• Journal of the Korean housing association
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• v.18 no.2
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• pp.49-58
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• 2007

Kitchen space is one of the most dangerous places for the elderly. Modifications of kitchen space for improving safety and independence for older residents are very important factor for aging in place. The purpose of this study was to identify the current situations and modifications of kitchen space by elderly-headed households. The sample included 108 respondents over the age 65 who consisted of elderly-couple or single person household with homeownership in Seoul. The data were analyzed by descriptive statistics. Based on the findings of the study, the present incidence and recognition of future need in kitchen modifications were identified. Changes made in kitchen space tended to be nonstructural or relatively inexpensive items. In conclusion, this study suggests several ideas for improving current physical problems of kitchen space to support safe and independent daily living of older residents.

• Journal of Electrical Engineering and Technology
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• v.7 no.3
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• pp.330-335
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• 2012

The shape optimization of a Thomson coil actuator used in an arc eliminator is done for fast response by adopting topology modification method. The displacement of the plate in a fixed calculation time is taken as the objective function. The objective function and contribution factor are calculated by using an adaptive equivalent circuit method which has been proved accurate and efficient. Both shape optimization and performance analysis are accomplished based on the segmentation of plate. Through the refinement of the sensitive segments a precise optimal plate shape can be obtained. The effectiveness of the proposed method is proved by the comparison of results before and after the shape optimization.

• Journal of Electrical Engineering and Technology
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• v.7 no.1
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• pp.58-63
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• 2012

The shape optimization of a Thomson coil actuator used in an arc eliminator is done for fast response by adopting topology modification method. The displacement of the plate in a fixed calculation time is taken as the objective function. The objective function and contribution factor are calculated by using an adaptive equivalent circuit method which has been proved accurate and efficient. Both shape optimization and performance analysis are accomplished based on the segmentation of plate. Through the refinement of the sensitive segments a precise optimal plate shape can be obtained. The effectiveness of the proposed method is proved by the comparison of results before and after the shape optimization.

• Journal of Pharmaceutical Investigation
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• v.30 no.2
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• pp.73-83
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• 2000

Polyethylene glycol (PEG) is a water soluble, biocompatible, non-toxic polymer and PEGylation is a well established technique for the modification of therapeutic proteins and peptides. PEG-protein drugs have been extensively studies in relation to therapies for various diseases: cancer, inflammation and others. The covalent attachment of PEG to proteins and peptides prolonged plasma half-life, reduced antigenicity and immunogenicity, increased thermal and mechanical stability, and prevented degradation by enzymes. Several chemical groups for general and site specific conjugation have been exploited to activate PEG for amino group, carboxyl group, and cysteine groups. PEGylation of many proteins and peptides have been studied to enhance their properties for the potential uses. Also, the different positional isomers in several PEG-proteins have shown the difference in vivo stability and biological indicating that the site of PEG molecule attachment is one of the important factor to develop PEG-proteins as potential therapeutic agents.

• Journal of the Earthquake Engineering Society of Korea
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• v.6 no.6
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• pp.33-39
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• 2002

Response Modification Factor(R-factor) approach is currently implemented to reflect inelastic ductile behavior of the structures and to reduce elastic spectral demands from earthquakes to the design level. However R factors were set empirically and simply based on the professional committee consensus on observed performance of building structures during past earthquakes. Consequently some major shortcomings linked to the current R factor approach have been pointed out. Using reinforced concrete intermediate moment-resisting frames(RC IMRFs), an analytical procedure is presented in this paper to establish R factor rationally. To this end, analytical R values were evaluated based on N2 Method and compared with the values recommended by IBC 2000. Overall, the analytical results correlated well with the code values. However the results also revealed that R factor might strongly depend on the system fundamental period. As evidenced by the interstory drift index(IDI) analysis results of this study, current R-factor based(or, Life Safety based) design tends to fail in fulfilling other implicit and hopeful performance objectives such as immediate Occupancy and Collapse Prevention. Performance based design(PBD) appears to be a promising approach to meet the multi level seismic performance objectives assigned to the building structures of nowadays.

• Tunnel and Underground Space
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• v.20 no.3
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• pp.225-232
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• 2010

In this study, a newly modified 3-dimensional strain-dependent hydraulic conductivity modification relation which incorporates the influences of normal deformation and shear dilation is suggested. Since rock mass is simulated as a orthogonally jointed medium, an anisotropic hydraulic conductivity field can be evaluated using that relation. The empirical relationship on the basis of GSI and disturbance factor has been used to estimate the value of a modulus reduction ratio (ratio of rock mass deformation modulus to rock matrix elastic modulus). Principal hydraulic conductivity directions is not generally coincident with the global coordinate due to the inclining of joint and the influence of joint inclination is evaluated under strain rotation. Result shows that change of hydraulic conductivity does decreases with the increase of GSI and disturbance factor has much effects on the hydraulic conductivity of rock mass getting GSI value above 50. It is found that the inclination of joint impacts on the variation of hydraulic conductivity.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.8
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• pp.1277-1286
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• 2001

Aluminum 5052/Aramid Fiber Reinforced Plastic(Al5052/AFRP) laminates are applied to the fuselage-wing intersection. The Al5052/AFRP laminates suffer from the cyclic bending moment of variable amplitude during the service. Therefore, the influence of cyclic bending moment on the delamination and the fatigue crack propagation behavior in Al5052/AFRP laminate was investigated in this study. Al5052/AFRP laminate composite consists of three thin sheets of Al5052 and two layers of unidirectional aramid fibers. The cyclic bending moment fatigue tests were performed with five different levels of bending moment. The shape and size of the delamination zone formed along the fatigue crack between Al5052 sheet and aramid fiber-adhesive layer were measured by an ultrasonic C-scan. The relationships between da/dN and ΔK, between the cyclic bending moment and the delamination zone size, and between the fiber bridging mechanism and the delamination zone were studied. Fiber failures were not observed in the delamination zone in this study. It represents that the fiber bridging modification factor should turn out to increase and that the fatigue crack growth rate should decrease. The shape of delamination zone turns out to be semi-elliptic with the contour decreased non-linearly toward the crack tip.

• Applied Chemistry for Engineering
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• v.10 no.2
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• pp.319-323
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• 1999

Asymmetric polyetherimide membranes were prepared by phase inversion method. In the modification of the skin layers of polyetherimide membranes, the effects of NaOH concentration on the morphology and pervaporation separation of water-isopropanol mixtures were investigated. With increasing concentration of NaOH solution, polyamicacid structure was formed by the hydrolysis of imide group of polyetherimide, and the thickness of dense layer of the asymmetric membrane increased. In the pervaporation separation of water-isopropanol mixtures the overall permeation rate decreased and the separation factor increased with increasing concentration of NaOH solution. However, when the concentration of NaOH solution was very high, the permeation rate increased but separation factor decreased. From these results, it was found that the permeation behaviors of asymmetric polyetherimide membranes depended upon the concentration of NaOH solution. These modified membranes showed that both the permeation rate and separation factor increased as the operating temperature increased.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.27 no.6
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• pp.643-651
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• 2014

In this paper the reliability analyses of the cable-supported bridge design code which is recently issued in Korea are performed and the results are presented. Governing load combinations for the member design and the statistical properties of the main members are introduced and the analysis is performed using an example cable-stayed bridge for which the design is performed following the load and resistance factors defined in the design code. The reliability analysis shows the target reliability index can be achieved by applying load and resistance factors and the application of the resistance modification factor can enhance the reliability level if the importance of the bridge needs to be increased. The sensitivity analysis reveals that decreasing uncertainty of the cable strength is critical for obtaining the target reliability index. The study results show that the design using the load and resistance factors of the code can achieve the target reliability indexes for the design of cable supported bridge.

• Journal of Life Science
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• v.23 no.11
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• pp.1311-1316
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• 2013

Heterogeneous nuclear ribonucleoprotein L (hnRNP L) is a major pre-mRNA binding protein and it is an abundant nuclear protein that shuttles between the nucleus and the cytoplasm. hnRNP L is known to be related to many cellular processes, including chromatin modification, pre-mRNA splicing, mRNA export of intronless genes, internal ribosomal entry site (IRES)-mediated translation, mRNA stability, and spermatogenesis. In order to identify the cellular proteins interacting with hnRNP L, this study performed a yeast two-hybrid screening, using a human liver cDNA library. The study identified insulin-like growth factor binding protein-4 (IGFBP-4) as a novel interaction partner of hnRNP L in the human liver. It then discovered, for the first time, that hnRNP L interacts specifically with IGFBP-4 in a yeast two-hybrid system. The authenticity of this two-hybrid interaction of hnRNP L and IGFBP-4 was confirmed by an in vitro pull-down assay.