• Korean Journal of Acupuncture
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• v.33 no.3
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• pp.139-147
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• 2016

Purpose : The acupuncture existed more than 2000 years and has flourished not only in Asia but also in medical field of modern world. In addition, empirical evidences from biomedicine have been expended in many ways in order to objectify the field of acupuncture. Thus, the effect and mechanism of the acupuncture has been revealed in human and other animals. In this article, I attempt to explain what doctors and patients subjectively experience through acupuncture treatment and its clinical significance based on mind-body medicine. Methods : The experience and clinical significance of the acupuncture was examined in the view of mind-body medicine, also reviewed research trends related to meditation understanding the clinical effectiveness of acupuncture. Results and Conclusions : Traditional Korean medical doctor perceive generally "jogi " and "chishin " meaning the regulation of the balance of the various functions in the human body and patient's consciousness and psychology state as mightily important concept concerning the therapeutic effect of acupuncture. Despite scientific approach to objective understanding of the acupuncture was performed in the meantime, practitioners put emphasis on experience based on sensate and interaction between doctor-patient. As it reflects the recent understanding of the psychological effects associated with the clinical efficacy of acupuncture, it has been presented one by one through neuroscience and cognitive science. Therefore it is important that interpreting the clinical effectiveness of acupuncture into Mind-body medicine can form a new awareness and attitudes toward traditional medicine.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.3
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• pp.251-262
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• 2014

This article is for understanding dementia with the perspective of Korean Medicine through research on syndrome differentiations of dementia clinically applied and relations between modern diseases and Korean Medicine pattern types of dementia. clinical papers were searched in China Academic Journals(CAJ) of China National Knowledge Infrastructure(CNKI) from 2012 to 2013. Conclusions are as follows. First, dementia was expressed in many ways such as imbecility, stupidity, fatuity, idiocy, vacuity, etc and was related with amnesia, forgetfulness, speech not in the right order, depressive psychosis(quiet insanity), manic psychosis, depression syndrome. Second, prescriptions such as QiFuYin and ZuoGuiWan from JingYueQuanShu, XiXinTang and ZhiMiTang from BianZhengLu, TongQiaoHuoXueTang, XueFuZhuYuTang and BuYangHaiWuTang from YiLinGaiCuo, HaiShaoDan from YiFangJiJie, HuangLianJieDuTang from WaiTaiMiYao were suggested for dementia. Third, syndrome differentiation pattern types of dementia are kidney deficiency and marrow decrease, qi-blood depletion, liver-kidney depletion, spleen-kidney depletion, heart-spleen deficiency as deficiency patterns and effulgent heart-liver fire, ascendant hyperactivity of liver yang, qi stagnation and blood stasis, phlegm turbidity obstructing orifice, phlegm-blood stasis obstructing orifice, intense heat toxin as excess patterns and qi deficiency with blood stasis, yin deficiency with yang hyperactivity as deficiency-excess complex patterns. Major pattern types are kidney deficiency and marrow decrease, phlegm-blood stasis obstructing orifice, qi stagnation and blood stasis, liver-kidney depletion, phlegm turbidity obstructing orifice.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2465-2472
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• 2014

Background: The American Joint Committee on Cancer (AJCC) published a new staging system ($7^{th}$ edition) in 2009. In our study, we evaluated the survival results and prognostic factors among T4 local advanced non-small cell lung cancer (LA-NSCLC) patients in a large heterogeneous group, in accordance with this new system. Materials and Methods: We retrospectively evaluated the files of 122 T4 N0-3 M0 LA-NSCLC patients, identified according to the new staging system, treated at two centers between November 2003 and June 2012. Variables correlating with univariate survival at p<0.20 were later included in multivariate Cox regression analysis. Here, selection of relevant predictors of survival was carried out in accordance with the likelihood ratio formula with p<0.05 regarded as significant. Results: The median age was 60 and the median follow-up period was 17.4 months. Median overall survival (OS) was 18.3 months, the 1 year overall survival (OS) rate was 72%, and the 5 year OS rate was 28%. Statistically significant predictors of survival were (p<0.20) ECOG-PS (Eastern Cooperative Oncology Group Performance Status), age, T4 factor subgroup, stage and primary treatment in OS univariate analysis. On multivariate analysis for OS ECOG-PS (p=0.001), diagnostic stage (p=0.021), and primary treatment (p=0.004) were significant. In the group receiving non-curative treatment, the median OS was 11.0 months, while it was 19.0 months in the definitive RT group and 26.6 months in the curative treatment group. There was a significant difference between the non-curative group and the groups which had definitive RT and curative operations (respectively p<0.001 and p=0.001) in terms of OS, but not between the groups which had definitive RT and curative operations. The median event free survival (EFS) rate was 9.9 months, with rates of 46% and 19% at 3 and 5 years, respectively. On univariate analysis of EFS rate with ECOG-PS, weight loss and staging, statistical significance was found only for thorax computerized tomography (CT)+18F-fluorodeoxy-glucose positron emission tomography-CT (PET-CT) use, stage and primary treatment (p<0.20). In multivariate analysis with EFS, only the primary treatment was statistically significant (p=0.001). In the group receiving non-curative treatment, the median EFS was 10.5 months while in the curative operation group it was 14.7 months. When all the primary treatment groups were taken into consideration, grade III/IV side effect swas observed in 57 patients (46.6%). Esophagitis was most prominent among those that received definitive radiotherapy. Conclusions: Independent prognostic factors among these 122 heterogeneous LA-NSCLC T4 N0-3 M0 patients were age at diagnosis, ECOG-PS, stage and primary treatment, the last also being a significant prognostic indicator of EFS. Our findings point to the importance of appropriate staging and a multidisciplinary approach with modern imaging methods in this patient group. In those with T4 lesions, treatment selection and the effective use of curative potential should be the most important goal of clinical care.

• Journal of Korean Medical classics
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• v.37 no.2
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• pp.101-119
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• 2024

Objectives : This study examined the characteristics of famine relief and fasting formulas in Korean Medical Texts from early Joseon to early modern period. Methods : In addition to previous studies and texts, basic materials were collected from various academic database such as the Korean Medical Classics Database, Korean History Database, Chinese Text Project, Weijiwenku, etc., then analyzed. Results : In Korean Medicine from the early Joseon to early modern Korea, there was a strong awareness to use fasting prescriptions which were applied in Daosim for the purpose of famine relief, using both medicinals and common food ingredients together as complex prescriptions rather than single ingredient formulas. Famine relief and fasting formulas were continuously listed in many medical texts published after the Donguibogam, in modified or newly improved forms. Moreover, the food ingredients and medicinals used in these formulas were consisted of those which could be easily found in the famished nation of the time. Many of these formulas were tried and tested prescriptions, frequently used in clinical settings. Most of the ingredients and medicinals used in the famine relief and fasting formulas were sweet, bland, and neutral in nature, supporting Qi circulation and tonifying the Spleen and Stomach. Therefore in times of famine, these medicinals could help prevent digestive problems and decline of stamina. Conclusions : Research and contemporary interpretation on the famine relief and fasting formulas could contribute to not only health management but to relieving nutrition imbalance and famine, expanding the field of Korean Medicine application.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.34 no.4
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• pp.29-54
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• 2023

This study aimed to analyze the research trends of journal articles published by medical schools representing Korean modern. A total of 682 were selected from two journals published by Medical College in Keijo and Keijo Imperial University Medical Faculty. In results, the affiliations of authors who participated in Acta Medicinalia in Keijo included various schools and hospitals, and the authors' major was found to be similar in basic medicine and clinical medicine. In The Keijo Journal of Medicine, only school-affiliated authors participated, and 96.33% of the authors were majors in basic medicine. Co-occurrence network analysis was conducted on MeSH terms from the title of the article using MeSH on Demand, and the keyword that derived in both journals was 'erythrocytes', which analyzed the condition of red blood cells according to organs and diseases. In frequency analysis, a common area of research in both journals was the study focusing on blood and blood cells, and the study of anemia and tuberculosis, which were prevalent diseases at the time. As for comparing each journal, Acta Medicinalia in Keijo has focused on inflammatory diseases and clinical pathological studies in humans, and The Keijo Journal of Medicine has focused on anatomical studies on animals and pharmacological studies on medicines. Through this study, it was possible to identify the research topics and major keywords in two medical schools with different founding goals.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.4
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• pp.878-883
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• 2005

The dream is a well-known experience in the routine life. It is the image and thought being occurred during the sleep, and the complex reaction of our mental world to the event of everyday. In particular, there are so many opinions of the reason why people have a dream and this thesis is telling about the physical and pathological changes in the human as one of that various opinions. The aspects of this thesis are often founded in the diverse texts of oriental Medicine, including the Internal Classics(내경), and there were some cases that regarded the dream as diagnostic object and put to clinical uses. These attempts were not only tried out by particular orient thoght, also the ancient Greeks thought that the dream would represent important informations about the health. But, these ideas have been treated lightly by the impacts of the western medicine since the modern age. Straightforwardly, before the psycho-analytics was not development, most of the doctors and scientists regarded the dream as things like dregs of mind. The central operating bodies of the dream are the Spirit(신) and Hon and Beak(혼백), and the Spirit(신) is more essential part between the two.

• The Journal of Pediatrics of Korean Medicine
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• v.38 no.1
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• pp.46-54
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• 2024

Purpose As modern science and medicine develop, the concept of life is changing, and the importance of patients' rights is emphasized, making it essential for medical professionals to think ethically. However, there is currently a lack of medical ethics research in the field of Oriental medicine, especially for pediatric and adolescent patients, we would like to take a look at this. Methods Through a literature review, we aim to discuss various ethical issues and human rights of children and adolescents that arise when Oriental medical doctors treat children and adolescents as medical professionals and use these as basic data for future research and education on Oriental medical ethics for children and adolescents. Results Medical ethics include the principles of autonomy, prohibition of evildoing, beneficence, and justice, and medical staff must make ethical judgments based on these principles. Ethical issues regarding children and adolescents arise in various clinical situations, and education on medical ethics is essential. Conclusions Discussions on the rights of children and adolescents are becoming active, and their importance is increasing. Therefore, sufficient explanation and consent must be provided to guardians, children, and adolescents with legal rightsand the opinions of the participants must be respected as far as possible.

• Journal of Korean Neurosurgical Society
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• v.30 no.3
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• pp.284-294
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• 2001

Objective : Stroke is leading cause of death and more importantly it is cause of serious disability. The effective treatment of acute ischemic stroke still remains a challenge to modern medicine. Recent clinical trials have shown that carotid endareterctomy(CEA) provide overwhelming benefits compared with medical therapy in preventing subsequent stroke for symptomatic carotid stenosis. For the asymptomatic ones, the data are less compelling, but highly suggestive that CEA do have benefits in properly selected patients. Materials and Methods : To investigate the clinical manifestations of carotid stenosis and results of CEAs, authors analyzed retrospectively 19 CEAs in 16 patients from June 1986 to June 1999. Age of patients ranged from 55 to 76 years(median, 66) and male to female ratio was 14 to 2. The duration of follow-up was 1 to 144 months (median, 26). All of CEAs were done on the side of stenosis more than 80% and bilateral CEAs were done in three. Six CEAs were performed in asymptomatic patients. Results : Seventeen of 19 CEAs showed excellent results and complication rate was low although ipsilateral ischemic stroke occurred in two. Conclusion : CEA may be a valuable surgical treatment for ischemic stroke caused by carotid stenosis and also for prevention of stroke of asymptomatic patients with carotid stenosis.

• Radiation Oncology Journal
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• v.29 no.3
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• pp.135-146
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• 2011

With the advance of modern radiation therapy technique, radiation dose conformation and dose distribution have improved dramatically. However, the progress does not completely fulfi ll the goal of cancer treatment such as improved local control or survival. The discordances with the clinical results are from the biophysical nature of photon, which is the main source of radiation therapy in current field, with the lower linear energy transfer to the target. As part of a natural progression, there recently has been a resurgence of interest in particle therapy, specifically using heavy charged particles, because these kinds of radiations serve theoretical advantages in both biological and physical aspects. The Korean government is to set up a heavy charged particle facility in Korea Institute of Radiological & Medical Sciences. This review introduces some of the elementary physics of the various particles for the sake of Korean radiation oncologists' interest.

• Radiation Oncology Journal
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• v.32 no.4
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• pp.213-220
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• 2014

Insufficiency fracture occurs when normal or physiological stress applied to weakened bone with demineralization and decreased elastic resistance. Recently, many studies reported the development of IF after radiation therapy (RT) in gynecological cancer, prostate cancer, anal cancer and rectal cancer. The RT-induced insufficiency fracture is a common complication during the follow-up using modern imaging studies. The clinical suspicion and knowledge the characteristic imaging patterns of insufficiency fracture is essential to differentiate it from metastatic bone lesions, because it sometimes cause severe pain, and it may be confused with bone metastasis.