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Phylogenetic Study of Ganoderma applanatum and Schizopora paradoxa Basd on 5S rRNA Sequences (5S rRNA 염기서열에 으한 잔나비걸상과 좀구멍버섯의 계통학적 연구)

  • Kim, Hak-Hyun;Jung, Hack-Sung
    • Korean Journal of Microbiology
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    • v.32 no.3
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    • pp.177-181
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    • 1994
  • The sequences of the cytoplasmic 5S rRNAs(EMBL accession number X73589 and X73890) from two polupores, Ganoderma applanatum and Schizopora paradoxa, were determined by the direct chemical method for sequencing RNA and compared to the sequences of 9 reported mushrooms. 5S rRNAs of Ganoderma applanatum and Schizopora paradoxa consisted of 118 bases and fit the secondary structure model of the 5S rRNAs of basidiomycetes proposed by Huysmans et al. Based on Kimura’s K_nuc values, the closest fungus to Ganoderma applanatum was Ceratobasidium cornigerum and the one to Schizopora paradoxa was Bjerkandera adusta. When the secondary structures of 5S rRNAs of 11 mushrooms were compared the base substitution occurred at helix regions more than at loop regions. When a phylogenetic tree was constructed using the Neighbor program of the PHYLIP package, it partially discriminated and separated the mushrooms of the Hymenomycetes by the order.

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Simplification of State Invariant with Mixed Reachability Analysis (혼합 도달성 분석을 이용한 상태 불변식의 단순화)

  • 권기현
    • Journal of KIISE:Software and Applications
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    • v.30 no.3_4
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    • pp.212-218
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    • 2003
  • State invariant is a property that holds in every reachable state. It can be used not only in understanding and analyzing complex software systems, but it can also be used for system verifications such as checking safety, liveness, and consistency. For these reasons, there are many vital researches for deriving state invariant from finite state machine models. In previous works every reachable state is to be considered to generate state invariant. Thus it is likely to be too complex for the user to understand. This paper seeks to answer the question `how to simplify state invariant\ulcorner`. Since the complexity of state invariant is strongly dependent upon the size of states to be considered, so the smaller the set of states to be considered is, the shorter the length of state invariant is. For doing so, we let the user focus on some interested scopes rather than a whole state space in a model. Computation Tree Logic(CTL) is used to specify scopes in which he/she is interested. Given a scope in CTL, mixed reachability analysis is used to find out a set of states inside it. Obviously, a set of states calculated in this way is a subset of every reachable state. Therefore, we give a weaker, but comprehensible, state invariant.

Comparison of Hospital Standardized Mortality Ratio Using National Hospital Discharge Injury Data (퇴원손상심층조사 자료를 이용한 의료기관 중증도 보정 사망비 비교)

  • Park, Jong-Ho;Kim, Yoo-Mi;Kim, Sung-Soo;Kim, Won-Joong;Kang, Sung-Hong
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.4
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    • pp.1739-1750
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    • 2012
  • This study was to develop the assessment of medical service outcome using administration data through compared with hospital standardized mortality ratios(HSMR) in various hospitals. This study analyzed 63,664 cases of Hospital Discharge Injury Data of 2007 and 2008, provided by Korea Centers for Disease Control and Prevention. We used data mining technique and compared decision tree and logistic regression for developing risk-adjustment model of in-hospital mortality. Our Analysis shows that gender, length of stay, Elixhauser comorbidity index, hospitalization path, and primary diagnosis are main variables which influence mortality ratio. By comparing hospital standardized mortality ratios(HSMR) with standardized variables, we found concrete differences (55.6-201.6) of hospital standardized mortality ratios(HSMR) among hospitals. This proves that there are quality-gaps of medical service among hospitals. This study outcome should be utilized more to achieve the improvement of the quality of medical service.

A New Clock Routing Algorithm for High Performance ICs (고성능 집적회로 설계를 위한 새로운 클락 배선)

  • 유광기;정정화
    • Journal of the Korean Institute of Telematics and Electronics C
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    • v.36C no.11
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    • pp.64-74
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    • 1999
  • A new clock skew optimization for clock routing using link-edge insertion is proposed in this paper. It satisfies the given skew bound and prevent the total wire length from increasing. As the clock skew is the major constraint for high speed synchronous ICs, it must be minimized in order to obtain high performance. But clock skew minimization can increase total wire length, therefore clock routing is performed within the given skew bound which can not induce the malfunction. Clock routing under the specified skew bound can decrease total wire length Not only total wire length and delay time minimization algorithm using merging point relocation method but also clock skew reduction algorithm using link-edge insertion technique between two nodes whose delay difference is large is proposed. The proposed algorithm construct a new clock routing topology which is generalized graph model while previous methods uses only tree-structured routing topology. A new cost function is designed in order to select two nodes which constitute link-edge. Using this cost function, delay difference or clock skew is reduced by connecting two nodes whose delay difference is large and distance difference is short. Furthermore, routing topology construction and wire sizing algorithm is developed to reduce clock delay. The proposed algorithm is implemented in C programming language. From the experimental results, we can get the delay reduction under the given skew bound.

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Development of Stem Analysis Program(Stemwin1.0) for Windows (Windows용 수간석해(樹幹析解) 프로그램(Stemwin1.0)의 개발(開發))

  • Lee, Joon-Hak;Lee, Woo-Kyun;Seo, Jeong-Ho
    • Journal of Korean Society of Forest Science
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    • v.90 no.3
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    • pp.331-337
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    • 2001
  • This study was performed to develope stem analysis program(Stemwin1.0) which can be used in PC with MS-Windows operating system. Stemwin1.0 uses width of annual tree ring measured with 1/100mm unit, and calculate increments of several growth factors such as DBH, height and volume with various methods. Mean DBH can be calculated by arithmetic and quadratic mean methods. Height can be estimated by parallel line, line extending and height curve methods. Volume can be estimated by Huber, Smalian, and Spline functions. Not only Total growth, Mean Annual Increment(MAI) and Current Annual Increment(CAI) of growth factors, but also merchantable volume and height, form factor, growth rate, and merchantable volume rate are automatically calculated. Stemwin1.0 can also output accurate stem taper curve with various scale, and prepare stem taper data(diameter at different disk heights) for statistical analysis for deriving stem taper model. Stemwin1.0 can export output data and graph to Excel for more compatible use of it.

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A Study on Improvement through Functionality Evaluation on Botanic Gardens and Arboreta in Korea (식물원·수목원 기능성 평가를 통한 개선방안 연구)

  • Kang, Hyun Kyung;Kim, Sun Hae;Kweon, Min-Hoon;Bang, Kwang Ja;Kim, Kwang Doo
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.15 no.3
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    • pp.29-43
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    • 2012
  • This study evaluated 23 botanic gardens and arboretums under two main categories including professional group and operational group. As for professional group, the main difference between the functions of botanic gardens and arboretums was analyzed. In the case of operational group compared professional group respectively, on categories including importance of function and implementation, seeking to provide fundamental data of botanic gardens and arboretums by enhancing the quality of visitors and examining functional differences. The result of a difference in arboretums' function between professional and operational groups, the study analyzed the importance of botanic gardens and arboretums in terms of detailed categories such as research, education, collection, display, retention, and service for visitors. As a result, professional group showed retention 4.32>education 4.11>research 4.09>service for visitors 4.05, and operational group showed retention 3.70>service 3.52>education 3.41>research 3.37, indicating that both groups had retention as the most selected answer. Looking closely at the functions of the currently implemented detailed categories of botanic gardens and arboretums, such as research, education, collection, display, retention, and service for visitors, the study showed that 91.3% selected rare species and individual multiplication for research function, 78.3% chose education of natural ecosystem for children for education, 73.9% answered space for experiencing nature for display, and 73.9% also replied managon, diof rare species, reproduction, and retention of native plants' species for retention category, and service for visitors showed 95.7% for implementation. The study could not clearly point out the influence between predictors due to absence of an established comprehensive evaluation model. Also, it analyzed and reviewed comparison of functions of professional group and operational group, but in the future, it should conduct study on a systemic and objective classification of botanic gardens and arboretums to clearly examine the difference in views between groups, which also requires, at the same time, study on management policy of botanic gardens and arboretums or suggesting guidelines that suit types of forms, and also study on facilities and program development that can be applied to each class.

Application of SWAT for the Estimation of Soil Loss in the Daecheong Dam Basin (대청댐 유역 토양 침식량 산정을 위한 SWAT 모델의 적용)

  • Ye, Lyeong;Yoon, Sung-Wan;Chung, Se-Woong
    • Journal of Korea Water Resources Association
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    • v.41 no.2
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    • pp.149-162
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    • 2008
  • The Soil and Water Assessment Tool (SWAT) developed by the USDA-Agricultural Research Service for the prediction of land management impact on water, sediment, and agricultural chemical yields in a large-scale basin was applied to Daecheong Reservoir basin to estimate the amount of soil losses from different land uses. The research outcomes provide important indications for reservoir managers and policy makers to search alternative watershed management practices for the mitigation of reservoir turbidity flow problems. After calibrations of key model parameters, SWAT showed fairly good performance by adequately simulating observed annual runoff components and replicating the monthly flow regimes in the basin. The specific soil losses from agricultural farm field, forest, urban area, and paddy field were 33.1, $2.3{\sim}5.4$ depending on the tree types, 1.0, and 0.1 tons/ha/yr, respectively in 2004. It was noticed that about 55.3% of the total annual soil loss is caused by agricultural activities although agricultural land occupies only 10% in the basin. Although the soil erosion assessment approach adopted in this study has some extent of uncertainties due to the lack of detailed information on crop types and management activities, the results at least imply that soil erosion control practices for the vulnerable agricultural farm lands can be one of the most effective alternatives to reduce the impact of turbidity flow in the river basin system.

Genetic signature of strong recent positive selection at interleukin-32 gene in goat

  • Asif, Akhtar Rasool;Qadri, Sumayyah;Ijaz, Nabeel;Javed, Ruheena;Ansari, Abdur Rahman;Awais, Muhammd;Younus, Muhammad;Riaz, Hasan;Du, Xiaoyong
    • Asian-Australasian Journal of Animal Sciences
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    • v.30 no.7
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    • pp.912-919
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    • 2017
  • Objective: Identification of the candidate genes that play key roles in phenotypic variations can provide new information about evolution and positive selection. Interleukin (IL)-32 is involved in many biological processes, however, its role for the immune response against various diseases in mammals is poorly understood. Therefore, the current investigation was performed for the better understanding of the molecular evolution and the positive selection of single nucleotide polymorphisms in IL-32 gene. Methods: By using fixation index ($F_{ST}$) based method, IL-32 (9375) gene was found to be outlier and under significant positive selection with the provisional combined allocation of mean heterozygosity and $F_{ST}$. Using nucleotide sequences of 11 mammalian species from National Center for Biotechnology Information database, the evolutionary selection of IL-32 gene was determined using Maximum likelihood model method, through four models (M1a, M2a, M7, and M8) in Codeml program of phylogenetic analysis by maximum liklihood. Results: IL-32 is detected under positive selection using the $F_{ST}$ simulations method. The phylogenetic tree revealed that goat IL-32 was in close resemblance with sheep IL-32. The coding nucleotide sequences were compared among 11 species and it was found that the goat IL-32 gene shared identity with sheep (96.54%), bison (91.97%), camel (58.39%), cat (56.59%), buffalo (56.50%), human (56.13%), dog (50.97%), horse (54.04%), and rabbit (53.41%) respectively. Conclusion: This study provides evidence for IL-32 gene as under significant positive selection in goat.

Implementation of an Efficient Microbial Medical Image Retrieval System Applying Knowledge Databases (지식 데이타베이스를 적용한 효율적인 세균 의료영상 검색 시스템의 구현)

  • Shin Yong Won;Koo Bong Oh
    • Journal of the Korea Society of Computer and Information
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    • v.10 no.1 s.33
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    • pp.93-100
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    • 2005
  • This study is to desist and implement an efficient microbial medical image retrieval system based on knowledge and content of them which can make use of more accurate decision on colony as doll as efficient education for new techicians. For this. re first address overall inference to set up flexible search path using rule-base in order U redure time required original microbial identification by searching the fastest path of microbial identification phase based on heuristics knowledge. Next, we propose a color ffature gfraction mtU, which is able to extract color feature vectors of visual contents from a inn microbial image based on especially bacteria image using HSV color model. In addition, for better retrieval performance based on large microbial databases, we present an integrated indexing technique that combines with B+-tree for indexing simple attributes, inverted file structure for text medical keywords list, and scan-based filtering method for high dimensional color feature vectors. Finally. the implemented system shows the possibility to manage and retrieve the complex microbial images using knowledge and visual contents itself effectively. We expect to decrease rapidly Loaming time for elementary technicians by tell organizing knowledge of clinical fields through proposed system.

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Effects of Human Error on the Optimal Test Internal and Unavailability of the Safety System (안전계통의 이용불능도 및 최적시험주기에 미치는 인간실수의 영향)

  • Chung, Dae-Wook;Koo, Bon-Hyun
    • Nuclear Engineering and Technology
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    • v.23 no.2
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    • pp.174-182
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    • 1991
  • Effects of human error relevant to the periodic test are incorporated in the evaluations of the unavailability and optimal test interval of a safety system. Two types of possible human error with respect to the test and maintenance are considered. One is the possibility that a good safety system is inadvertently left in a bad state after test(Type A human error) and the other is the possibility that a bad safety system is undetected upon the test(Type B human error). An event tree model is developed for the steady-state unavailability of a safety system in order to determine the effects of human errors on the system unavailability and the optimal test interval. A reliability analysis of the Safety Injection System (SIS) was peformed to evaluate the effects of human error on the SIS unavailability. Results of various sensitivity analyses show that ; (1) the steady-state unavailability of the safety system increases as the probabilities of both types of human error increase and it is far more sensitive to Type A human error, (2) the optimal test interval increases slightly as the probability of Type A human error increases but it decreases as the probability of Type B human error increases, and (3) provided that the test interval of the safety injction pump is kept unchanged, the unavailability of SIS increases significantly as the probability of Type A human error increases but slightly as the probability of Type B human error increases. Therefore, to obtain the realistic result of reliability analysis, one should take shorter test interval (not optimal test interval) so that the unavailability of SIS can be maintained at the same level irrespective of human error. Since Type A human error during test & maintenance influeces greatly on the system unavailability, special efforts to reduce the possibility of Type A human error are essential in the course of test & maintenance.

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