• Journal of Biomedical Engineering Research
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• v.43 no.4
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• pp.193-198
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• 2022

Contrast enhanced magnetic resonance imaging using gadolinium-based contrast agent (GBCA) is a very useful in vivo technique to visualize the inner ear pathology including endolymphatic hydrops. Although systemic intravenous (IV) administration can visualize the perilymph space, the visualization was possible by indirect passage of contrast agent through blood-perilymph barrier. All animal experimental procedures were performed under anesthesia with 5% isoflurane. Lipopolysaccharide (LPS) was instilled into the left tympanic cavity through the tympanic membrane using a sterile 27gauge needle to induce hydrops model. Tucker-Davis Technologies system was used to measure Auditory Brainstem Responses (ABRs). For intracerebroven-tricular (ICV) administration, 25 µmol of GADOVIST (Bayer, Berlin, Germany) was used and diluted GADOVIST injection was 10 µl. MR imaging was acquired with a 9.4 Tesla MRI scanner. Transmit-receive volume coil with 40 mm inner diameter and 75 mm out diameter was used. ICV administration well demonstrated the strong enhancement along the cerebrospinal fluid (CSF) microcirculation pathway including CSF fluid in the subarachnoid space and CSF space of the inner ear structures. On the other hand, IV administration showed no contrast enhancement along the CSF microcirculation pathway and showed weak enhancement in the inner ear structures. In case of rat hydrops model, ICV administration showed that the reduced contrast enhancement in the perilymph space of the hydrops induced inner ear compared to the contrast enhancement in the perilymph space of the normal inner ear. New systemic ICV administration method provide contrast enhancement of GBCA in the inner ear through CSF microcirculation pathway.

• The Journal of the Acoustical Society of Korea
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• v.38 no.1
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• pp.51-55
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• 2019

This paper proposes a speech enhancement method utilizing the feature compensation gain for robust speech recognition performances in noisy environments. In this paper we propose a speech enhancement method utilizing the feature compensation gain which is obtained from the PCGMM (Parallel Combined Gaussian Mixture Model)-based feature compensation method employing variational model composition. The experimental results show that the proposed method significantly outperforms the conventional front-end algorithms and our previous research over various background noise types and SNR (Signal to Noise Ratio) conditions in mismatched ASR (Automatic Speech Recognition) system condition. The computation complexity is significantly reduced by employing the noise model selection technique with maintaining the speech recognition performance at a similar level.

• Journal of Industrial Technology
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• v.18
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• pp.439-442
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• 1998

In this paper, we firstly suggested C&D (Common mode and Differential mode) model for the representation of a stereophonic signal. Then a measure of stereophonic channel separability is defined as the ratio of differential mode energy to total energy in frequency domain. After that, a new channel separability enhancement scheme is proposed by the control of common mode rejection. Finally, some experimental results are presented in order to verify our scheme.

• Proceedings of the IEEK Conference
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• 2002.07b
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• pp.1149-1152
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• 2002

This paper presents the computerised simulation of colour-blindness and proposes a colour enhancement technique to aid colour-blinded people to use Visual Display Units (VDU). With the red-green colour perception difficulties, the ISH model has been used to develop the algorithms. The simulator and colour enhancement have been tested by colour-blind people and compared to existing simulators for colour-blindness.

• Journal of the Optical Society of Korea
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• v.15 no.1
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• pp.38-43
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• 2011

We have developed a simple model of a bright-room contrast ratio (BRCR) measurement system for plasma display panels (PDPs) adopting a contrast enhancement film (CEF) by using an illumination design tool. Only four model parameters were used, namely, total ambient illumination power delivered by fluorescent lamps, a panel scattering rate, illuminance of PDP white patterns, and the absorption coefficient of a color adjusting film. These parameters were determined by simple optical measurements and matching simulations. The proposed model was employed to predict the BRCR values of four different CEF samples, and the simulated ones were found to be in agreement with measured ones within about 10% relative-error.

• Journal of Digital Convergence
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• v.17 no.5
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• pp.385-390
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• 2019

This study aimed to identify the model fit of various versions of Performance Enhancement Attitude Scale (PEAS) developed for measuring quantitatively the attitude toward doping and to provide the information on Korean version of PEAS. One hundred and eighty elite athletic players participated in this study and they filled out 17 items PEAS under the supervision. And 17 items, 11 items, 9 items, 8 items and 6 items PEAS were analyzed by using confirmatory factor analysis. The result of this study showed that an 8 items PEAS was fit for Korean elite athletic players, and a 6 items PEAS was for adolescents, but insignificant. Therefore, further studies of the relationship between psychosocial factors and attitudes toward doping by using 8-items PEAS would provide precise and useful information for developing anti-doping strategy.

• Biomolecules & Therapeutics
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• v.19 no.1
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• pp.109-117
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• 2011

In this work, we have investigated the effect of polyoxyethylene alkyl ester nonionic surfactants on percutaneous permeation enhancement of a model drug, ketoprofen. We also investigated the mechanism involved in the enhancement using impedance and solubility measurement. Three groups of nonionic surfactants with different ethylene oxide content were studied. The permeation results showed that all surfactants enhanced the percutaneous absorption, irrespective of the molecular weight. The permeation results from PEG-45 monostearate (PEGMS45) were rather unexpected. Impedance and solubility results indicate that the mechanism involved in the enhancement of permeation by PEG-10 monooleate (PEGMO10) and PEGMS45 is rather different. The results from PEGMS45 suggest that it could be a potential candidate as a skin penetration enhancer with high molecular weight, which may poses less skin irritation and systemic side effect than the smaller surfactant molecules. Overall, this work provided some useful information on percutaneous transport enhancement and the mechanistic insights involved in skin permeation for these nonionic surfactants.

• Proceedings of the KSMRM Conference
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• 2002.11a
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• pp.130-130
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• 2002

Purpose： To evaluate the liver enhancement pattern of MR images obtained after administration of manganese phthalocyanine (MnPC), which is a newly developed macromolecular MR contrast agent, In experimentally implanted VX2 tumor of rabbits and compare with G4-DTPA and Mn-DPDP.

• Asian Journal of Atmospheric Environment
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• v.3 no.1
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• pp.1-8
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• 2009

Enhancement of aerosol optical thickness (AOT) and surface aerosol mass concentration in Korea for an active forest fire episode in Northeast Asia were estimated by Community Multi-scale Air Quality (CMAQ) model. MODIS/TERRA remote detects of fires in Northeast Asia for May 2003 gave a constraint for estimation of wildfire emissions with an NDVI distribution for recent five years. The simulated wildfire plumes and enhancement of AOT were evaluated and well resolved by comparing multiple satellite observations such as MODIS, TOMS, and others. Scatter plots of observed daily mean aerosol extinction coefficient versus $PM_{10}$ concentration in ground level in Korea showed distinctively different trends based on the ambient relative humidity.

• Proceedings of the IEEK Conference
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• 2003.11a
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• pp.57-60
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• 2003

In this paper, we propose a new excitation enhancement technique to improve the speech quality of low bit rate speech coders. The proposed technique is based on a harmonic model and it is employed only in the decoding process of speech coders without any additional bits. We develop the procedure of harmonic model parameters estimation and harmonic generation. and apply the technique to a current state of the art low bit rate speech coder, ITU-T G.729 Annex D. Also its performance is measured by using the ITU-T P.862 PESQ score and compared to those of the phase dispersion filter and the long-term postfilter applied to the decoded excitation. It is shown that the proposed excitation enhancement technique can improve the quality of decoded speech and provide better quality for male speech than other techniques.