통합 기반 악기연주 중재를 제공하여 초기 사회기술이 향상하는지를 알아보고자 하였다. 대상자는 평균 만5.6세의 ASD 아동 총 9명로, 개별로 30분씩 주 2회, 총 12회의 세션에 참여하였다. 중재는 자기 감각 증진 및 자기조절(1단계), 상호작용에 대한 의도 형성(2단계), 상호적 활동에 대한 수용(3단계), 상호적 맥락에서의 움직임 조정(4단계), 공동행동 수행(5단계)의 5단계로 구성되었다. 중재 전후 초기 사회-의사소통 평가 척도(ESCS) 내 과제를 참고해 공동주의 행동 및 상호작용 행동을 측정하였고, 참여 아동의 보호자가 사회적 반응성 척도(SRS-2)를 평정하도록 하였다. 또한, 타인(연구자)에 맞추어 움직임(드럼 연주)의 타이밍을 조절하는지 측정하는 사회적 동기화 과제를 실시하였다. 연구 결과, 참여 ASD 아동은 초기 사회기술에 있어 유의한 향상을 보였고, 사회적 동기화 과제에서도 동기화 반응 속도를 제외한 동기화 정확도 및 지속시간에 있어 유의한 향상이 나타났다. SRS-2 척도에서는 유의한 차이가 나타나지 않았는데 이는 장기간 개입이 필요함을 시사한다. ASD 아동의 초기 사회기술 발달에 있어 인지-운동 통합이 중요한 역할을 하는 점을 고려할 때, 본 연구 결과는 인지-운동 통합 기반 악기 연주가 사회적 정보를 인지적으로 처리하고 이를 바탕으로 사회적 맥락에서 움직임을 조정하는 과정의 측면에서 ASD 아동의 사회기술 발달 증진을 위한 효과적인 방안이 될 수 있음을 시사한다.

• The Journal of Korean Physical Therapy
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• 제20권3호
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• pp.9-18
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• 2008

Purpose: We determined the effect of global synkinesis(GS) on gait ability, muscle contraction, and central neuron action potentials in post-stroke hemiplegic subjects. Methods: Thirty hemiplegia patients were evaluated for walking ability, muscle contraction, central neuron action potential, and comparing differences between the H-GS(high-global synkinesis) group and L-GS(low-global synkinesis) group. To obtain the GS level, surface electromyography(EMG) data were digitized and processed to root mean square(RMS). Walking ability was tested with a modified motor assessment scale(MMAS), a 10 m walking test, timed up and go(TUG) test, and a Fugl-Meyer assessment(FMA). Muscle contraction ability was measured as maximal isometric contraction(MIC) peak, MIC slope, and MIC ramp up using mechanomyography(MMG). Central neuron action potential was measured as the H/Mmax ratio or V/Mmax ratio using EMG. The data were analyzed with t-tests to determine the statistical significance. Results: MMAS(p<0.01), 10 m walking velocity(p<0.01), TUG(p<0.01), FMA-HKA(Hip, Knee, Ankle)(p<0.05), FMA-coordination(p<0.05), MIC peak (p<0.05), MIC slope(p<0.01), and MIC ramp up(p<0.05) were significantly different between H-GS and L-GS, as was the V/Mmax ratio(p<0.05), but H/Mmax was not. Conclusion: Lower GS levels indicated better walking ability and motor function. Therefore, intervention programs should consider GS levels in gait training of chronic hemiplegia.