• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.9
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• pp.226-235
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• 2017

This study was conducted to analyze new nurse satisfaction and factors of the new nurse orientation program and improve their effectiveness. The CIPP evaluation model was applied in this study to assess each module of the program systematically. The respondents of the survey were 452 of five affiliated hospitals of an educational foundation. The respondents' perceptions were 'Senior', 'Operating', 'Introduction', 'Unity', 'Usefulness', and 'Needs' (from highest to lowest). Multiple regression analysis indicated that 'Operating', 'Unity', 'Usefulness', and 'Hospital Introduction' had a significant impact on satisfaction. The results presented herein indicate that planners and operators should improve effectiveness of new nurse orientation programs by enhancing sense of unity, instilling confidence as a nurse, and increasing personal utilization of subjects.

• Food Science of Animal Resources
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• v.37 no.5
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• pp.682-689
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• 2017

The aim of this study was to investigate the digestibility of different Korean Hanwoo beef cuts using an in vitro digestion model, in vitro physicochemical upper gastrointestinal system (IPUGS). The four most commonly consumed cuts - tenderloin, sirloin, brisket and flank, and bottom round - were chosen for this study. Beef samples (75 g) were cooked and ingested into IPUGS, which was composed of mouth, esophagus, and stomach, thereby simulating the digestion conditions of humans. Digested samples were collected every 15 min for 4 h of simulation and their pH monitored. Samples were visualized under a scanning electron microscope (SEM) to examine changes in the smoothness of the surface after digestion. Analysis of the amino acid composition and molecular weight (MW) of peptides was performed using reverse-phase high performance liquid chromatography and sodium dodecyl sulfate polyacrylamide gel electrophoresis, respectively. Following proteolysis by the gastric pepsin, beef proteins were digested into peptides. The amount of peptides with higher MW decreased over the course of digestion. SEM results revealed that the surface of the digested samples became visibly smoother. Total indispensable and dispensable amino acids were the highest for the bottom round cut prior to digestion simulation. However, the total amount of indispensable amino acids were maximum for the tenderloin cut after digestion. These results may provide guidelines for the elderly population to choose easily digestible meat cuts and products to improve their nutritional and health status.

• Journal of the Society of Naval Architects of Korea
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• v.46 no.5
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• pp.488-497
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• 2009

The freak wave, also known as New-Year-Wave in the north Atlantic, is relatively large and spontaneous ocean surface wave that can sink even large ships and destroy maritime structures. To understand oceanic conditions that develop freak waves, we simulated and generated two versions of scale-downed waves (1:64 and 1:42) in a numerical wave tank and compared the results with the experiment in wave flume. Both of the breaking and non-breaking waves were generated in the simulation. The numerical simulation was implemented based on the finite volume method and a genetic optimization algorithm. Random values were assigned as the initial values for the parameter in the control function, which produced signals representing the motion of wave-maker. The same signal obtained from the optimization process was used for both of the simulation and the experiment. By varying the object function and restrictions of the simulation, a best profile of design wave was selected based on the characteristics, height and period of simulated waves. Results showed that the simulation and experiment with the scale of 1:42 agreed better with freak waves in the natural condition. The presented simulation method will contribute to saving the time and cost for conducting subsequent response analyses of motion under freak waves in the course of the model test for ship and maritime structure.

• Spatial Information Research
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• v.2 no.1
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• pp.3-14
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• 1994

The external diseconomy has been accelerated by the megaspatial structure of metropolis such as Seoul Capital Region(below SCR), Korea in which the more than 10 million populations inhabit. The main course for It could be elaborated by the overconcentration of the urban and regional function of various kinds. The study is performed to analyze quantitatively the status quo of the region as described above and proceed into forecasting the future population trend, the land use at location for the increment of regional population and to set the location of new towns in Seoul Capital Region System projected by the methods in computer algorithm of descriptive models such as the simple and multiple regress ion analysis models, the gravity model and the facility location on a plane model analysis. The goal and object ive of the metropolitan planning are to decentralize the regional growth management to the optimum degree, which will not hinder the economic growth of the region, but the result of the study is that we can not discourage the functional concentration of Seoul Capital Region and, we have to provide the region with the appropriate new towns.

• The KIPS Transactions:PartC
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• v.12C no.5 s.101
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• pp.757-764
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• 2005

With the increasing service Qualify and security in the Mobile Internet Diameter technology based on the AAAv6 is being used in the user authentication. But there are some Problems on the authentication Procedures of the Diameter in which the security falls down from a loaming service or Internet transmission course. We combine it with the cipher algorithm like EAP-MD5 and accomplish a user authentication processing. If we want to supply the user authentication with the mobility among domains by AAAv6-based Diameter, we need the efficient capacity allocation among AAA attendent, AAAv, AhAb, AAAh, HA servers in the AAAv6. Therefore in this paper, we propose to make the authentication capacity index to carry out user authentication ability by analyzing an EAP-MD5S server capacity model of AAAv6 authentication models for users with mobility among domains, and to find the optimized condition for the AAAv6 capacity by the index.

• The KIPS Transactions:PartA
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• v.13A no.1 s.98
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• pp.57-70
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• 2006

This paper describes a new effective algorithm to estimate routing congestion and to resolve highly congested regions for a given detailed placement. The major features of the proposed technique can be summarized as follows. Firstly, if there are congested regions due to some nets which pass through the regions it can determine which cells affect those congested spots seriously and moves some of them to resolve congestion effectively. Secondly, since the proposed technique uses the ripple movement technique to move cells it resolves congestion without sacrificing wire length. Thirdly, we use an efficient incremental data structure to trace the changes in congestion and wire length as cells move. Hence, selection of cells to move could be very accurate and fast in the course of iteration. Finally, although an MST net model is used to resolve congestion in this paper, proposed technique can be work with any net model. Particularly, if proposed technique can obtain routing information from a real router, congestion can be resolved more effectively. Experimental results show that the proposed technique can resolve congestion effectively and efficiently without sacrificing wire length.

• Ocean and Polar Research
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• v.33 no.4
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• pp.447-455
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• 2011

Using results from an earth system model, the distribution of partial pressure of $CO_2$ ($pCO_2$) in surface seawater over the East China Sea is investigated. In this area $pCO_2$ shows minimum along the edge of the continental break along the path of the Taiwan-Tsushima Current System. Apparently modelled chlorophyll is also great along the current but the maximum of the chlorophyll and the minimum of $pCO_2$ do not coincide suggesting that the primary production is not the main cause of the $pCO_2$ minimum. As we move toward the Yellow Sea from the Kuroshio area the temperature decreases so that the $pCO_2$ becomes smaller. If we move further toward the Yellow Sea beyond the Taiwan-Tsushima Current System, alkalinity starts to drop substantially to intensify $pCO_2$ while overcoming the effect of decreasing temperature and salinity. Thus $pCO_2$ minimum occurs along the Taiwan-Tsushima Current System. Of course, the primary production lower $pCO_2$ during spring when it is high but the effect is local. Near the Yangtze river mouth and northeastern corner of the Yellow Sea the fresh water input is large enough and dissolved inorganic carbon (DIC) becomes low enough so that $pCO_2$ becomes lower again.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.3 no.2
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• pp.1-29
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• 2008

The objective of this study is to develop new entrepreneurship education program and to enhance the program by applying new program. First, this paper examined domestic studies for preceding research on entrepreneurship education, and did foreign studies as theoretical background based on the examination. And this paper drew new models for entrepreneurship education program by analyzing education program from American and Japanese graduate school of entrepreneurship. The model of entrepreneurship education program was drawn by theoretical range, educational system and practical model, and presented reform measures by applying that on the Graduate School of Entrepreneurship. The range of entrepreneurship education program is defined from the moment when an entrepreneur decided to his entrepreneurship to initial growth stage, and should educate specific knowledge required to the development of companies and measures against potential problems on the way to growth it. An entrepreneurship training program should be organized curriculum by the growth stages of company.

• Journal of Microbiology and Biotechnology
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• v.21 no.2
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• pp.162-169
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• 2011

A dynamic model of lactic acid fermentation using Lactococcus lactis was constructed, and a metabolic flux analysis (MFA) and metabolic control analysis (MCA) were performed to reveal an intensive metabolic understanding of lactic acid bacteria (LAB). The parameter estimation was conducted with COPASI software to construct a more accurate metabolic model. The experimental data used in the parameter estimation were obtained from an LC-MS/MS analysis and time-course simulation study. The MFA results were a reasonable explanation of the experimental data. Through the parameter estimation, the metabolic system of lactic acid bacteria can be thoroughly understood through comparisons with the original parameters. The coefficients derived from the MCA indicated that the reaction rate of L-lactate dehydrogenase was activated by fructose 1,6-bisphosphate and pyruvate, and pyruvate appeared to be a stronger activator of L-lactate dehydrogenase than fructose 1,6-bisphosphate. Additionally, pyruvate acted as an inhibitor to pyruvate kinase and the phosphotransferase system. Glucose 6-phosphate and phosphoenolpyruvate showed activation effects on pyruvate kinase. Hexose transporter was the strongest effector on the flux through L-lactate dehydrogenase. The concentration control coefficient (CCC) showed similar results to the flux control coefficient (FCC).

• The Korean Journal of Physiology and Pharmacology
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• v.1 no.1
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• pp.35-43
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• 1997

Cis-dichlorodiammine platin${\mu}M$II (Cisplatin), an effective chemotherapeutic agent, induces acute renal failure by unknown mechanisms. To investigate direct toxic effects of cisplatin on the renal proximal tubular transport system, LLC-$PK_1$ cell line was selected as a cell model and the sugar transport activity was evaluated during a course of cisplatin treatment. Cells grown to confluence were treated with cisplatin for 60 min, washed, and then incubated for up to 5 days. At appropriate intervals, cells were tested for sugar transport activity using ${\alpha}-methyl-D-[^{14}C]glucopyranoside$ (AMG) as a model substrate. In cells treated with 100 ${\mu}M$ cisplatin, the AMG uptake was progressively impaired after 3 days. The viability of cells was not substantially changed with cisplatin of less than 100 ${\mu}M$, but it decreased markedly with 150 and 200 ${\mu}M$. In cisplatin-treated cells, the $Na^+$ -dependent AMG uptake was drastically inhibited with no change in the $Na^+$ -independent uptake. Kinetic analysis indicated that Vmax was suppressed, but Km was not altered. The $Na^+$ -dependent phlorizin binding was also decreased in cisplatin-treated cells. However, the AMG efflux from preloaded cells was not apparently retarded by cisplatin treatment. These data indicate that the cisplatin treatment impairs $Na^+$ -hexose cotransporters in LLC-$PK_1$ cells and suggest strongly that defects in transporter function at the luminal plasma membrane of the proximal tubular cells constitute an important pathogenic mechanism of cisplatin nephrotoxicity.