• Proceedings of the Korean Vacuum Society Conference
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• 2007.02a
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• pp.116-116
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• 2007

• Proceedings of the Korean Vacuum Society Conference
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• 2007.02a
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• pp.117-117
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• 2007

• Proceedings of the Korean Vacuum Society Conference
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• 2007.08a
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• pp.269-269
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• 2007

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.17 no.5
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• pp.111-116
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• 2018

Thermal fusion bonding is a method to enclose open microchannels fabricated on polymer chips for use in lab-on-a-chip (LOC) devices. Polymethyl methacrylate (PMMA) is utilized in various biomedical-microelectromechanical systems (bio-MEMS) applications, such as medical diagnostic kits, biosensors, and drug delivery systems. These applications utilize PMMAs biochemical compatibility, optical transparency, and mold characteristics. In this paper, we elucidate both the conformational entanglement of PMMA molecules at the contact interfacial regime, and the qualitative nature of the thermal fusion bonding phenomena through systematic molecular dynamics simulations.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.24 no.2
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• pp.160-165
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• 2015

The 14k, 45k, and 70k Mw PCL have different crystallization temperatures and therefore have slightly different characteristics affecting the fiber diameter. To observe these behaviors, the fiber was produced at every step of $10^{\circ}C$ for each molecular weights and the diameter was measured. Moreover, the fiber was fabricated over the cooled ground plate to observe the change in fiber diameter in comparison to the normal ground plate. In case of molecular Mw 14k PCL, the diameter increased as the temperature increased. For Mw 45k PCL, the fiber diameter decreased as the temperature increased. As of Mw 70k PCL, the fiber diameter decreased with increasing temperature as well. When the experiment was conducted over the cooled collector plate, the data did not change significantly from the previous lexperiments.

• Journal of the Korean Society for Precision Engineering
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• v.20 no.4
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• pp.12-19
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• 2003

• Molecules and Cells
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• v.45 no.5
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• pp.284-290
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• 2022

Exosome, a type of nanoparticles also known as small extracellular vesicles are gaining attention as novel therapeutics for various diseases because of their ability to deliver genetic or bioactive molecules to recipient cells. Although many pharmaceutical companies are gradually developing exosome therapeutics, numerous hurdles remain regarding manufacture of clinical-grade exosomes for therapeutic use. In this mini-review, we will discuss the manufacturing challenges of therapeutic exosomes, including cell line development, upstream cell culture, and downstream purification process. In addition, developing proper formulations for exosome storage and, establishing good manufacturing practice facility for producing therapeutic exosomes remains as challenges for developing clinical-grade exosomes. However, owing to the lack of consensus regarding the guidelines for manufacturing therapeutic exosomes, close communication between regulators and companies is required for the successful development of exosome therapeutics. This review shares the challenges and perspectives regarding the manufacture and quality control of clinical grade exosomes.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.13 no.1
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• pp.43-49
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• 2005

There are several ways to mold the complex material, and it is divided to vacuum pack mold, compression mold, and hand lay up for a high molecular substance as a basic material. Moreover, it can be divided to general manufacturing (Single form) and mold manufacturing(Mold form) under normal temperature for Firefly. Firefly was manufactured with hand lay up and general manufacturing that using the foam core, glass fabric, and template without mold. However, mold manufacturing that is producing the surface by semi-sandwich using thin foam core and glass fabric then reinforce the inside with spar and rib is on developing. Mold manufacturing can make easy to production, standardize the quality, and possible to mass producing. In this paper, we present the mold producing process for canard aircraft "Firefly", and the problems and solutions during producing Firefly. Moreover, it complements the defect that the problems caused by master manufacturing error when produce several masters of a large part, and make the manufacturing process to be shortened by the replacement from the supplementary plate to the foam that is installed when producing lay up mold.

• Design & Manufacturing
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• v.17 no.3
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• pp.28-33
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• 2023

The conventional FRP (Fiber Reinforced Plastic) manufacturing process used thermoset resins for ease of molding but faced the issue of non-recyclability. To address these shortcomings, a new process utilizing thermal plastic resin was developed. However, due to the high viscosity of thermal plastic resin, problems such as fiber deformation and a reduced fiber volume fraction occurred during the high-temperature, high-pressure process. In this study, to overcome the limitations of the conventional process, fiber-reinforced composite materials were manufactured through in-situ polymerization using PLA (Poly L-Lactide) resin in the VA-RTM (Vacuum Assistance Resin Transfer Molding) process. The fiber volume of the produced specimens was calculated, and resin impregnation and porosity were confirmed through optical microscopy. Additionally, molecular weight analysis using GPC (Gel Permission Chromatography) demonstrated improvements over the conventional process and emphasized the essential requirement of temperature control.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.2 no.2
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• pp.137-142
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• 2016

We have successfully synthesized of 4-cyano-1-(2,4-dichlorophenyl)-5-(4-[$^{11}C$]methoxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxzmide ([$^{11}C$]OMAR), which has been shown a progressing candidate to human brain PET study, from fully automated loop method using ethanol as the only solvent for the entire manufacturing process. The radiochemical yield of [$^{11}C$]OMAR was observed in $4.1{\pm}0.2%$ with $4990{\pm}384Ci/mmol$ of the specific activity and total synthesis time was about 45 minutes after HPLC purification (n = 3, decay corrected) from ethanolic loop system, which was exhibited to better results compared with conventional methods. Ethanolic loop chemistry is favorable and efficient method by simplifies manufacturing procedures as well as satisfied suitable for human administration.