• Journal of Biomedical Engineering Research
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• v.37 no.2
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• pp.90-103
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• 2016

This research was aimed to analyze load sharing ratios between cortical shell and trabecular bone of a degraded lumbar vertebra with aging, and also evaluate elastic moduli assigned into an FE model, using finite element method. For the better analysis of trabecular bone, effective elastic moduli, that is, nominal elastic moduli divided by the volumetric porosities was used. The elastic moduli of the cortical shell suitable for the trabecular bone were obtained from the equations on the basis of idealized stress-strain relations, including areal porosities. To minimize numerical errors, p-element was used. Using eight parameters that refer to some published papers, the geometry of L3 with a removed posterior part. After the constant compressive displacement was applied, the load sharing ratios were obtained by using both every elastic strain energy and every vertical force between two bones in each 8-volume. As results, 1) according to an increase in age from 20-year to 80-year, load sharing ratios of trabecular bone decreased from 55% to 49%; 2) the maximal ratios of each bone were occurred in the mid-plane of centrums and the endplate of cortical shells, respectively; 3) effective elastic moduli assigned into a porous centrum/cortex were found to be adequate; 4) for load sharing ratios, the difference of two methods showed that the total ratios were almost same within less than 1% but the partial ratios at every depth were more or less different each other.

• Journal of Preventive Medicine and Public Health
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• v.37 no.4
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• pp.381-389
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• 2004

Objective : To compare the efficacy between SKI306X and Diclofenac by using generalized estimating equations (GEE) methodology in the analysis of correlated bivariate binary outcome data in Osteoarthritis (OA) diseases. Methods : A randomized, double-blind, active comparator-controlled, non-inferiority clinical trial was conducted at 5 institutions in Korea with the random assignment of 248 patients aged 35 to 75 years old with OA of the knee and clinical evidence of OA. Patients were enrolled in this study if they had at least moderate pain in the affected knee joint and a score larger than 35mm as assessed by VAS (Visual Analog Scale). The main exposure variable was treatment (SKI 306X vs. Diclofenac) and other covariates were age, sex, BMI, baseline VAS, center, operation history (Yes/No), NSAIDS (Y/N), acupuncture (Y/N), herbal medicine (Y/N), past history of musculoskeletal disease (Y/N), and previous therapy related with OA (Y/N). The main study outcome was the change of VAS pain scores from baseline to the 2nd and 4th weeks after treatment. Pain scores were obtained as baseline, 2nd and 4th weeks after treatment. We applied GEE approach with empirical covariance matrix and independent(or exchangeable) working correlation matrix to evaluate the relation of several risk factors to the change of VAS pain scores with correlated binary bivariate outcomes. Results : While baseline VAS, age, and acupuncture variables had protective effects for reducing the OA pain, its treatment (Joins/Diclofenac) was not statistically significant through GEE methodology (ITT:aOR=1.37, 95% CI=(0.8200, 2.26), PP:aOR=1.47, 95% CI=(0.73, 2.95)). The goodness-of-fit statistic for GEE (6.55, p=0.68) was computed to assess the adequacy of the fitted final model. Conclusions : Both ANCOVA and GEE methods yielded non statistical significance in the evaluation of non-inferiority of the efficacy between SKI306X and Diclofenac. While VAS outcome for each visit was applied in GEE, only VAS outcome for the fourth visit was applied in ANCOVA. So the GEE methodology is more accurate for the analysis of correlated outcomes.

• Journal of Technology Innovation
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• v.23 no.1
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• pp.61-86
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• 2015

This study provides an empirical analysis based on 2012 Korea Innovation Survey (STEPI) to investigate the relation between R&D cooperation and in-house R&D investment. The study further analyzes the effect of the R&D cooperation and in-house R&D investment on technical innovation. First, the relation between company's in-house R&D investment and R&D cooperations is estimated with the two equations using SUR models. Second, the effect of in-house R&D investment and R&D cooperation on the company's technical innovation is estimated using Probit model. This study differs from other existing R&D studies using Korean data in that empirical models are based on structural relationships among in-house R&D, R&D cooperation, and technical innovation. The results can be summarized as follows; the R&D cooperation expands the in-house R&D investment and the in-house R&D strengthen the R&D cooperation. Furthermore, In-house R&D investment increases the chances of success in innovation. As we obtain evidence of complementary relation between R&D cooperation and in-house R&D investment, it is necessary to develop environment conducive to this complementarity in order to have more efficient R&D system.

• Journal of the Korean Society of Tobacco Science
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• v.20 no.2
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• pp.183-190
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• 1998

This study was conducted to analyze chemical components in flue-cured tobacco using near infrared spectroscopy(NIRS). Samples were collected in '96 and '97 crop year and were scanned in the wavelengths of 400 ～ 2500 nm by near infrared analyzer(NIRSystem Co., Model 6500). Calibration equations were developed and then analyzed flue-cured samples by NIRS. The standard error of calibration(SEC) and performance (SEP) of '96 crop year samples between NIRS and standard laboratory analysis(SLA) were 0.18% and 0.24% for nicotine, 1.60% and 1.77% for total sugar, 0.13% and 0.15% for total nitrogen, 0.58% and 0.68% for crude ash, 0.23% and 0.28% for ether extracts, and 0.09% and 0.08% for chlorine, respectively. The coefficient of determination($R^2$) of calibration and prediction samples between NIRS and SLA of '96 crop year samples was 0.94～0.99 and 0.83～0.97 depending on chemical components, respectively. The SEC and SEP of '97 crop year samples were similar to those of '96 crop year samples. The SEP of '97 crop year samples which were analyzed using '96 calibration equation was 0.32 % for nicotine, 2.72% for total sugar, 0.14 % for total nitrogen, 1.00 % for crude ash, 0.48 for ether extracts and 0.17% for chlorine, respectively. The prediction result was more accurate when calibration and prediction samples were produced in the same crop year than those of the different crop year. The SEP of '96 and '97 crop year samples using calibration equation which was developed '96 plus '97 crop year samples was similar to that of '96 crop year samples using 96 calibration equation and that of '97 crop year samples using '97 calibration equation, respectively. The SEP of '97 crop year samples using calibration equation which was developed '96 plus '97 crop year samples was lower than that of '97 crop year samples analyzed by '96 calibration equation. To improve the analytical inaccuracy caused by the difference of crop year between calibration and prediction samples, we need to include the prediction sample spectra which are different from calibration sample spectra in recalibration sample spectra, and then develop recalibration equation. Although the analytical result using NIR is not as good as SLA, the chemical component analysis using NIR can apply to tobacco leaves, leaf process or tobacco manufacturing process which demand the rapid analytical result.

• The Korean Journal of Nuclear Medicine
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• v.29 no.1
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• pp.125-132
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• 1995

The purpose of this study was to establish mononuclear cell cultures such as lymphocytes or buffy coat for the biological dosimetry of in vitro Irradiation of the radionuclide Tc-99m in order to exclude the effect of residual doses seen in the cultures of whole blood. Biological do simetry of Tc-99m on cultured mononuclear cells at doses ranging from 0.05 to 6.00 Gy, by scoring unstable chromosomal aberrations(Ydr) observed in cultured lymphocytes, were performed using peripheral venous blood of healthy normal person. The results showed that; (1) In vitro irradiation of radioisotope in separated lymphocyte or buffy coat showed trace amount of residual doses of isotope after washing. Residual doses of isotopes are increased in proportion to exposed time and irradiated dose without difference between I-131 and Tc-99m. (2) We obtained these linear-quadratic dose response equations in lymphocyte and buffy coat culture after in vitro irradiation of Tc-99m, respectively (Ydr = 0.001949 $D^2$ +0.006279D + 0.000185; Ydr= 0.002531 $D^2$-0.003274 D+0.003488). In conclusion, the linear quadratic dose-response equation from in vitro irradiation of Tc-99m with lymphocyte and buffy coat culture was thought to be useful for assessing Tc-99m induced biological effects. And mono-nuclear cell cultures seem to be the most appropriate experimental model for the assessment of biological dosimetry of internal irradiation of radionuclides.

• Magazine of the Korean Society of Agricultural Engineers
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• v.40 no.5
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• pp.91-99
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• 1998

The widespread use of thin shell structures has created a need for a systematic method of analysis which can adequately account for arbitrary geometric form and boundary conditions as well as arbitrary general type of loading. Therefore, the stress and analysis of thin shell has been one of the more challenging areas of structural mechanics. A wide variety of numerical methods have been applied to the governing differential equations for spherical and cylindrical structures with a few results applicable to practice. The analysis of axisymmetric spherical shell is almost an every day occurrence in many industrial applications. A reliable and accurate finite element analysis procedure for such structures was needed. Dynamic loading of structures often causes excursions of stresses well into the inelastic range and the influence of geometry changes on the response is also significant in many cases. Therefore both material and geometric nonlinear effects should be considered. In general, the shell structures designed according to quasi-static analysis may fail under conditions of dynamic loading. For a more realistic prediction on the load carrying capacity of these shell, in addition to the dynamic effect, consideration should also include other factors such as nonlinearities in both material and geometry since these factors, in different manner, may also affect the magnitude of this capacity. The objective of this paper is to demonstrate the dynamic characteristics of spherical shell. For these purposes, the spherical shell subjected to uniformly distributed step load was analyzed for its large displacements elasto-viscoplastic static and dynamic response. Geometrically nonlinear behaviour is taken into account using a Total Lagrangian formulation and the material behaviour is assumed to elasto-viscoplastic model highly corresponding to the real behaviour of the material. The results for the dynamic characteristics of spherical shell in the cases under various conditions of base-radius/central height(a/H) and thickness/shell radius(t/R) were summarized as follows : The dynamic characteristics with a/H. 1) AS the a/H increases, the amplitude of displacement in creased. 2) The values of displacement dynamic magnification factor (DMF) were ranges from 2.9 to 6.3 in the crown of shell and the values of factor in the mid-point of shell were ranged from 1.8 to 2.6. 3) As the a/H increases, the values of DMF in the crown of shell is decreased rapidly but the values of DMF in mid-point shell is increased gradually. 4) The values of DMF of hoop-stresses were range from 3.6 to 6.8 in the crown of shell and the values of factor in the mid-point of shell were ranged from 2.3 to 2.6, and the values of DMF of stress were larger than that of displacement. The dynamic characteristics with t/R. 5) With the thickness of shell decreases, the amplitude of the displacement and the period increased. 6) The values of DMF of the displacement were ranged from 2.8 to 3.6 in the crown of shell and the values of factor in the mid-point of shell were ranged from 2.1 to 2.2.

• Applied Chemistry for Engineering
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• v.2 no.2
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• pp.108-118
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• 1991

Interactions between pyridine hydrodenitrogenation (HDN) and m-cresol hydrodeoxygenation(HDO), and the kinetic analysis were studied over sulfided $CoMo/{\gamma}-Al_2O_3$ catalyst at the range of temperatures between 473 K and 723 K, the total pressures between $10{\times}10^5Pa$ and $50{\times}10^5Pa$, and the contact times between 0.0125 g-cat. hr/ml-feed and 0.03g-cat. hr/ml-feed. HDN of pyridine and HDO of m-cresol were inhibited by each other and the inhibition effect of HDO by pyridine is higher than that of HDN by m-cresol. But reactivity of m-cresol is higher than that of pyridine. The rate equations of pyridine and m-cresol were given to be ${\gamma}_{HDN}=k_{HDN}{\cdot}K_pC_p/(1+K_cC_c+K_pC_p)$ and ${\gamma}_{HDO}=k_{HDO}{\cdot}K_cC_c/(1+K_cC_c+K_pC_p)$ in terms of Langmuir-Hinshellwood-Hougen-Watson model. At each temperature, reaction rate constants and adsorption equilibrium constants were determined and activation energies of pyridine HDN and m-cresol HDO are 13.83kcal/mol, respectively and the heat of adsorption are -6.458 and -5.045kcal/mol, respectively.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.25 no.6
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• pp.365-373
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• 2013

Representative tidal gauging (TG) stations are selected to cover the tidal characteristics of the Korean peninsula coastal seas, and the statistical parameters of the data are analysed from the perspective of the probability distribution at that TG station. The shape of the distribution in the Incheon and Gunsan TG stations, which are tide-dominated areas, shows two clear modes at HWONT and LWONT in the distributions, and in the Mokpo station, shows an asymmetric double peak distribution. In contrast, the frequency distribution shape shows a smoothed flat peak in the Jeju, Yeosu and Busan TG stations, and a single peak in the Pohang and Sokcho TG stations. The emersion and submersion equations suggested as the 6-parameter Gaussian mixture models in this study are accurate, and well fitted to the observed tidal elevation data. The ${\mu}_1$, ${\mu}_2$ parameters are highly correlated to the LWONT and HWONT, and the ${\sigma}_1$ and ${\sigma}_2$ parameters are also closely correlated to the mean tidal range. The ${\mu}_1$ and ${\mu}_2$ parameters coincide with the modes of the suggested probability distribution of the hourly tidal level data.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.47 no.12
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• pp.831-840
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• 2019

Flush Air Data Sensing system (FADS) estimates air data states using pressure data measured at the surface of flight vehicles. The FADS system does not require intrusive probes, so it is suitable for high performance aircrafts, stealth vehicles, and hypersonic flight vehicles. In this study, calibration procedures and solution algorithms of the FADS for a sphere-cone shape vehicle are presented for the prediction of air data from subsonic to supersonic flights. Five flush pressure ports are arranged on the surface of nose section in order to measure surface pressure data. The algorithm selects the concept of separation for the prediction of flow angles and the prediction of pressure related variables, and it uses the pressure model which combines the potential flow solution for a subsonic flow with the modified Newtonian flow theory for a hypersonic flow. The CFD code which solves Euler equations is developed and used for the construction of calibration pressure data in the Mach number range of 0.5~3.0. Tests are conducted with various flight conditions for flight Mach numbers in the range of 0.6~3.0 and flow angles in the range of -10°~+10°. Air data such as angle of attack, angle of sideslip, Mach number, and freestream static pressure are predicted and their accuracies are analyzed by comparing predicted data with reference data.

• Applied Chemistry for Engineering
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• v.7 no.6
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• pp.1043-1052
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• 1996

Supercritical fluid chromatographic method was recommended as an alternative separation method of fatty acids of the conventional method such as distillation or extraction. Although diffusion characteristics are varied by the carbon numbers and the degree of unsaturation of fatty acids, the quantitative data were so rare that the commercialization of supercritical fluid chromatographic method has been hindered. In this study, diffusion coefficients of fatty acids which are differently unsaturated are measured by CPB method in the range of 308.15K to 328.15K and 13MPa to 17MPa in supercritical carbon dioxide. A decrease in the binary diffusion coefficient was observed with an increase in temperature and pressure. Also, the decrease in the binary diffusion coefficient with increasing fluid density and viscosity. Wilke-Chang equation, Funazukuri empirical equation, and Matthews-Akgerman equation are used to correlate the experimental diffusion coefficients of fatty acids in supercritical carbon dioxide. Among the various theoretical equations, Matthews-Akgerman equation based on RHS theory was suggested as a more successful correlation model with experimental data.