• Molecules and Cells
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• 제26권4호
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• pp.350-355
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• 2008

Chk2 is a well characterized protein kinase with key roles in the DNA damage response. Chk2 is activated by phosphorylation following DNA damage, and relays that signal to various substrate proteins to induce cell cycle arrest, DNA repair, and apoptosis. In order to identify novel components of the Chk2 signaling pathway in Drosophila, we screened 2,240 EP misexpression lines for dominant modifiers of an adult rough eye phenotype caused by Chk2 overexpression in postmitotic cells of the eye imaginal disc. The rough eye phenotype was suppressed by mutation of the ATM kinase, a well-described activator of Chk2. Twenty-five EP modifiers were identified (three enhancers and 22 suppressors), none of which correspond to previously known components of Chk2 signaling. Three EPs caused defects in G2 arrest after irradiation with incomplete penetrance when homozygous, and are likely directly involved in the response to DNA damage. Possible roles for these modifiers in the DNA damage response and Chk2 signaling are discussed.

• Bulletin of the Korean Chemical Society
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• 제13권2호
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• pp.110-112
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• 1992

• Asian-Australasian Journal of Animal Sciences
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• 제13권1호
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• pp.86-95
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• 2000

Animal feed additives are used worldwide for many different reasons. Some help to cover the needs of essential nutrients and others to increase growth performance, feed intake and therefore optimize feed utilization. They can positively effect technological properties and product quality. The health status of animals with a high growth performance is a predominant argument in the choice of feed additives. In many countries the use of feed additives is more and more questioned by the consumers: substances such as antibiotics and $\beta$-agonists with expected high risks are banned in animal diets. Therefore, the feed industry is highly interested in valuable alternatives which could be accepted by the consumers. Probiotics, prebiotics, enzymes and highly available minerals as well as herbs can be seen as alternatives to metabolic modifiers and antibiotics.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2015년도 제49회 하계 정기학술대회 초록집
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• pp.66.2-66.2
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• 2015

There is the urgent need of new human health care's technology against cancers or tumors based on plasma electronics, medicine and biology. Main target of our study is to enhance efficacy and selectivity of plasma on cancer cells with metabolic modifiers and by inducing immune-modulations. We have evaluated the combination effect of plasma with metabolic modifiers (2-DG) on various solid and liquid cancers. Our findings suggest that 2-DG enhances the efficacy and selectivity of plasma and induces apoptosis in blood cancer cells through glucose deprivation. Finally, we conclude that 2-DG with non-thermal plasma may be used as a combination treatment against cancer cells. Our work also comprises plasma induced activation of immune cells; which find applications for curing various kinds of resistant tumors and other dreadful diseases. Plasma significantly activates immune cells which increases cell death in solid tumors in co-culture conditions.

• Molecules and Cells
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• 제41권4호
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• pp.264-270
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• 2018

Cells cope with diverse intrinsic and extrinsic stimuli in order to make adaptations for survival. The epigenetic landscape plays a crucial role in cellular adaptation, as it integrates the information generated from stimuli. Signaling pathways induced by stimuli communicate with chromatin to change the epigenetic landscape through regulation of epigenetic modifiers. Metabolic dynamics altered by these stimuli also affect the activity of epigenetic modifiers. Here, I review the current understanding of epigenetic regulation via signaling and metabolic pathways. In addition, I will discuss possible ways to achieve specificity of epigenetic modifications through the cooperation of stimuli-induced signal transduction and metabolic reprogramming.

• Journal of Photoscience
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• 제1권1호
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• pp.63-66
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• 1994

Silver chlorobromoiodide cubic seed emulsion was prepared'in the presence of ammonia and phenylcarbamyl gelatin solution. When benzenethiosulfonate sodium salt (BTS) and 4-hydroxy6-methyl-1,3,3a,7-tetraazaindene (TAI), as growth modifiers, were added in the seed emulsion, the silver halide microcrystals were obtained in the forms of cubo-octahedrons, octahedrons, rhombic dodecahedron by variation of pAg value through controlled double jet. The crystal habits and shapes were determined by means of X-ray diffraction (D/MAX BIB, Rigaku) and electron microscopy (JSM-840, JEOL), respectively.

• 한국고분자학회:학술대회논문집
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• 한국고분자학회 2006년도 IUPAC International Symposium on Advanced Polymers for Emerging Technologies
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• pp.95-96
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• 2006

Surface modification of clay minerals has become increasingly important for improving the practical applications of clays such as polymeric nanocomposites. We used the copolymer as modifiers having phenyl components, and successfully developed a route for the preparation of amine functionalized polymer based on oligostyrene and its block copolymers. The oligo(St-co-VBC)s with controlled molecular weight were synthesized via nitroxide mediated polymerization method. We also successfully prepared organophilic layered silicates whose surface is covered with styrenic copolymers. Through the analysis of chemical structure and morphology, we concluded that copolymers were very effective organic modifiers to change the surface characteristics of layered silicates.

• The Journal of the Acoustical Society of Korea
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• 제22권2E호
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• pp.56-61
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• 2003

Recently a number of social surveys on community response to environmental noises have been conducted to summarize response relationship obtained from different areas. Some problems have been pointed out in comparing the result of surveys using verbal scales with different number of categories. ICBEN (International Commission on Biological Environment of Noise) Team 6 planned a international joint study and constructed comparable standardized noise annoyance scales using the same method. In Korea the survey was conducted in four areas such as Seoul, Taejon, Taegu, Kwangju. About 100 subjects participated in each area approximately. Finally five verbal annoyance were constructed as follows; 1 (Jeonhyu), 2 (Jokm), 3 (Bikyojerk), 4 (Ajoo), 5 (Umcheongnage).

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2005년도 추계 학술발표회 제17권2호
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• pp.793-797
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• 2005

This study was undertaken to examine the feasibility of recycling waste concrete fine aggregate to prepare polymer-modified mortars. The specimens of polymer-modified mortars were prepared by using styrene-butadiene rubber(SBR) latex and polyacrylic ester(PAE) emulsion as a polymer modifier. The formulations for specimens were prepared with various replacing ratios of waste concrete fine aggregates as parts of standard sand and various polymer cement ratios. For the evaluation of the performance of polymer-modified mortars, various physical properties were investigated. As a results, water cement ratio of polymer-modified fresh mortars increased with an increase of recycled fine aggregate, but decreased with an increase of polymer modifiers. The compressive and flexural strengths of polymer-modified mortars decreased with an increase of recycled fine aggregate, but flexural strengths increased with an increase of polymer modifiers.

• 공업화학
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• 제5권1호
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• pp.121-126
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• 1994

초산의 반응추출에 미치는 영향을 규명하기 위하여 추출제로 2급과 3급 아민 및 용매화 추출제, 용매로 n-butylacetate, modifier로 4-nonylphenol, TBP 및 isodecanol을 이용하였다. 그외에 수용액상의 pH와 온도의 영향을 연구하였다. 실험결과 초산의 추출에서 3급 아민인 tril-n-octyl과 tri-n-decylamine의 50% 혼합 추출제인 MODA가 추출도 및 선택도에서 가장 좋았다. Modifier로서는 4-nonylphenol이 우수하였다. 이외에도 수용액의 pH와 추출계의 온도가 낮을수록 추출도가 높았다.