• Applied Chemistry for Engineering
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• v.32 no.3
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• pp.253-259
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• 2021

Colorectal cancer (CRC) is one of the most prevalent diseases in modern society, constituting a serious threat to global health. Currently, routine clinical screening and early removal of precancerous polyps are the most successful methods for reducing CRC incidence and mortality. However, the high cost and invasive detection of sigmoidoscopy and colonoscopy limited the CRC-screening participation and prevention. The emergence of biosensors provides an inexpensive, sensitive, less invasive tool for detecting CRC disease biomarkers. This review highlights some of recent efforts made on developing biosensors with electrochemical and optical techniques targeting CRC specific protein biomarkers for early diagnosis and prognosis, potential applications, and future perspectives.

• The Ewha Medical Journal
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• v.40 no.3
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• pp.99-103
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• 2017

Antimicrobials were one of the great invention of modern era. However, the abuse of antimicrobial both in human and animals has led to a high rate of occurrence of antimicrobial resistant microbes. Disease treatment caused by antimicrobial resistant microbes including superbacteria has emerged as critical issue worldwide. Communication and cooperation among researchers in diverse fields are needed to solve the resistance to antimicrobials. Culture Collection of Antimicrobial Resistant Microbes (CCARM) has taken a leadership role an intermediary among various research fields by providing certified antimicrobial resistant microbes with their information since 1999. CCARM collects antimicrobial resistant microbes from clinical, agricultural animals and products, and environmental fields, and classifies and stores them according to their origins, species and antimicrobial resistance mechanisms. CCARM is performing the roles (collection, deposit, preservation, distribution, service, and consulting) of Biological Resource Center designated by Organisation for Economic Co-operation and Development.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.24 no.1
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• pp.29-52
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• 2020

Objectives In this study, we tried to analyze the expression status and diagnostic application of the disease according to the characteristics of Six Qi. Methods Suwenxuanjiyuanbingshi (Exploration to Mysterious Pathogenesis and Etiology Based on the Plain Questions, 1152), Shoushibaoyuan (Longevity and Life Preservation, 1615), Dongeuibogam (Treasured Mirror of Eastern Medicine, 1613) and two modern works on Six Qi were analyzed for this study. Results Some substrate characteristics presenting Six Qi were extracted from original literatures. Also, we found that the characteristics of Six Qi can be applied to clinical trials by presenting them as three criteria as wind, humidity, and temperature. Conclusions This study suggests.

• Journal of Korean Academy of Nursing
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• v.44 no.3
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• pp.328-338
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• 2014

Purpose: This study was done to explore experiences of persons living through the periods of cancer diagnosis, treatment, and self-care. Methods: With permission, texts of 29 cancer survival narratives (8 men and 21 women, winners in contests sponsored by two institutes), were analyzed using Kang's Korean-Computerized-Text-Analysis-Program where the commonly used Korean-Morphological-Analyzer and the 21st-century-Sejong-Modern-Korean-Corpora representing laymen's Korean-language-use are connected. Experiences were explored based on words included in 100 highly-used-morphemes. For interpretation, we used 'categorizing words by meaning', 'comparing use-rate by periods and to the 21st-century-Sejong-Modern-Korean-Corpora', and highly-used-morphemes that appeared only in a specific period. Results: The most highly-used-word-morpheme was first-person-pronouns followed by, diagnosis treatment-related- words, mind-expression-words, cancer, persons-in-meaningful-interaction, living and eating, information-related-verbs, emotion-expression- words, with 240 to 0.8 times for layman use-rate. 'Diagnosis-process', 'cancer-thought', 'things-to-come-after-diagnosis', 'physician husband', 'result-related-information', 'meaningful-things before diagnosis-period', and 'locus-of-cause' dominated the life of the diagnosis-period. 'Treatment', 'unreliable-body', 'husband people mother physician', 'treatment-related-uncertainty', 'hard-time', and 'waiting-time represented experiences in the treatment-period. Themes of living in the self-care-period were complex and included 'living-as-a-human', 'self-managing-of-diseased-body', 'positive-emotion', and 'connecting past present future'. Conclusion: The results show that the experience of living for persons with cancer is influenced by each period's own situational-characteristics. Experiences of the diagnosis and treatment-period are negative disease-oriented while that of the self-care period is positive present-oriented.

• The Journal of Korean Medicine
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• v.39 no.3
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• pp.17-27
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• 2018

Objectives: Ukgan-san does not appear in Traditional Korean Medicine classics. However, it has been used in research and clinical applications in Korea. In this paper, we are aiming to examine the records concerned with Ukgan-san to the present, and announce the present usage state in Korea. Methods: We searched and summarized the contents of previous medical books about Ukgan-san. In order to investigate the current status of utilization of Ukgan-san in Korea, a bibliographic database of Korea, a database of clinical researches, and a database of pharmaceuticals of the Korea Food and Drug Administration were searched. Results: As a result of searching Ukgan-san related documents, Ukgan-san has been developed in China (Ming dynasty). However, its clinical application has been expanded by modern Japanese kampo medicine doctors. In Korea, cases of Parkinson's disease, other movement disorders, and psychiatric disorders have been reported, and randomized controlled trials had been done and planned. In addition, some extracts which are consisted of Ukgan-san are also available. Conclusions: In Korea, Ukgan-san has been influenced by Japan and has been used for clinical and research purposes. The utilization rate in Korea is still small, but the utilization rate will increase according to the results of clinical studies.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.4
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• pp.683-690
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• 2016

In modern society, disasters frequently occur, and the effect is getting more massive. Also, unpredictable future increases anxiety about social security. Accordingly, in order to prevent national-scale emergency from happening, it is highly required governments' role as ICT power nation and transition to disaster management system using big data applied service. Thus, e-gov necessarily acquires disaster response system in order to predict and manage disasters. Disasters are linked with some attributes of modern society in diversity, complexity and unpredictability, so various approach and remedies of them will appease the nation's anxiety upon them. For this reason, this manuscript suggests epidemics preactive warning algorithm model as a mean of reduce national anxiety on disaster using big data for social security. Also, by recognizing the importance of e-gov and analyzing problems in weak disaster management system, it suggests political implication for disaster response.

• The Journal of Pediatrics of Korean Medicine
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• v.24 no.1
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• pp.104-116
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• 2010

Objectives The Medical record consist of symptoms, the cause of a disease, diagnostic studies, medical treatment, prescription, and so on. Doctors can use medical records as data for diagnosis, treatment, and education. Therefore, medical records are beneficial. Methods Translating $\ll$Xiao Er Yao Zheng Zhi Jue$\gg$ into modern Korean, and studying the medical records of Qian Yi(錢乙)'s Medical concept in $\ll$Xiao Er Yao Zheng Zhi Jue$\gg$ were examined. Results Regarding the diagnosis of the pediatric diseases, Si Zhen He Can(四該合參), consider in the eye exam closely. In addition, he closely combined the concept of Wu Zang Bian Zheng(五藏辨證), and diagnosis the pediatric diseases. Wu Zang Bian Zheng(五藏辨證). what Qian-Yi(錢乙) established method was based on Zheng Ti Guan(整體觀) in Huang Di Nei Jing(黃帝內經). Qian-Yi(錢乙) took a close look on Chuang Zhen(瘡疹) which had been an inadequate field in those days. He criticized on the habitual misuse of medications. He treated Ji Jing(急驚) and Man Jing(慢驚) separately; Ji Jing(急驚) as Liang Xie(凉瀉) and Man Jing(慢驚) as Wen Bu(溫補). He proposed Zong Gan Zhu Feng and Xin Zhu Jing(縱肝主風, 心主驚) theory and formulated Jing Feng(驚風) theory as well. He emphasized the treatment to Gong Bu Shang Zheng, Bu Bu Zhi Xie, Xiao Bu Jian Shi(攻不傷正, 補不滯邪, 消補兼施) because he had a clear demonstration to Han Re Xu Shi(寒熱虛實) of the five viscera in the field of Fang yao(方藥). Conclusions Understanding $\ll$Xiao Er Yao Zheng Zhi Jue$\gg$ and its medical records of Qian Yi(錢乙)'s medical concept had quintessential meaning to both modern pediatrician and oriental medical doctors of all medical fields in treating children.

• The Korean Journal of Physiology and Pharmacology
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• v.15 no.2
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• pp.67-81
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• 2011

Epilepsy is a chronic disease occurring in approximately 1.0% of the world's population. About 30% of the epileptic patients treated with availably antiepileptic drugs (AEDs) continue to have seizures and are considered therapy-resistant or refractory patients. The ultimate goal for the use of AEDs is complete cessation of seizures without side effects. Because of a narrow therapeutic index of AEDs, a complete understanding of its clinical pharmacokinetics is essential for understanding of the pharmacodynamics of these drugs. These drug concentrations in biological fluids serve as surrogate markers and can be used to guide or target drug dosing. Because early studies demonstrated clinical and/or electroencephalographic correlations with serum concentrations of several AEDs, It has been almost 50 years since clinicians started using plasma concentrations of AEDs to optimize pharmacotherapy in patients with epilepsy. Therefore, validated analytical method for concentrations of AEDs in biological fluids is a necessity in order to explore pharmacokinetics, bioequivalence and TDM in various clinical situations. There are hundreds of published articles on the analysis of specific AEDs by a wide variety of analytical methods in biological samples have appears over the past decade. This review intends to provide an updated, concise overview on the modern method development for monitoring AEDs for pharmacokinetic studies, bioequivalence and therapeutic drug monitoring.

• Journal of Oriental Medical Thermology
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• v.3 no.1
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• pp.27-35
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• 2004

Today, everybody lives in the stress. So 50% to 80% or 60% to 80% of the modern diseases are estimated what is caused by the stress. And one of the most important point of the stress is a too serious and continuos tension state. Therefore the best way to promotion, persistence, prevention and treatment of the modern man's health will be the relaxion from the tension state. The relax therapy as known as am effective method to the disease which as concerned with stress. that can be adapted to the treatment of anxiety-related diseases, insomnia, hypertension, tension headache, migraine, asthma, preparation of delivery, G-I disorders and menstrual disorders. Until now we guess the change of a relaxed state by the observation to the change of autonomic nervous system(ANS) and EEG. From the point of the ANS, sympathetic nervous system progresses slowly but parasympathetic nervous system increases the activity. In the EEG, both the alpha-wave concerned with the deep physical relaxed state and emotional stability and the theta-wave appeared in the state of meditation are increased. Current studies show that among the biochemical changes, especially serotinin like body hormone is increased by the feeling of the stability or the happiness. So, to see the change of the relaxed state in the image of the D.I.T.I., we used the deviational differences between the pre-relaxed state and the post-relaxed state of 70 people. As a result, the portional deviation of the face is decreased in the image of the D.I.T.I. So it can be thaught that we can determine the changes of the relaxed state by the D.I.T.I.

• CELLMED
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• v.9 no.4
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• pp.9.1-9.4
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• 2019

Ayurveda is one of the ancient systems of traditional medicine in India, however, there is a lack of proper scientific research and controlled studies on efficacy and toxicity of several Ayurvedic formulations using the methods of modern science, which hinders the proper development of Ayurveda, both in India and abroad. The present study was undertaken to further corroborate the efficacy of some popular anthelmintic Ayurvedic medicines, as evident by the pharmacological effects of Ayurvedic formulations on body surface of a cestode parasite. This study employed a common intestinal cestode of domestic fowl, Raillietina sp., as a model parasite, that was exposed in vitro to different concentrations of three common Indian Ayurvedic anthelmintic drugs, namely Krimimudgar Ras, Kriminol and Vidangasava, and also to a modern anthelmintic drug, praziquantel (PZQ). After the paralysis of parasites, the specimens from the highest drug-treated concentration (50 mg/ml), praziquantel (1 mg/ml), and control groups, were collected and processed for scanning electron microscopic studies to document the effects of drugs on the body surface of parasite. In this study, maximum degree of alterations on parasite body surface was observed in the worms exposed to Krimimudgar Ras, indicating this drug to be highly efficacious against intestinal worms and brings out a transtegumental mode of action on parasite. In conclusion, the findings of present study suggest that of the three Ayurvedic formulations tested, Krimimudgar Ras possesses significant anthelmintic effects, which are mediated through parasite's body surface. Therefore, Krimimudgar Ras may be considered as a reliable anthelmintic Ayurvedic formulation, as validated through this study.