The osmotic delivery systems are based on osmosis. The transverse diffusion of water through a porous membrane from a medium with a low osmotic pressure to a medium with a high osmotic pressure. Nifedipine tablet dosage forms of Procardia $XL^{(R)}$(Pfizer) and $Adalat^{(R)}$(Bayer) are commercialized systems of this type that push-pull osmotic tablet operates successfully in delivering water-insoluble drugs. We prepared osmotic pellet system by fluidized bed coating method, and model-drug used nifedipine. The osmotic pellet system was composed of the core material. the swelling and osmotic pressure layer, the drug coating layer, and the porous membrane. This work is performed to investigate the effect of different factors, such as composition and thickness of membrane. The osmotic pellet has been successfully prepared by fluidized bed coating technology. The drug release behavior depended on the increase of CA ratio and thickness in porous membrane. The morphology of the osmotic pellet before and after the dissolution test were observed by SEM. In conclusion, we found that the drug release of osmotic pellet depended on the composition and coating thickness of porous membrane.
KSCE Journal of Civil and Environmental Engineering Research
/
v.33
no.1
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pp.81-92
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2013
The ultimate flexural strength of HSB I-girders, considering the effect of local bucking, was investigated through a series of nonlinear finite element analysis. The girders were selected such that the inelastic local flange buckling or the plastic yielding of compression flanges governs the flexural strength. Both homogeneous sections fabricated from HSB600 or HSB800 steel and hybrid sections with HSB800 flanges and SM570-TMC web were considered. In the FE analysis, the flanges and web were modeled using thin shell elements and initial imperfections and residual stresses were imposed on the FE model. An elasto-plastic strain hardening material was used for steels. After establishing the validity of present FE analysis by comparing FE results with test results published in the literature, the effects of initial imperfection and residual stress on the inelastic flange local buckling behavior were assessed. The ultimate flexural strengths of 60 I-girders with various compression flange slenderness were obtained by FE analysis and compared with those calculated from the KHBDC, AASHTO LRFD and Eurocode 3 provisions. Based on the comparison, the applicability of design equations in these specifications for the flexural strength of I-girder considering flange local buckling was evaluated.
Journal of the Earthquake Engineering Society of Korea
/
v.14
no.3
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pp.23-30
/
2010
Seismic qualification (SQ) is required prior to the installation of safety related electrical cabinets in nuclear power plants (NPPs). Modal identification of the electrical equipment is one of the most significant steps to perform SQ, and is an essential process to construct a realistic analytical model. In this study, shaking table tests were conducted to identify a variation of the dynamic characteristics of a seismic monitoring system cabinet installed in NPPs according to the excitation level. Modal identification of the cabinet has been performed by a frequency domain decomposition method. The results of this study show that the dynamic properties of the cabinet are nonlinearly varied according to the excitation level and the specimen behaves significantly in a nonlinear manner under safe shutdown earthquake motion in Korea. The main sources of the nonlinear behavior of the specimen have been judged by friction forces and geometrical nonlinearity rather than material nonlinearity. The nonlinear variation of the dynamic characteristics of the electrical cabinet might be accepted as an important fact that should be considered during the SQ of safety related equipment.
People store information not only in their Drain but also material things. Norman called it knowledge in the world. The general way to store the information is to paste labels. 4 burner gas range force user to make conceptual model between burner and switch to see labels. but those are cognitive stress. Norman suggested spatial analogies for natural mapping between display and control. However the way of his methods in spatial analogies was not compatible with kitchen atmosphere. To solve those problems 1 suggested color coding . This study hypothesized that the mapping between burner and switch is realized by color coding. To testy the hypothesis 1 compared A group using general gas range with B group using color coded gas range. The result showed difference between A and B in accuracy ( F (1, 38) = 17.892, p < 0.01) and response time ( F (1, 38) = 6.726 p < 0.05). The result of this test is to certify that color coding affect peoples by presenting the difference accuracy and response time. As result this study presents that color coding can be compatible the product having importance to certify in the design process.
The flexural behavior of HSB I-girder with a non-slender web attributed to inelastic lateral-torsional buckling under uniform bending was investigated using nonlinear finite element analysis of ABAQUS. The girder was assumed to have a compact or noncompact web in order to prevent premature bend-buckling of the web. The unbraced length of the girder was selected so that inelastic lateral-torsional buckling governs the ultimate flexural strength. The compression flange was also assumed to be either compact or noncompact to prevent local buckling of the elastic flange. Both homogeneous sections fabricated from HSB600 or HSB800 steel and hybrid sections with HSB800 flanges and SM570-TMC web were considered. In the FE analysis, the flanges and web of I-girder were modeled as thin shell elements. Initial imperfections and residual stresses were imposed on the FE model. An elasto-plastic strain hardening material was assumed for steel. After establishing the validity of the present FE analysis by comparing FE results with test results in existing literature, the effects of initial imperfection and residual stress on the inelastic lateral-torsional buckling behavior were analyzed. Finite element analysis results for 96 sections demonstrated that the current inelastic strength equations for the compression flange in AASHTO LTFD can be applied to predict the inelastic lateral torsional buckling strength of homogeneous and hybrid HSB I-girders with a non-slender web.
Seo, Hyung-Joon;Kim, Hyun-Rae;Jeong, Nam-Soo;Lee, In-Mo
Proceedings of the Korean Geotechical Society Conference
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2010.03a
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pp.523-534
/
2010
A hybrid system of soil-nailing and compression anchor is proposed in this paper; the system is composed of an anchor bar (installed at the tip) with two PC strands and a steel bar. After drilling a hole, installing proposed hybrid systems, and filling the hole with grouting material, prestress is applied to the anchor bar to restrict the deformation at the head and/or to prevent shallow slope failures. However, since the elongation rate of PC strand is much larger than that of steel bar, yield at the steel bar will occur much earlier than the PC strand. It means that the yield load of the hybrid system will be overestimated if we simply add yield loads of the two - anchor bar and PC strands. It might be needed to try to match the yielding time of the two materials by applying the prestress to the anchor bar. It means that the main purpose of applying prestress to the anchor bar should be two-fold: to restrict the deformation at the nail head; and more importantly, to maximize the design load of the hybrid system by utilizing load transfer mechanism that transfers the prestress applied at the tip to the head through anchor bar. In order to study the load transfer mechanism in a systematic way, in-situ pullout tests were performed with the following conditions: soil-nailing only; hybrid system with the variation of prestress stresses from 0kN to 196kN. It was found that the prestress applied to the anchor system will induce the compressive stress to the steel bar; it will result in decrease in the slope of load-displacement curve of the steel bar. Then, the elongation at which the steel bar will reach yield stress might become similar to that of PC strands. By taking advantage of prestress to match elongations at yield, the pullout design load of the hybrid system can be increased up to twice that of the soil-nailing system.
The Journal of Korean Academic Society of Nursing Education
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v.5
no.1
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pp.118-132
/
1999
To improve the effectiveness and efficiency of public health personnel training, we evaluated not only how appropriate the students felt the objectives, contents, methods and multimedia used in the train ing courses, but also how much the students accomplished the objectives and applied skill and knowledge to their own works. We selected 5 courses for the study : Tuberculosis control, Radiological technique, Public health information, Immunization, Mental health management courses used by Kirkpatrick's evaluation model. Reaction evaluation was carried out in final day by questionnaire. The results showed that all of them were very satisfied with educational input and curricula, learn Ing environment. Secondly, we measured the degree of learning achievement on pre and post training by questionaire of specific behavioral objectives. The degree of learning achievement was statistically higher just after training than pre training (paired t-test, p<0.01). Thirdly, evaluation of behavioral change to job was conducted to find out how much students applied skill and knowledge to their own job in 3 months after training by questionnaire. The results of behavioral change evaluation showed that 43.5% of the students who were performing job related with the training courses in 3 months after training applied the learned skill and knowledge to their own job quite well and 37.8% of them applied relatively well, therefore total 81.4% of them applied to their own job. And effectiveness of training for the above mentioned students showed that 41.9 % of them had improved or enforced their jobs after training, 35.5% of them had had no remarkable changes, and 15.7% had newly applied the learned skill and knowledge to their jobs. For evaluating the degree of usefulness of material predistribution in two weeks before training, we compared experimental groups with control groups. The results showed that general reactions are helpful but the degree of learning achievement is no discrepancy.
The purpose of the present study is first to refine the mathematical material models for moisture and temperature distributions in early-age concrete and then to incorporate those models into finite element procedure. The three dimensional finite element program developed in the present study can determine the degree of hydration, temperature and moisture distribution in hardening concrete. It is assumed that temperature and humidity fields are fully uncoupled and only the degree of hydration is coupled with two state variables. Mathematical formulation of degree of hydration Is based on the combination of three rate functions of reaction. The effect of moisture condition as well as temperature on the rate of reaction is considered in the degree of hydration model. In moisture transfer, diffusion coefficient is strongly dependent on the moisture content in pore system. Many existing models describe this phenomenon according to the composition of mixture, especially water to cement ratio, but do not consider the age dependency. Microstructure is changing with the hydration and thus transport coefficients at early ages are significantly higher because the pore structure in the cement matrix is more open. The moisture capacity and sink are derived from age-dependent desorption isotherm. Prediction of a moisture sink due to the hydration process, i.e. self-desiccation, is related to autogenous shrinkage, which may cause early-age cracking in high strength and high performance concrete. The realistic models and finite element program developed in this study provide fairly good results on the temperature and moisture distribution for early-age concrete and correlate very well with actual test data.
Kim, Hyung-Tae;Han, Jung-Suk;Yang, Jae-Ho;Lee, Jai-Bong;Kim, Sung-Hun
The Journal of Advanced Prosthodontics
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v.1
no.3
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pp.113-117
/
2009
STATEMENT OF PROBLEM. Recently Yttrium-stabilized tetragonal zirconia polycrystal (Y-TZP) has been introduced due to superior flexural strength and fracture toughness compared to other dental ceramic systems. Although zirconia has outstanding mechanical properties, the phenomenon of decrease in the life-time of zirconia resulted from degradation in flexural strength after low temperature aging has been reported. PURPOSE. The objective of this study was to investigate degradation of flexural strength of Y-TZP ceramics after various low temperature aging treatments and to evaluate the phase stability and micro-structural change after aging by using X-ray diffraction analysis and a scanning electron microscope (SEM). MATERIAL AND METHODS. Y-TZP blocks of Vita In-Ceram YZ (Vita Zahnfabrik, Bad $S\ddot{a}ckingen$, Germany) were prepared in 40 mm (length) $\times$ 4 mm (width) $\times$ 3 mm (height) samples. Specimens were artificially aged in distilled water by heat-treatment at a temperature of 75, 100, 125, 150, 175, 200, and $225^{\circ}C$ for 10 hours, in order to induce the phase transformation at the surface. To measure the mechanical property, the specimens were subjected to a four-point bending test using a universal testing machine (Instron model 3365; Instron, Canton, Mass, USA). In addition, X-ray diffraction analysis (DMAX 2500; Rigaku, Tokyo, Japan) and SEM (Hitachi s4700; Jeol Ltd, Tokyo, Japan) were performed to estimate the phase transformation. The statistical analysis was done using SAS 9.1.3 (SAS institute, USA). The flexural strength data of the experimental groups were analyzed by one-way analysis of variance and to detect statistically significant differences ($\alpha$= .05). RESULTS. The mean flexural strength of sintered Vita In-Ceram YZ without autoclaving was 798 MPa. When applied aging temperature at below $125^{\circ}C$ for 10 hours, the flexural strength of Vita In-Ceram YZ increased up to 1,161 MPa. However, at above $150^{\circ}C$, the flexural strength started to decrease. Although low temperature aging caused the tetragonal-to-monoclinic phase transformation related to temperature, the minimum flexural strength was above 700 MPa. CONCLUSION. The monoclinic phase started to appear after aging treatment above $100^{\circ}C$. With the higher aging temperature, the fraction of monoclinic phase increased. The ratio of monoclinic/tetragonal + monoclinic phase reached a plateau value, circa 75% above $175^{\circ}C$. The point of monoclinic concentration at which the flexural strength begins to decrease was between 12% and 54%.
A condition evaluation procedure for the pavement foundations using multi-load level Falling Weight Deflectometer(FWD) deflections is presented in this paper. A dynamic finite element program incorporating a stress-dependent material model, was used to generate the synthetic deflection database. Based on this synthetic database, the relationships between surface deflections and critical responses, such as stresses and strains in base and subgrade layers, have been established. FWD deflection data, Dynamic Cone Penetrometer(UP) data, and repeated load resilient modulus testing results used in developing this procedure were collected from the Long Term Pavement Performance (LTPP) and North Carolina Department of Transportation (NCDOT) database. Research effort focused on investigation of the effect of the FWD load level on the condition evaluation procedures. The results indicate that the proposed procedure can estimate the pavement foundation conditions. It is also found that structurally adjusted Base Damage Index (BDI) and Base Curvature Index (BCI) are good indicators for the prediction of stiffness characteristics of aggregate base and subgrade respectively. A FWD test with a load of 66.7 kN or less does not improve the accuracy of this procedure. Results from the study for the nonlinear behavior of a pavement foundations indicate that the deflection ratio obtained from multi-load level deflections can predict the type and quality of the pavement foundation materials.
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