• Bulletin of the Korean Chemical Society
• /
• v.28 no.7
• /
• pp.1141-1150
• /
• 2007

Molecular modeling study has been performed to assist in the design of PTP1B inhibitors using FlexX. FlexX dockings with 19 test ligands, whose structures have been determined by X-ray crystallography, were successful in reproducing the experimental conformations within the protein. An increase in biological activity is observed as hydrophobic character of formylchromone derivatives increases. Most ligands bind to the activesite regions of the protein successfully in two different score runs. The Drug score run gave better results than the FlexX score run based on the score, rank, binding modes and bond distance of docked structures. Consensus values from the CScore scoring function are between 3 and 5, suggesting that the scoring scheme is reliable. All formylchromone inhibitors considered in this work show unidirectional binding modes in the active site pocket, which is contrary to the bidirectional X-ray results by Malamas et al. and amino acid residues responsible for such orientation are identified to help further development of the inhibitors.

• Korea-Australia Rheology Journal
• /
• v.21 no.1
• /
• pp.47-58
• /
• 2009

We have investigated the transient behavior of 1D fully developed Poiseuille viscoelastic flow under finite pressure gradient described by the Oldroyd-B and Leonov constitutive equations. For analysis we employ a simple $2^{nd}$ order discretization scheme such as central difference for space and the Crank-Nicolson for time approximation. For the analysis of the Oldroyd-B model, we also apply the analytical solution, which is obtained again in this work in terms of elementary solution procedure simpler than the previous one (Waters and King, 1970). Both models demonstrate qualitatively similar solutions, but their eventual steady flowrate exhibits noticeable difference due to the absence or presence of shear thinning behavior. In the inertialess flow, the flowrate instantaneously attains a large value corresponding to the Newtonian creeping flow and then decreases to its steady value when the applied pressure gradient is low. However with finite liquid density the flow field shows severe fluctuation even accompanying reversals of flow directions. As the assigned pressure gradient increases, the flowrate achieves its steady value significantly higher than its value during oscillations after quite long period of time. We have also illustrated comparison between 1D and 2D results and possible mechanism of complex 2D flow rearrangement employing a previous solution of [mite element computation. In addition, we discuss some mathematical points regarding missing boundary conditions in 2D modeling due to the change of the type of differential equations when varying from inertialess to inertial flow.

• Journal of Korean Society for Quality Management
• /
• v.42 no.4
• /
• pp.701-716
• /
• 2014

Purpose: In the paper, I studied success factors and measures for win-win quality management for boosting corporate competitiveness through the achievement of high quality. Methods: As such, to that end, data of companies' win-win quality management activities and Cooperation performance were gathered. Also, I had a literature review and working staffs'opinions were gathered to develop items related to trade dependence, quality cooperation, and mutual trust and cooperation. To develop the questionnaire, sufficient literature survey was conducted, and advice was sought from experts of manufacturing companies which practice Win-Win Cooperation. Results: Based on these previous researches and analysis by structural equation modeling, among trade dependence factors, overall, other factors except financial dependence and some detailed factors were found to have a relatively significant influence relation. Conclusion: The findings of this study suggest that if individual organizations can construct an effective quality improvement system and positively pursue win-win activities, it will contribute greatly to achieving high quality and improving financial performance. However, given the time and regional limits of this study, more in-depth studies need to be conducted on measures for boosting quality competitiveness through Win-Win Cooperation.

• Journal of Institute of Control, Robotics and Systems
• /
• v.15 no.12
• /
• pp.1232-1239
• /
• 2009

This paper proposes an exploration strategy to efficiently find a specific place in large unknown environments with wall-following based path planning. Many exploration methods proposed so far showed good performance but they focused only on efficient planning for modeling unknown environments. Therefore, to successfully accomplish the room finding task, two additional requirements should be considered. First, suitable path-planning is needed to recognize the room number. Most conventional exploration schemes used the gradient method to extract the optimal path. In these schemes, the paths are extracted in the middle of the free space which is usually far from the wall. If the robot follows such a path, it is not likely to recognize the room number written on the wall because room numbers are usually too small to be recognized by camera image from a distance. Second, the behavior which re-explores the explored area is needed. Even though the robot completes exploration, it is possible that some rooms are not registered in the constructed map for some reasons such as poor recognition performance, occlusion by a human and so on. With this scheme, the robot does not have to visit and model the whole environment. This proposed method is very simple but it guarantees that the robot can find a specific room in most cases. The proposed exploration strategy was verified by various experiments.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.27 no.3
• /
• pp.381-386
• /
• 2003

Gradually engineering designers are determined based on computer simulations. Modeling of the computer simulation however is too expensive and time consuming in a complicate system. Thus, designers often use approximation models called metamodels, which represent approximately the relations between design and response variables. There arc general metamodels such as response surface model and kriging metamodel. Response surface model is easy to obtain and provides explicit function. but it is not suitable for highly nonlinear and large scaled problems. For complicate case, we may use kriging model that employs an interpolation scheme developed in the fields of spatial statistics and geostatistics. This class of into interpolating model has flexibility to model response data with multiple local extreme. In this study. metamodeling techniques are adopted to carry out the shape optimization of a funnel of Cathode Ray Tube. which finds the shape minimizing the local maximum principal stress Optimum designs using two metamodels are compared and proper metamodel is recommended based on this research.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.20 no.10
• /
• pp.3186-3198
• /
• 1996

When a robot is to have contact with its enviornment, such as a medi-care robot, it would be advantageous for the robot to have a high compliance. For this reason, a robot having not only a flexible link but also an actuator with compliance, is desirable. This paper is concerned with the position and vibration control of 1 degree of freedom flexible robot using a pneumatic artificial muscle actuator. The dynamics of the manipulator assumed to be and Euler-Bernoulli beam are derived on the basis of the linear mathematical modle. Although this pneumatic artifical muscle actuator has many merits for the compliance robot, it is difficult to make an effective control scheme of this system because of ths nonlinearity and uncertainty on the dynamics of the actuator. By designing a controller using .mu.-synthesis, robust performance against measurement noise, various modeling uncertainties on the dynamics of the servo valve, actuator and mainpulator, is achieved. The effectiveness of the proposed control method is illustrated through simulations and experiments.

• Proceedings of the KSME Conference
• /
• 2003.04a
• /
• pp.786-791
• /
• 2003

This paper proposes an adaptive control algorithm for nonholonomic mobile robots with unknown parameters and the proposed control method is used in numerical simulations for applying to a practical twowheeled welding mobile robot(WMR). The proposed adaptive controller to track an arbitrary given welding path is designed by using back-stepping technique and is derived for a nonlinear model under the assumption such that the system parameters are partially known. Moreover, the proposed adaptive control system is stable in the sense of Lyapunov stability. Inertia moments of system are considered to be unknown parameters and their values can be estimated simply by using update laws proposed in an adaptive control scheme of this research. The simulation results are provided to show the effectiveness of the accurate tracking capability of the proposed controller for two-wheeled welding mobile robot with a smooth curved reference welding path.

• Journal of the Korean Society for Precision Engineering
• /
• v.21 no.10
• /
• pp.65-77
• /
• 2004

In this paper, we propose an adaptive mechanism based on immune algorithm and neural network identifier technique. It is also applied fur an autonomous guided vehicle (AGV) system. When the immune algorithm is applied to the PID controller, there exists the case that the plant is damaged due to the abrupt change of PID parameters since the parameters are almost adjusted randomly. To solve this problem, we use the neural network identifier (NNI) technique fur modeling the plant and humoral immune algorithm (HIA) which performs the parameter tuning of the considered model, respectively. After the PID parameters are determined in this off-line manner, these gains are then applied to the plant for the on-line control using an immune adaptive algorithm. Moreover, even though the neural network model may not be accurate enough initially, the weighting parameters are adjusted to be accurate through the on-line fine tuning. Finally, the simulation and experimental result fur the control of steering and speed of AGV system illustrate the validity of the proposed control scheme. These results for the proposed method also show that it has better performance than other conventional controller design methods.

• Journal of Mechanical Science and Technology
• /
• v.15 no.8
• /
• pp.1165-1173
• /
• 2001

This paper deals with dynamic analysis of Pipeline Inspection Gauge (PIG) flow control in natural gas pipelines. The dynamic behaviour of PIG depends on the pressure differential generated by injected gas flow behind the tail of the PIG and expelled gas flow in front of its nose. To analyze dynamic behaviour characteristics (e.g. gas flow, the PIG position and velocity) mathematical models are derived. Tow types of nonlinear hyperbolic partial differential equations are developed for unsteady flow analysis of the PIG driving and expelled gas. Also, a non-homogeneous differential equation for dynamic analysis of the PIG is given. The nonlinear equations are solved by method of characteristics (MOC) with a regular rectangular grid under appropriate initial and boundary conditions. Runge-Kutta method is used for solving the steady flow equations to get the initial flow values and for solving the dynamic equation of the PIG. The upstream and downstream regions are divided into a number of elements of equal length. The sampling time and distance are chosen under Courant-Friedrich-Lewy (CFL) restriction. Simulation is performed with a pipeline segment in the Korea gas corporation (KOGAS) low pressure system. Ueijungboo-Sangye line. The simulation results show that the derived mathematical models and the proposed computational scheme are effective for estimating the position and velocity of the PIG with a given operational condition of pipeline.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.24 no.3 s.174
• /
• pp.634-644
• /
• 2000

Fatigue crack growth and life is estimated by various fracture mechanical parameters but affected by load, material and environment. Fatigue character of component without surface notch cannot be e valuated by above-mentioned parameters due to microstructure of in-service material. Single fracture mechanical parameter or nondestructive parameter cannot predict fatigue damage in arbitrary boundary condition but multiple fracture mechanical parameters or nondestructive parameters can Fatigue crack growth modelling with three point representation scheme uses this merit but has limit on real-time monitoring. Therefore, this study shows fatigue damage model using backpropagatior. neural networks on the basis of X-ray half breadth ratio B/$B_o$ fractal dimension $D_f$ and fracture mechanical parameters can predict fatigue crack growth rate da/dN and cycle ratioN/$N_f$ at the same time within engineering estimated mean error(5%).