• Korean Institute of Interior Design Journal
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• no.25
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• pp.155-161
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• 2000

'Transparency', which has been an important topic of architectural discourse in the recent past, is playing an even greater role in architectural expression nowadays. The purpose of this study is to define the prevailing conceptions about transparency and to discover the various modes of this design effect in architectural space. By using partial or complete of transparency in a structure, designers are able to express themselves more profoundly. The perception between exterior and interior, transformation of day into night and conditions arising from spatial overlapping create an atmosphere which deepens the quickly of architectural design. Transparency can present as void what in reality is solid. Following the period of de-construction, transparency has asserts itself in late part of the century and transparency can be considered synonymous with modernistic and refers to structure that are optically luminant or pleasant in its simplicity. Along with advancement of climate control, construction and design technologies and new material with versatility should combine to even further the diversity of transparency in architectural expression.

• Proceedings of the IEEK Conference
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• 2000.07b
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• pp.1005-1008
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• 2000

This paper presents a simple method to estimate short-circuit power dissipation and propagation delay for static CMOS logic circuits. Short-circuit current expression is derived by accurately interpolating peak points of actual current curves which is influenced by the gate-to-drain coupling capacitance. The macro model and its expressions estimating the delay of CMOS circuits, which is based on the current modeling expression, are also proposed after investigating the voltage waveforms at transistor output modes. It is shown through simulations that the proposed technique yields better accuracy than previous methods when signal transition time and/or load capacitance decreases, which is a characteristic of the present technological evolution.

• Molecules and Cells
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• v.37 no.3
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• pp.241-247
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• 2014

Sudden cardiac death (SCD), which is primarily caused by lethal heart disorders resulting in structural and arrhythmogenic abnormalities, is one of the prevalent modes of death in most developed countries. Myocardial ischemia, mainly due to coronary artery disease, is the most common type of heart disease leading to SCD. However, postmortem diagnosis of SCD is frequently complicated by obscure histological evidence. Here, we show that certain mRNA species, namely those encoding hemoglobin A1/2 and B (Hba1/2 and Hbb, respectively) as well as pyruvate dehydrogenase kinase 4 (Pdk4), exhibit distinct postmortem expression patterns in the left ventricular free wall of SCD subjects when compared with their expression patterns in the corresponding tissues from control subjects with non-cardiac causes of death. Hba1/2 and Hbb mRNA expression levels were higher in ischemic SCD cases with acute myocardial infarction or ischemic heart disease without recent infarction, and even in cardiac death subjects without apparent pathological signs of heart injuries, than control subjects. By contrast, Pdk4 mRNA was expressed at lower levels in SCD subjects. In conclusion, we found that altered myocardial Hba1/2, Hbb, and Pdk4 mRNA expression patterns can be employed as molecular signatures of fatal cardiac dysfunction to forensically implicate SCD as the primary cause of death.

• Steel and Composite Structures
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• v.44 no.4
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• pp.531-543
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• 2022

An exact dynamic analytical method for free vibrations of continuous partial-interaction composite beams is proposed based on the Timoshenko beam theory. The main advantage of this method is that the independent shear deformations and rotary inertia of sub-beams are considered, which is more in line with the reality. Therefore, the accuracy of eigenfrequencies obtained by this method is significantly improved, especially for higher order modes, compared to the existing methods where the rotary angles of both sub-beams are assumed to be equal irrespective of the differences in the shear stiffness of each sub-beam. Furthermore, the solutions obtained by the proposed method are exact owing to no introduction of approximated displacement and force fields in the derivation. In addition, an exact analytical solution for the case of simply supported is obtained. Based on this, an approximate expression for the fundamental frequency of continuous partial-interaction composite beams is also proposed, which is useful for practical engineering applications. Finally, the practicability and effectiveness of the proposed method and the approximate expression are explored using numerical and experimental examples; The influence factors including the interfacial interaction, shear modulus ratio, span-to-depth ratio, and side-to-main span length ratio on the eigenfrequencies are presented and discussed in detail.

• Steel and Composite Structures
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• v.23 no.3
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• pp.331-338
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• 2017

Cold-formed lipped channel columns (CFLCCs) have been widely used in light gauge steel constructions. The distortional buckling is one of the important buckling modes for CFLCCs and the distortional buckling critical load depends significantly on the rotational restrain stiffness generated by the web to the lipped flange. First, a simplified explicit expression for the rotational restraint stiffness of the lipped flange has been derived. Using the expression, the characteristics of the rotational restraint stiffness of the lipped flange have been investigated. The results show that there is a linear coupling relationship between the applied forces and the rotational restraint stiffness of the lipped flange. Based on the explicit expression of the rotational restraint stiffness of the lipped flange, a simplified analytical formula has been derived which can determine the elastic distortional buckling critical stress of the CFLCCs subjected to axial compression. The simplified analytical formula developed in this study has been shown to be accurate through the comparisons with results from the distortional buckling analyses using the ANSYS finite element software. The developed analytical formula is easy to apply, and can be used directly in practical design and incorporated into future design codes and guidelines.

• Journal of Gastric Cancer
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• v.14 no.3
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• pp.147-155
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• 2014

Homeostatic imbalance between cell proliferation and death in gastric mucosal epithelia may lead to gastritis and gastric cancer. Despite abundant gastrokine 1 (GKN1) expression in the normal stomach, the loss of GKN1 expression is frequently detected in gastric mucosa infected with Helicobacter pylori, as well as in intestinal metaplasia and gastric cancer tissues, suggesting that GKN1 plays an important role in gastric mucosal defense, and the gene functions as a gastric tumor suppressor. In the stomach, GKN1 is involved in gastric mucosal inflammation by regulating cytokine production, the nuclear factor-${\kappa}B$ signaling pathway, and cyclooxygenase-2 expression. GKN1 also inhibits the carcinogenic potential of H. pylori protein CagA by binding to it, and up-regulates antioxidant enzymes. In addition, GKN1 reduces cell viability, proliferation, and colony formation by inhibiting cell cycle progression and epigenetic modification by down-regulating the expression levels of DNMT1 and EZH2, and DNMT1 activity, and inducing apoptosis through the death receptor-dependent pathway. Furthermore, GKN1 also inhibits gastric cancer cell invasion and metastasis via coordinated regulation of epithelial mesenchymal transition-related protein expression, reactive oxygen species production, and PI3K/Akt signaling pathway activation. Although the modes of action of GKN1 have not been clearly described, recent limited evidence suggests that GKN1 acts as a gastricspecific tumor suppressor. This review aims to discuss, comment, and summarize the recent progress in the understanding of the role of GKN1 in gastric cancer development and progression.

• Biotechnology and Bioprocess Engineering:BBE
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• v.9 no.3
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• pp.184-190
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• 2004

The influences of impeller types on morphology and protein expression were investigated in a submerged culture of Aspergillus oryzae. The impeller types strongly affected mycelial morphology and protein production in batch and fed-batch fermentations. Cells that were cultured by propeller agitation grew in the form of a pellet, whereas cells that were cultured by turbine agitation grew in a freely dispersed-hyphal manner and in a clumped form. Pellet-grown cells showed high levels of protein production for both the intracellularly heterologous protein (${\beta}$-glucuronidase) and the extracellularly homologous protein (${\alpha}$-amylase). The feeding mode of the carbon source also influenced the morphological distribution and protein expression in fed-batch fermentation of A. oryzae. Pulsed-feeding mainly showed high protein expression and homogeneous distribution of pellet whereas continuous feeding resulted in less protein expression and heterogeneous distribution with pellet and dispersed-hyphae. The pellet growth with propeller agitation paralleling with the pulsed-feeding of carbon source showed a high level of protein production in the submerged fed-batch fermentation of recombinant A. oryzae.

• The Korean Journal of Food & Health Convergence
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• v.6 no.6
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• pp.17-23
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• 2020

The main task of agro-industrial production is to provide the population with food products for the production of which energy is expended in the form of electricity, technical means, fuels and lubricants, mineral fertilizers, etc. Accordingly, we have developed a concept and general methodological principles for the analysis of ecological and biotechnical systems in animal husbandry, it makes it possible to simulate the influence of various factors on the energy and ecological efficiency of systems, to compare and search for energy-saving modes and technologies. General methodological principles have been developed for the analysis of energy efficiency and environmental safety of agricultural ecological and biotechnical systems, which are based on the definition of the bioenergy efficiency coefficient, the quantitative expression of which is the ratio of energy accumulated in products to the total energy consumption for its production. This makes it possible to model with sufficient accuracy the influence of various factors on the energy and environmental efficiency of the system, to compare and search for energy-saving modes and technologies in order to find and select the most energy efficient ones to increase the energy efficiency of the complex.

• International Journal of Costume and Fashion
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• v.7 no.2
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• pp.49-63
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• 2007

In this study, we inquire into the general concepts of eroticism as it appears in literature and the arts, and use this as a foundation to meditate on the eroticism of attire throughout history. We also ascertained external forms based on the range of "The way we look" by Delong. In this way we inclusively studied both the content and form of modes of eroticism in the perspective of Brodsky's "linked solution." The original concept of eroticism is a technique by which one attains physical passion, referring to a nature which is deeply rooted in the cultural traditions, myths, habits. religion and arts of mankind, inducing expressions of sensual love. We integrated this eroticism in 4 categories: sensuality, which induces beauty; naturality, denoting idealization or rational beauty; primitivity, characterized by grotesque expressions or direct and natural sexual depictions; and symbolism by which sex is symbolically or mechanically projected. The concept of eroticism contains both positive and negative aspects, but rather than dealing with sex in a mechanical or perverted manner to express eroticism, it is more appropriate to guide the direction of modes of eroticism by stimulating the "desire to show" and the "desire to see" with the dialectic of obstruction and exposure as a figurative expression of true passion, and narcistic phenomena in which beauty is expressed through exaggeration or magnification and adhesion.

• International Journal of Concrete Structures and Materials
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• v.10 no.3
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• pp.393-406
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• 2016

Axially loaded reinforced concrete columns are hardly exist in practice due to the development of some bending moments. These moments could be produced by gravity loads or the lateral loads. First, the current paper presents a detailed analysis on the overall structural behavior of 15 eccentrically loaded columns as well as one concentrically loaded control one. Columns bent in either single curvature or double curvature modes are tested experimentally up to failure under the effect of different end eccentricities combinations. Three end eccentricities ratio were studied, namely, 0.1b, 0.3b and 0.5b, where b is the column width. Second, an expression correlated the decay in the normalized axial capacity of the column and the acting end eccentricities was developed based on the experimental results and then verified against the available formula. Third, based on the equivalent column concept, the equivalent pin-ended columns were obtained for columns bent in either single or double curvature modes. And then, the effect of end eccentricity ratio was correlated to the equivalent column length. Finally, a simplified design procedure was proposed for eccentrically loaded braced column by transferring it to an equivalent axially loaded pin-ended slender column. The results of the proposed design procedure showed comparable results against the results of the ACI 318-14 code.