• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.1
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• pp.28-40
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• 2014

Objectives: This study was to evaluate the single dose toxicity of Sobokchuko-tang (SBC) in male and female mice. Methods: Aqueous extract of SBC (yield=6.60%) was administered to female and male mice as an oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) Guidelines. Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after dosing, upon necropsy; organ weight and histopathology of 14 principle organs were also examined. Results: we could not find any SBC treatment related mortality and clinical signs, changes in the body and organ weights, gross findings and changes in histopathology of principle organs, except for pharmacological immunomodulatory effects related findings including significant increases of submandibular lymph node weights, hypertrophy and hyperplasia of lymphoid cells in the submandibular lymph nodes restrictly detected in 2,000 mg/kg treated female and male mice with some sporadic accidental findings. Conclusions: The results obtained in this study suggest that the 50% lethal dose and approximate lethal dose of SBC aqueous extracts in both female and male mice were considered as over 2,000 mg/kg, the limited highest dosage recommended by KFDA Guidelines, and can be safety used in clinics.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.1
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• pp.191-197
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• 2012

In this paper we propose the FQSM(Fairness and QoS Supporting MAC) protocol that supports fairness and Quality of Service(QoS). The received or measured data traffics will be assigned a priority level according to its transmission urgency in the FQSM. And the load prediction algorithm is used to support the fairness between different priority traffics. For this, the buffer length values of the nodes are continuously monitored for a some period. Based on the buffer length variations for this period, the order of transmission is determined. FQSM also adapts cross-layer concept to rearrange the data transmission order in each sensor node's buffer, saves energy consumption by allowing few nodes in data transmission, and prolongs the network lifetime.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4263-4266
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• 2012

Colorectal cancer has become a major disease threatening human health. To establish animal models that exhibit the characteristics of human colorectal cancer will not only help to study the mechanisms underlying the genesis and development effectively, but also provide ideal carriers for the screening of medicines and examining their therapeutic effects. In this study, we established a stable, colon cancer nude mouse model highly expressing green fluorescent protein (GFP) for spontaneous metastasis after surgical orthotopic implantation (SOI). GFP-labeled colon cancer models for metastasis after SOI were successfully established in all of 15 nude mice and there were no surgery-related complications or deaths. In week 3, primary tumors expressing GFP were observed in all model animals under fluoroscopy and two metastatic tumors were monitored by fluorescent imaging at the same time. The tumor volumes progressively increased with time. Seven out of 15 tumor transplanted mice died and the major causes of death were intestinal obstruction and cachexia resulting from malignant tumor growth. Eight model animals survived at the end of the experiment, 6 of which had metastases (6 cases to mesenteric lymph nodes, 4 hepatic, 2 pancreatic and 1 mediastinal lymph node). Our results indicate that our GFP-labeled colon cancer orthotopic transplantation model is useful with a high success rate; the transplanted tumors exhibit similar biological properties to human colorectal cancer, and can be used for real-time, in vivo, non-invasive and dynamic observation and analysis of the growth and metastasis of tumor cells.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.11
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• pp.2736-2744
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• 2013

In this paper, we present a Smart Water Treatment Plant using Zigbee USN devices and a real-time monitoring system in K-water Flow Meter Calibration Center Building. For verification, the data of vertical type WTP such as flow rate, pressure, water level and water temperature are obtained by the Zigbee USN devices, operating in 2.45 GHz band, and be wirelessly surveilled by the real-time monitoring system. The received data from the sensor is transmitted to the data processing device, and then the processed data can be monitored on a smart phone. Consequently, the pilot plant based on the low-cost and high-efficiency USN has been developed with the performance analysis for the communication network and remote monitoring system on mobile devices.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6889-6892
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• 2013

Background: Testicular germ cell tumors (TGCTs) are a relatively common malignancy in young men. The aim of this study was to investigate the clinicopathological features and survival of young Turkish patients with TGCT. Materials and Methods: In this retrospective study, the clinical and pathological characteristics of young Turkish patients with TGCT who were monitored by the Department of Medical Oncology of a military hospital between 2008 and 2013 were investigated. Overall survival data were analyzed. Results: Ninety-six patients were included in the study. The mean age was 26.4 years. Among the patients, 17.7% had seminoma and 43.8% had mixed non-seminomatous germ cell tumors. Some 46.9% were Stage I, 30.2% were Stage II, and 22.9 were Stage III. Of the patients, 83.3% received chemotherapy, 25% underwent retroperitoneal lymph node dissection (RPLND), 3.1% received radiotherapy, and 12.5% were followed-up without treatment. In addition, 18.8% of the patients were administered salvage chemotherapy due to relapse or progression. The 5-year overall survival rate was 90.2% for all patients. The 2-year overall survival rate was 100% for Stage I patients, 94% for Stage II patients, and 70.2% for Stage III patients. The difference between the survival curves of stages was statistically significant (p=0.029). Conclusions: In young Turkish patients with TGCT, good results were obtained with appropriate treatment, most receiving chemotherapy. The prognosis of the disease was good even in the advanced stage.

• Smart Structures and Systems
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• v.14 no.1
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• pp.39-54
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• 2014

Node layout optimization of structural wireless systems is investigated as a means to prolong the network lifetime without, if possible, compromising information quality of the measurement data. The trade-off between these antagonistic objectives is studied within a multi-objective layout optimization framework. A Genetic Algorithm is adopted to obtain a set of Pareto-optimal solutions from which the end user can select the final layout. The information quality of the measurement data collected from a heterogeneous WSN is quantified from the placement quality indicators of strain and acceleration sensors. The network lifetime or equivalently the network energy consumption is estimated through WSN simulation that provides realistic results by capturing the dynamics of the wireless communication protocols. A layout optimization study of a monitoring system on the Great Belt Bridge is conducted to evaluate the proposed approach. The placement quality of strain gauges and accelerometers is obtained as a ratio of the Modal Clarity Index and Mode Shape Expansion values that are computed from a Finite Element model of the monitored bridge. To estimate the energy consumption of the WSN platform in a realistic scenario, we use a discrete-event simulator with stochastic communication models. Finally, we compare the optimization results with those obtained in a previous work where the network energy consumption is obtained via deterministic communication models.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2006.05a
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• pp.513-514
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• 2006

Recently intradiscal electrothermal therapy is introduced, which is a new and minimally invasive technique fer the treatment of discogenic low back pain. This procedure involves the percutaneous threading of a flexible catheter into the disc under fluoroscopic guidance. The catheter, composed of thermal resistive coil, heats the posterior annulus of the disc, causing contraction of collagen fibers and destruction of afferent nociceptors. This study tries to investigate the effects of the important factors of this procedure such as heat source temperature and heat applying time on the temperature distribution within the intervertebral disc. This study utilized both computer simulation and the experiment for the verification of finite element analysis. FE analysis was carried out with ANSYS v7.0 (ANSYS Inc, USA) using 10,980 number of brick element and 12,551 number of node. The functional spinal units of 5 month old swine were used for the experiment and the temperature was monitored using 10 channel temperature measurement device MV200. Through this study, it was able to analyze the temperature range of inner intervertebral disc by two mechanisms which are known to alleviate pain clinically. The results showed that when the heat source temperature was kept up 80 degree for 1,020 seconds, the temperature of inner annulus reached at 45 degree up to the distance of 15.6mm from heat source, which explains coagulation of inner annulus by heat. When the same heat source was used, the temperature of inner nucleus reached at 60 degree up to the distance of 9mm from heat source, which explains contraction of inner nucleus by heat.

• Journal of KIISE:Computing Practices and Letters
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• v.12 no.1
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• pp.21-30
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• 2006

As the amount of information to be processed by computers has recently been increased, there has been cluster computing systems developed by connecting PCs and workstations using high-speed networks. hs a result, the studies on a cluster-based DBMS have been done with a wide range and it is necessary to develop a cluster manager for monitoring and managing cluster-based DBMSs. But, a cluster manager for efficiently managing cluster-based DBMSs has been studied in a first step. In this paper, we design and implement a high-availability cluster manager for a cluster-based DBMS. It monitors the status of nodes in cluster systems as well as the status of DBMS instances in a node, by using a graphic user interface (GUI). Our cluster manager supports the high-availability for a cluster-based DBMS by perceiving errors and recovering them, based on the monitored information on the status of a server.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2010.05a
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• pp.223-225
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• 2010

In order to minimize the casualties and damages from natural disasters, local terrain and weather phenomena need to be constantly monitored. Various weather monitoring systems are designed to collect and monitor the weather information for disaster prevention. Nowadays, wireless sensor networks have been widely used to transmit the weather information and collected by the base station at a regular interval. In this paper, disaster prevention monitoring system for efficient data transfer of weather information such as temperature, humidity and illumination are designed. Weather information is able to burst the data transmission based on storage of flash memory. Telosb sensor node are used in the research; programmed by nesC language used by TinyOS.

• The Journal of Korean Institute of Information Technology
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• v.16 no.12
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• pp.57-68
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• 2018

A system to prevent disasters by collecting and analyzing environmental information such as road surface sedimentation, sinkholes, collapse risk of bridges, temperature and humidity around tram station is continuously monitored by monitoring the condition of road surface when constructing tram which is one of the urban railways. In this paper, we propose a wireless network security management system for tram roads based on LPWA that can recognize risk factors of road surface, bridge and tram station of tram in advance and prevent risk. The proposed system consists of a sensor node that detects the state of the tram road surface, a gateway that collects sensor information, and a safety management system that monitors the safety and environmental conditions of the tram road surface, and applies the low power long distance communication technology. As a result of comparing the proposed system with the LTE system in the field test, it was confirmed that there is no significant difference between the sensor information value and the critical alarm level in the monitoring system.