• Natural Product Sciences
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• v.25 no.3
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• pp.268-274
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• 2019

Morus alba L., known as white mulberry, is a medicinal plant belongs to family Moraceae. It has long been used commonly in Ayurvedic for the treatment of lung-heat, cough, asthma, hematemesis, dropsy and hypertension. In the present study, seven prenylated flavonoids, along with four benzofuran compounds were isolated by means of repeated column chromatography. The structures of the known compounds were identified as kuwanon G (1), kuwanon E (2), kuwanon T (3), morusin (4), sanggenon A (5), sanggenon M (6), sanggenol A (7), moracin R (8), mulberofuran G (9), mulberofuran A (10) and mulberofuran B (11), by comparing their spectroscopic data with those reported in the literature. For these isolates, containing trace compounds, the inhibitory activity against IL-6 production in $TNF-{\alpha}$ stimulated MG-63 cells was examined. All isolated compounds (1 - 11) showed excellent inhibitory activity against IL-6 production in $TNF-{\alpha}$ stimulated MG-63 cells. Especially this study is first time to report that sanggenon A (5), sanggenon M (6), sanggenol A (7), mulberofuran G (9), mulberofuran A (10) and mulberofuran B (11) showed the inhibitory activity of IL-6 production. Our study suggested the possibility of anti-inflammatory regulation by compounds (1 - 11) isolated from M. alba.

• Bulletin of the Korean Chemical Society
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• v.34 no.8
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• pp.2528-2530
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• 2013

• Archives of Pharmacal Research
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• v.12 no.1
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• pp.39-41
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• 1989

From the stem of Cudrania tricuspidata, ${\beta}$-sitosterol, ${\beta}$-sitosterol glucoside, arthocarpesin, norarthocarpetin, and 5-O-methyl genistein were isolated and characterized by spectral data.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3071-3075
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• 2016

Morin, a flavonoid found in figs and other Moraceae species, displays a variety of biological actions, exerting anti-oxidant, anti-inflammatory and anti-carcinogenic effects. Here, we investigated the anti-cancer activity of morin focusing on anti-adhesive influence. We performed experiments with MDA-MB-231 human breast cancer cells. Morin inhibited TNF-induced cancer cell adhesion to human umbilical vein endothelial cells (HUVECs) without showing any toxicity. It further inhibited the expression of VCAM-1 on MDA-MB-231 cells as well as HUVECs. Morin also decreased the expression of N-cadherin on MDA-MB-231 cells. In addition, there was apparent anti-metastatic activity in vivo. In conclusion, this study suggested that morin inhibits cancer cell adhesion to HUVECs by reducing VCAM-1, and EMT by targeting N-cadherin, and that it features anti-metastatic activity in vivo. Further investigation of possible anti-metastatic activity of morin against human breast cancer cells is warranted.

• Korean Journal of Plant Resources
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• v.1 no.1
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• pp.93-116
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• 1988

The plants medicinal resourees of Mt. Joghe were investigeted 10 times from January, 1988 to October, 1988. In order to analyze the vegetation of Joghemountain area, herb plants structure and distribution. Herb plants of Joghe moun-tain consisted of 102 families, 265 species in all. The resources of important herbdrugs were Gramineae, Cyperaceae Oleaceae, Araceae, Polygonaceae, Caryophyllaceae,Ranunculaceae, Theaceae, Cruciferae, Liliaceae, Rosaceae, Geranjaceae, Violaceae,Vitaceae, Umbelliferae, Labiatae, Solanaceae, Campanulaceae, Rutaceae, Compositae,Dioscoreaceae, Fagaeeae, Moraceae, Anacardiaceae, Legum inosae, Cupressaceae, andJuelandaceae. The herb drugs were comparatively more than in other mountains inour country.

• Korean Journal of Pharmacognosy
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• v.39 no.3
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• pp.246-248
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• 2008

Six prenylated xanthones, cudraxanthone B (1), isocudraxanthone K (2), cudraxanthone H (3), cudratricusxanthone A (4), cudraxanthone L (5) and macluraxanthone B (6), have been isolated from the MeOH extract of Cudrania tricuspidata root barks. The evaluation for antibacterial effect of compounds 1-6 against the pathogenic microorganisms concerning with public health or zoonosis was conducted. Of these, compound 4 showed significant antibacterial effect in disk diffusion method.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1992.05a
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• pp.19-19
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• 1992

해를 거듭할수록 증가추세에 있는 악성종양은 우리나라의 3대 사망원인 질환의 하나이다. 그러나 현재 암의 화학적 치료법은 40여종의 암치료제가 주종을 이루고 있으나 그 효과면에서 한계점에 도달하고 있어 식물추출물, 해양식물, 미생물 등으로부터 얻어지는 천연물 성분에서 강력하고 부작용이 적은 항암제를 발굴하기 위한 연구가 국내외에서 많이 수행되고 있다. 본 연구는 파푸아뉴기니아산 열대식물 13과 23종의 항암작용을 검색할 목적으로 실시하였는데, 실험동물은 ICR계의 암컷생쥐를 이용하였으며 Sarcoma 180 동물복수암세포에 대한 열대 식물 엑스 투여에 의한 수명 연장 효과를 측정함으로써 항암작용의 지표로 삼았다. 항암작용의 지표는 ILS(Increased Life Span)를 사용하였으며 ILS가 20％이상인 것을 항암성이 있는 것으로 간주하였다. 실험의 결과 Apocynaceae에 속하는 Plumiera rubra의 줄기껍질 및 잎 추출물 Leguminosae과의 Pterocarpus indicus의 잎 추출물과, 같은 과의 Derris trifoliata, Moraceae과의 Artocarpus altilis의 뿌리 및 줄기 껍질, 잎 추출물과 Sterculiaceae과의 Kleinhovia hospita의 잎 추출물, Verbenaceae과의 Vitex trifolia의 5과 5종 8시료가 의의있는 항암작용이 있는 것으로 나타났다.

• Korean Journal of Plant Taxonomy
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• v.40 no.1
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• pp.74-77
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• 2010

The Illam district, situated in the extreme North Eastern part (Latitude 26.58N and 87.58E Longitude) of Nepal, is a hot spot for floral diversity. The study of wild edible plants of this region was an attempt to highlight the types of wild flowering plants found there and mode of use by the people of the Illam hills. In this respect, a survey of natural resources of some of the representative regions of the district was undertaken and more than 74 major varieties of plant species were found to be used frequently by the people of the hills. The rich diversity occurring in Dioscoriaceae, Moraceae, Rosaceae, Myrtaceae, Poaceae, Urticaceae and Arecaceae provided the wild angiospermic species commonly used by the people of the hills.

• Korean Journal of Plant Taxonomy
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• v.49 no.4
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• pp.282-293
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• 2019

Broussonetia × kazinoki Siebold has long been utilized as a major component in the manufacturing of Korean traditional paper, hanji, and has been suggested as a hybrid species of B. papyrifera and B. monoica. By applying three molecular markers, chloroplast (cp) ndhF-rpl32 IGS, a nuclear ribosomal internal transcribed spacer, and the TOPO6 gene, the hybrid origin of B. × kazinoki is tested. As a result, B. × kazinoki in Korea is demonstrated to be a hybrid of B. monoica × B. papyrifera, most likely formed naturally in Korea. The cp haplotypes detected provided information about the origins and genetic diversity of the maternal lineage B. monoica and paternal lineage B. papyrifera. The two nuclear markers were supplemented to each other, leading to the discovery of introgression in Broussonetia.

• Korean Journal of Pharmacognosy
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• v.48 no.2
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• pp.155-159
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• 2017

Cudrania tricuspidata Bureau (Moraceae) is a traditional oriental medicine that has been widely used as anti-oxidant, anti-inflammatory and immunomodulatory in Korea. This study was performed that the 70% ethanol extract of the roots of C. tricuspidata (CTE) suppressed receptor activator of NF-${\kappa}B$ ligand (RANKL)-induced osteoclastogenesis, actin ring formation in RAW 264.7 cell lines. CTE significantly inhibited the JNK/mitogen-activated protein kinase (MAPK) signaling pathway without affecting ERK and p38 signaling in RANKL-stimulated RAW 264.7 cells. Also, CTE inhibited RANKL-induced expression of c-Fos, an upstream activator of NFATc1. Consequently, CTE suppresses osteoclast differentiation by inhibiting RANKL induced MAPK signaling pathways and disrupts the actin rings in mature osteoclasts. Thus, CTE can be used for the development of osteoporosis treatment drug with a natural material.