• Biomolecules & Therapeutics
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• v.22 no.1
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• pp.27-34
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• 2014

Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, and to investigate its inhibitory mechanisms in immunoglobulin E (IgE)/Ag-induced mouse bone marrow-derived mast cells (BMMCs) and in a mouse model of IgE/Ag-mediated passive systemic anaphylaxis (PSA). Curcumin inhibited cyclooxygenase-2 (COX-2) dependent prostaglandin $D_2$ ($PGD_2$) and 5-lipoxygenase (5-LO) dependent leukotriene $C_4$ ($LTC_4$) generation dose-dependently in BMMCs. To probe the mechanism involved, we assessed the effects of curcumin on the phosphorylation of Syk and its downstream signal molecules. Curcumin inhibited intracellular $Ca^{2+}$ influx via phospholipase $C{\gamma}1$ ($PLC{\gamma}1$) activation and the phosphorylation of mitogen-activated protein kinases (MAPKs) and the nuclear factor-${\kappa}B$ (NF-${\kappa}B$) pathway. Furthermore, the oral administration of curcumin significantly attenuated IgE/Ag-induced PSA, as determined by serum $LTC_4$, $PGD_2$, and histamine levels. Taken together, this study shows that curcumin offers a basis for drug development for the treatment of allergic inflammatory diseases.

• Journal of the Korean Society of Radiology
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• v.10 no.8
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• pp.571-576
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• 2016

3D printing has recently been used in various fields. Among various applications, 3D face data must be generated for 3D face printing. A laser scanner is used to acquire 3D face data, but there is a restriction that a person should not move during scanning. In this paper, we propose a 3D face modeling method based on a single image and a face transformation system to use the generated 3D face for virtual cosmetic surgery. We have defined facial feature points from the 3D face database for 3D face data generation. After extracting feature points from a single face image, 3D face of the input face image is generated corresponding to the 3D face feature points defined from the 3D face database. After 3D face modeling, 3D face modification part is applied for use such as virtual cosmetic surgery.

• Review of Korean Society for Internet Information
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• v.14 no.4
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• pp.63-76
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• 2013

This short report introduces the general background why Brazil conference is being prepared and what topics would be undertaken and what goals are being taken into account. It overviews what differences from traditional telecommunication governance, internet governance has had in its historical development and how such differences had been formed from its technological differences and the regulatory policy shift from common carrier regulation to privatization. Moreover, the fact that open, voluntary, bottom-up, diverse stakeholder's participation had evolved throughout the historical development of the internet, had established the present multistakeholder governance model from technological standardization to addressing scheme policies. ICANN, which has governed internet addressing schemes since the earlier 2000s, had developed address policies including IANA function from Jon Postel and technical community's legacy management system into contract based formation between ICANN and gTLD, ccTLD registries. And it made dispute resolution policies responding to trademark disputes and resolved gTLD monopoly issue by introducing new TLD generation and the separation of registry and registar. However, there had been challenges on the legitimacy of ICANN due to its dependency on the Federal Government of the U.S. particularly in its oversight role over ICANN and IANA contract. WSIS raised up internet governance issues including addressing governance, and set up IGF as a discussion platform for multistakeholders to discuss and share all views on other internet related public policies. IGF's loose and non-binding discussion once frustrated governments and other stakeholders, but more focused discussion and visible outcomes have consolidated its unique role for internet governance discourses. Particularly, IGF addressed many emerging internet related issues like cybersecurity, privacy, net neuratlity, development related issues. WTPF of 2013, after WCIT debate on whether traditional telecommunication regulation could be applied to internet infrastructure, suggested other governance issues such as the transition to ipv6, IXP coordination etc. How to make sure the legitimacy of internet addressing governance and how and where other internet related public policies could be undertaken are fundamental tasks for internet governance. Brazil conference, which has been motivated by the breakdown of trust in internet governance from NSA mass surveillance revealed by Snowden, faces these questions and try to make consensus on principles, institutions and roadmap for internet governance in multistakeholder participation way.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.11
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• pp.4268-4290
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• 2015

Future mobile communications face enormous challenges as traditional voice services are replaced with increasing mobile multimedia and data services. To address the vast data traffic volume and the requirement of user Quality of Experience (QoE) in the next generation mobile networks, it is imperative to develop efficient content distribution technique, aiming at significantly reducing redundant data transmissions and improving content delivery performance. On the other hand, in recent years cloud computing as a promising new content-centric paradigm is exploited to fulfil the multimedia requirements by provisioning data and computing resources on demand. In this paper, we propose a cooperative caching framework which implements State based Content Distribution (SCD) algorithm for future mobile networks. In our proposed framework, cloud service providers deploy a plurality of cloudlets in the network forming a Distributed Cloud Service Network (DCSN), and pre-allocate content services in local cloudlets to avoid redundant content transmissions. We use content popularity and content state which is determined by content requests, editorial updates and new arrivals to formulate a content distribution optimization model. Data contents are deployed in local cloudlets according to the optimal solution to achieve the lowest average content delivery latency. We use simulation experiments to validate the effectiveness of our proposed framework. Numerical results show that the proposed framework can significantly improve content cache hit rate, reduce content delivery latency and outbound traffic volume in comparison with known existing caching strategies.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.24 no.2
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• pp.183-191
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• 2006

The accuracy of the upward continuation is assessed through the gravity modeling using an ultra-high degree spherical harmonic expansion. The difficulties in the numerical calculation of Legendre function with ultra-high degree, underflow and/or overflow, is successfully resolved in 128 bit calculation scheme. Using the generated Legendre function, the gravity anomaly with spatial resolution of $1'{\times}1'$ on the geoid is calculated. The generated gravity anomaly is degraded and extracted with various noise levels and data intervals, then upward continuation is applied to each data sets. The comparison between the upward continued gravity disturbances and the directly calculated from the spherical harmonics showed that the accuracy on the direct method was significantly better than that of Poisson method. In addition, it is verified that the denser and less noised gravity data on the geoid generates better gravity disturbance vectors at an altitude. Especially, it is found that the gravity noise level less than 5mGal, and the data interval less than 2arcmin is necessary for next generation precision INS navigation which requires the accuracy of 5mGal or better at an altitude.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.24 no.5
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• pp.443-451
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• 2006

DEM has been used for various purposes overall fields of engineering, the fields of civil engineering, military, communication, environment, and so forth and its applications are being extending increasingly. It is well hewn that LiDAR DEM is definitely superior to the other surveying methods. But LiDAR DEM run short of a full study about vertical accuracy. In order to assess LiDAR DEM, total 35 stations were selected and surveyed by GPS for utilizing as reference data. And then accuracy of LiDAR DEM was analyzed by comparison between both LiDAR DEM and CPS surveying. The RMSE of ${\pm}0.109m$ was shown in vertical direction. It is within the permissible accuracy required for mapping on a scale of 1 to 500 and 1 to 1000 on the mapping rule notified by the National Geographic Information Institute. It is expected that the results of this study will be fully used in the field of large scale DEM generation and be utilized as basic information in applied field of LiDAR DEM.

• Journal of Preventive Medicine and Public Health
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• v.38 no.1
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• pp.61-70
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• 2005

Objectives : To develop a tool for multidimensional measurement of the quality of life, which was psychometrically sound, short, and easy to administer for patients with hypertension. Methods : A sample of 1,115 hypertensive patients aged 20 or above in Cheong-Song County was studied from June 1997 to October 1998. In the development of the instrumental stage, the authors first conceptualized the quality of life. Item generation, item reduction, and questionnaire formatting were followed. Item-level (item descriptive, missing%, item internal consistency, item discriminant validity) analysis, scale-level (scale descriptive, floor and ceiling effect) analysis, and other tests(Cronbach's alpha, inter-dimension correlations, factor analysis, clinical validity) were performed to evaluate the validity and reliability of the new measurement scale. After 1 year, responsiveness and confirmatory factor analysis were performed. Results : The results of both item-level and scale-level analyses were acceptable. An acceptable degree of internal consistency was observed for each of the dimensions (Cronbach's alpha was 0.60 or higher). Inter-dimension correlations were below 0.50 and the factor analysis result was the same as the intended dimension structure. Correlation coefficients between perceived health status, stress and dimensions were proven to be acceptable. The result of comparing dimensional score means among ADL and MMSE-K groups above 60 years was statistically significant(p<0.05). The result of confirmatory factor analysis concluded that the dimensional structure model was well fitted. However, the result of responsiveness test using sensitivity and specificity was unsatisfactory. Conclusions : The newly developed measurement scale is psychometrically reliable and valid instrument for measuring quality of life in hypertensive patients.

• Proceedings of the KSRS Conference
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• 1998.09a
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• pp.153-158
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• 1998

Since the mid-1990′s, researches on 3D GIS have been regarded as one of main issues both in the academic sites and commercial vendors; recently, some prototyped systems or the first versioned software systems of commercial basis are being reported and released. Unlike conventional 2D GIS, which consists in intelligent structured GIS or desktop GIS, every 3D GIS has its own distinguished features according to data structure-supporting capability, GIS-styled functionality, external database accessibility, interfacing extents with 2D GIS, 3D visualization/texture mapping ability, and so forth. In this study, technical aspects related to system development, SERI-Web3D GIS ver. 1.2, are explained. Main features in this revised 3D GIS can be summarized: 2-tier system model(client-server), VGFF(Virtual GIS File Format), internal GIS import, Feature manager(zoning, layering, visualization evironment), Scene manager(manage 3D geographic world), Scene editor, Spatial analyzer(Intersect, Buffering, Network analysis), VRML exporter. While, most other 3D GISes or cartographic mapping systems may be categorized into 3D visualization systems handling terrain height-field processing, 2D GIS extension modules, or 3D geometric feature generation system using orthophoto image: actually, these are eventually considered as several parts of "real 3D GIS". As well as these things, other components, especially web-based 3D GIS, are being implemented in this study: Surface/feature integration, Java/VRML linkage, Mesh/Grid problem, LOD(Level of Detail)/Tiling, Public access security problem, 3-tier architecture extension, Surface handling strategy for VRML.

• Toxicological Research
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• v.31 no.2
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• pp.97-104
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• 2015

The skin exposure to solar irradiation and photoreactive xenobiotics may produce abnormal skin reaction, phototoxicity. Phototoxicity is an acute light-induced response, which occurs when photoreacive chemicals are activated by solar lights and transformed into products cytotoxic against the skin cells. Multifarious symptoms of phototoxicity are identified, skin irritation, erythema, pruritis, and edema that are similar to those of the exaggerated sunburn. Diverse organic chemicals, especially drugs, are known to induce phototoxicity, which is probably from the common possession of UV-absorbing benzene or heterocyclic rings in their molecular structures. Both UVB (290~320 nm) and UVA (320~400 nm) are responsible for the manifestation of phototoxicity. Absorption of photons and absorbed energy (hv) by photoactive chemicals results in molecular changes or generates reactive oxygen species and depending on the way how endogenous molecules are affected by phototoxicants, mechanisms of phototoxcity is categorized into two modes of action: Direct when unstable species from excited state directly react with the endogenous molecules, and indirect when endogeneous molecules react with secondary photoproducts. In order to identify phototoxic potential of a chemical, various test methods have been introduced. Focus is given to animal alternative test methods, i.e., in vitro, and in chemico assays as well as in vivo. 3T3 neutral red uptake assay, erythrocyte photohemolysis test, and phototoxicity test using human 3-dimensional (3D) epidermis model are examples of in vitro assays. In chemico methods evaluate the generation of reactive oxygen species or DNA strand break activity employing plasmid for chemicals, or drugs with phototoxic potential.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.7
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• pp.805-812
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• 2011

In this study, a cantilevered energy harvester comprising piezoelectric fiber and epoxy composites was designed and analyzed electro-mechanically. In order to maximize the power of the cantilevered energy harvester, its exciting frequency was tuned to the first natural frequency of the beam. An efficient analysis method for predicting the output voltage of the beam was developed by using the finite element method coupled with piezoelectric behavior. By using this method, the effects of geometric parameters and various piezoelectric materials on power generation were investigated and the electric characteristics were evaluated. Design optimization of the beam geometries was performed for a base model. The optimum MFC design generated a maximum electric output of 40.1 V at a first natural frequency of 24.5 Hz.